• Study Resource
  • Explore
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
Use of Subcutaneous IgG in Patients on Concomitant
Use of Subcutaneous IgG in Patients on Concomitant

... – ie, pulmonary embolism, congenital heart disease, chronic atrial fibrillation/flutter ...
Codeine Intoxication in the Neonate
Codeine Intoxication in the Neonate

... The primary metabolic pathway of glucuronidation is low at birth, and the adult level is not reached until 3 years of age.13 Newborns have been noted to have a reduced ability to conjugate drugs with glucuronic acid and glycine but an increased capacity to conjugate them with sulfate.15 Therefore, c ...
pharmacokinetics-25
pharmacokinetics-25

... concentration to fall 50% during the elimination phase (beta phase) • Context-sensitive half time: Measures half time after an infusion is stopped. • Elimination half-life: the time needed eliminate 50% of the drug from the body. • Effect-site equilibrium: delay between IV administration and desired ...
Sulfin® Tablets 100 mg
Sulfin® Tablets 100 mg

... animals have yielded inconclusive results. Up to the present time, however, there have been no reported cases of human congenital malformation proved to be due to the use of the drug. It is suggested that Sulfin be used with caution in pregnant women, weighing the potential risks against the possibl ...
Interactions, Chronic Effects & Nonspecific Factors
Interactions, Chronic Effects & Nonspecific Factors

...  half-life important  Time course different  Subjective effects  blood concentrtions ~ ...
Ch.5
Ch.5

... 7)Pleiotropic-refers to the appearance of several apparently unrelated phenotypic effects caused by a single gene a. Marfan syndrome -autosomal dominant gene produces a defect in an elastic connective tissue. b.Porphyria-inherited as a dominant trait that leads to intermittent attacks of pain and de ...
Medication Labels
Medication Labels

... • Medication labels vary in appearance from manufacturer to manufacturer • The Federal Drug Administration (FDA) does regulate what information must be included on the label but not the format in which the information is displayed ...
An Efficient Reward System for Pharmaceutical Innovation
An Efficient Reward System for Pharmaceutical Innovation

... • Vertex needs the revenues to support its on-going program of research into drugs for CF and other diseases. – This puts the normal way of funding research on its head. Firms don’t have a right to get a boatload of cash just because they are going to do research. They get paid money because they de ...
3 Annual Drug Abuse Symposium rd
3 Annual Drug Abuse Symposium rd

... all the capsules up, separating the colors. My boss figured out (through trial and error I guess) that the white ones were the 'non-drowsy' part, (i.e. a stimulant!). We'd then line them up and sniff them through an empty screw driver handle". ...
Drugs and hormones (they often go hand in hand…..)
Drugs and hormones (they often go hand in hand…..)

...  Plot response as a function of dose  One drink and I am relaxed  4 drinks and I am tipsy  8 drinks and I am ‘relaxed’ again.  This shape is very common in DRCs ...
Table 13. Drug Metabolism Basics Bioavailability and Half
Table 13. Drug Metabolism Basics Bioavailability and Half

... Lipophilic = distributes through membranes with preference for adipose tissue and muscle (greater volume of distribution) ...
R o OCT 1 P12
R o OCT 1 P12

... (section 403(r)(6) of the Federal Food, Drug, and Cosmetic Act (the Act)) and Title 21 of the Code of Federal Regulations (21 CFR) Part 101 .93(a') it did not meet the requirements for that submission. Accordingly, a failure to submit a notice in compliance with those requirement MAY (emphasis added ...
Presentation
Presentation

... • Appropriateness – drugs of limited value – agreement with clinical practice guidelines • ASA after AMI • ACE-s in CHF • Statins in secondary prevention ...
Definitions
Definitions

... A fertilised egg that has the potential to develop into a foetus ...
CNS Adverse Events: What can we do about them
CNS Adverse Events: What can we do about them

... • Capture and reporting of adverse effects in clinical trials, for the most part, has become standard • We have processed their collection, categorization, and reporting • They are integral to any risk/benefit assessment during drug development as well as post-marketing assessment • We endeavor to u ...
Aithal, 1999
Aithal, 1999

... • In the clinic control, 311.1 patient years had 6 minor, 5 serious and 2 life threatening episodes in 11 patients • Significantly higher number of serious and life threatening episodes in low dose group ...
Learning Target Unit #5 AP Biology Genetic Basis of Life Chapters
Learning Target Unit #5 AP Biology Genetic Basis of Life Chapters

... I can explain how the change in the genetic makeup of a population over time is evolution. I can explain how heritable information provides for continuity of life. I can explain why the processing of genetic information is imperfect and is a source of genetic variation. I can describe how naturally ...
Dr. Carl Davis presentation
Dr. Carl Davis presentation

... by direct elimination (biliary and/or renal) or by enzyme-mediated metabolism – Generally this is a detoxication process that prevents accumulation of bioactive compounds in the body • can also produce reactive metabolites and toxicity • The contribution of these processes to total clearance of a dr ...
Illegal Drugs - cloudfront.net
Illegal Drugs - cloudfront.net

... 2. Marijuana: “Weed”- a natural drug with the active ingredient THC. • Used for pain relief, as an appetite stimulant, and euphoria (both legally and illegally) • Hashish: resin from the plant which is solid an smoked in a pipe or boiled and mixed with tobacco ...
15_Gas Exchange and Oxygenation_Upper Respiratory System
15_Gas Exchange and Oxygenation_Upper Respiratory System

Antibiotic
Antibiotic

... The main reason for the development of drug-resistant microbes is the inappropriate use of antibiotics. The more an antibiotic is used the faster drug resistance develops. Improper prescribing by health care workers and patients not finishing the course of therapy contribute. No excuse for casual or ...
(CNS) Stimulant.
(CNS) Stimulant.

... the coca plant native to South America ž  It produces short-term euphoria, energy, and talkativeness in addition to potentially dangerous physical effects like raising heart rate and blood pressure. ž  High is quick but doesn’t last long, so people use over and over in short periods of time ...
Introduction to Psychology
Introduction to Psychology

...  physiological need for a drug  marked by unpleasant withdrawal symptoms ...
PROCEDURE
PROCEDURE

... TASC-Arizona: Codeine, Morphine, Hydrocodone, Hydromorphone, Oxycodone, Oxymorphone and Heroin (6-MAM). Quest Diagnostics: Codeine, Morphine, Hydrocodone and Hydromorphone. NOTE: Oxycodone or Heroin require additional request. Expectations: The assay will detect opiates and their synthetic counterpa ...
Chapter 4: Modification of Mendelian Ratios Incomplete or Partial
Chapter 4: Modification of Mendelian Ratios Incomplete or Partial

... Chapter 4: Modification of Mendelian Ratios Allele *Wild-type allele *Mutant allele Conventional symbols for alleles: recessive allele- initial letter of the name of the recessive trait, lowercased and italicized dominant allele- same letter in uppercase Genetic nomenclature is extremely diverse! ...
< 1 ... 1181 1182 1183 1184 1185 1186 1187 1188 1189 ... 1254 >

Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
  • studyres.com © 2025
  • DMCA
  • Privacy
  • Terms
  • Report