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shands - UF Health Professionals
shands - UF Health Professionals

... an effect on serum lipids and other metabolic effects (eg, less effect on prolactin and blood glucose). However, there are limited comparative data published on the efficacy and safety of ziprasidone compared with other atypical agents. The limited data that are available are poor quality. The weigh ...
Drug Action Measurement
Drug Action Measurement

... More potent than D2 ...
Jay Williams, PhD`s Blog
Jay Williams, PhD`s Blog

... metabolic syndrome...a dangerous condition currently affecting 35% of Americans. At the 2014 annual meeting of the American College of Gastroenterologists, Dr. James Ehrlich presented data proving that 38% BPF significantly improved liver structure and function in patients with both metabolic syndro ...
Adverse Drug Reactions - The Coagulation Information Source
Adverse Drug Reactions - The Coagulation Information Source

... • Not related to drug’s actions • Related to immune response (allergy) ...
ha-loe-per-i - DavisPlus
ha-loe-per-i - DavisPlus

... which may appear within 6 hr of 1st dose and may be difficult to distinguish from psychotic agitation. Benztropine may be used to differentiate agitation from akathisia. Observe closely for extrapyramidal side effects (parkinsonian— difficulty speaking or swallowing, loss of balance control, pill ro ...
教案- Pharmacologic Management of Parkinsonism
教案- Pharmacologic Management of Parkinsonism

... barrier and if given into the peripheral circulation has no therapeutic effect in parkinsonism. However, (–)-3-(3,4-dihydroxyphenyl)-L-alanine (levodopa), the immediate metabolic precursor of dopamine, does enter the brain (via an L-amino acid transporter, LAT), where it is decarboxylated to dopamin ...
VHA_Genetics_Core _Little_Rock
VHA_Genetics_Core _Little_Rock

...  Large scale cohorts (SMI, PTSD, ALS)  Million Veteran Program (non-disease based) ...
Moisture Transfer between Formulation Components in a
Moisture Transfer between Formulation Components in a

... Disease induction in animal models (e.g. cancer) ...
Chapter 2 Law and Ethics of Pharmacy Teresa Hopper
Chapter 2 Law and Ethics of Pharmacy Teresa Hopper

... drugs, their uses, adverse reactions, and other pertinent information • Formularies are lists of approved uses of medications ...
PATIENT`S NAME: MEDICATION: famotidine (Brand names include
PATIENT`S NAME: MEDICATION: famotidine (Brand names include

... reactions. Notify your prescriber if any of these symptoms become bothersome. INTERACTIONS Although famotidine may not interact with others drugs, you should avoid alcohol and caffeine when taking it because they may increase gastric irritation. Don’t use herbal remedies without consulting your pres ...
uses_drugtargets.pdf
uses_drugtargets.pdf

... on drugs in 2001, and the number of visits to doctors involving drug therapy in 2000 was 545 million. The development of new, more effective drugs is a very active and potentially profitable field of research. Drugs typically work on specific chemicals or targets in the body. Many targets are either ...
Types/Sources of Genetic Data Mendelian Genetics
Types/Sources of Genetic Data Mendelian Genetics

... ­ “balance hypothesis” ² abundant genetic variation is maintained by some form of balancing selection ² e.g., heterozygote advantage or frequency dependent selection ...
(5-Hydroxytryptamine 3).
(5-Hydroxytryptamine 3).

... o Transient - lasting only for a short time; impermanent o What does elevation of liver enzymes mean - Any agent that damages the liver may cause elevation of the liver enzymes ...
What is “Krokodil”? - Maryland Poison Center
What is “Krokodil”? - Maryland Poison Center

... cases in the United States. The first two possible cases occurred in the Phoenix area in September 2013, and involved soft tissue injury consistent with what has been seen with Krokodil. Other similar cases quickly surfaced in Illinois, Utah and elsewhere, with patients developing tissue damage at i ...
Modern Treatment of Disease and the Challenge of Medication
Modern Treatment of Disease and the Challenge of Medication

... Thorazine, and others • Side effects are problematic: metabolic, parkinsonlike symptoms, drooling, somnolence, excitement, ...
Baron Shopsin by Andrea Tone
Baron Shopsin by Andrea Tone

... AT: I am struck by your comment about Wellbutrin being a very potent antidepressant. Many of the SSRI's are now being marketed for both depression and anxiety, and one of the things about Wellbutrin is that it supposedly exacerbates anxiety. BS: The aim of psychopharmacology should be to come up wit ...
Patient Care Process Assessment: Information Gathering
Patient Care Process Assessment: Information Gathering

... 1. Reason for the encounter / main complaint 2. Patient Demographics 3. Patient’s understanding, expectations & concerns 4. Current medications & conditions 5. Past medications & conditions (allergies, immunizations, what worked well, what did not and why) 6. Medication-related review of systems ...
Medication Labels
Medication Labels

DSMB recommends continuing the PLEO-CMT study
DSMB recommends continuing the PLEO-CMT study

... About CMT1A Charcot-Marie-Tooth (CMT) disease encompasses a heterogeneous group of inherited, progressive, chronic peripheral neuropathies. CMT type 1A (CMT1A), the most common type of CMT, is an orphan disease affecting at least 125,000 people in Europe and the U.S. The genetic mutation responsible ...
Getting a gripon drug side
Getting a gripon drug side

... organs presented a severe risk to survival. The patient’s brother was then evaluated as a potential living-related liver donor and his BSEP gene was sequenced. Luckily, the brother had inherited the healthy allele from both the mother and the father (a 1:4 chance) and was thus found to be suitable a ...
Gene Expression - Valhalla High School
Gene Expression - Valhalla High School

... Dr.Timmel ...
Common Childhood Illnesses: Considerations for - Power
Common Childhood Illnesses: Considerations for - Power

... C. When single-ingredient products are administered D. When children are older than 6 years of age Correct answer: B The risk of medication errors in young children is increased when a medication is used for sedation, when a medication is used in a daycare setting, when two medications with the same ...
When to Spare Some Pharmaceutical Care
When to Spare Some Pharmaceutical Care

... Recognize the incidence of polypharmacy Identify The Risk Associated with Polypharmacy Classify Agents that Pose the Most Risk to the Elderly Population Develop Strategies to Decrease Polypharmacy ...
avoid these drugs for the elderly
avoid these drugs for the elderly

... • On 10/5/09, the following drugs will have an age restriction for all new prescriptions and will be covered for age < 65 years only. • Members > 65 years of age with prescription claims history for the drug prior to 10/5/09 will be grandfathered for a limited time period until 12/31/09 to allow tim ...
FENTANYL Lollipop Study
FENTANYL Lollipop Study

... • Fully orientated and able to understand instructions on how to use device.   • Consents to be included in study both at time of inclusion and reaffirms consent  >24 hours post admission, when pain free and not under the influence of potent  analgesic or hypnotic agents.   ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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