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Medications - Delaware Association of Home and Community Care
Medications - Delaware Association of Home and Community Care

... • Body systems within one individual can age at different rates. • Each person increasingly becomes “one of a kind” over time. ...
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... How are Prescription Drugs abused? • It depends—some people take other people’s drugs for their intended purposes (to relieve pain, to stay awake, or to fall asleep). • Others take them to get high, often at larger doses than prescribed, or by a different route of administration. ...
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... The undersigned certifies that, to their best knowledge and belief, this Citizen Petition includes all information and views upon which the Petition relies, and includes representative data and information known to Petitioner which are unfavorable to the Petition . Respectfully submitted, ...
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... for the great changes in organisms that have transpired over time and the differences that have developed among species as they diverged from theif common ancestors all originated as genetic variants within species.” Review of vocabulary: _Penotype__-refers to a characteristic in an individual organ ...
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... Outpatient Pharmacy (Main Pharmacy) at Ground Floor. Currently patients obtain their drug supply from First Floor Satellite Pharmacy, but due to substantial increase in number of prescriptions, this action is deemed necessary to reduce patient’s waiting time. We hope that this information can be dis ...


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... Access to genetic and phenotypic information from specific subpopulations is becoming very attractive to drug developers. The Importance of New Genetic Bioresources The use of genetics-based drug discovery strategies has represented a very successful approach for the development of therapeutics. In ...
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... clinical development strategy for the TM601 tumor-targeting platform,” said Michael Egan, President and Chief Executive Officer of TransMolecular. “We are pleased that this designation represents another step toward our goal of delivering a new therapy to patients battling this difficult disease. Fu ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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