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1. Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis
1. Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis

... suspected offending agent(s) or to related compounds. For example, cross-reactions have been reported between different anticonvulsant agents or non- steroidal anti-inflammatory drugs, such as the oxicams. Drugs of the same pharmacologic class can be used provided they are structurally different fro ...
GENES CHROMOSOMES FEATURES chromosomes:  code for features of organisms
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... ...
Slide 1
Slide 1

... • Memory loss in at least 1/3 of patients, sometimes long term • Cardiovascular change (e.g. irregular heartbeat) • Headaches • EEG studies have shown general slowing of brain patterns following ECT, which takes weeks to return to normal • Dept of Health found 30% ECT patients suffered fear and anxi ...
Effects of Illicit Drugs on the Heart and Brain
Effects of Illicit Drugs on the Heart and Brain

... Synthetic marijuana (often known as “K2” or “Spice”) and bath salts products are often sold in legal retail outlets as “herbal incense” and “plant food,” respectively, and labeled “not for human consumption” to mask their intended purpose and avoid FDA regulatory oversight of the manufacturing proce ...
In Search of Alcoholism Genes, Part I
In Search of Alcoholism Genes, Part I

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Pharmacology and the Nursing Process
Pharmacology and the Nursing Process

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Guidelines for the use of zuclopenthixol acetate
Guidelines for the use of zuclopenthixol acetate

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... • Fraction of administered dose that reaches the systemic circulation in the unchanged form and the target tissue • After intravenous administration, the drug is completely bioavailable (F=1) • For oral administration, incomplete bioavailability may be due to: ...
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Administration and Preparations available Drug Interactions Patient

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SiGMA: Prescribing antipsychotic drugs in schizophrenia
SiGMA: Prescribing antipsychotic drugs in schizophrenia

... The SiGMA algorithm and corresponding guidelines for the antipsychotic treatment of schizophrenia and related disorders were developed out of the finding that across the twelve provider units of Greater Manchester, the use of, and expenditure on, clozapine and the other new atypical antipsychotic dr ...
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... 7.2.d Students know plant and animal cells contain many thousands of different genes and typically have two copies of every gene. The two copies (or alleles) of the gene may or may not be identical, and one may be dominant in determining the phenotype while the other is recessive. ...
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amantadine - DavisPlus
amantadine - DavisPlus

... or candy may decrease dry mouth. Consult health care professional if dry mouth persists for ⬎2 wk. Advise patient to confer with health care professional before taking OTC medications, especially cold remedies, or drinking alcoholic beverages. Instruct patient to notify health care professional if c ...
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prescribing - Centre for Medicines Optimisation
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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