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Genetics Notes C
Genetics Notes C

Chapter 11: Medication Administration
Chapter 11: Medication Administration

... • You must consider two factors when choosing an IV catheter: gauge and length. The larger the gauge (the smaller the number), and the shorter the length, the more fluid that can be infused through it. Over-the-needle catheters are the most commonly used IV catheters in the prehospital setting. • Ca ...
Steroids, Aspergillus and antifungals
Steroids, Aspergillus and antifungals

Botulinum Toxin - Warwickshire Urology
Botulinum Toxin - Warwickshire Urology

... be used on a named patient basis. It is NICE approved for use in selected patients before being considered for more radical treatment i.e. clam cystoplasty. It has been approved by the Drugs and Therapeutic Committee locally. Criteria to be fulfilled before patient has Botulinum Toxin A a. The patie ...
Mr.  Steve Lee V.  P. Technical  Affairs
Mr. Steve Lee V. P. Technical Affairs

... 21 U.S.C. 343(r)(6) makes clear that a statement included in labeling under the authority of that section may not claim to diagnose, mitigate, treat, cure, or prevent a specific disease or class of diseases. The statements that you are making for this product suggest that it is intended to treat, pr ...
pharmacology review
pharmacology review

... molecules to pass through shunts without exposure to enzyme system, resulting in lower metabolism; cardiac failure influences elimination (hepatically and renally); causes diminished hepatic BF, alters regional BF, decreases renal BF, and alters tissue clearance Postoperative period: absorption from ...
A Proactive Approach to Specialty Management
A Proactive Approach to Specialty Management

... cancer, rheumatoid arthritis, HIV, and multiple sclerosis. While they are usually associated with increased patient quality of life, better disease management, and in some cases, cures, specialty drugs are expensive therapies that are catching the attention of key stakeholders, such as payers and pr ...
The MS Disease- Modifying Drugs Gener al inforMaTion
The MS Disease- Modifying Drugs Gener al inforMaTion

... acute myelogenous leukemia (AML), a type of cancer, has been reported in MS patients and cancer patients treated with Novantrone. AML can be fatal. ...
PowerPoint Chapter 12
PowerPoint Chapter 12

... • Most antitubercular drugs are bacteriostatic, (some bacterialcidal) • INH (Isoniazid) only drug recommended for prophylactic therapy. • What is the current duration of prophylactic treatment? ...
Whiplash Rove Beetle Dermatitis Among Students at University
Whiplash Rove Beetle Dermatitis Among Students at University

... identification of drugs that were used reveals that isoniazid was used in 44.31% of patients; rifampicin in 43.41%, pyrazinamide in 11.07% and ethambutol in 1.19% of patients. Anti-tuberculosis drugs were used in single medication in 0%; two-drug combination in 56.1%; and three-drug combination in 4 ...
(off-label) and without (unlicensed)
(off-label) and without (unlicensed)

... evidence the more difficult it is to justify its prescription. The PIL will not contain information about unlicensed indications. Thus, it is important that prescribers (or those authorizing treatment on their behalf) provide sufficient information to patients about the drug’s expected benefits and ...
exam model-ii
exam model-ii

... 2. Which one of the following statements concerning the parasympathetic nervous system is correct? A. The parasympathetic system uses noradrenaline as a neurotransmitter. B. The parasympathetic system emerges from the cranial and sacral nerves. C. Parasympathetic activity increases in stress (fight- ...
Drug Distribution systems in Hospitals
Drug Distribution systems in Hospitals

... (1) Patients receive improved pharmaceutical service 24 hours a day and are charged for only those doses, which are administered to them. (2) All doses of medication required at the nursing station are prepared by the pharmacy thus allowing the nurse more time for direct patient care. (3) Allow the ...
Binomial Distribution (annotated)
Binomial Distribution (annotated)

... Binomial Distribution and Random Variable A binomial random variable X is defined to the number of “successes” in n independent trials where the P(success) = p is constant. In the definition above notice the following conditions need to be satisfied for a binomial experiment: 1. There is a fixed num ...
CARDIAC- PSYCHOTROPIC DRUG INTERVENTIONS Drug
CARDIAC- PSYCHOTROPIC DRUG INTERVENTIONS Drug

... have occurred in patients with HMG-CoA reductase inhibitors alone, or in conjunction with nefazodone. //Action: Monitor for signs and symptoms of myopathy and rhabdomyolysis. Monitor creatine kinase (CK) levels. Carvedilol/Fluoxetine: (2): Fluoxetine increases the plasma concentrations of carvedilol ...
La Jolla Pharmaceutical Company (Nasdaq: LJPC) said that
La Jolla Pharmaceutical Company (Nasdaq: LJPC) said that

... BCOR) and La Jolla Pharmaceutical Company (Nasdaq: LJPC) announced today at the JP Morgan H & Q Healthcare Conference the first use of a surface plasmon resonance (SPR)based pharmacoproteomics assay in clinical development. The assay will be used to identify the target patient population for the Pha ...
Therefore, need to be used during pregnancy
Therefore, need to be used during pregnancy

des St
des St

... 399 patients aged 12 to 24 months has been demonstrated in a placebo-controlled 18month trial, in which the average dose was 0.25 mg/kg bid, corresponding to a range of 4 to 11 mg/day. The safety of ZYRTEC syrup has been demonstrated in 42 patients aged 6 to 11 months in a placebo-controlled 7-day t ...
Pediatric Poisoning
Pediatric Poisoning

... – Activated charcoal:  May Prevent /delay absorption of some drugs/toxins  Almost always indicated Only in the 1st hour !!!! – Naso/oro-gastric Lavage – Bowel Irrigation:  Used in recent ingestions  In awake alert patient  By using 500 cc NS Children / 2000cc adults  Orally / Nasogastric tube ...
Dacogen® (Decitabine) for Injection Phase III AML Results Announced
Dacogen® (Decitabine) for Injection Phase III AML Results Announced

... the need for early institution of growth factors and/or antimicrobial agents for the prevention or treatment of infections in patients with MDS. Dacogen may cause fetal harm when administered to a pregnant woman. Women of childbearing potential should be advised to avoid becoming pregnant while rece ...
Factors influencing drug effects in older adults
Factors influencing drug effects in older adults

... 2. At a new visit, her blood pressure was found to be 170/90. This was recorded on two other occasions during the following week 3. She had recently been complaining of nasal congestion. So she had bought an OTC preparation for relief of these symptoms. 4. The preparation contained phenylpropanolami ...
from Prescription Drugs to Street Heroin, Dr. Abraham Popoola
from Prescription Drugs to Street Heroin, Dr. Abraham Popoola

... Breathe for the patient while waiting to get naloxone Give 0.4mg-2mg IM Naloxone Continue to breathe for the patient (one breath every 5 second and wait for up to 3mins for response) If no response in 3mins, repeat another injection and breathe for the patient for 3mins) This can be repeated up to m ...
Answers to revision questions
Answers to revision questions

... c) The child they wish to conceive is being used as a means to an end. It goes against the autonomy of this child as a person in its own right. d) This decision does not ensure justice, couples who can afford to will be able to pay for several rounds of IVF and greatly increase their chance of havin ...
Read the updated advice - Association of Paediatric Anaesthetists
Read the updated advice - Association of Paediatric Anaesthetists

... paracetamol  and  a  NSAID  are  inadequate.  This  can  represent  a  problem  in  that  dosing  after   discharge  may  not  be  followed  by  parents  or  carers.  Inadequate  dosing  may  result  in   avoidable  pain  while  excess ...
BIO101 Objectives Unit 2 1 Chapter 14 1. Describe the work of
BIO101 Objectives Unit 2 1 Chapter 14 1. Describe the work of

... View achondroplasia as an example of a dominantly inherited trait List examples of disorders that have a multifactorial component (genetics + environment) ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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