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Pharmacotherapy - Geriatrics Care Online
Pharmacotherapy - Geriatrics Care Online

... • Ask patient to bring in all medications (prescribed, OTC, supplements) for review • Ask about side effects and screen for drug and disease interactions • Look for duplicate therapies or pharmacologic effect ...
Drug Regulation and Control
Drug Regulation and Control

... distributor, drug formulation, size and type of packaging.! • FDA requests, but does not require, that the NDC appear on all drug labels. ...
Genetic Variation
Genetic Variation

... for natural selections – Example: The peppered moth color variation was naturally selected according to the color of the forest that it lives within. – If the phenotype white is preferred in a light forest then the black moths find it hard to survive to reproduce thus leaving the white moths to repr ...
Doxorubicin liposome
Doxorubicin liposome

... reduction is required in the setting of liver dysfunction. Infusions of liposomal doxorubicin should be given at an initial rate of 1 mg/min over a period of at least 30 minutes to avoid the risk of infusion-associated reactions. This reaction is thought to be related to the lipid component of lipos ...
CHAPTER 15 Quiz Yourself 1. The choice of drug therapy for
CHAPTER 15 Quiz Yourself 1. The choice of drug therapy for

... 3. Hydantoin drugs, benzodiazepine drugs, succinimide drugs, barbiturate drugs. 4. [Only need to name five.] Topamax is used to treat tonic-clonic seizures and simple and complex partial seizures, migraine headaches, bipolar disorder, alcohol and cocaine dependence, bulimia, and used to help lose we ...
Ocular Pharmacology - Faculty of Medical and Health Sciences
Ocular Pharmacology - Faculty of Medical and Health Sciences

... internal solid phase (drug) is dispersed throughout the external liquid phase (buffer) steroids (Pred Forte, Maxidex, Flucon) reduced drainage as particles remain in lower lid prolonged residence time  higher drug bioavailability high cost, sterilisation may cause physical instability ...
Genetics of Childhood Diseases
Genetics of Childhood Diseases

... clubbed foot, hip dislocation. It occurs late in the pregnancy and conveys a good prognosis since organ is normal in structure. Syndrome – this is a consistent pattern of abnormalities for a specific underlying cause e.g. Down’s syndrome. It is caused by chromosome abnormalities. Sequence – this is ...
06. ANTHELMINTIC DRUGS 2006(nov 25).
06. ANTHELMINTIC DRUGS 2006(nov 25).

...  Absorbed drug is 90 % protein bound  Converted to inactive metabolites .  Half- life of 2-6 hours  Excreted mostly in urine . ...
Pharmacy Intro
Pharmacy Intro

... Opioids and other drugs we use on palliative care ...
Chapter 7 Drugs for Pain and Sleep Problems Barriers to Good Pain
Chapter 7 Drugs for Pain and Sleep Problems Barriers to Good Pain

... Does not improve and may even worsen Intensity may increase over time Deeper pain Described as burning, aching, throbbing ...
Human karyotype preparation
Human karyotype preparation

... Polar body of eggs examined for presence of defective gene - if present in polar body, then the gene in the egg is normal and egg is used. If the polar body chromosomes are normal, the egg carries the defective gene and is discarded. Eggs that pass screening can be used for IVF to eliminate transmis ...
M10e Mod 10 Drugs and Consciousness
M10e Mod 10 Drugs and Consciousness

...  impaired memory and slowed thinking ...
Anitmicrobial Agents General Considerations 4 Pharmacology Prof
Anitmicrobial Agents General Considerations 4 Pharmacology Prof

... Site of Infection Will the antibiotic get there? • Choice of Agent, Dose, and Route important (ADR) – Oral vs. IV administration • Bioavailability, severity of infection, site of infection, function of GI tract ...
Potent Direct Vasodilators
Potent Direct Vasodilators

... Fall in total peripheral resistance and arterial pressure results in reflex cardio stimulation with frequent tachycardia and palpitation unless cardiac reflex responses are offset by concomitant beta-blockade. Sodium retention requires co-treatment with diuretic in most. A loop diuretic, sometimes a ...
Anticoagulation choices in non valvular AF
Anticoagulation choices in non valvular AF

... o Time in therapeutic range (TTR) less than 65% within the past 6 months excluding measurements taken during the first six weeks. (TTR cannot currently be calculated by the Anticoagulant Clinic so they will continue to use INR’s under 50% in range) ...
Antimicrobial Agents (General considerations 4)
Antimicrobial Agents (General considerations 4)

... Site of Infection Will the antibiotic get there? • Choice of Agent, Dose, and Route important (ADR) – Oral vs. IV administration • Bioavailability, severity of infection, site of infection, function of GI tract ...
Complementation
Complementation

... - Nonrandom distribution ...
Typical antipsychotic depots shared care guideline
Typical antipsychotic depots shared care guideline

Fatality Involving the Ingestion of Phenazepam and Poppy Seed Tea Case Report
Fatality Involving the Ingestion of Phenazepam and Poppy Seed Tea Case Report

... factor to be considered was the assessment of the decedent’s natural disease and associated respiratory insufficiency, which may have left the decedent more vulnerable to fatal respiratory depression in the presence of these compounds. Interpretation of toxicity produced by opiate compounds is depen ...
Quick guide Assessment of current medication management
Quick guide Assessment of current medication management

... Quick guide Assessment of current medication management ...
1 Lecture 43 – Quantitative genetics I. Multifactorial traits – eg
1 Lecture 43 – Quantitative genetics I. Multifactorial traits – eg

... - weight F2 fruit and genotype across genome “p/l” vs “l/l” - does weight differ? - For most genotypes, the answer is no but for a few it is yes (these are loci that contribute to the trait, in this case fruit size) - identified 28 loci responsible for fruit size B. How can we study QTLs in humans? ...
Ch. 11.3 Other Patterns of Inheritance
Ch. 11.3 Other Patterns of Inheritance

... A cross between a recessive white flowered four o’ clock plant (rr) and a homozygous dominant red flowered four o’ clock plant (RR). ...
Introduction To Drugs
Introduction To Drugs

... known biological effects on humans or other animals. Foods are generally excluded from this definition, in spite of their physiological effects on animal species. In pharmacology, a drug is "a chemical substance used in the treatment, cure, prevention, or diagnosis of disease or used to otherwise en ...
Medication
Medication

...  Suppositories or enemas can also be used ...
Clinical Considerations During Phase 2 and Phase 3 of - M
Clinical Considerations During Phase 2 and Phase 3 of - M

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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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