• Study Resource
  • Explore
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
Neuroakanthozytosen als Differentialdiagnose zur Chorea
Neuroakanthozytosen als Differentialdiagnose zur Chorea

... skin, kidneys, lungs, and heart, which lead to significant morbidity. TSC is caused by mutations in the TSC1 or TSC2 genes, whose products, hamartin and tuberin, form a tumor suppressor complex that regulates the PI3K/Akt/mTOR pathway. Early clinical trials show that TSC-related kidney tumors (angio ...
Zusammenfassung EN
Zusammenfassung EN

... Consultations with physicians, or genetic counselling by means of face-to-face encounters with genetic counsellors, are not typically part of this process. This situation was the point of departure for this study. Since the beginning of the direct-toconsumer (DTC) marketing of genomewide tests on th ...
B.C. PharmaCare Drug Information Sheet for drug generic name
B.C. PharmaCare Drug Information Sheet for drug generic name

... A manufacturer submits a request to the Ministry of Health (Ministry). An independent group called the Drug Benefit Council (DBC) gives advice to the Ministry. The DBC looks at: • whether the drug is safe and effective • advice from a national group called the Common Drug Review (CDR) • what the dru ...
OPEN JHU phenotyping Pathology Submission Form
OPEN JHU phenotyping Pathology Submission Form

... Serology Culture PCR Parasit Fur Tape Float PCR Behav QNMR Other: Bleed Site: Retroorbital/ Facial/ Saphenous/ Tail/ Cardiac/ Volume: ml. _____________________________________________________________________________________________ History and Clinical Signs (Include correct nomenclatu ...
Linear Mixed Models for Genome and Epigenome-Wide Association Studies
Linear Mixed Models for Genome and Epigenome-Wide Association Studies

Drugs prescription during pregnancy
Drugs prescription during pregnancy

... women, or animal-reproduction studies have shown an adverse effect that was not confirmed in controlled studies in women in the first and late trimester. ...
Gender Related Differences in Pharmacokinetics and
Gender Related Differences in Pharmacokinetics and

... • Response to drugs can be sex-specific • Differences can be observed even for those receptors and enzymes for which a sexspecific response is not expected! • Clinical relevance?? • Relevant for gender differences in drug efficacy and incidence of side effects? ...
RA Epidemiology
RA Epidemiology

... • Single weekly dose, usually orally • Starting dose 7.5 - 10 mg • The MTX dose is increased as tolerated and as needed to control symptoms and signs of arthritis (25-30 mg) ...
Food/Nutrient Effects on Drugs
Food/Nutrient Effects on Drugs

... X-chromosome-linked Can lead to neonatal jaundice, hemolytic anemia or acute hemolysis Most common in African, Middle Eastern, and Southeast Asians Also called favism Fava beans or pollen, Vitamin K or Vitamin C can cause hemolysis ...
Instantaneous Inhibitory Potential and Inhibitory Quotient Show a
Instantaneous Inhibitory Potential and Inhibitory Quotient Show a

... In this issue of Clinical Infectious Diseases, Henrich et al [2] compare 2 measures of antiviral activity by correlating differences in predicted inhibitory quotient (IQ) or instantaneous inhibitory potential (IIP) with differences in virologic outcome (percentage of participants with HIV RNA level ...
Pharmacokinetics - Christopher Hobbs
Pharmacokinetics - Christopher Hobbs

... • Most drugs, other chemicals that enter the blood are metabolized by the liver • Although metabolism typically inactivates drugs, some drug metabolites are pharmacologically active—sometimes even more so than the parent compound • Drug (or active herbal compound metabolism) by the liver and body’s ...
Self-management advice for acute exacerbations
Self-management advice for acute exacerbations

... Do not prescribe with known prolonged QT interval or risk factors (other medicines, CV disease, family history sudden cardiac death, significant electrolyte imbalance - low K or Mg, significant bradycardia). Avoid in the elderly. Consider risks if patient taking medicines that lower heart rate or po ...
What do you know about ECSTASY?
What do you know about ECSTASY?

... • First synthesized in Germany in 1914 • First used in the 1970s in the U.S. as an adjunct to psychotherapy ...
What do you know about ECSTASY?
What do you know about ECSTASY?

... • First synthesized in Germany in 1914 • First used in the 1970s in the U.S. as an adjunct to psychotherapy ...
Evolution of Populations
Evolution of Populations

... Occurs if the phenotypes are not equal in their fitness Relative frequencies within the gene pool change as some phenotypes are selected for (or some are selected against) This is evolution (a change in allele frequencies within a population over time) Natural Selection Refresher ...
CHAPTER 11 Cardiovascular Drugs Quiz Yourself 1. Beta
CHAPTER 11 Cardiovascular Drugs Quiz Yourself 1. Beta

... negative chronotropic effect that causes the heart to beat more slowly. 5. Vincent van Gogh’s painting, The Starry Night, could show evidence that the painter suffered from digitalis toxicity. It is known that he had mania and epilepsy; he may have been treated with digitalis for lack of a more spec ...
Word Version in English
Word Version in English

... I understand the need for local anesthesia to reduce the discomfort of the procedure and consent to the topical application of anesthetic gel and/or injections for a nerve block or local infiltrative anesthesia. I understand the above, and have had the risks, benefits, and alternatives explained to ...
CONSENT FOR RESTYLANE INJECTION PLACE LETTERHEAD
CONSENT FOR RESTYLANE INJECTION PLACE LETTERHEAD

... I understand the need for local anesthesia to reduce the discomfort of the procedure and consent to the topical application of anesthetic gel and/or injections for a nerve block or local infiltrative anesthesia. I understand the above, and have had the risks, benefits, and alternatives explained to ...
Slide 1
Slide 1

...  Bad genes expressed in southern KNP, link to BTB, what the Y is going on?….  Females can also affect sex ratio… ...
Candidate Gene Approach
Candidate Gene Approach

... Which genes will escape the scan? 1. Maternally supplied genes i.e. the reason why maternal effect screen had to be conducted separately. 2. Involved in patterning/differentiation of internal structures 3. Only first instance of essential function may be scored ...
Pharmacology Objectives 2
Pharmacology Objectives 2

... Quantal dose-response curves – the response is present or absent (all-or-none) for a given dose such that patient responses range from a low dose (threshold) to a dose at which all patients experience the effect (maximum). 4. Explain why potency is often expressed as D50 or ED50. The D50 or ED50 (th ...
3. GINA Safe Harbor familyofemployee
3. GINA Safe Harbor familyofemployee

... March 28, 2012 Re: ...
Top Prescription Drugs Older Adults Should Avoid
Top Prescription Drugs Older Adults Should Avoid

... Sleep and Anti-Anxiety Medications ...
Chapter 2 - Single–gene inheritance
Chapter 2 - Single–gene inheritance

Opioids
Opioids

... Receptor dimerization to give different subtypes (may be important)* ...
< 1 ... 1124 1125 1126 1127 1128 1129 1130 1131 1132 ... 1254 >

Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
  • studyres.com © 2025
  • DMCA
  • Privacy
  • Terms
  • Report