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Antidepressants and suicide
Antidepressants and suicide

... Reviews 35 (2011):1722-1739. W. Carlezon, “Enduring behavioral effects of early exposure to methylphenidate in rats,” Biological Psychiatry 54 (2003):1330-37; C. Bolanos, “Methylphenidate treatment during pre-and periadolescence alters behavioral responses to emotional stimuli at adulthood,” Biologi ...
Horizontal gene transfer of antimicrobial
Horizontal gene transfer of antimicrobial

... bacteria exchange AMR genes with other bacteria by horizontal gene transfer mechanisms – “bacterial sex”. Our recent studies have suggested that the important AMR pathogen methicillin-resistant Staphylococcus aureus (MRSA) acquires AMR genes at very high frequency as it colonizes the host, but also ...
FDA approves Lymphoseek to help locate lymph nodes in patients
FDA approves Lymphoseek to help locate lymph nodes in patients

Antifungal Drugs
Antifungal Drugs

... together is greater than the effect of either alone  Antagonism occurs when the effect of two drugs together is less than the effect of either alone ...
Short Communication A Null Allele Impairs Function of CYP2C76
Short Communication A Null Allele Impairs Function of CYP2C76

... fate of drugs in humans due to their similar pharmacokinetics to humans. However, differences are occasionally seen between the two species for some drugs (Stevens et al., 1993; Sharer et al., 1995; Weaver et al., 1999). To predict the metabolism of drugs and the influence of drug-drug interactions ...
Pharmacology Basics
Pharmacology Basics

... – With pharmacokinetic drug interactions, one drug affects the absorption, distribution, metabolism, or excretion of another. – With pharmacodynamic drug interactions, two drugs have interactive effects in the brain. – Either type of drug interaction can result in adverse effects in some individuals ...
Alcohol and drug withdrawal
Alcohol and drug withdrawal

... Alcohol and drug withdrawal is a set of signs and symptoms that develop in association with a sudden cessation or taper in alcohol intake or use of prescription (particularly narcotic medications), over-the-counter (OTC), or illicit drugs. Withdrawal may occur prior to hospitalization or during the ...
PRODUCT INFORMATION
PRODUCT INFORMATION

... at high doses. Withdrawal of the drugs did not lead to regression of the tumour in all cases. Chronic androgen deficiency is a protective factor for prostatic disease and hypogonadal men receiving androgen replacement therapy require surveillance for prostate disease similar to that recommended for ...
MANAGEMENT OF DRUG ADDICTION / SUBSTANCE ABUSE
MANAGEMENT OF DRUG ADDICTION / SUBSTANCE ABUSE

... prevent or reduce negative health consequences associated with certain behaviours • Concerns about transmission of HIV; epidemics in >110 countries; relapsing nature of Addiction • Focuses on minimising health, personal and social harms associated with drug use - the spread of blood-borne diseases, ...
Atomoxetine SCG – ADHD in Children and Young People – May 2016
Atomoxetine SCG – ADHD in Children and Young People – May 2016

... controlled drug. ...
7.3 Prazosin factsheet
7.3 Prazosin factsheet

... Dose should be titrated upwards to 2mg after a 2-3 days, and then upwards in steps of 1mg every 2-7 days depending on benefit and side effects (dizziness 10%, headache 8% Drowsiness 8%, lack of energy 7%, weakness 7%, palpitation 5%, nausea 5%) US Veterans PTSD guidelines state that the target dose ...
Διαφάνεια 1 - Aristotle University of Thessaloniki
Διαφάνεια 1 - Aristotle University of Thessaloniki

... The normal gene produces a functional CFTR protein. Antibiotics: Τhey are used against infections. Aerosol sprays: Τhey fight breathing problems. ...
• The smallest effective dose of a laxative should be used, and this
• The smallest effective dose of a laxative should be used, and this

... – Chronic constipation in women that has failed to respond to at least 2 laxatives from different classes at the highest tolerated doses for at least 6 months and where invasive treatment is being considered. – Efficacy of prucalopride to be reviewed after 4 weeks and drug discontinued if ineffectiv ...
MRHA, ADRs and the Yellow Card Scheme Presentation
MRHA, ADRs and the Yellow Card Scheme Presentation

... 2 Pirmohamed M et al. Adverse drug reactions as cause of admission to hospital: prospective analysis of 18 820 patients. BMJ. 2004; 329(7456):15-9. 3. Blower et al. Emergency admissions for upper gastrointestinal disease and their relation to NSAID use. Aliment Pharmacol Ther 1997; 11: 283-291 ...
Good Prescribing to support Criminal Justice Interventions
Good Prescribing to support Criminal Justice Interventions

... addiction and its consequences –ie cause and effect ...
Competency Medication Administration by RN or EEN Answer Sheet
Competency Medication Administration by RN or EEN Answer Sheet

... c. The patient refused medications or medication was not given? 1) Document ‘R’ or ‘NG’ on resident medication chart against order & date 2) Notify MO and seek orders 3) Raise exception report on resident progress notes d. During your medication round, there was a drug that your are not familiar wit ...
Click here
Click here

... Idiosyncratic Adverse Effects Risk Factors • Previous history of allergic drug reactions – Cross‐sensitivity occurs in about 50% • Especially when using lamotrigine or oxcarbazepine ...
General
General

... 2. What is the pattern of expression for autosomal genes? For sex-linked genes? ...
Genetics
Genetics

... Some genes are dominant and can be clearly seen, e.g. The colour of your hair Some genes are recessive genes for example you may have brown eyes but be the carrier of blue and so could pass this on to your children. ...
Deuterium Modification Offers Great Promise to Improve the Profiles
Deuterium Modification Offers Great Promise to Improve the Profiles

... that failed to enter clinical development due to poor pharmacokinetics. The technical risks are higher for such a drug because there is no hydrogen version that has survived clinical trials with proven safety and efficacy. On the other hand, these drugs might satisfy an unmet need where there is no ...
HIV Negative
HIV Negative

... epidermal necrolysis, and hypersensitivity reactions characterized by rash, constitutional findings, and organ dysfunction. Patients developing signs or symptoms of severe skin reactions or hypersensitivity reactions must discontinue Viramune as soon as possible.” ...
Food-Drug Interactions
Food-Drug Interactions

... X-chromosome-linked Can lead to neonatal jaundice, hemolytic anemia or acute hemolysis Most common in African, Middle Eastern, and Southeast Asians Also called favism Fava beans or pollen, Vitamin K or Vitamin C can cause hemolysis ...
Pharm Test 2 - Glory Cubed Productions
Pharm Test 2 - Glory Cubed Productions

... mouth, bitter taste, and CNS depression; dysrhythmias may occur with large doses. Anticholinergic:  ipratropium (Atrovent) Combivent – a combination of ipratropium & albuterol in a single MDI canister. Obtain respiration rate before and after each dose; measure I&O b/c can cause diuresis. Report im ...
100 colorectal adenomatous polyps
100 colorectal adenomatous polyps

... I am writing to request coverage for analysis of the APC and MYH genes for __________________________________________________due to a personal history of ________________________________________________________ diagnosed at age(s) ______________________________. The number of adenomatous colorectal ...
Use in hepatic Impairment: Monoamine oxidase Inhibitors: Children
Use in hepatic Impairment: Monoamine oxidase Inhibitors: Children

... should commence at 25mg/day increasing to 50mg/day after 1 week. Subsequent doses may be increased in case of lack ot response in 50mg/day increments up to 200mg/day as needed. However, the generally lower body weights of children compared to adults should be taken into consideration in advancing th ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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