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Mendel`s Laws and Genetics Quiz
Mendel`s Laws and Genetics Quiz

... Mendel’s Laws and Genetics Quiz 1. The two versions of a gene for a characteristic are called a) genotypes. b) phenotypes. c) alleles. d) chromosomes. ...
1- Renal function can be impaired in children with primary
1- Renal function can be impaired in children with primary

... PH3 (11.0% of families) showed the slowest decline in renal function but the earliest symptoms. A group of patients with disease progression similar to that of PH3, but for whom no mutation was detected (11.3% of families), suggested further genetic heterogeneity. We confirmed that the AGXT p.G170R ...
Basic Principles of Pharmacology
Basic Principles of Pharmacology

... All pharmacokinetic processes (abs., distr., met. excr.) occur at a rate directly proportional to conc. of drug e.g. increasing dose increases these processes 2. zero-order (saturation) kinetics Apply mainly to met. And elimination where their rates reach saturation (maximum) and a further increase ...
Practice Name - RefHelp Borders
Practice Name - RefHelp Borders

... conditions may be found within the British Journal of Haematology, Guidelines on oral anticoagulation with warfarin - 4th edition. Warfarin is the number one drug which causes harm to patients in Scotland. Warfarin is a vitamin K antagonist, interferes with the operation of vitamin K in blood coagul ...
药理概论2
药理概论2

... A, B – relatively safe ...
ZORVOLEX® (diclofenac) Capsules Fact Sheet
ZORVOLEX® (diclofenac) Capsules Fact Sheet

... NSAIDs cause an increased risk of serious gastrointestinal adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients are at greater risk for serious gas ...
Dose - Professional Events
Dose - Professional Events

... Constituent of many cold and ‘flu relief remedies Does not cause gastric irritation Does not have marked anti-platelet effect ...
Implications of the Human Genome Project for Medical
Implications of the Human Genome Project for Medical

... responses is often attributable to the genetic endowment of the individual. Examples have been identified where common variants in genes involved in drug metabolism or drug action are associated with the likelihood of a good or bad response. The expectation is that such correlations will be found fo ...
The drugs discussed in this chapter are used to alter an individual`s
The drugs discussed in this chapter are used to alter an individual`s

... The antipsychotic drugs, which are essentially dopamine receptor blockers, are used to treat disorders that involve thought processes. Classic, typical antipsychotics -older drugs ...
Where Do Your Genes Comes From? Methods for Studying
Where Do Your Genes Comes From? Methods for Studying

... usually only expressed if you inherit TWO of them (one from each parent). ...
CeleBREX - DavisPlus
CeleBREX - DavisPlus

Variation in Drug Responsiveness
Variation in Drug Responsiveness

Genomics: A new Revolution in Science
Genomics: A new Revolution in Science

... The genetic difference between one person and another is less than 0.1 % • But because only a few regions of DNA actively encode life functions, the real difference between one person and another is only 0.0003 percent ...
Samples of exam questions and answers
Samples of exam questions and answers

... C) Vancomycin D) Streptomycin 9. All of the following statement about the biodisposition of penicillins are accurate, EXCEPT: A) the oral bioavailability of a penicillin drug depends on its acid lability B) probenecid increases penicillin excretion by blocking renal tubular ...
Three ethical theories
Three ethical theories

... Nurses need to have a a sound knowledte base of the medications that they are administering. They need to know; - The indication for the use of the medication - the desired effects of the medication - the absorption, distribution and adimistration of the medication - the side effects of the medicati ...
document - Herts Valleys CCG
document - Herts Valleys CCG

... If monitoring reveals signs of disease activity, e.g. reduced visual acuity and/or signs of lesion activity, further treatment is recommended. Monitoring for disease activity may include clinical examination, optical coherence tomography (OCT) or fluorescein angiography (FA). While many patients may ...
Mysimba - Letter sent to Andrzej Rys – DG SANTE (EC)
Mysimba - Letter sent to Andrzej Rys – DG SANTE (EC)

... The EMA recommends that patients who take Mysimba should be evaluated after 16 weeks, and if they have not lost at least 5% of body weight, the treatment should be stopped. However experience shows that in reality, patients and health care professionals do not necessarily follow these kind of recomm ...
Principlesofdruguseinpregnancy2
Principlesofdruguseinpregnancy2

... Teratogenicity and drugs  In the UK, the spontaneous malformation rate at birth is 2-3% i.e. approximately 1 in 40 babies will be born with a malformation  The incidence of malformations increases to approximately 5% by 4-5 years of age  Drugs are thought to cause less than 1% of ...
Types of Therapy
Types of Therapy

... that helps control symptoms of schizophrenia. This allowed many individuals to leave psychiatric hospitals and live with family, friends, in supportive care facilities, or on their own *Psychoactive drugs may mimic the normal effects of neurotransmitters, or increase the amount of the neurotransmitt ...
ISTRUZIONI PER PREPARARE POSTER DA ESPORRE A …
ISTRUZIONI PER PREPARARE POSTER DA ESPORRE A …

... (http://rarediseases.info.nih.gov/asp/diseases/diseases.asp?this=A#toplist will be considered. ...
Jeff Azevedo CEO - Advanced Rx Sales Team Area
Jeff Azevedo CEO - Advanced Rx Sales Team Area

File
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... Herbal and Dietary Suppliments • 80% of world’s population relies on herbs • Not without adverse effects • Can be toxic especially in combination with another medication ...
arlington_2
arlington_2

... Patient information leaflets need to be designed to convey potential adverse reactions more clearly, so that the relative likelihood of these occuring is included and people know what to do if they do occur. ...
Absorption, distribution, metabolism and excretion
Absorption, distribution, metabolism and excretion

... * Two drugs may have affinity for plasma protein binding sites, thus compete with each other leading to drug interactions. * An example: Phenylbutazone and salicylates can displace warfarin (oral anticoagulant) and oral hypoglycemics from plasma proteins. * Drugs highly bound to plasma proteins are ...
Chapter 9 - Mantachie High School
Chapter 9 - Mantachie High School

... receives one gene of a pair Molecular genetics—the study of the structure and function of chromosomes and genes P1 generation—a strain obtained through self-pollination; the parental generation in a genetic cross Pollination—the transfer of pollen from an anther (male) to a stigma (female) of a flow ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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