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1 Top Pediatric Medications Common Pediatric
1 Top Pediatric Medications Common Pediatric

... Ń This may mean increased dosage or dosing frequency for drugs eliminated by hepatic metabolism. ...
PPT
PPT

... Duration of Inhibitory Effects ...
Hypertrophic Cardiomyopathy - Dr. Ben
Hypertrophic Cardiomyopathy - Dr. Ben

Oral thrush in baby - North Derbyshire CCG
Oral thrush in baby - North Derbyshire CCG

... using levomepromazine as a possible alternative. DCHS considering updating the anticipatory prescription sheet, at which point MMT will update JIC autoconsultations In the meantime, if haloperidol not available, levomepromazine injection may need to be prescribed separately and added to the anticipa ...
Biodiveristy/Bioprospecting - Novartis Pharmaceuticals Corporation
Biodiveristy/Bioprospecting - Novartis Pharmaceuticals Corporation

... quest to develop new therapies to cure diseases, we maintain a strong commitment not only to biodiversity, but also to basic principles of human rights and social justice. As such, our efforts at using natural sources for obtaining potential drugs or lead substances are conducted only in accordance ...
Genes and Health
Genes and Health

... Irish people, with 1 in 19 carrying the defective gene), and sickle-cell disease (a blood disorder common among people of sub-Saharan African descent; the disorder protects against malaria, which is endemic in the region). Multiple sclerosis is particularly common among people of Scandinavian descen ...
Monohybrid Crosses - Life is a journey: Mr. T finding his way
Monohybrid Crosses - Life is a journey: Mr. T finding his way

...  Alleles – different forms of a gene  F1 generation – the offspring of two parents  F2 generation – the offspring of parents from F1 generation  Homozygous – having two identical alleles of a gene (have same allele)  Heterozygous – having two different alleles of a gene ...
Collection of Real World Data in the Context of Rare
Collection of Real World Data in the Context of Rare

... who otherwise do not qualify to participate in a clinical trial; + for large groups of patients who do not have other treatment options available (once more is known about the safety and potential effectiveness of a drug from ongoing or completed clinical trials). In all of the above cases the prima ...
Genetic Markers Linked to Alcoholism Recovery Traumatic
Genetic Markers Linked to Alcoholism Recovery Traumatic

... researchers and collaborators identified genetic markers that may help identify individuals who could benefit from the alcoholism treatment drug acamprosate. Patients carrying these genetic variants have longer periods of abstinence during the first 3 months of treatment. The association between var ...
Why is Pharma So Scared of Psychiatric Drug Discovery?
Why is Pharma So Scared of Psychiatric Drug Discovery?

... prevented unambiguous identification of genes and/or molecular targets for mental health disorders, as has happened to some ...
Genetics and Heredity
Genetics and Heredity

... defective protein in certain cell membranes; causes multiple effects: thicker & stickier mucus membranes, poor nutrient absorption, chronic bronchitis, recurrent bacterial infections ...
Failure Mode Effect Analysis on Anticoagulation Across the Continuum
Failure Mode Effect Analysis on Anticoagulation Across the Continuum

... Potential Failure Mode Potential Effect(s) of Failure Potential Cause(s) of Failure Current Controls Rate Potential causes of failure based on Severity, Occurrence, Detection and assigned a Risk Priority ...
About ATODA
About ATODA

... • Naloxone (Narcan ®) is a schedule 4 opioid antagonist used to reverse the effects of opioid overdose. Naloxone is widely used in Australia and internationally by paramedics and emergency room staff in cases of suspected opioid overdose. It has no psychoactive effect, is not a drug of dependence, a ...
What Does Your Positive Drug Screen Really Tell You?
What Does Your Positive Drug Screen Really Tell You?

...  2500 BC, first used by Incas of South America  1800s, refined by healthcare industry as treatment for various ailments  Added to wines, received rave reviews from Pope Pius X and Grand Rabbi of France ...
Chapter 5 PPT Review
Chapter 5 PPT Review

... the practice of changing the arrangement of DNA through biological and chemical methods. ...
New Oral Medication Tecfidera ™ is approved by FDA
New Oral Medication Tecfidera ™ is approved by FDA

... How does dimethyl fumarate (Tecfidera™) compare with other medications for MS? Tecfidera™ has not been tested in a head-to-head trial against other MS medications. In the CONFIRM trial there was a group assigned to receive Copaxone, however, the study was not done to compare the effectiveness of on ...
Concomitant Medications: What a Programmer Needs to Know
Concomitant Medications: What a Programmer Needs to Know

... available for a compound containing the same active ingredient. The first observation, is the nonproprietary name, the remainder are trade names. The issue however, is not the variety of trade names available but the variability in how concomitant medication data is manually recorded on the case rep ...
breedingandfertilisationlesson6
breedingandfertilisationlesson6

...  The genes for a particular characteristic can give different instructions  Different forms of the same gene are called ALLELES ...
NUH list of critical drugs which should not be omitted or delayed
NUH list of critical drugs which should not be omitted or delayed

... delayed without a clinical reason which has been discussed with the medical team. The reason for the omission and a plan of action must be documented on the Medicines Management Plan found on the back pages of the Prescription Chart. If you are unfamiliar with a drug name, you must check to find out ...
The Multi Drug Resistance Gene Defect and Collie
The Multi Drug Resistance Gene Defect and Collie

... agents) – these drugs have better safety profiles than the older drug, Ivermectin, and are SAFE in dogs with two copies of the mutation if used at the manufacturer’s recommended dose and via the correct route of administration. Higher doses (generally 5 times higher than the recommended dose) have b ...
Absorption mechanism of drugs from the GI tract
Absorption mechanism of drugs from the GI tract

... (un-dissociated or un-protonated) drug species, therefore, solubility/concentration of the nonionized species at the site of absorption is to be considered and not that of the ionized (protonated or salt) form. For example, drugs such as diltiazem, metoprolol and propranolol are considered highly wa ...
Psychopharmacology for the Clinician
Psychopharmacology for the Clinician

... ­undergo efficacy and safety studies before being marketed.8 Bioequivalence studies of generics involve single-dose studies in young, healthy volunteers, and are then generalized to patient populations that can vary by numerous parameters, such as age, sex, race and disorder.9–11 A recently publishe ...
VASODILATORS
VASODILATORS

... available for oral, intravenous, and intramuscular; and minoxidil is available as an oral agent only. These drugs are rapidly absorbed and widely distributed. They are metabolized in the liver and primarily excreted in urine. They cross the placenta and enter breast milk . ...
sample - Mouse Genome Informatics
sample - Mouse Genome Informatics

... the same set of genes • Individual differences are due to allelic variation • “natural” background (eg. inbred line) • engineered variation (eg. knockout) ...
Anti Depressants Do you need them?
Anti Depressants Do you need them?

...  Other studies deepened this suspicion. In 1985, a U.K. group reported that in a 2-year study comparing drug therapy to cognitive therapy, relapse "was significantly higher in the pharma-therapy group" (Blackburn, Eunson, & Bishop, 1986, p . 67).  In 1994, researchers found that "long-term use of ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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