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Management of Ocular Pain and Inflammation
Management of Ocular Pain and Inflammation

... •NSAID’s are both analgesic and anti-inflammatory agents •Anti-inflammatory dose is higher thyan analgesic dose •Higher dosages = greater side-effects Analgesic Pharmacology •Tylenol/Acetaminophen/(N-Acetyl-P-aminophenol)/APAP •Unknown central mechanism •Anti-pyretic: Hypothalmus ...
famotidine (fa-moe-ti-deen) - DavisPlus
famotidine (fa-moe-ti-deen) - DavisPlus

... mg twice daily for up to 8 wk. Duodenal ulcer prophylaxis— 20 mg once daily at bedtime. GERD— 20 mg twice daily for up to 6 wk; up to 40 mg twice daily for up to 12 wk for esophagitis with erosions, ulcerations, and continuing symptoms. Gastric hypersecretory conditions— 20 mg q 6 hr initially, up t ...
September 2013: IND Determinations
September 2013: IND Determinations

... When the IRB has determined that an IND is not required, the IRB minutes must indicate the following: * the condition/disorder to be treated * the variance from current FDA approval (e.g., different indication or population) * determination that the risks associated with its use in the disorder/cond ...
Genetics - Kawameeh Middle School
Genetics - Kawameeh Middle School

... O A trait controlled by a recessive allele will only show if the dominant allele is not present ...
ISMP Medication Safety Alert - Institute For Safe Medication Practices
ISMP Medication Safety Alert - Institute For Safe Medication Practices

... Oneof themost important ways toprevent medication errors is tolearn about problems that haveoccurred in other organizations and tousethat information toprevent similar problems at your practicesite. To promotesuch aprocess, thefollowing selected items fromthe January-March 2009 ISMP Medication Safet ...
Recommendation to restrict the use of
Recommendation to restrict the use of

... 2) As a ‘metabolic agent’ (a medicine which has an effect on metabolism). It is believed to protect against myocardial ischaemia (reduced blood supply to the heart muscle) by increasing the rate at which glucose is broken down. 3) To treat the symptoms of vertigo (a spinning sensation) and tinnitus ...
8-K - corporate
8-K - corporate

... REDWOOD CITY, California, September 15, 2016 – AcelRx Pharmaceuticals, Inc. (NASDAQ: ACRX) today announced that in an open-label Phase 3 trial (SAP303), investigational product candidate ARX-04 (sufentanil sublingual tablet 30 mcg) was well tolerated in the management of moderate-to-severe acute pai ...
Diabetes Therapy and Problems for the Cardiologist. Quali
Diabetes Therapy and Problems for the Cardiologist. Quali

... mechanism of action • bind to and activate peroxisome proliferatoractivated receptors (PPARs), which regulate gene expression in response to ligand binding • increase insulin sensitivity by acting on adipose, muscle, and liver to increase glucose utilization and decrease glucose production • drugs i ...
Key Terms Foldable CH. 5 Heredity
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... A process in cell division during which the number of chromosomes decreases to half the original number by two divisions of the nucleus, which results in the production of sex cells (gametes or spores). One of the pair of chromosomes that determines the sex of an individual. ...
one gene - Central Magnet School
one gene - Central Magnet School

... for the production of a protein. Diseases and disorders result when a gene is mutated resulting in a protein product that can no longer carry out its normal job. ...
Carrier transport
Carrier transport

... between the maximum and minimum levels is less if smaller doses are repeated more frequently. ...
Research and Development of Olopatadine hydrochloride, an
Research and Development of Olopatadine hydrochloride, an

... (Kyowa Hakko Kogyo Co., Ltd.) In terms of chemical structure, olopatadine would be distinguished from the other antiallergic drugs marketed so far. The compound possesses a dimethylamine moiety at the terminal of the side chain and a directly substituted acetic acid moiety on its tricyclic core stru ...
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... Prioritization - Which taxa do we assess in detail? • We have to highlight the taxa where more detailed assessment of genetic erosion/pollution and subsequent monitoring is needed. • The Red List threat category could be a determining factor in choosing the level of assessment of genetic erosion/po ...
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... release preparation of opioid antagonist, Naltrexone, given as monthly injections. It is imperative to determine the time of last dose of opioids to finalize our choice of drugs [15]. Naltrexone should be discontinued at least 24-72 hours prior, if opioid based anesthesia is planned and then restart ...
Discussion Continuum 1: Who pays to develop drugs? Introduction
Discussion Continuum 1: Who pays to develop drugs? Introduction

... regulatory agencies in each country or geographical area (the European Medical Evaluation Agency, EMEA, or the Food and Drug Administration Agency, FDA, for example). These agencies analyse the documentation and either approve the new drug to enter the market, or request additional tests, or deny ap ...
INTRODUCTION
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... Iron pills are regularly used by large numbers of the population including pregnant mothers. In overdose, especially in children, they are exceedingly dangerous. They may cause extensive damage to the liver and gut and these patients will require hospital assessment and treatment. Charcoal is contra ...
(Title of Presentation) - Oregon Psychiatric Association
(Title of Presentation) - Oregon Psychiatric Association

... • All APDs are generally effective but have various limitations as reflected by high rates of discontinuation, intolerable side effects and failure to adequately control symptoms. • In non-refractory patients olanzapine is more efficacious than the other SGAs (other than clozapine) but also was asso ...
Pharmacogenetics: more than skin deep
Pharmacogenetics: more than skin deep

... effectiveness of two methods of identifying clusters of people who have distinct patterns of drug-metabolizing enzyme SNPs. They show that clusters identified by genotyping (using microsatellite DNA) are far more robust than those identified using geographic and ethnic labels. These findings suggest ...
Pharmacokinetics
Pharmacokinetics

... One, two, and three compartment pharmacokinetic models. Fortunately many of the processes involved in drug movement around the body are not saturated at normal therapeutic dose levels. The pharmacokinetic - mathematical models that can be used to describe plasma concentration as a function of time ...
Pharmacokinetic introduction
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... One, two, and three compartment pharmacokinetic models. Fortunately many of the processes involved in drug movement around the body are not saturated at normal therapeutic dose levels. The pharmacokinetic - mathematical models that can be used to describe plasma concentration as a function of time ...
Herbal / Drug Interactions PHARM 512: Clinical Applications of Drug
Herbal / Drug Interactions PHARM 512: Clinical Applications of Drug

... Drug interactions: Pharmacodynamic: don’t give to patients taking immunosuppressive drugs Pharmacokinetic: may inhibit 1A2; may inhibit intestinal 3A4 but induce hepatic so clinical significance unclear; effect on 2C9 is considered minor ...
C: Acknowledgements
C: Acknowledgements

... placebo may be given to patients in control groups as a means to blind investigators and patients as to whether an individual is receiving the experimental or control treatment. Polydrug abuse: Substance abuse characterized by use of multiple drugs. Premature births: Babies born between 20 to 36 wee ...
Drug Therapy in Pediatric Patients
Drug Therapy in Pediatric Patients

... pregnant women have failed to demonstrate a risk to the fetus. C - Studies have’ shown that the drug exerts animal teratogenic or embryocidal effects, but there are no controlled studies in women, or no studies are available in either animals or women. D - Positive evidence of human fetal risk exist ...
albuterol (al-byoo-ter-ole) - DavisPlus
albuterol (al-byoo-ter-ole) - DavisPlus

... take missed dose as soon as remembered, spacing remaining doses at regular intervals. Do not double doses or increase the dose or frequency of doses. Caution patient not to exceed recommended dose; may cause adverse effects, paradoxical bronchospasm (more likely with first dose from new canister), o ...
spinraza
spinraza

... option for patients with SMA • Thrombocytopenia and nephrotoxicity are potential complications associated with nusinersen therapy • Common side effects include respiratory ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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