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150528EN_ASCO Data Release Beleodaq
150528EN_ASCO Data Release Beleodaq

... The completed Phase I/II, open-label, multi-center, dose-escalation study (NCT00878800) evaluated the safety and efficacy of belinostat in combination with standard chemotherapy doxorubicin in a total of 41 patients and found the combination was well-tolerated and exhibited anti-cancer activity in ...
PDR - Norpramin Tablets(Aventis)
PDR - Norpramin Tablets(Aventis)

... CNS. In patients with CNS depression, early intubation is advised because of the potential for abrupt deterioration. Seizures should be controlled with benzodiazepines. If these are ineffective or seizures recur, other anticonvulsants (eg, phenobarbital, phenytoin) may be used. Physostigmine is not ...
chapter_12-ppt
chapter_12-ppt

... • Toxicologists must be able to analyze small amounts of drug and isolate them from a complex biological matrix • In contrast to the work typically done by drug chemists, a toxicologists needs quantitative information in order to determine if the amount is consistent with a therapeutic dose or an ab ...
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... • Label a diagram to show how human insulin can be produced using genetic engineering; • Look at modelled exam questions and complete your own based on the model ...
m5zn_a3fbaa5e67759b8
m5zn_a3fbaa5e67759b8

... • Frequency of medication scheduling is also influenced by the patient's physical condition and the nature and severity of the illness or condition being treated. • Indigestion: may require a single dose of medication for correction. • A systemic infection: may require multiple daily, around-the clo ...
Anaesthetic implications of psychoactive drugs
Anaesthetic implications of psychoactive drugs

... conjunction with an SSRI. The serotonin syndrome features hyperreflexia, agitation, and hyperthermia. SSRIs ( particularly fluoxetine) may interfere with the metabolism of codeine to morphine by inhibiting CYP2D6. This means that patients given codeine may not receive adequate analgesia.1 There is a ...
View Event Presentation
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... pharmacology, pharmacokinetics, drug availability, cost, drug interactions and adverse reactions. Optimize therapeutic management by influencing drug therapy selection, implementation, monitoring and follow-up. Investigate unusual drug orders or doses. Assimilate additional information about the pat ...
The Pharmacological Management of Hypertension
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... If treatment is necessary, getting the pressure down is more important than worrying too much about which drug to use Thiazides are first choice for most people, CCB’s probably less so, doxazosin (α-blocker) first choice for almost no one! ...
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Medication Mishaps in the Elderly Peron P, Marcum Z, Boyce R
Medication Mishaps in the Elderly Peron P, Marcum Z, Boyce R

... week of educational intervention regarding geriatric ...
Chapter 7 pt. 2: States of Consciousness
Chapter 7 pt. 2: States of Consciousness

... drawback to using the drug medically.  Marijuana also disrupts memory formation and may cause sexual dysfunctions. ...
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Management of Adverse Drug Reactions-2

... • If an anti-tuberculosis medication is highly suspected and the reaction was life-threatening, discontinue medication and replace with equally efficacious anti-tuberculosis drug. • When any of the severe allergic reactions are present, all anti-tuberculosis medications should be suspended. • Desens ...
Genetic Mapping
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... DNA marker, chances are high that the gene responsible for the disease lies near that marker. The more DNA markers there are on a genetic map, the more likely it is that one will be closely linked to a disease gene - and the easier it will be for researchers to zero-in on that gene. One of the first ...
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... of  drugs.  Unfortunately,  reports  of  interactions  among  multiple  drugs  are  rare  and  this  is   when   this   program’s   algorithmic   database   is   truly   valuable.   YouScript   will   account   for:   narrow   therapeutic   ind ...
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... unresponsive to drug treatment which can lead to respiratory failure Adams, M., Leland, N. Pearson Education 2008 & 2011 Katzung, B., 2007 ...
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... said during the consultation with their doctor. Although it is reassuring to know that patients do read the contained information leaflets and listen to the prescribing doctor’s advice, it is somewhat disturbing that so few were actually aware of the potential GI sideeffects of NSAIDs. Though patients ...
Questcor Finds Profit for Acthar Drug, at $28,000 a Vial
Questcor Finds Profit for Acthar Drug, at $28,000 a Vial

... lead to kidney failure. In June, it began selling to rheumatologists. For all these diseases, there are cheaper alternatives. Oral prednisone, which might be used for some rheumatological diseases, can cost $10 a month. Intravenous steroids, used to treat multiple sclerosis flares, cost several hund ...
Mendel and the Gene Idea
Mendel and the Gene Idea

... It allow continuing biological species. ...
The Nursing Process and Drug Therapy
The Nursing Process and Drug Therapy

... its passage from the liver into the circulation – A drug given via the oral route may be extensively metabolized by the liver before reaching the systemic circulation (high firstpass effect) – The same drug—given IV— bypasses the liver, preventing the first-pass effect from taking place, and more dr ...
170321_EN_Onxeo AACR
170321_EN_Onxeo AACR

... chemo-resistance compared to free doxorubicin in hepatocellular carcinoma (HCC, primary liver cancer), pancreatic cancer and sarcoma models. Livatag® showed a dose-dependent inhibition of cell proliferation in all tested resistant cancer cell lines with superior activity compared to free doxorubicin ...
HESS 525 - The Citadel
HESS 525 - The Citadel

... C. a trace of bull's blood. D. cocaine. 23. The International Olympics Committee first established rules disqualifying competitors who failed or who refused to take drug tests in A. 1936. B. 1968. C. 1980. D. 1992. 24. During and after World War II, it was found that malnourished people could gain w ...
INTRA-NASAL DRUG DELIVERY SYSTEM A SEMINAR ON BY:
INTRA-NASAL DRUG DELIVERY SYSTEM A SEMINAR ON BY:

...  NDDS provides route of drug administration for drugs, which degrade due to first pass metabolism  Though it also poses many challenges such as low absorption, toxicological problems, high dose requirements etc.,, thus use of absorption enhancers is proving to be useful increasing the absorption. ...
AH-7921: the list of new psychoactive opioids is expanded
AH-7921: the list of new psychoactive opioids is expanded

... were also involved to its analgesic effect against chemically induced pain [19]. This moderate selectivity towards l- over j-opioid receptors was also confirmed in vitro using opioid receptor preparations from guinea pig brains [22]. Hayes and Tyers [8] studied the antinociceptive effects, as well a ...
Caring for adult patients suspected of having concealed illicit drugs
Caring for adult patients suspected of having concealed illicit drugs

... The evidence of the police officers witnessing the swallowing is important. The majority of detainees will deny any drug swallowing as they do not wish to incriminate themselves ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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