A1985AKB0400002
... filled with fluid, resulting in vacuolation of the myelin sheaths. I recalled having read about such a brain lesion that had been caused by triethyltin. Such lesions in the white matter therefore could indeed be produced by chemicals. I concluded that hexachlorophene, which had been considered safe, ...
... filled with fluid, resulting in vacuolation of the myelin sheaths. I recalled having read about such a brain lesion that had been caused by triethyltin. Such lesions in the white matter therefore could indeed be produced by chemicals. I concluded that hexachlorophene, which had been considered safe, ...
Toxicological Summary for Carbamazepine (PDF)
... Note: Even if testing for a specific health effect was not conducted for this chemical, information about that effect might be available from studies conducted for other purposes. Most chemicals have been subject to multiple studies in which researchers identify a dose where no effects were observed ...
... Note: Even if testing for a specific health effect was not conducted for this chemical, information about that effect might be available from studies conducted for other purposes. Most chemicals have been subject to multiple studies in which researchers identify a dose where no effects were observed ...
un/sceghs/7/inf
... to consider the possible influence of maternal toxicity. This is a complex issue because of uncertainties surrounding the relationship between maternal toxicity and developmental outcome. Expert judgement and a weight of evidence approach, using all available studies, should be used to determine the ...
... to consider the possible influence of maternal toxicity. This is a complex issue because of uncertainties surrounding the relationship between maternal toxicity and developmental outcome. Expert judgement and a weight of evidence approach, using all available studies, should be used to determine the ...
8523 7cp110 Ponce pc..
... Route of exposure: – should be the same as clinical route – additional routes of exposure may be needed to achieve systemic toxicity ...
... Route of exposure: – should be the same as clinical route – additional routes of exposure may be needed to achieve systemic toxicity ...
Pyrethroid-Induced Reproductive Toxico-Pathology in Non
... cyclopropane of permethrin, while for trans-position an esterase is involved. In case of cypermethrin both isomers need esterase for hydrolysis (Holden, 1979). In either case, due to oxidative stress reactive oxygen species are produced which can cause cellular damage (Shashikumar and Rajini, 2010). ...
... cyclopropane of permethrin, while for trans-position an esterase is involved. In case of cypermethrin both isomers need esterase for hydrolysis (Holden, 1979). In either case, due to oxidative stress reactive oxygen species are produced which can cause cellular damage (Shashikumar and Rajini, 2010). ...
Imported food risk statement Peanuts/pistachios and aflatoxins
... Dietary modelling using the 2011 National Nutrition Survey of Australia (NNS) revealed that the mean consumption of peanut and peanut products, such as satay sauces, is 0.45 g/kg bw/day for children aged between 2 and 6 years, and 0.16 g/kg bw/day for all consumers 2 years or older. For pistachio nu ...
... Dietary modelling using the 2011 National Nutrition Survey of Australia (NNS) revealed that the mean consumption of peanut and peanut products, such as satay sauces, is 0.45 g/kg bw/day for children aged between 2 and 6 years, and 0.16 g/kg bw/day for all consumers 2 years or older. For pistachio nu ...
Perfluorooctanoic Acid (PFOA): A Global Water
... Perfluorooctanoic Acid (PFOA): A Global Water Contaminant Brandon M. Montes, Ernesto M. Garcia and Antonio F. Machado Department of Environmental and Occupational Health, California State University, Northridge Perfluorooctanoic Acid (PFOA) is an anthropogenic perfluoroalkyl that was widely produced ...
... Perfluorooctanoic Acid (PFOA): A Global Water Contaminant Brandon M. Montes, Ernesto M. Garcia and Antonio F. Machado Department of Environmental and Occupational Health, California State University, Northridge Perfluorooctanoic Acid (PFOA) is an anthropogenic perfluoroalkyl that was widely produced ...
NELUMBO NUCIFERA
... p.o. Furosimide (20 mg/kg) was used as positive control in study. The diuretic effect of the extract was evaluated by measuring urine volume, sodium, potassium and chloride content. Results: In the normal rats diuresis began with low volumes of urine excreted until completing 24hrs. The level of Na+ ...
... p.o. Furosimide (20 mg/kg) was used as positive control in study. The diuretic effect of the extract was evaluated by measuring urine volume, sodium, potassium and chloride content. Results: In the normal rats diuresis began with low volumes of urine excreted until completing 24hrs. The level of Na+ ...
Cc50 cytotoxicity
... serum protein binding. . death is defined as the therapeutic or selectivity index (i.e., CC50 value/EC50. The cytotoxic concentration 50 (CC50), determined three hours after exposure, revealed that B. diporus venom was significantly more cytotoxic (CC50: 2 µg/mL) . No statistical difference was foun ...
... serum protein binding. . death is defined as the therapeutic or selectivity index (i.e., CC50 value/EC50. The cytotoxic concentration 50 (CC50), determined three hours after exposure, revealed that B. diporus venom was significantly more cytotoxic (CC50: 2 µg/mL) . No statistical difference was foun ...
MSDS Sheet
... Occupational exposure to free silica is known to produce silicosis, a chronic, disabling lung disease characterized by the formation of silica-containing nodules of scar tissue in the lungs. Simple silicosis, in which the nodules are less than 1 cm in diameter is generally asymptomatic but can be sl ...
... Occupational exposure to free silica is known to produce silicosis, a chronic, disabling lung disease characterized by the formation of silica-containing nodules of scar tissue in the lungs. Simple silicosis, in which the nodules are less than 1 cm in diameter is generally asymptomatic but can be sl ...
Respiratory Irritant Gases - Military Medical Science Letters
... epithelial sloughing which, left untreated, can result in scar formation and pulmonary and airway remodeling. There are hundreds of substances that can pollute air and harm lungs. Harmful gases and chemicals are just one type of airborne pollutants that can adversely affect the lungs. Examples of re ...
... epithelial sloughing which, left untreated, can result in scar formation and pulmonary and airway remodeling. There are hundreds of substances that can pollute air and harm lungs. Harmful gases and chemicals are just one type of airborne pollutants that can adversely affect the lungs. Examples of re ...
Chapter 5.10 Polychlorinated biphenyls (PCBs)
... Local eating habits, e.g. intake of fatty fish from contaminated waters, may significantly increase the daily intake of PCBs. Thus, Swedish fishermen active in the Baltic sea and with much higher than average intakes of herring and salmon, were found to have blood levels of PCBs two times higher tha ...
... Local eating habits, e.g. intake of fatty fish from contaminated waters, may significantly increase the daily intake of PCBs. Thus, Swedish fishermen active in the Baltic sea and with much higher than average intakes of herring and salmon, were found to have blood levels of PCBs two times higher tha ...
toxicity
... Toxicity of chemical compounds is characterized by distribution coefficient R which is a quotient of concentration of substance presence in two inmiscible liquids after equlibriom state is reached. R values are indicating on lipophilic substance character and consequently it ability to overcome ...
... Toxicity of chemical compounds is characterized by distribution coefficient R which is a quotient of concentration of substance presence in two inmiscible liquids after equlibriom state is reached. R values are indicating on lipophilic substance character and consequently it ability to overcome ...
N-(n-butyl) thiophosphoric triamide (NBPT)—secondary
... thiophosphoric triamide (NBPT). Applicants for assessment are given a draft copy of the report and 28 days to advise the Director of any errors. Following the correction of any errors, the Director provides applicants and other interested parties with a copy of the draft assessment report for consid ...
... thiophosphoric triamide (NBPT). Applicants for assessment are given a draft copy of the report and 28 days to advise the Director of any errors. Following the correction of any errors, the Director provides applicants and other interested parties with a copy of the draft assessment report for consid ...
Mixed messages~pesticides that confuse hormones(colourforPDF
... disruptor. When given to female pregnant rats at low to oestrogen mimicking substances, anti-androlevels of 1-100mg/kg, it has been shown to depress genic substances, substances which inhibit the acetylcholinesterase activity more in the foetus than formation of steroids, and substances which increa ...
... disruptor. When given to female pregnant rats at low to oestrogen mimicking substances, anti-androlevels of 1-100mg/kg, it has been shown to depress genic substances, substances which inhibit the acetylcholinesterase activity more in the foetus than formation of steroids, and substances which increa ...
Arsenic-Induces Dysfunction in Poly (ADP-Ribose)
... The methylation reaction, which is a phase II biotransformation reaction, stress [12]. In vitro and in vivo experiments on rat pancreatic β-cell lines serves the purpose of increasing the hydrophilic of a compound in order to facilitate excretion. The metabolism of iAs compounds significantly influe ...
... The methylation reaction, which is a phase II biotransformation reaction, stress [12]. In vitro and in vivo experiments on rat pancreatic β-cell lines serves the purpose of increasing the hydrophilic of a compound in order to facilitate excretion. The metabolism of iAs compounds significantly influe ...
File No: NA/415 Date: September 1996 NATIONAL INDUSTRIAL
... was 10-100 g/mL without metabolic activation provided by rat liver S9 and 10-200 g/mL with S9; for the 28 h treatment time the concentration was 100 g/mL without S9 and 200 g/mL with S9 ...
... was 10-100 g/mL without metabolic activation provided by rat liver S9 and 10-200 g/mL with S9; for the 28 h treatment time the concentration was 100 g/mL without S9 and 200 g/mL with S9 ...
Chlordecone - Stockholm Convention
... musculoskeletal and liver toxicity at doses between 1 - 10 mg/kg bw/day in experimental animal studies. Liver cancer was induced in rats at a dose of 1 mg/kg body weight per day, and reproductive effects are seen at similar dose levels. The International Agency for Research on Cancer has classified ...
... musculoskeletal and liver toxicity at doses between 1 - 10 mg/kg bw/day in experimental animal studies. Liver cancer was induced in rats at a dose of 1 mg/kg body weight per day, and reproductive effects are seen at similar dose levels. The International Agency for Research on Cancer has classified ...
TOX/2013/02 - Committee on Toxicity
... ingestion, aspartame is fully hydrolysed within the gastro-intestinal tract. The products resulting from these reactions are methanol and the amino acids aspartic acid and phenylalanine, which are absorbed and enter normal endogenous metabolic pathways. Hydrolysis of aspartame releases a correspondi ...
... ingestion, aspartame is fully hydrolysed within the gastro-intestinal tract. The products resulting from these reactions are methanol and the amino acids aspartic acid and phenylalanine, which are absorbed and enter normal endogenous metabolic pathways. Hydrolysis of aspartame releases a correspondi ...
Nanoparticle Toxicity Article Titles
... Oxidative stress and inflammatory responses of rat following acute inhalation exposure to iron oxide nanoparticles Involvement of reactive oxygen species and high-voltage-activated calcium currents in nanoparticle zinc oxide-induced cytotoxicity in vitro Cd2+ toxicity as affected by bare TiO2 nanopa ...
... Oxidative stress and inflammatory responses of rat following acute inhalation exposure to iron oxide nanoparticles Involvement of reactive oxygen species and high-voltage-activated calcium currents in nanoparticle zinc oxide-induced cytotoxicity in vitro Cd2+ toxicity as affected by bare TiO2 nanopa ...
1_02 Toxicity and Toxicology
... In 1840, Marie LaFarge was accused for the murder of her husband using arsenic. Mysteriously, although arsenic was available to the killer and was found in the food, none could be found in the body. Orfila was asked by the court to make further investigations. He discovered that the test used, the M ...
... In 1840, Marie LaFarge was accused for the murder of her husband using arsenic. Mysteriously, although arsenic was available to the killer and was found in the food, none could be found in the body. Orfila was asked by the court to make further investigations. He discovered that the test used, the M ...
ERPGs - American Industrial Hygiene Association
... attempted by use of the Haber relationship (expressing the product of exposure concentration and exposure duration as a constant), or modifications thereof, without specific validating data. The Haber relationship, with or without some of the proposed modifications, does not hold true over more than ...
... attempted by use of the Haber relationship (expressing the product of exposure concentration and exposure duration as a constant), or modifications thereof, without specific validating data. The Haber relationship, with or without some of the proposed modifications, does not hold true over more than ...
The Alchemist`s Approach to Metal Poisoning: Transforming the
... metabolism and pharmacology, would be useful in metal exposure by any route, and has been directly and indirectly suggested previously [4–7]. The purpose of this review is to synthesize the various points of view and strategies into a whole. It is certainly not possible to summarize all knowledge of ...
... metabolism and pharmacology, would be useful in metal exposure by any route, and has been directly and indirectly suggested previously [4–7]. The purpose of this review is to synthesize the various points of view and strategies into a whole. It is certainly not possible to summarize all knowledge of ...
TOXICOLOGY I :
... who first prepared a systematic correlation between the chemical and biological properties of poisons of the time. He demonstrated effects of poisons on specific organs by analyzing autopsy materials for poisons and their associated tissue damage. The 20th century is marked by an advanced level of u ...
... who first prepared a systematic correlation between the chemical and biological properties of poisons of the time. He demonstrated effects of poisons on specific organs by analyzing autopsy materials for poisons and their associated tissue damage. The 20th century is marked by an advanced level of u ...
Fumonisin B1
Fumonisin B1 is the most prevalent member of a family of toxins, known as fumonisins, produced by several species of Fusarium molds, such as Fusarium verticillioides, which occur mainly in maize (corn), wheat and other cereals. Fumonisin B1 contamination of maize has been reported worldwide at mg/kg levels. Human exposure occurs at levels of micrograms to milligrams per day and is greatest in regions where maize products are the dietary staple.Fumonisin B1 is hepatotoxic and nephrotoxic in all animal species tested. The earliest histological change to appear in either the liver or kidney of fumonisin-treated animals is increased apoptosis followed by regenerative cell proliferation. While the acute toxicity of fumonisin is low, it is the known cause of two diseases which occur in domestic animals with rapid onset: equine leukoencephalomalacia and porcine pulmonary oedema syndrome. Both of these diseases involve disturbed sphingolipid metabolism and cardiovascular dysfunction.