Sodium hypochlorite
... EDC can be toxic to humans, and can cause skin and eye irritation. Inhalation of the vapours can also cause lung irritation. The substance is classified as a probable human carcinogen by IARC. An inhalation study indicates formation of mammary tissue tumours in rats, though the mode of action ...
... EDC can be toxic to humans, and can cause skin and eye irritation. Inhalation of the vapours can also cause lung irritation. The substance is classified as a probable human carcinogen by IARC. An inhalation study indicates formation of mammary tissue tumours in rats, though the mode of action ...
Potassium Permanganate
... states” While there is not a published, systematic review of how PP is commonly used in aquaculture, experience by several aquaculturusts, fish health managers and fisheries managers identify” certain characteristics. In other words, the findings published on PP so far, are mostly anecdotal! Ecologi ...
... states” While there is not a published, systematic review of how PP is commonly used in aquaculture, experience by several aquaculturusts, fish health managers and fisheries managers identify” certain characteristics. In other words, the findings published on PP so far, are mostly anecdotal! Ecologi ...
aristolochic_acid
... and overall same symptoms, but with minor variations as patients with Aristolochic acid nephropathy (AAN). It is highly suspected that BEN is caused by long-term exposure to small amounts of AA. This conclusion is popular due to the fact that many third-world countries use herbal remedies contai ...
... and overall same symptoms, but with minor variations as patients with Aristolochic acid nephropathy (AAN). It is highly suspected that BEN is caused by long-term exposure to small amounts of AA. This conclusion is popular due to the fact that many third-world countries use herbal remedies contai ...
sids initial assessment profile
... Neither the acid nor a sodium salt induced gene mutations in bacteria. ATMP induced gene mutations in mouse lymphoma cells but this effect was not seen when a neutralized test solution was tested up to the solubility limit and is therefore considered to be an artefact of pH. The pentasodium salt of ...
... Neither the acid nor a sodium salt induced gene mutations in bacteria. ATMP induced gene mutations in mouse lymphoma cells but this effect was not seen when a neutralized test solution was tested up to the solubility limit and is therefore considered to be an artefact of pH. The pentasodium salt of ...
Toxicant
... • Target or test organism: from single cell to higher animal. (cost and availability) • Dose unit. ( milligrams of agent per kilogram of body weight) • Period of the test. Acute toxicity is the effect of a single exposure or a series of exposures close together in a short period of time. Chronic tox ...
... • Target or test organism: from single cell to higher animal. (cost and availability) • Dose unit. ( milligrams of agent per kilogram of body weight) • Period of the test. Acute toxicity is the effect of a single exposure or a series of exposures close together in a short period of time. Chronic tox ...
SB1379 Fact Sheet The California Environmental Contaminant
... the levels of the pesticide DDT as other participants, despite the fact that DDT has been banned in the United States for over 30 years. The study also found that children have twice the level of the pesticide Dursban than adults. Virtually across the board, women had higher levels of phthalates th ...
... the levels of the pesticide DDT as other participants, despite the fact that DDT has been banned in the United States for over 30 years. The study also found that children have twice the level of the pesticide Dursban than adults. Virtually across the board, women had higher levels of phthalates th ...
Protective Effect of Honey and Propolis against Carbon Tetrachloride
... untreated diabetic group, the SOD activities and CAT levels have significantly decreased, while GSH-PX and GSH activities was increased in the CAPE-treated diabetic rats compared to those observed in untreated diabetic rats. Moreover, The GSH-PX activities in blood, liver and kidneys of heat stresse ...
... untreated diabetic group, the SOD activities and CAT levels have significantly decreased, while GSH-PX and GSH activities was increased in the CAPE-treated diabetic rats compared to those observed in untreated diabetic rats. Moreover, The GSH-PX activities in blood, liver and kidneys of heat stresse ...
METABOLISM OF XENOBIOTICS - Keluarga IKMA FKMUA 2010
... compounds that are foreign to the body. It includes drugs, food additives, pollutants etc. Understanding how xenobiotics are handled at the cellular level is important in learning how to cope with the chemical attack. ...
... compounds that are foreign to the body. It includes drugs, food additives, pollutants etc. Understanding how xenobiotics are handled at the cellular level is important in learning how to cope with the chemical attack. ...
Guidelines for application of chemical
... critical effects most often in animals by an uncertainty factor. The factor is generally the product principally of two 10-fold factors, one for interspecies differences (i.e. the variation in response between animals and a representative healthy human population) and one for inter-individual variab ...
... critical effects most often in animals by an uncertainty factor. The factor is generally the product principally of two 10-fold factors, one for interspecies differences (i.e. the variation in response between animals and a representative healthy human population) and one for inter-individual variab ...
Response Number of individuals affected
... Toxicant - A chemical or physical agent, including dusts, fibers, noise and radiation Toxicity – property of the toxicants describing its effect on biological organisms Toxic hazard – a likelihood of damage to biological organisms based on exposure resulting from transport and other physical factors ...
... Toxicant - A chemical or physical agent, including dusts, fibers, noise and radiation Toxicity – property of the toxicants describing its effect on biological organisms Toxic hazard – a likelihood of damage to biological organisms based on exposure resulting from transport and other physical factors ...
as file - Meetings, agendas, and minutes
... Following odour arising from the Finmere Quarry Landfill, the Environment Agency approached the Health Protection Agency for information on hydrogen sulphide and the possible health effects when exposed to elevated concentrations. Currently there is a temporary cap over the waste with some landfill ...
... Following odour arising from the Finmere Quarry Landfill, the Environment Agency approached the Health Protection Agency for information on hydrogen sulphide and the possible health effects when exposed to elevated concentrations. Currently there is a temporary cap over the waste with some landfill ...
Toxicology (Introduction) - Home
... -These reactions range from mild, itchy ,severe skin rash to anaphylaxis -Intensity is determined by degree of sensitization and not by the dose. Penicillin as an example: We can get sensitization from molds in the air or from antibiotics given to animals we eat, we don’t necessarily have to be give ...
... -These reactions range from mild, itchy ,severe skin rash to anaphylaxis -Intensity is determined by degree of sensitization and not by the dose. Penicillin as an example: We can get sensitization from molds in the air or from antibiotics given to animals we eat, we don’t necessarily have to be give ...
Motor Neuron Disease (ALS) - Anti
... glutamate toxicity, mitochondrial dysfunction and even viral infections as possible causes of MND. It is believed that these factors may work synergistically to cause and advance the disease. Heavy metals, inflammation and environmental agents are also possible factors to consider. 1 Exposure to neu ...
... glutamate toxicity, mitochondrial dysfunction and even viral infections as possible causes of MND. It is believed that these factors may work synergistically to cause and advance the disease. Heavy metals, inflammation and environmental agents are also possible factors to consider. 1 Exposure to neu ...
Benzene
... and respiratory tract irritation, and, at high levels, unconsciousness. Chronic (longterm) inhalation exposure has caused various disorders in the blood, including reduced numbers of red blood cells and aplastic anemia, in occupational settings. Reproductive effects have been reported for women expo ...
... and respiratory tract irritation, and, at high levels, unconsciousness. Chronic (longterm) inhalation exposure has caused various disorders in the blood, including reduced numbers of red blood cells and aplastic anemia, in occupational settings. Reproductive effects have been reported for women expo ...
CI Acid Orange 3 - IARC Monographs on the Evaluation of
... ln 14-day studies, groups of fIve Fischer 344/N rats of each sex received 0, 94, 187,375, 750 or 1500 mg/kg bw CI Acid Orange 3 (purity, 90%) and groups of five B6C3Fi mice of each sex received 0, 62, 125, 250, 500 or 1000 mg/kg bw CI Acid Orange 3 in corn oil by gavage for 14 consecutive days. No c ...
... ln 14-day studies, groups of fIve Fischer 344/N rats of each sex received 0, 94, 187,375, 750 or 1500 mg/kg bw CI Acid Orange 3 (purity, 90%) and groups of five B6C3Fi mice of each sex received 0, 62, 125, 250, 500 or 1000 mg/kg bw CI Acid Orange 3 in corn oil by gavage for 14 consecutive days. No c ...
Uremic Toxicity
... • “sick” uremic patients tend to have higher MMs in plasma than patients free of complications • Some studies support MMs involve in uremic neurotoxicity • Correlation have been found between plasma levels of immunoreactive parathyroid hormone and MMs • Patients on CAPD have been shown to have lower ...
... • “sick” uremic patients tend to have higher MMs in plasma than patients free of complications • Some studies support MMs involve in uremic neurotoxicity • Correlation have been found between plasma levels of immunoreactive parathyroid hormone and MMs • Patients on CAPD have been shown to have lower ...
Dioxins and PCBs
... In fish and shellfish, mercury is present in the form of methylmercury, while in most other food groups it is present in its inorganic form. Methylmercury is formed from inorganic mercury by the action of micro-organisms in marine and freshwater sediments. Predatory species of fish at the top of the ...
... In fish and shellfish, mercury is present in the form of methylmercury, while in most other food groups it is present in its inorganic form. Methylmercury is formed from inorganic mercury by the action of micro-organisms in marine and freshwater sediments. Predatory species of fish at the top of the ...
Toxicology in Drug Development
... • Monitor PK, antibody formation • Gross observations, histopathology on major organs and tissues • Include other clinical endpoints as appropriate (EKG, ophthalmology, BP) • Perform specialty testing on tissues/blood (immunohistochemistry, FACS) ...
... • Monitor PK, antibody formation • Gross observations, histopathology on major organs and tissues • Include other clinical endpoints as appropriate (EKG, ophthalmology, BP) • Perform specialty testing on tissues/blood (immunohistochemistry, FACS) ...
Six Common Errors Relating to Environmental Pollution
... the genetic material in cells). There was the previous precedent from research on radiation. which is both a mutagen and carcinogen. for thinking that there possibly. could be effects of chemicals even at low doses. . Our own work was critical in establishing the idea that most of the classical carc ...
... the genetic material in cells). There was the previous precedent from research on radiation. which is both a mutagen and carcinogen. for thinking that there possibly. could be effects of chemicals even at low doses. . Our own work was critical in establishing the idea that most of the classical carc ...
Toxicological Summary for Fluoranthene (PDF)
... Summary of toxicity testing for health effects identified in the Health Standards Statute ...
... Summary of toxicity testing for health effects identified in the Health Standards Statute ...
Chapter 5: ACUTE, SUBACUTE AND CHRONIC TOXICITY IN
... time of death or sacrifice; − date and time of death if prior to scheduled sacrifice; − time course of onset of signs of toxicity and whether these were reversible for each animal; − necropsy findings and histopathological findings for each animal, if available. ...
... time of death or sacrifice; − date and time of death if prior to scheduled sacrifice; − time course of onset of signs of toxicity and whether these were reversible for each animal; − necropsy findings and histopathological findings for each animal, if available. ...
Toxicology and Epidemiology (1st of 10 lectures on toxicological
... alcohol contaminated with TOCP. • 10,000 cases reported in Morocco in 1959, related to consumption of food cooked in oil contaminated with TOCP. • The association was initiated by two Oklahoma doctors: Miles and Goldfain. ...
... alcohol contaminated with TOCP. • 10,000 cases reported in Morocco in 1959, related to consumption of food cooked in oil contaminated with TOCP. • The association was initiated by two Oklahoma doctors: Miles and Goldfain. ...
Heavy Metals - Inno-Vita
... Lead and Cadmium. Other elements in trace forms (proper amounts and proper grades), such as Zinc, Copper, Chromium, Cobalt, Selenium, Iron and Manganese are essential for our own cellular metabolism and normal organ function. In the wrong amounts, even essential elements are unhealthy and can cause ...
... Lead and Cadmium. Other elements in trace forms (proper amounts and proper grades), such as Zinc, Copper, Chromium, Cobalt, Selenium, Iron and Manganese are essential for our own cellular metabolism and normal organ function. In the wrong amounts, even essential elements are unhealthy and can cause ...
Fumonisin B1
Fumonisin B1 is the most prevalent member of a family of toxins, known as fumonisins, produced by several species of Fusarium molds, such as Fusarium verticillioides, which occur mainly in maize (corn), wheat and other cereals. Fumonisin B1 contamination of maize has been reported worldwide at mg/kg levels. Human exposure occurs at levels of micrograms to milligrams per day and is greatest in regions where maize products are the dietary staple.Fumonisin B1 is hepatotoxic and nephrotoxic in all animal species tested. The earliest histological change to appear in either the liver or kidney of fumonisin-treated animals is increased apoptosis followed by regenerative cell proliferation. While the acute toxicity of fumonisin is low, it is the known cause of two diseases which occur in domestic animals with rapid onset: equine leukoencephalomalacia and porcine pulmonary oedema syndrome. Both of these diseases involve disturbed sphingolipid metabolism and cardiovascular dysfunction.