Handouts
... • Listbasedwithrelationships:inputsare – Asubsetofallgenes – Alistofannotations,eachlinkedtogenes,organizedin somerelationship(e.g.,ahierarchy) ...
... • Listbasedwithrelationships:inputsare – Asubsetofallgenes – Alistofannotations,eachlinkedtogenes,organizedin somerelationship(e.g.,ahierarchy) ...
EAWAG news 56e: Genomic Islands and Horizontal Gene Transfer
... the chromosome and for subsequent reintegration. It is an enzyme called “integrase”. Comparison of the biochemical composition of the integrase from strain B13 with other proteins showed that it was related to integrases from bacterial viruses (bacteriophages), which place their genomes into the chr ...
... the chromosome and for subsequent reintegration. It is an enzyme called “integrase”. Comparison of the biochemical composition of the integrase from strain B13 with other proteins showed that it was related to integrases from bacterial viruses (bacteriophages), which place their genomes into the chr ...
Mendel and the Gene Idea
... – Codominance - carriers may experience discomfort during periods of low blood Ox levels - other wise function normally – Believed to be result of malaria infestation in tropical regions ...
... – Codominance - carriers may experience discomfort during periods of low blood Ox levels - other wise function normally – Believed to be result of malaria infestation in tropical regions ...
HNA alleles and antigens, up-date 2015 Allele Description
... Recently a single nucleotide exchange of the CD177 gene has been addressed as a cause for the HNA-2 negative phenotype in cases of HNA-2 antibody formation (Li Y et al. PloS Genet 2015;29:e1005255, Bayat B et al. Transfusion 2016;56:2127-2132). This is under further investigation. 04.11.2016 Brigitt ...
... Recently a single nucleotide exchange of the CD177 gene has been addressed as a cause for the HNA-2 negative phenotype in cases of HNA-2 antibody formation (Li Y et al. PloS Genet 2015;29:e1005255, Bayat B et al. Transfusion 2016;56:2127-2132). This is under further investigation. 04.11.2016 Brigitt ...
Permanent draft genome of Thermithiobaclillus tepidarius DSM
... or confined to rare ecosystems. It forms white colonies of 2–5 mm diameter in 48 h that smell faintly of elementary sulfur if grown on thiosulfate-containing basal salts agar. In batch cultures, thiosulfate is oxidized stoichiometrically to tetrathionate early in the exponential phase, resulting in ...
... or confined to rare ecosystems. It forms white colonies of 2–5 mm diameter in 48 h that smell faintly of elementary sulfur if grown on thiosulfate-containing basal salts agar. In batch cultures, thiosulfate is oxidized stoichiometrically to tetrathionate early in the exponential phase, resulting in ...
... response element (DRE) (Table 1). A number of cis elements have been defined based on in silico and functional analysis data on a large number of promoters and is available in the database. The tools like PLACE help in identifying these sequences based on homology searches and help to predict functi ...
Signatures of Selection in the Human Olfactory Receptor OR5I1 Gene
... Investigación Biomédica en Red de Epidemiologı́a y Salud Pública, Barcelona, Catalonia, Spain The human olfactory receptor (OR) repertoire is reduced in comparison to other mammals and to other nonhuman primates. Nonetheless, this olfactory decline opens an opportunity for evolutionary innovation ...
... Investigación Biomédica en Red de Epidemiologı́a y Salud Pública, Barcelona, Catalonia, Spain The human olfactory receptor (OR) repertoire is reduced in comparison to other mammals and to other nonhuman primates. Nonetheless, this olfactory decline opens an opportunity for evolutionary innovation ...
emboj2008205-sup
... et al., 2005). Arrays were analyzed using GenePix pro 4.1 (Axon Instruments) and Gene Spring ...
... et al., 2005). Arrays were analyzed using GenePix pro 4.1 (Axon Instruments) and Gene Spring ...
Why the
... the SRY gene and an adjacent nonrecombining region. These differences implied that the SRY gene arose, and nearby recombination halted, close to when the mammalian lineage emerged, roughly 300 million years ago. We gained more information about the timing by applying a “molecular clock” analysis. Bi ...
... the SRY gene and an adjacent nonrecombining region. These differences implied that the SRY gene arose, and nearby recombination halted, close to when the mammalian lineage emerged, roughly 300 million years ago. We gained more information about the timing by applying a “molecular clock” analysis. Bi ...
The α-globin gene cluster: genetics and disorders
... packaged within circulating erythrocytes. It has been extensively studied in terms of its structure–function relationship, genetics and hereditary disorders. In 1949, Pauling and colleagues1 described sickle cell anemia as the first molecular disease. Globin genes were the first to be cloned and to ...
... packaged within circulating erythrocytes. It has been extensively studied in terms of its structure–function relationship, genetics and hereditary disorders. In 1949, Pauling and colleagues1 described sickle cell anemia as the first molecular disease. Globin genes were the first to be cloned and to ...
PDF - Oxford Academic - Oxford University Press
... acquisitions correspond to the origins of MAL, they employed an ad hoc phylogenetic test, which compares distributions of splits in the “import” and “recipient” set of gene trees. The recipient set is comprised of gene families only present in a single MAL, whereas members of the import set, discuss ...
... acquisitions correspond to the origins of MAL, they employed an ad hoc phylogenetic test, which compares distributions of splits in the “import” and “recipient” set of gene trees. The recipient set is comprised of gene families only present in a single MAL, whereas members of the import set, discuss ...
russell-silver syndrome
... copy of H19 is methylated (off). Individuals with RSS due to H19 abnormalities have both the maternal AND paternal copies of H19 expressed (both on). In ~10% of RSS patients the cause is uniparental disomy (UPD) of chromosome 7. Patients with RSS due to UPD have two copies of chromosome 7 from their ...
... copy of H19 is methylated (off). Individuals with RSS due to H19 abnormalities have both the maternal AND paternal copies of H19 expressed (both on). In ~10% of RSS patients the cause is uniparental disomy (UPD) of chromosome 7. Patients with RSS due to UPD have two copies of chromosome 7 from their ...
Inferring Ancestral Chloroplast Genomes with Inverted
... Abstract— Genome evolution is shaped not only by nucleotide substitutions, but also by structural changes including gene and genome duplications, insertions/deletions and gene order rearrangements. Reconstruction of phylogeny based on gene order changes has been limited to cases where equal gene con ...
... Abstract— Genome evolution is shaped not only by nucleotide substitutions, but also by structural changes including gene and genome duplications, insertions/deletions and gene order rearrangements. Reconstruction of phylogeny based on gene order changes has been limited to cases where equal gene con ...
Individual gene function 4A. Inferring gene function from mutations
... Loss-of-function are the gold standard for inferring gene function The strongest inference of gene function can be made by completely eliminating the function of the gene. Other types of alterations in gene activity can be highly informative but occasionally misleading, as discussed below. If we rem ...
... Loss-of-function are the gold standard for inferring gene function The strongest inference of gene function can be made by completely eliminating the function of the gene. Other types of alterations in gene activity can be highly informative but occasionally misleading, as discussed below. If we rem ...
The Cystic Fibrosis Gene
... Fig.1. Schematic model o f the Cystic Fibrosis gene product (CFTR). TM =Transmembrane region. NBF -nucleotide binding folds. As I have already stated, the actual pro tein, and its function in man, is not known, however the sequence of the amino-acids forming the gene is known and this can be used, ...
... Fig.1. Schematic model o f the Cystic Fibrosis gene product (CFTR). TM =Transmembrane region. NBF -nucleotide binding folds. As I have already stated, the actual pro tein, and its function in man, is not known, however the sequence of the amino-acids forming the gene is known and this can be used, ...
the genetics of tyrosinemia type i
... population, approximately 1/110, 000 is born with tyrosinemia. That means that about 1/150 people in the general population are carriers for tyrosinemia type 1. In the Saquenay-Lac St-Jean region of Quebec, Canada, it is much more common, and occurs in approximately 1/2000 people. Among individuals ...
... population, approximately 1/110, 000 is born with tyrosinemia. That means that about 1/150 people in the general population are carriers for tyrosinemia type 1. In the Saquenay-Lac St-Jean region of Quebec, Canada, it is much more common, and occurs in approximately 1/2000 people. Among individuals ...
Introduction to GeneBreak
... The GeneBreak package aims to systematically identify genes recurrently affected by copy number aberration-associated breakpoint locations that indicate underlying DNA breaks and thereby genes involved in structural variants. This is a short tutorial on how to use the GeneBreak package. It describes ...
... The GeneBreak package aims to systematically identify genes recurrently affected by copy number aberration-associated breakpoint locations that indicate underlying DNA breaks and thereby genes involved in structural variants. This is a short tutorial on how to use the GeneBreak package. It describes ...
Slide 1
... Figure 8. Comparison to other coexpression analysis methods We compared our method of combining global coexpression from different platforms (2PC) to two other recent methods. One analyzes experimental subsets separately and employs a ‘vote-counting’ method to identify gene pairs that appear highly ...
... Figure 8. Comparison to other coexpression analysis methods We compared our method of combining global coexpression from different platforms (2PC) to two other recent methods. One analyzes experimental subsets separately and employs a ‘vote-counting’ method to identify gene pairs that appear highly ...
Gene Mapping using 3 Point Test Crosses: Outlined below are the
... By adding a third gene, we now have several different types of crossing over products that can be obtained. The following figure shows the different recombinant products that are possible. ...
... By adding a third gene, we now have several different types of crossing over products that can be obtained. The following figure shows the different recombinant products that are possible. ...
I A
... Outline of extensions to Mendel’s analysis • Single-gene inheritance – In which pairs of alleles show deviations from complete dominance and recessiveness – In which different forms of the gene are not limited to two alleles – Where one gene may determine more than one trait ...
... Outline of extensions to Mendel’s analysis • Single-gene inheritance – In which pairs of alleles show deviations from complete dominance and recessiveness – In which different forms of the gene are not limited to two alleles – Where one gene may determine more than one trait ...
Copy-number variation
Copy-number variations (CNVs)—a form of structural variation—are alterations of the DNA of a genome that results in the cell having an abnormal or, for certain genes, a normal variation in the number of copies of one or more sections of the DNA. CNVs correspond to relatively large regions of the genome that have been deleted (fewer than the normal number) or duplicated (more than the normal number) on certain chromosomes. For example, the chromosome that normally has sections in order as A-B-C-D might instead have sections A-B-C-C-D (a duplication of ""C"") or A-B-D (a deletion of ""C"").This variation accounts for roughly 13% of human genomic DNA and each variation may range from about one kilobase (1,000 nucleotide bases) to several megabases in size. CNVs contrast with single-nucleotide polymorphisms (SNPs), which affect only one single nucleotide base.