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lecture23_AnnotatePr..
lecture23_AnnotatePr..

SilkDB: a knowledgebase for silkworm biology and genomics
SilkDB: a knowledgebase for silkworm biology and genomics

... The Silkworm Knowledgebase (SilkDB) is a webbased repository for the curation, integration and study of silkworm genetic and genomic data. With the recent accomplishment of a 6X draft genome sequence of the domestic silkworm (Bombyx mori ), SilkDB provides an integrated representation of the large- ...
CHANGES TO THE GENETIC CODE
CHANGES TO THE GENETIC CODE

... Changes that build up in the genes in our body cells during our lifetime cannot be passed on to our children Changes to the DNA can be due to exposure to radiation such as that produced by the sun or by certain chemicals in our diets and in our external environment. Changes may also occur in our DNA ...
Gene Flow Up to now, we have dealt with local populations in which
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Letter Detecting Sequence Homology at the

... encoded by genes that are physically clustered together on the chromosome in operons or gene clusters (Fischbach and Voigt 2010). The architectures of these gene clusters are sometimes well-conserved between species, but they may also evolve quickly through rearrangements, insertions, deletions, and ...
Baldness genetics – more than skin deep. Stephen B Harrap The
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Copies of Student Information pages
Copies of Student Information pages

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Exercise - GEP Community Server - Washington University in St. Louis
Exercise - GEP Community Server - Washington University in St. Louis

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MMG 232: Methods In Bioinformatics Spring 2016, 3 credits
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Class VII Using cloned DNA fragments to study gene expression 1

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... benefitted if animals are developed that can withstand hypoxic stress. It would also be important to know if this gene has any relationship with growth, to determine whether normal growth is affected during prolonged periods of hypoxia. HIF-1α has been widely studied in various mammalian and fish sp ...
An intron nucleotide sequence variant in a
An intron nucleotide sequence variant in a

... the pre-mRNA. Unfortunately experimental data on the mechanism of intron excision is insufficient to predict whether or not this particular G-»A replacement could cause ineffective pre-mRNA processing. In two studies insertions or deletions made in intron sequences had no apparent effect on gene tra ...
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Leukaemia Section t(5;11)(q35;q12) NSD1/FEN1 Atlas of Genetics and Cytogenetics in Oncology and Haematology

... The protein has 380 amino acids and localizes to the nucleus. It is a structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. It acts as a genome stabilization factor that prevents flaps from equilibrating into structures that le ...
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Copy-number variation



Copy-number variations (CNVs)—a form of structural variation—are alterations of the DNA of a genome that results in the cell having an abnormal or, for certain genes, a normal variation in the number of copies of one or more sections of the DNA. CNVs correspond to relatively large regions of the genome that have been deleted (fewer than the normal number) or duplicated (more than the normal number) on certain chromosomes. For example, the chromosome that normally has sections in order as A-B-C-D might instead have sections A-B-C-C-D (a duplication of ""C"") or A-B-D (a deletion of ""C"").This variation accounts for roughly 13% of human genomic DNA and each variation may range from about one kilobase (1,000 nucleotide bases) to several megabases in size. CNVs contrast with single-nucleotide polymorphisms (SNPs), which affect only one single nucleotide base.
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