Genetically Essential and Nonessential a-Tubulin Genes Specify Functionally Interchangeable Proteins.
... Both a-tubulin genes map to chromosome 13. Some of the most extensively studied gene families in higher organisms, such as histones and globins, are clustered. In yeast, linkage of related genes occurs only occasionally (e.g., the genes involved in galactose metabolism). Both TUB] and TUB3 were mapp ...
... Both a-tubulin genes map to chromosome 13. Some of the most extensively studied gene families in higher organisms, such as histones and globins, are clustered. In yeast, linkage of related genes occurs only occasionally (e.g., the genes involved in galactose metabolism). Both TUB] and TUB3 were mapp ...
Molecular Microbial Ecology of the Rhizosphere
... in surface adhesion or biofilm formation (Chen et al., 2007). Notably, triple helix repeat-containing collagen proteins were not detected in other representatives of the B. subtilis species complex, except for B. atrophaeus and B. pumilus. However, in the plant-associated B. amyloliquefaciens YAU Y2 ...
... in surface adhesion or biofilm formation (Chen et al., 2007). Notably, triple helix repeat-containing collagen proteins were not detected in other representatives of the B. subtilis species complex, except for B. atrophaeus and B. pumilus. However, in the plant-associated B. amyloliquefaciens YAU Y2 ...
GCAT-SEEK Workshop - Prokaryotic Genomics Module – Jeff
... libraries and sequence the DNA using NextGen technologies, probably MiSeq or HiSeq, to 100x coverage.(steps 1-3 above). We will then use example data to learn how to assemble the sequences into contigs, with or without a reference, manually edit the sequence to identify more overlaps and gaps that a ...
... libraries and sequence the DNA using NextGen technologies, probably MiSeq or HiSeq, to 100x coverage.(steps 1-3 above). We will then use example data to learn how to assemble the sequences into contigs, with or without a reference, manually edit the sequence to identify more overlaps and gaps that a ...
Glutathione S-transferase copy number variation alters lung gene expression M.W. Butler*
... the gene expression chips was then performed, followed by processing by the Affymetrix GeneChip Fluidics Station 450, and scanning with an Affymetrix GeneChip Scanner 3000 7G. The strict quality control measures employed included ensuring: 1) RNA quality, assessed as RNA integrity number .7.0; 2) cR ...
... the gene expression chips was then performed, followed by processing by the Affymetrix GeneChip Fluidics Station 450, and scanning with an Affymetrix GeneChip Scanner 3000 7G. The strict quality control measures employed included ensuring: 1) RNA quality, assessed as RNA integrity number .7.0; 2) cR ...
CHAPTER 2 Genome Sequence Acquisition and
... Epidemiologic studies suggest that 30 to 70% of the variation in body weight may be attributable to genetic factors. Hager et al. (1998) undertook a genomewide scan in affected sib pairs to identify chromosomal regions linked to obesity in a collection of French families. Model-free multipoint linka ...
... Epidemiologic studies suggest that 30 to 70% of the variation in body weight may be attributable to genetic factors. Hager et al. (1998) undertook a genomewide scan in affected sib pairs to identify chromosomal regions linked to obesity in a collection of French families. Model-free multipoint linka ...
Gene Conversion as a Source of Nucleotide Diversity in
... Examination of polymorphisms in the Plasmodium falciparum gene for falcipain 2 revealed that this gene is one of two paralogs separated by 10.8 kb in chromosome 11. We designate the annotated gene denoted chr11.gen_424 as encoding falcipain 2A and the annotated gene denoted chr11.gen_427 as encoding ...
... Examination of polymorphisms in the Plasmodium falciparum gene for falcipain 2 revealed that this gene is one of two paralogs separated by 10.8 kb in chromosome 11. We designate the annotated gene denoted chr11.gen_424 as encoding falcipain 2A and the annotated gene denoted chr11.gen_427 as encoding ...
Background and Overview of Comparative Genomics
... are derived from the majority noncoding and therefore more variable class of DNA (type I markers). However, these highly polymorphic markers are of very limited use for comparisons between genomes because their variability makes it impossible to detect homology across species. Although they may be e ...
... are derived from the majority noncoding and therefore more variable class of DNA (type I markers). However, these highly polymorphic markers are of very limited use for comparisons between genomes because their variability makes it impossible to detect homology across species. Although they may be e ...
Full Text
... protein sequences. For each pair of plant species (P1, P2) and each type of sequence (DNA, protein), four BLAST runs are executed: P1 against P2, P2 against P1, P1 against P1, and P2 against P2. The first two BLAST output files are used for orthology prediction, while the last two are used for the d ...
... protein sequences. For each pair of plant species (P1, P2) and each type of sequence (DNA, protein), four BLAST runs are executed: P1 against P2, P2 against P1, P1 against P1, and P2 against P2. The first two BLAST output files are used for orthology prediction, while the last two are used for the d ...
Fact Sheet 52|HAEMOPHILIA WHAT IS HAEMOPHILIA
... Female carriers of Haemophilia may not have abnormal levels of clotting factor. Genetic testing is the only way to confidently confirm or exclude your carrier status if the gene mutations have been identified in your family. Prenatal testing and PGD For females who are known genetic carriers for hae ...
... Female carriers of Haemophilia may not have abnormal levels of clotting factor. Genetic testing is the only way to confidently confirm or exclude your carrier status if the gene mutations have been identified in your family. Prenatal testing and PGD For females who are known genetic carriers for hae ...
Exercise II - GEP Community Server
... more plant genome sequences on the Red Line but take things a bit further. All of the available evidence is analyzed in Apollo. Like DNA Subway, Apollo allows you to view the evidence for a particular gene. But Apollo is more than a DNA viewer; it is also a genome editor. In this exercise you will e ...
... more plant genome sequences on the Red Line but take things a bit further. All of the available evidence is analyzed in Apollo. Like DNA Subway, Apollo allows you to view the evidence for a particular gene. But Apollo is more than a DNA viewer; it is also a genome editor. In this exercise you will e ...
PDF
... Oryza–Zizania divergence time (c. 26.7 Mya) is similar to previous estimations based on single genes (Ge et al., 1999; Guo and Ge, 2005), and is consistent with our estimate of the Zizania-specific WGD event. The Zizania genome shares high genomic synteny with the Oryza genome, with 1498 syntenic bl ...
... Oryza–Zizania divergence time (c. 26.7 Mya) is similar to previous estimations based on single genes (Ge et al., 1999; Guo and Ge, 2005), and is consistent with our estimate of the Zizania-specific WGD event. The Zizania genome shares high genomic synteny with the Oryza genome, with 1498 syntenic bl ...
Influence of industrial contamination on mobile genetic elements
... detected MGEs including plasmids, transposons and integrons across a wide variety of habitats (for example, Sobecky, 1999; Smalla and Sobecky, 2002; van Elsas and Bailey, 2002; Frost et al., 2005), but rarely in a quantitative manner due to previous methodological constraints. In those studies that ...
... detected MGEs including plasmids, transposons and integrons across a wide variety of habitats (for example, Sobecky, 1999; Smalla and Sobecky, 2002; van Elsas and Bailey, 2002; Frost et al., 2005), but rarely in a quantitative manner due to previous methodological constraints. In those studies that ...
WheatNet: A genome-scale functional network for hexaploid bread
... genome-scale network, which facilitates the prediction of novel candidate genes for a trait, can be constructed. Network-based predictions have been useful in the model plant Arabidopsis thaliana (Lee et al., 2010). However, such a predictive gene network is not yet available for bread wheat, Tritic ...
... genome-scale network, which facilitates the prediction of novel candidate genes for a trait, can be constructed. Network-based predictions have been useful in the model plant Arabidopsis thaliana (Lee et al., 2010). However, such a predictive gene network is not yet available for bread wheat, Tritic ...
The Birth- and- Death Evolution of Multigene Families Revisited
... many, if not most, gene families, and (2) the lack of accurate methods for inferring orthologous-paralogous gene relationships [4]. Gene families can be classified according to a number of criteria [3, 5, 6]. Such criteria may include, for example, (1) function, (2) how members are distributed acros ...
... many, if not most, gene families, and (2) the lack of accurate methods for inferring orthologous-paralogous gene relationships [4]. Gene families can be classified according to a number of criteria [3, 5, 6]. Such criteria may include, for example, (1) function, (2) how members are distributed acros ...
Leptin
... often coupled with a distorted self image which may be maintained by various cognitive biases that alter how the patient evaluates and thinks about her or his body, food and eating. Patients continue to feel hunger, but deny themselves all but very small quantities of food. ...
... often coupled with a distorted self image which may be maintained by various cognitive biases that alter how the patient evaluates and thinks about her or his body, food and eating. Patients continue to feel hunger, but deny themselves all but very small quantities of food. ...
Genome analysis of Desulfotomaculum gibsoniae strain
... from a freshwater ditch and is of interest because it can grow with a large variety of organic substrates, in particular several aromatic compounds, short-chain and mediumchain fatty acids, which are degraded completely to carbon dioxide coupled to the reduction of sulfate. It can grow autotrophical ...
... from a freshwater ditch and is of interest because it can grow with a large variety of organic substrates, in particular several aromatic compounds, short-chain and mediumchain fatty acids, which are degraded completely to carbon dioxide coupled to the reduction of sulfate. It can grow autotrophical ...
Large-Scale Variation Among Human and Great Ape Genomes
... comparative genomic hybridization (array CGH), measuring copy-number gains and losses among these species. Using an array of 2460 human bacterial artificial chromosomes (BACs) (12% of the genome), we identified a total of 63 sites of putative DNA copy-number variation between humans and the great ap ...
... comparative genomic hybridization (array CGH), measuring copy-number gains and losses among these species. Using an array of 2460 human bacterial artificial chromosomes (BACs) (12% of the genome), we identified a total of 63 sites of putative DNA copy-number variation between humans and the great ap ...
Determining the cause of patchwork HBA1 and HBA2 genes
... borderline low normal MCV of ~85 fL or less, we identified one additional individual of Asian Indian ethnicity who was heterozygous for the α121 patchwork allele, and a further eight unrelated individuals of different ethnicity who were heterozygous for α212 (Table 1). The single α121-positive indiv ...
... borderline low normal MCV of ~85 fL or less, we identified one additional individual of Asian Indian ethnicity who was heterozygous for the α121 patchwork allele, and a further eight unrelated individuals of different ethnicity who were heterozygous for α212 (Table 1). The single α121-positive indiv ...
Chromosome_Mutations_Tutorial_2015
... As you learn about different sex chromosome trisomy and monosomy syndromes, you will notice their symptoms are relatively mild despite the gain or loss of an entire sex chromosome. Extra X chromosomes (in a female or a male) will be deactivated so there is always a single working X in the cell. In a ...
... As you learn about different sex chromosome trisomy and monosomy syndromes, you will notice their symptoms are relatively mild despite the gain or loss of an entire sex chromosome. Extra X chromosomes (in a female or a male) will be deactivated so there is always a single working X in the cell. In a ...
Opposite deletions/duplications of the X chromosome: two
... Paralogous sequences on the same chromosome allow refolding of the chromosome into itself and homologous recombination. Recombinant chromosomes have microscopic or submicroscopic rearrangements according to the distance between repeats. Examples are the submicroscopic inversions of factor VIII, of t ...
... Paralogous sequences on the same chromosome allow refolding of the chromosome into itself and homologous recombination. Recombinant chromosomes have microscopic or submicroscopic rearrangements according to the distance between repeats. Examples are the submicroscopic inversions of factor VIII, of t ...
Copy-number variation
Copy-number variations (CNVs)—a form of structural variation—are alterations of the DNA of a genome that results in the cell having an abnormal or, for certain genes, a normal variation in the number of copies of one or more sections of the DNA. CNVs correspond to relatively large regions of the genome that have been deleted (fewer than the normal number) or duplicated (more than the normal number) on certain chromosomes. For example, the chromosome that normally has sections in order as A-B-C-D might instead have sections A-B-C-C-D (a duplication of ""C"") or A-B-D (a deletion of ""C"").This variation accounts for roughly 13% of human genomic DNA and each variation may range from about one kilobase (1,000 nucleotide bases) to several megabases in size. CNVs contrast with single-nucleotide polymorphisms (SNPs), which affect only one single nucleotide base.