2000 Genome Biology paper
... important in the evolution of species. Previously, these large-scale genome-changing events were studied through genetic or cytological studies. With the availability of many complete genome sequences it is now possible to study such events through comparative genomics. The publication of the yeast ...
... important in the evolution of species. Previously, these large-scale genome-changing events were studied through genetic or cytological studies. With the availability of many complete genome sequences it is now possible to study such events through comparative genomics. The publication of the yeast ...
Is there a gene for liking broccoli?
... preparing DNA samples for electrophoresis has become so affordable, that even some high school laboratories have this equipment and run these gels. The electrophoresis gel creates a pattern that indicates whether the genes from two DNA samples are the same or not. A process called PCR (polymerase ch ...
... preparing DNA samples for electrophoresis has become so affordable, that even some high school laboratories have this equipment and run these gels. The electrophoresis gel creates a pattern that indicates whether the genes from two DNA samples are the same or not. A process called PCR (polymerase ch ...
RNA-guided gene drives can efficiently bias inheritance in wild yeast
... observed a perfect 4:0 ratio of red:cream haploids, confirming that all copies of the ADE2 locus were disrupted. In contrast, 18 cream-colored cas9— diploids yielded a 2:2 red:cream ratio, indicating normal inheritance of the inactivated drive and the wild-type alleles (Fig. 2D). To determine whethe ...
... observed a perfect 4:0 ratio of red:cream haploids, confirming that all copies of the ADE2 locus were disrupted. In contrast, 18 cream-colored cas9— diploids yielded a 2:2 red:cream ratio, indicating normal inheritance of the inactivated drive and the wild-type alleles (Fig. 2D). To determine whethe ...
Evolutionary dynamics of full genome content in Escherichia coli
... and gene content has also been observed for divergent bacterial taxa (Fitz-Gibbon and House, 1999; Snel et al., 1999), but there is no reason why such an association should exist within species where it might be erased by either very high or very low rates of gene transfer and loss. The gene content ...
... and gene content has also been observed for divergent bacterial taxa (Fitz-Gibbon and House, 1999; Snel et al., 1999), but there is no reason why such an association should exist within species where it might be erased by either very high or very low rates of gene transfer and loss. The gene content ...
Comparative Genomics II.
... • D. pseudoobscura and D. persimilis are subling species – morphologically similar and able to be interbred in the laboratory. However, hybrid males from these crosses are sterile and hybrid females have severely reduced fertility. • D. mirand is less closely related to other two species. It rarely ...
... • D. pseudoobscura and D. persimilis are subling species – morphologically similar and able to be interbred in the laboratory. However, hybrid males from these crosses are sterile and hybrid females have severely reduced fertility. • D. mirand is less closely related to other two species. It rarely ...
Conservation and Coevolution in the Scale
... nonessential genes. Similarly, genes that encode proteins involved in numerous protein-protein interactions have been reported to be more evolutionarily conserved than genes encoding less-prolific interactors (Fraser et al. 2002; Fraser, Wall, and Hirsh 2003). A recent study that dealt with several ...
... nonessential genes. Similarly, genes that encode proteins involved in numerous protein-protein interactions have been reported to be more evolutionarily conserved than genes encoding less-prolific interactors (Fraser et al. 2002; Fraser, Wall, and Hirsh 2003). A recent study that dealt with several ...
Letter Neighboring Genes Show
... show only intrachromosomal but not interchromosomal 3D proximity in the human nucleus (Véron et al. 2011). Using high-resolution interchromosomal and intrachromosomal interaction data, we found that gene pairs that were genomic neighbors in some yeast species, but are separated in S. cerevisiae, sh ...
... show only intrachromosomal but not interchromosomal 3D proximity in the human nucleus (Véron et al. 2011). Using high-resolution interchromosomal and intrachromosomal interaction data, we found that gene pairs that were genomic neighbors in some yeast species, but are separated in S. cerevisiae, sh ...
Chapter 11 - Chromosome Mutations
... nullisomic: a cell or individual with one chromosomal type missing, with a chromosome number such as n - 1 or 2n - 2 trisomic: basically a diploid with an extra chromosome of one type, producing a chromosome number of the form 2n + 1 In polyploids x is not equivalent to n (see table 8-1) x= a set of ...
... nullisomic: a cell or individual with one chromosomal type missing, with a chromosome number such as n - 1 or 2n - 2 trisomic: basically a diploid with an extra chromosome of one type, producing a chromosome number of the form 2n + 1 In polyploids x is not equivalent to n (see table 8-1) x= a set of ...
Analysis of the mitochondrial COI gene and its
... Nucleotide substitution patterns may play an important role in obtaining information about phylogenetic relationships and the population structure of different organisms, and such variations may show increased diversification among independent lineages and increasingly divergent taxa (Galtier et al. ...
... Nucleotide substitution patterns may play an important role in obtaining information about phylogenetic relationships and the population structure of different organisms, and such variations may show increased diversification among independent lineages and increasingly divergent taxa (Galtier et al. ...
Saccharopolyspora erythraea that are involved
... After alteration, the gene and its surrounding DNA were transferred to plasmid pWHM3, an E . coli-Streptornyces shuttle plasmid that replicates poorly in Sac. erythraea. Homology-based, integrative transformation of Sac. erythraea protoplasts with the pWHM3 derivatives was then carried out as descri ...
... After alteration, the gene and its surrounding DNA were transferred to plasmid pWHM3, an E . coli-Streptornyces shuttle plasmid that replicates poorly in Sac. erythraea. Homology-based, integrative transformation of Sac. erythraea protoplasts with the pWHM3 derivatives was then carried out as descri ...
Alternative Splicing Analysis Tools Through the UCSC Genome
... 6. Select and copy the entire sequence of exon 5, along with 14 nucleotides in the upstream intron and 6 nucleotides in the downstream intron (you’ll also be copying the numbers, but don’t worry). 7. Getting rid of the numbers: Use sequence massager (http://www.attotron.com/cybertory/analysis/seqMas ...
... 6. Select and copy the entire sequence of exon 5, along with 14 nucleotides in the upstream intron and 6 nucleotides in the downstream intron (you’ll also be copying the numbers, but don’t worry). 7. Getting rid of the numbers: Use sequence massager (http://www.attotron.com/cybertory/analysis/seqMas ...
Becker Muscular Dystrophy (BMD)
... The symptoms of BMD vary greatly from one person to another. Some people lose their ability to walk in early adulthood. Others are able to continue walking throughout their lives. Life expectancy can be reduced, but many people with BMD live into their 70s and 80s. Some may develop heart problems ea ...
... The symptoms of BMD vary greatly from one person to another. Some people lose their ability to walk in early adulthood. Others are able to continue walking throughout their lives. Life expectancy can be reduced, but many people with BMD live into their 70s and 80s. Some may develop heart problems ea ...
Plumage Genes and Little Else Distinguish the Genomes of
... habitat change but also shows that hybridization has likely occurred over many millennia. These genomic inferences have multifaceted implications for the conservation of these taxa. The golden-winged warbler is currently listed as ‘‘threatened’’ under the Canadian Species at Risk Act and is being co ...
... habitat change but also shows that hybridization has likely occurred over many millennia. These genomic inferences have multifaceted implications for the conservation of these taxa. The golden-winged warbler is currently listed as ‘‘threatened’’ under the Canadian Species at Risk Act and is being co ...
Rare genomic changes and mitochondrial sequences
... have also proven to be phylogenetically informative within some groups, such as ticks (Murrell et al., 2003) and spiders (Masta and Boore, 2008). Besides potentially providing new types of genome structure characters for making phylogenetic inferences, mitochondrial genomes provide a rich source of ...
... have also proven to be phylogenetically informative within some groups, such as ticks (Murrell et al., 2003) and spiders (Masta and Boore, 2008). Besides potentially providing new types of genome structure characters for making phylogenetic inferences, mitochondrial genomes provide a rich source of ...
The genomic substrate for adaptive radiation in African cichlid fish
... RNA was re-suspended in water. P. nyererei: 9 tissues (brain, eye, gills, heart, kidney, muscle, ovary, skin and testis) were isolated from three individuals inbred for ∼ 5 generations in the laboratory of Dr. Ole Seehausen (Eawag, Switzerland). Tissues were harvested immediately after sacrificing f ...
... RNA was re-suspended in water. P. nyererei: 9 tissues (brain, eye, gills, heart, kidney, muscle, ovary, skin and testis) were isolated from three individuals inbred for ∼ 5 generations in the laboratory of Dr. Ole Seehausen (Eawag, Switzerland). Tissues were harvested immediately after sacrificing f ...
VCS: Tool for Visualizing Copy Number Variation and Single Nucleotide Polymorphism
... values for different research purposes. In addition, user can draw a Manhattan plot which easily can define appropriate significance value, and can perform the comparison among samples selected in this menu. The input file needs matrix format data with the information of physical location and the va ...
... values for different research purposes. In addition, user can draw a Manhattan plot which easily can define appropriate significance value, and can perform the comparison among samples selected in this menu. The input file needs matrix format data with the information of physical location and the va ...
Fusion Detection using Archer Analysis
... Reads with the same molecular barcode are consolidated into a single consensus read, since they are considered PCR duplicates. Reads with different molecular barcodes have a very high probability to be derived from different original fragments. Fusion candidates identified from multiple original fra ...
... Reads with the same molecular barcode are consolidated into a single consensus read, since they are considered PCR duplicates. Reads with different molecular barcodes have a very high probability to be derived from different original fragments. Fusion candidates identified from multiple original fra ...
Molecular Cloning and Nucleotide Sequence of the 3
... difference in species (Fig. 5). The 3-IMDH gene from Cundidu multosu has been cloned (Kawamura et ul., 1983), and its recently determined nucleotide sequence also has a high homology (76%) with the 3-IMDH gene of S . cerevisiue (M. Takagi, personal communication). The C. utilis 3-IMDH was one amino ...
... difference in species (Fig. 5). The 3-IMDH gene from Cundidu multosu has been cloned (Kawamura et ul., 1983), and its recently determined nucleotide sequence also has a high homology (76%) with the 3-IMDH gene of S . cerevisiue (M. Takagi, personal communication). The C. utilis 3-IMDH was one amino ...
The dual nature of homologous recombination in plants
... metabolic activities. Numbers are not available for plants, but it has been estimated that 5–10% of first passage primary fibroblasts from mice or humans have a chromosome break (discussed in Ref. [33]). In plants and vertebrates most of these breaks are repaired by nonhomologous-end joining (NHEJ), ...
... metabolic activities. Numbers are not available for plants, but it has been estimated that 5–10% of first passage primary fibroblasts from mice or humans have a chromosome break (discussed in Ref. [33]). In plants and vertebrates most of these breaks are repaired by nonhomologous-end joining (NHEJ), ...
PubMed Advanced: Linking PubMed to NCBI Genetics Databases
... Not the same as keyword searching! Ex: SOD1 becomes “superoxide dismutase 1[substance name]” ...
... Not the same as keyword searching! Ex: SOD1 becomes “superoxide dismutase 1[substance name]” ...
SNPs and Haplotypes
... • SNPs are the most simple form and most common source of genetic polymorphism in the human genome (90% of all human DNA polymorphisms are associated with SNPs). ...
... • SNPs are the most simple form and most common source of genetic polymorphism in the human genome (90% of all human DNA polymorphisms are associated with SNPs). ...
The Chicken (Gallus gallus) Z Chromosome Contains at Least Three
... Birds have female heterogamety with Z and W sex chromosomes. These evolved from different autosomal precursor chromosomes than the mammalian X and Y. However, previous work has suggested that the pattern and process of sex chromosome evolution show many similarities across distantly related organism ...
... Birds have female heterogamety with Z and W sex chromosomes. These evolved from different autosomal precursor chromosomes than the mammalian X and Y. However, previous work has suggested that the pattern and process of sex chromosome evolution show many similarities across distantly related organism ...
Supplementary Information 410 475
... product (CG12410) highly similar in sequence to TSG. Thus, vertebrate species are also each likely to contain more than one gene for TSG proteins. Although all characterized vertebrate TSG sequences are slightly more similar to TSG than to CG12410 (Fig. 1B), it is not possible at this time to conclu ...
... product (CG12410) highly similar in sequence to TSG. Thus, vertebrate species are also each likely to contain more than one gene for TSG proteins. Although all characterized vertebrate TSG sequences are slightly more similar to TSG than to CG12410 (Fig. 1B), it is not possible at this time to conclu ...
Copy-number variation
Copy-number variations (CNVs)—a form of structural variation—are alterations of the DNA of a genome that results in the cell having an abnormal or, for certain genes, a normal variation in the number of copies of one or more sections of the DNA. CNVs correspond to relatively large regions of the genome that have been deleted (fewer than the normal number) or duplicated (more than the normal number) on certain chromosomes. For example, the chromosome that normally has sections in order as A-B-C-D might instead have sections A-B-C-C-D (a duplication of ""C"") or A-B-D (a deletion of ""C"").This variation accounts for roughly 13% of human genomic DNA and each variation may range from about one kilobase (1,000 nucleotide bases) to several megabases in size. CNVs contrast with single-nucleotide polymorphisms (SNPs), which affect only one single nucleotide base.