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CHRONIC HEART FAILURE Ivabradine
CHRONIC HEART FAILURE Ivabradine

... Ivabradine (Procoralan®) is a pure heart-rate lowering agent licensed for use in heart failure. Data from the SHIFT study demonstrated that heart rate reduction using ivabradine in selected patients with chronic heart failure can significantly reduce hospitalisations due to worsening heart failure, ...
ABCD- Airway, Breathing, Circulation, and Defibrillation
ABCD- Airway, Breathing, Circulation, and Defibrillation

... BLS- Basic Life Support (CPR)- a combination of compressions and breaths given for the purpose providing artificial circulation of blood and oxygen to the organs Brachial artery- pulse site in the arm Bradycardia- a slow heart rate (less than 60 beats per minute) Cardiac Arrest- when the heart stops ...
Case Study CAD Equivalent
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... • Complete cessation • Avoidance of environmental tobacco smoke • Blood pressure • BP < 140/85 • Initial agents beta blocker and ACE-I • Add HCTZ or other agent as needed Smith SC et al. Circulation 2011;124:2458-2473 ...
Cardiovasculat presentation from Kay Elliot
Cardiovasculat presentation from Kay Elliot

... How to use GTN When to stop clopidogrel Eplerenone? ...
cardiovascular3
cardiovascular3

... Events are same for Cardiac Cycle for Right Side of Heart; only difference is lower systolic pressures in right atrium and right ventricle. ...
The CHF Patient - Edwards Lifesciences
The CHF Patient - Edwards Lifesciences

... Dysfunction in systole and/or diastole may result in CHF, related to passive backup of blood into the pulmonary and systemic venous beds and/or resistance in ventricular filling. It has been shown that “although there is some degree of diastolic dysfunction in most patients who present clinically wi ...
Podstawy patofizjologii chorób serca
Podstawy patofizjologii chorób serca

... Ventricular pressure continues to rise isovolumic ventricular contraction (semilunar valves closed) until the pulmonary and aortic valves open (ejection phase). At the end of ejection phase pressure in ventricles falls below pressure of the aorta and pulmonary trunc and semilunar valves close (secon ...
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... 1. The resting membrane potential of contractile cardiac muscle is - 85 mV 2. The depolarization is caused by opening: fast sodium channels. 3. The repolarization is caused by opening calcium and potassium channels. 4. The obligatory refractory period of cardiac muscle- between onset of depolarizati ...
Diastolic Dysfunction - Annals of Internal Medicine
Diastolic Dysfunction - Annals of Internal Medicine

... • Unlike in other patients with heart failure, a measurement of how well the heart beats, the ejection fraction, is normal. ...
Cardiac Resynchronization Therapy for HF - 2002
Cardiac Resynchronization Therapy for HF - 2002

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Heart Failure Presentation - Dorset County Hospital NHS

... Heart Pump Inefficiency – either primarily a disorder of filling or of emptying (Tinsley R Harrison, 1950) Most common cause is LV muscle damage Various conditions may predispose to, or cause, such muscle damage ...
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... b) His heart ejects 75 ml of blood per contraction c) His kidneys produce 320 ml of urine per hour d) All of his wisdom teeth have been removed e) His heart contracts 70 times per minute f) His systolic blood pressure is 130 mmHg g) His diastolic blood pressure is 80 mmHg h) The pressure in his left ...
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How to deal with heart attacks

... coronary artery which feeds the heart with blood. Over time this clogging causes narrowing of the artery and reduced blood supply. During excitement or exercise; the heart requires more blood which cannot get to the heart muscle and the heart is starved of oxygen causing pain in the chest area. ...
Heart Failure Fact Sheet-B100-0115-redline
Heart Failure Fact Sheet-B100-0115-redline

... Heart failure is the only major cardiovascular disease that is rising, with the number of deaths in the United States more than doubling since 1979.4 Typical care for managing advanced-stage heart failure patients often involves drug therapy combined with a strict diet and exercise program. In many ...
The importance of basic science in clinical cardiology
The importance of basic science in clinical cardiology

... UK). ‘Without that sort of development clinical practice wouldn’t evolve’. But, some clinicians may ask, how long does it take for a basic science advance to make a practical difference in the clinic? ‘Basic science discoveries have the potential of being translated into practice much more quickly t ...
10 .Congenitally corrected TGA- A case diagnosed incidentally
10 .Congenitally corrected TGA- A case diagnosed incidentally

... The progressive risk of spontaneous complete AV block throughout life in patients with CCTGA is 2% per year [2]. The prognosis rests on clinical presentation, progression of disease, and the effect of systemic pressure on the functional SV .Patients undiagnosed until adulthood usually have no associ ...
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2014 Johansen Trial

NURS 315/501 Bootcamp
NURS 315/501 Bootcamp

... Describe how ACE-I and ARB’s achieve the goals for HF management. Describe the function of beta-blockers in the management of HF. Describe the function of digoxin in the management of HF. What role does calcium channel blockers play in the management of HF? ...
Multaq : EPAR - Summary for the public - EMA
Multaq : EPAR - Summary for the public - EMA

... A sixth study (PALLAS) compared Multaq with placebo in patients over 65 years of age with permanent atrial fibrillation and several risk factors. The study was stopped early because of severe cardiovascular events (such as cardiovascular death or hospitalisation and stroke) in some patients taking M ...
Myocardial Infarction
Myocardial Infarction

... Direct activity against factors Xa and IIa Proven to be effective in treating ACS that are characterized by unstable angina or non ST- elevation MI Their fixed doses are easy to administer and laboratory testing to measure their therapeutic effect is not necessary makes them attractive alternative o ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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