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Cardiac Arrhythmias
Cardiac Arrhythmias

...  Hyper/Hypo-thyroid ...
Monitoring EKGs
Monitoring EKGs

... the heart. A typical EKG tracing consists of five identifiable deflections. Each deflection is noted by one of the letters P, Q, R, S, or T. The P wave is the first waveform in a tracing and represents the depolarization of the heart’s atria. The next waveform is a complex and consists of the Q, R, ...
Minimal Semptomlu Dev Sol Atriyal Miksoma: Olgu Sunumu
Minimal Semptomlu Dev Sol Atriyal Miksoma: Olgu Sunumu

... performed. The ascending aorta and the bicaval cannulation were completed. Cardiopulmonary bypass was established. The left atrium was opened. A huge left atrial mass originated from interatrial septum and occupying almost the entire left atrial cavity was seen. The right atrium then was opened and ...
A Closer Look Using a Magnet to Inhibit Tachy
A Closer Look Using a Magnet to Inhibit Tachy

... The PUNCTUA , ENERGEN , and INCEPTA Cardiac Resynchronization Therapy Defibrillators (CRT-Ds) are indicated for patients with heart failure who receive stable optimal pharmacologic therapy (OPT) for heart failure and who meet any one of the following classifications: • Moderate to severe heart failu ...
Basic Cardiovascular Physiology
Basic Cardiovascular Physiology

... Heart rate is an intrinsic property of the SA (pacemaker) node in the heart, and it is modified by autonomic, humoral, and local factors. For example: 1. An increase in vagal activity, via M2 cholinergic receptors in the heart, will decrease the heart rate. 2. An increase in sympathetic activity, vi ...
Heart Failure
Heart Failure

... amount of LV volume expelled during systole , normal EF ≥ 50 %  EF misleading may occurred with mitral stenosis , ...
High-tension electrical injury to the heart as assessed by
High-tension electrical injury to the heart as assessed by

... study indicates that even in patients without definite evidence of severe cardiac abnormality in the conventional test, radionuclide myocardial imaging detects significant myocardial damage due to electrical injury. Myocardial perfusion defects and/or decreased accumulation of radioisotopes were see ...
PDF - Circulation Research
PDF - Circulation Research

... situs solitus in the setting of a right-handed ventricular loop, irrespective of the junctions between the atrial and ventricular segments. It is {S,D,*}, and {I,L*} that represent atrioventricular concordance in the segmental system, with {S,L,*} and {I,D,*} accounting for atrioventricular discorda ...
The Heart
The Heart

... The atrio-ventricular septum completely separates the 2 sides of the heart. Unless there is a septal defect, the 2 sides of the heart never directly communicate. Blood travels from right side to left side via the lungs only. However the chambers themselves work together . The 2 atria contract simult ...
Pathogenesis of heart failure
Pathogenesis of heart failure

... Case of HF A 60-year-old man sustained an extensive acute myocardial infarction in left ventricle 4 years before his recent admission. Since that time, he has become progressively more breathless on exertion. The questions are: (a) What is the etiological cause? (b) What type of HF the patient is a ...
Post Mortems after Medical Interventions
Post Mortems after Medical Interventions

... Increasing age ...
The breathless patient - Phil Boreham
The breathless patient - Phil Boreham

... NI – lowers endothelin, vasopressin, sympathetic activity and RAASS NI+ACEinh results in raised bradykinin levels > facial angioedema NI+ARB blocks Angitensin II receptors(good vasodilatory effect) with not too much ...
Successful Surgical Correction of Congenital Heart Disease in Adults
Successful Surgical Correction of Congenital Heart Disease in Adults

... Introduction: The long term consequences of untreated or residual/recurrent lesions pose unique challenges in the growing population of adults with congenital heart disease (CHD). This study summarizes the results of the surgical treatment of these patients. Methods: From October 1997 to October 200 ...
File - Groby Bio Page
File - Groby Bio Page

... - The heart muscle depolarises (loses electrical charge) when it contracts, and repolarises (regains charge) when it relaxes. - Patches with wires are placed on the patients chest and wires are connected to a monitor. - Electric charges are recorded by an electrocardiograph, as a electrocardiogram/E ...
Structure of the Human Heart
Structure of the Human Heart

... The heart is a muscular organ found in all animals with circulatory system (including all vertebrates), that is responsible for pumping blood throughout the blood vessels by repeated, rhythmic contractions. The vertebrate heart is composed of cardiac muscle, contain involuntary striated muscle tissu ...
Impact of Pregnancy in Women after Atrial Repair for Transposition
Impact of Pregnancy in Women after Atrial Repair for Transposition

... arteries (TGA) are now in reproductive age. Atrial baffle leaks and obstruction. Supraventricular arrhythmias: • Synus disfunction. • Tachyarrhythmias. Tricuspid regurgitation. Systemic Right ventricle: progressive dilation and dysfunction. Asymptomatic  Exercise capacity ...
Heart Rhythm UK - British Heart Rhythm Society
Heart Rhythm UK - British Heart Rhythm Society

... cardiac device therapy to all patients who may benefit. This includes identification of patients with device indications, implantation of appropriate devices, patient and device follow-up, and data collection, storage and submission. It includes the best available evidence and expert opinion on curr ...
Heart Failure Guideline – Jun 2016 - North Of Tyne Area Prescribing
Heart Failure Guideline – Jun 2016 - North Of Tyne Area Prescribing

... antagonist (MRAs) are confined to second line treatment in patients with more severe heart failure, and generally to be used with advice from specialist care. However, more recent evidence5 has shown that eplerenone is also effective in patients with milder symptoms of heart failure if they have oth ...
Is Transesophageal Echocardiography May Be Useful Diagnosis of
Is Transesophageal Echocardiography May Be Useful Diagnosis of

... echocardiography (2DE), contrast-enhanced 2DE [5]. 2DE is by far the most commonly used diagnostic modality. Usually, multiple 2DE studies are needed before the diagnosis is made. The new technic of real-time tree-dimensional echocardiography (3DE) could provide an enhanced capability to diagnose an ...
Locum Consultant Cardiologist with an interest in Cardiac
Locum Consultant Cardiologist with an interest in Cardiac

Dr.Yoused Aljeesh Dr. Motasem Salah The Heartbeat
Dr.Yoused Aljeesh Dr. Motasem Salah The Heartbeat

... On completion of this chapter, the learner will be able to: 1. Explain cardiac physiology in relation to cardiac anatomy and the conduction system of the heart. 2. Incorporate assessment of functional health patterns and cardiac risk factors into the health. 3. Identify the clinical significance and ...
The heart transplant patient
The heart transplant patient

... Anticholinesterase inhibitors – no bradycardia BUT reports of cardiac arrest following neostgimine to reverse NDNMBs • Sugammadex has been used in a HTx patient ...
A Case of Wide Complex Tachycardia in a Patient with a
A Case of Wide Complex Tachycardia in a Patient with a

... arrhythmias that negatively impacted survival and other outcomes.1 Nevertheless, it has also been demonstrated that atrial arrhythmias are fairly common in patients with VADs and have affected outcomes including mortality by a variety of proposed mechanisms.2, 3 This case illustrated that in patient ...
Cardiovascular Agents Primary Factors Responsible for Blood
Cardiovascular Agents Primary Factors Responsible for Blood

Abnormal Left Ventricular Relaxation in Hypertensive Patients
Abnormal Left Ventricular Relaxation in Hypertensive Patients

... function. More precise estimates of left ventricular wall thickness by echocardiography are needed to correlate left ventricular wall thickness with changes in ejection and filling velocity since the echocardiogram is more sensitive than electrocardiographic studies in determining the structural con ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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