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УДК
УДК

... recognized marker of fibrosis, and pro-inflammatory cytokine interleukin-15 (IL-15) has not been studied in the formation of heart failure. Osteopontin is a secretory sialoproteid belonging to the class of matrix protein cells [4]. Proved his involvement in the inflammatory processes with increasing ...
About Electrophysiology Study of the Heart
About Electrophysiology Study of the Heart

... born with heart rhythm problems. Problems may also be caused by aging or heart disease. There are many different kinds of arrhythmias. Problems occur when the heart beats too fast or too slow. When this happens you may feel:  dizzy  faint  short of breath  very tired  palpitations (pounding in ...
Physiology – Biology 219
Physiology – Biology 219

... lobule to the central vein. What are the sinusoids? Identify two specific functions of the hepatocytes. On a microscope slide of the pancreas, distinguish between the acini and a pancreatic islet. Identify two substances secreted by the exocrine pancreas (acini and ducts) and two major hormones secr ...
Cardiovascular System - North Seattle College
Cardiovascular System - North Seattle College

... Exercise And The Heart Sedentary people  Increase in HR more dramatic  Stroke volume only goes up by 10-35% ...
Evaluating strict and conventional left bundle
Evaluating strict and conventional left bundle

... bundle branches into the LV and RV endocardium. Activation starts from activation foci at a given time and spreads to adjacent nodes via circular wavefronts. The conduction speed is defined for the endocardium, epicardium, and mid-myocardium (transmural conduction) independently. The normal activati ...
HEART SOUNDS
HEART SOUNDS

... • Murmurs are abnormal sounds produced due to abnormal flow of blood [turbulent blood flow] through abnormal heart valves e.g.. stenosis or incompetence. • Stenosis means narrow or stiff, valve that does not open completely. • Incompetent means valve which does not close properly and remains open. ...
Heart transplantation
Heart transplantation

... or significant risk of infection (eg hepatitis, HIV, CJD) in order to prevent transmission to the recipient. Despite these precautions, there is still the possibility of transmitting unknown chronic infection (usually viral) at the time of transplant surgery. Specific details are generally only pass ...
Chapter 18 ()
Chapter 18 ()

... surrounds and anchors valves; prevents overdilation serves as insertion for cardiac muscle bundles blocks electrical impulses H. conducting system 1. autorhythmic cells vs contractile cells a. contractile cells (99%) are specialized for contraction b. autorhythmic cells (1%) are specialized for gene ...
Genotype-phenotype correlation in long QT syndrome
Genotype-phenotype correlation in long QT syndrome

... de-polarizations and resultant TdP.18,19 Due to unclear reasons, women with LQT2 are also at higher risk for cardiac events in the post-partum period. This is thought to be multifactorial which likely includes hormonal changes, sleep disruption and the sudden auditory stimuli caused by the crying ne ...
Third and fourth heart sounds had low sensitivity but moderate to
Third and fourth heart sounds had low sensitivity but moderate to

... While the importance of these physical exam findings has been taught for decades, no study has determined their sensitivity and specificity using reproducible methods. Most studies rely on human detection, which is often variable and usually in the context of highly experienced physicians. Several s ...
PoST MyoCArDIAL InFArCTIon LEFT VEnTrICuLAr DySFunCTIon
PoST MyoCArDIAL InFArCTIon LEFT VEnTrICuLAr DySFunCTIon

... predictor of both short- and long-term survival after MI.Although a higher LVEF is associated with increased survival, SCD risk does not correlate well with LVEF. This was demonstrated in the Oregon Sudden Unexpected Death Study, where an LVEF of ≤0.35 was observed in only 30% of cases of sudden car ...
Surgical therapy for ischemic heart failure: Single
Surgical therapy for ischemic heart failure: Single

... Major findings from our results are as follow: (1) Significant volume reduction and improvement in EF are observed at the predischarge echo evaluation, and this improvement is still significant at late follow-up, despite a slight but significant increase in volumes and in MR, in respect to early aft ...
Chapter 18 ()
Chapter 18 ()

... surrounds and anchors valves; prevents overdilation serves as insertion for cardiac muscle bundles blocks electrical impulses H. conducting system 1. autorhythmic cells vs contractile cells a. contractile cells (99%) are specialized for contraction b. autorhythmic cells (1%) are specialized for gene ...
Clinical Anatomy Series – Cardiac Anatomy
Clinical Anatomy Series – Cardiac Anatomy

... A  combined  pattern  of  stenosis  and  incompetence  is  often  present,  although  one  may be more prominent clinically.  This leads to dysfunctional blood flow which can  produce  left  ventricular  hypertrophy,  increased  pulmonary  pressure,  pulmonary  oedema and left atrial dilatation.  Ty ...
The diagnosis and management of heart failure
The diagnosis and management of heart failure

... By observing or palpating the apical impulse and percussing the left cardiac borders, the examiner can determine heart size. A characteristic holosystolic murmur of mitral insufficiency or aortic stenosis is heard in many heart failure patients. Tricuspid insufficiency, which is also common, can be ...
Notes: Cardiovascular 2
Notes: Cardiovascular 2

... Coronary Circulation  Angina pectoris: -Chest pain due to inadequate supply of oxygen to the muscle -Indication some degree of coronary vessels blockage  Myocardial infarction: - Medical term for heart attack -Heart cells die from lack of blood supply ...
anticoagulation for atrial fibrillation pipe and cigar use lead to
anticoagulation for atrial fibrillation pipe and cigar use lead to

... with an ejection fraction of > 35%. PROSPECT study is a post-market was recommended for clinical study that enrolled 426 congestive heart failure patients with wide patients with advanced QRS duration. At six months after implant, the study showed that 63% of CRT patients with an ejection fraction o ...
Successful Resuscitation of a Cardiac Arrest Patient with Ruptured
Successful Resuscitation of a Cardiac Arrest Patient with Ruptured

... When the pericardial pressure rises to a level greater than the normal filling pressure of the right heart ...
CHF from HTN
CHF from HTN

... Mrs. B has noticed that she is most short of breath when she is laying down flat. She is able to sleep with three or four pillows but she prefers to sleep in her recliner chair. She enjoys walking about the neighborhood and talking to friends, but lately she does this much less because she comes hom ...
Cardiac Tamponade
Cardiac Tamponade

... • Pericardiocentesis is a procedure where fluid is aspirated from the pericardium (the sac enveloping the heart). ...
Subclinical left ventricle dysfunction revealed by echocardiography
Subclinical left ventricle dysfunction revealed by echocardiography

... digoxin and diuretics (furosemide and spironolactone) was initiated along with propranolol and after 6 months of follow-up left ventricle had recovered and the hemangioma showed a marked regression. However, it remains unclear whether it was the regression of the hemangioma itself or the heart failu ...
Chelation Therapy for Ischemic Heart Disease
Chelation Therapy for Ischemic Heart Disease

... mean (SD) baseline exercise time to ischemia was 572 (172) and 589 (176) seconds in the placebo and chelation groups, respectively. The corresponding mean changes in time to ischemia at 27 weeks were 54 seconds (95% confidence interval [CI], 23-84 seconds; P⬍.001) and 63 seconds (95% CI, 29-95 secon ...
Betaloc ZOK 25mg Composition Pharmaceutical form Indications
Betaloc ZOK 25mg Composition Pharmaceutical form Indications

... Metoprolol reduces or inhibits the agonistic effect on the heart of catecholamines (which are released during physical and mental stress). This means that the usual increase in heart rate, cardiac output, cardiac contractility and blood pressure, produced by the acute increase in catecholamines, is ...
Heart
Heart

... •The blood flow distal to the cuff is detected with a stethoscope placed over the brachial artery, near the elbow. When the pressure in the cuff is greater than in the artery, the vessel is occluded and there is no blood flow. When the pressure in the cuff is reduced to less than in the artery, the ...
I P
I P

... by Celladon Corporation. The vector in MYDICAR® is a virus made from adenoassociated virus (AAV) and the human gene SERCA2a. The AAV virus is not known to cause disease in humans. AAV is also replication defective, which means that it cannot duplicate without the presence of a helper virus. In addit ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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