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... 42. Can both tricuspid and pulmonary semilunar valves stay open simultaneously at any time in a cardiac cycle of a normal person? A. yes. B. no. 43. The QRS complex corresponds to ___. A. ventricular repolarization. B. ventricular depolarization. C. atrial depolarization. 44. A patient's ECG displa ...
Advanced Heart Failure Care
Advanced Heart Failure Care

... – Risk of stroke – clots and bleeding ...
presentation ()
presentation ()

... • To explore how regional wall thickening in patients with chronic IHD is affected by both infarct transmurality and the function of adjacent segments. • To compare with results from healthy subjects. ...
Volume 10, N .2 March 2013
Volume 10, N .2 March 2013

... At Hadassah Ein Kerem, the Electrophysiology department physicians (Heart Rhythm Specialists) have been performing these procedures for many years. We are constantly improving are approach with the most advanced catheter technologies. Our results and procedure times are comparable to world-wide sta ...
incidence of complications after cardiac
incidence of complications after cardiac

Beta Blocker Therapy for Long QT Syndrome and
Beta Blocker Therapy for Long QT Syndrome and

... preferable to beta 1-selective agents, the limited comparative data and less favorable pharmacokinetic profile raise concerns that it may be inferior to nadolol. Abu-Zeitone and colleagues found differences in likelihood of recurrent events in patients with LQTS, with propranolol therapy being the l ...
Decreased serum vascular endothelial growth factor - Heart
Decreased serum vascular endothelial growth factor - Heart

... severity of CHF (LVEF and BNP concentrations), and the mechanism by which circulating VEGF concentrations are decreased in CHF is unknown. It may be due to decreased VEGF production and/or enhanced VEGF clearance. Previously, Kraus and colleagues5 reported that VEGF concentrations in skeletal muscle ...
Exercise training in chronic heart failure: why, when and how
Exercise training in chronic heart failure: why, when and how

... [24, 25], while others have shown favourable effects on left ventricular remodeling [26]. Jugdutt et al. [27] reported a significant deterioration of both global and regional ventricular function after 12 weeks of exercise training in a program that was initiated 15 weeks after an acute anterior myo ...
Pathophysiology, risk stratification, and management
Pathophysiology, risk stratification, and management

... [44]. BNP level was shown to be a strong predictor ...
Arrhythmias in Pulmonary Arterial Hypertension
Arrhythmias in Pulmonary Arterial Hypertension

... al. demonstrated that AFL cavotricuspid isthmus ablation can be performed successfully and without complications, and was accompanied with a statistically significant improvement in functional class after ablation. In addition, there were no observable changes in echocardiographic parameters before v ...
Evidence of apoptosis in right ventricular dysfunction in
Evidence of apoptosis in right ventricular dysfunction in

... of RV is a poor prognostic factor in valvular heart disease4. Moreover, the presence of pulmonary arterial hypertension (PAH) is associated with a poor prognosis, with a median survival of 2.8 years5. PAH develops very slowly and over a long period. Thus, most of the studies on PAH and RV are from a ...
Determination of reference values for tricuspid annular plane
Determination of reference values for tricuspid annular plane

... Objective: Tricuspid annular plane systolic excursion (TAPSE) is an echocardiographic measurement used for evaluating right ventricular systolic function. While established reference values of TAPSE exist for the adult population, only a limited number of studies have attempted to evaluate reference ...
Long-term follow-up of primary and secondary prevention
Long-term follow-up of primary and secondary prevention

... specific patient criteria for inclusion and might, therefore, not be representative for the overall population presently considered for ICD treatment. The current study is of additive value to the current literature since it assesses long-term follow-up in a large population of primary and secondary ...
Percutaneous Mitral Valve Repair
Percutaneous Mitral Valve Repair

... Patient groups in which significant clinical benefits have been reported: • Degenerative MR, declined for surgery1 • Severe LV dysfunction refractory to medical therapy2 • Severe Heart Failure, despite optimal medical therapy3 • CRT non-responders4 • Bivalvular Disease: Severe Aortic Stenosis and Mi ...
Complete heart block in Acute Rheumatic fever
Complete heart block in Acute Rheumatic fever

... remained afebrile. Her NYHA functional class decreased to II. Her counts decreased to normal. Her steroid dose was tapered and she was discharged with ASA after 4 weeks of hospital admission. ...
Cardiac Surgery in Adults with Congenital Heart Disease: An
Cardiac Surgery in Adults with Congenital Heart Disease: An

... in Bethesda (2-3 October, 2000) the American College of Cardiology endorsed an investigation into the subject: “Care of the Adult with Congenital Heart Disease.” The associated report was published in the College’s journal in the spring of 2001.1 Epidemiology It is estimated that the number of adult ...
National Coverage Determination (NCD) for Cardiac PACEMAKERs
National Coverage Determination (NCD) for Cardiac PACEMAKERs

... Note: This may not be an exhaustive list of all applicable Medicare benefit categories for this item or service. Item/Service Description  A. General Permanent cardiac pacemakers refer to a group of self­contained, battery operated, implanted devices that send electrical stimulation to the heart thr ...
- Surrey Research Insight Open Access
- Surrey Research Insight Open Access

... Summary and conclusions The pre-hospital phase is the most critical in STEMI treatment. Minimising patient-related delay is the first key step in STEMI treatment: public/patient education campaigns, community organisation, and the presence of an unique European-wide emergency telephone number may be ...
The use of BNP to monitor and guide treatment of heart failure patients
The use of BNP to monitor and guide treatment of heart failure patients

... where the heart fails to effectively contract in systole, is the most common cause of chronic HF. Diastolic HF, which is more common in the elderly, retains systolic function and is indicated by the impairment of left ventricle filling during diastole. 2 There are two types of cardiac natriuretic pe ...
Ambulatory Monitoring for Heart Failure Patients – a Systematic
Ambulatory Monitoring for Heart Failure Patients – a Systematic

... 5. Cleland JG, Swedberg K, Follath F et al. The EuroHeart Failure survey programme-a survey on the quality of care among patients with heart failure in Europe. Part 1: patients characteristics and diagnosis. Eur Heart J 2003; 24: 442-463 ...
Full version (PDF file)
Full version (PDF file)

... hypertension is associated with lower peak oxygen uptake (VO2peak) and the antihypertensive treatment increases VO2peak (Missault et al. 1992). As resting BP is increased in patients with PA, it can be hypothesised that they will also have an inadequately increased BP during exercise and thus have a ...
Ch.-20-Lecture-wo
Ch.-20-Lecture-wo

... blood B. to allow complete ventricular contraction C. to allow complete atrial emptying D. to create more forceful ventricular contraction ...
I. Cardiac cycle A. Consists of one beat, or one P-QRS
I. Cardiac cycle A. Consists of one beat, or one P-QRS

... (1) Varies according to heart rate, influence of medications, and other factors (2) Should not be greater than half the distance between two regular R waves 3. Abnormal: a) Long - indicates that ventricular repolarization time has slowed, which means that the relative refractory period (the vulnerab ...
Exercise Training in Chronic Heart Failure
Exercise Training in Chronic Heart Failure

... Heart Disease: A Textbook of Cardiovascular Medicine. Third Edition. Braunwald E. (ed). WB Saunders Company, ...
Indications for dual-chamber cardioverter defibrillators at
Indications for dual-chamber cardioverter defibrillators at

... pacing indications and who were in New York Heart Association (NYHA) functional class III or IV. Dualchamber ICD therapy was considered possibly indicated in another 35 patients (14%), due to the presence of less than 20% left ventricular ejection fraction or a history of paroxysmal atrial fibrillat ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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