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Ch.-20-Lecture-wo
Ch.-20-Lecture-wo

... blood B. to allow complete ventricular contraction C. to allow complete atrial emptying D. to create more forceful ventricular contraction ...
Sudden Cardiac Death and Malignant Arrhythmias The Scope of the
Sudden Cardiac Death and Malignant Arrhythmias The Scope of the

... • “loss of sinus rhythm” - 20-60% at 20 yrs • pacing and HF • effects of slow HR on vent funct not wellstudied • dilation due to increased stroke volume contributes to HF, VA’s ...
Transcript
Transcript

... renin angiotensin system with ACE inhibitors and ARBs. And, this is just a slide reviewing a number of trials, heart failure, hypertension, arrhythmia trials in which the risk of developing atrial fibrillation was reduced with ACE inhibitors and ARBs. So, this is a well-established target in the pro ...
BRINAVESS, INN-vernakalant hydrochloride
BRINAVESS, INN-vernakalant hydrochloride

... Bradycardia was observed predominantly at the time of conversion to sinus rhythm. With a significantly higher conversion rate in patients treated with BRINAVESS, the incidence of bradycardia events was higher within the first 2 hours in vernakalant treated patients than in placebotreated patients (5 ...
Ivabradine in the management of coronary artery disease with or
Ivabradine in the management of coronary artery disease with or

... Provided that it is used at the recommended dose, ivabradine has been proved to be an effective, useful antianginal agent in patients with preserved or reduced EF. The angina substudy of BEAUTIfUL and an analysis of SHIfT patients with angina at entry seem to support a prognostic benefit, but these d ...
Study of the Correlation between Brain natriuretic peptide and Each
Study of the Correlation between Brain natriuretic peptide and Each

The Non Invasive Assessment of Risk of Sudden Death
The Non Invasive Assessment of Risk of Sudden Death

... also contain automatic triggers for prespecified high and low heart rates that will allow storage of data without patient activation. Eventually algorithms will be available that also allow the automatic detection of irregular rhythms such as atrial fibrillation. Unlike external recorders, implantab ...
Is Heart Rate Important for Patients With Heart Failure in Atrial
Is Heart Rate Important for Patients With Heart Failure in Atrial

... ventricular rates were not associated with increased mortality in patients with CHF, LVSD, and AF. Similar conclusions have been found from post-hoc analysis of the CHARM (Candesartan in Heart Failure: Assessment of Reduction in Mortality and morbidity) studies (15). There is a strong association be ...
cpr guidelines introduced
cpr guidelines introduced

... rhythm. Guidelines for defibrillation have also changed. Immediate defibrillation is no longer recommended for an unwitnessed cardiac arrest. Recommendations also do not include the use of stacked defibrillations. Rather, defibrillation should proceed two minutes of CPR with external cardiac compres ...
slide_2
slide_2

... inflammatory cell infiltrates, cytokine activation and virusmediated cell death. More useful when high sensitivity thresholds are used Troponin T threshold of >0.1ng/mL increases sensitivity from 34% to 53% and a specificity of 94% Cardiac biomarkers i.e. creatine kinase and troponin T and I ( elvat ...
lecture16_C
lecture16_C

... IABP gains wide acceptance as temporary cardiac assist system Cyclosporine, an anti-rejection drug, makes human heart transplants feasible PTCA to treat coronary artery disease with a balloon catheter External & implantable ventricular assist devices enter clinical trials ...
DISEASEDEX™ General Medicine Summary Heart failure, chronic
DISEASEDEX™ General Medicine Summary Heart failure, chronic

...  Plain chest X-ray: Radiographic findings in heart failure may include evidence of cardiac chamber enlargement, increased pulmonary venous pressure, interstitial or alveolar edema, pleural effusions, valvular or pericardial calcification, or lung disease , but a chest x-ray should not be used as a ...
DRGs 138/139
DRGs 138/139

... occasioning the admission of the patient to the hospital for care. Two or more diagnoses may equally meet the definition for principal diagnosis as determined by the circumstances of admission, diagnostic work-up and/or therapy provided. Be aware that there is a difference between admitting a patien ...
12 Analyzing Heart EKG LQ
12 Analyzing Heart EKG LQ

... An electrocardiogram (ECG or EKG) is a graphical recording of the electrical events occurring within the heart. In a healthy heart there is a natural pacemaker in the right atrium (the sinoatrial node) which initiates an electrical sequence. This impulse then passes down natural conduction pathways ...
ECG of thE Month ECG in a Cyanotic 22-Year
ECG of thE Month ECG in a Cyanotic 22-Year

... changes in the lateral precordial leads are signs of left ventricular hypertrophy, and those in the inferior leads suggest right ventricular hypertrophy. Congenital malformations that can result in cyanosis, increased pulmonary blood flow, and biventricular enlargement on electrocardiogram include t ...
Lecture : 1
Lecture : 1

... • Gap junctions is important in action potential spreads and cardiac muscle Syncytium • Resting membrane potential -85 mV • Phases of Action Potential in Cardiac Muscle:  Rapid depolarization (Na+ in ,+20 mV)  Partial repolarization (K+ out ,5-10 mV)  Action potential plateau (Ca2+ in ,0 mV)  R ...
Post thrombolytic ST segment resolution predict better outcome in MI
Post thrombolytic ST segment resolution predict better outcome in MI

... changes i.e. Segment elevation >0.2mv in at least two contiguous chest leads or >0.1mv in at least two contiguous limb leads, 3) New or presumably New left bundle branch block on Electrocardiogram and 4) raised levels of cardiac enzymes CPK-MB more than double of the reference value or positive Trop ...
Heart murmurs
Heart murmurs

FUNCTIONAL MITRAL REGURGITATION: IF THE MYOCARDIUM IS
FUNCTIONAL MITRAL REGURGITATION: IF THE MYOCARDIUM IS

... that a quote of about 30% of patients have little or no benefits from CRT. This failure can be attributed to procedural issues (inappropriate LV lead positioning), and to the extent and location of the scar tissue in ischaemic patients, as well as to the natural history of the underlying progressive ...
Autonomic Abnormality in Chronic Heart Failure
Autonomic Abnormality in Chronic Heart Failure

... day and night-time HR and the expected inverse correlation between LF and HF (r = -0.92). However. no method correlated significantly with peak oxygen uptake. exercise tolerance or ejection fraction. Thus in CHF the individual parameters of autonomic control seemed to reflect different aspects of th ...
Congenital heart disease in cats - Acapulco-Vet
Congenital heart disease in cats - Acapulco-Vet

... tricuspid insufficiency and can be easily confounded with a ventricular septal defect murmur; however the latter is often louder and hence not uncommonly associated with a thrill. In cases of severe TD the regurgitant flow might become laminar and no murmur will be audible. Clinical signs of right- ...
Should you evaluate for CAD in seniors with premature ventricular
Should you evaluate for CAD in seniors with premature ventricular

... The Framingham study looked at the prognostic implications of frequent PVCs (>30 per hour) in a cohort of symptomatic patients examined over a 6-year period.1 Men, but not women, had a significant increase in all-cause mortality (relative risk [RR]=2.36; 95% confidence interval [CI], 1.65-3.2) and m ...
Assessing left ventricular systolic function in shock: evaluation of
Assessing left ventricular systolic function in shock: evaluation of

... used the transesophageal approach [9,10]. Serial evaluation of LV systolic function by echocardiography may provide additional insight into the relation between cardiac function and critical illness. A number of methods can be used to assess LV systolic function with echocardiography. These are well ...
The Adult With Congenital Heart Disease
The Adult With Congenital Heart Disease

... young patients with a functionally normal aortic valve have echocardiographic evidence of aortic dilation (21,22). This diagnosis, too, should prompt the beginning of lifelong surveillance of the arterial tree. Both coarctation and BAV are part of a spectrum of arteriopathy, and the search for a com ...
Cardiac muscle
Cardiac muscle

... sarcoplasmic reticulum that must occur under normal excitation-contraction (EC) coupling to cause contraction. Once the intracellular concentration of calcium increases, calcium ions bind to the protein troponin, which initiates contraction by allowing the contractile proteins, myosin and actin to a ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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