Predictors of Cardiac Events After Major Vascular Surgery
... Main Outcome Measure Cardiac death or nonfatal myocardial infarction within 30 days after surgery, compared by clinical characteristics, DSE results, and b-blocker use. Results Forty-five patients (3.3%) had perioperative cardiac death or nonfatal myocardial infarction. In multivariable analysis, im ...
... Main Outcome Measure Cardiac death or nonfatal myocardial infarction within 30 days after surgery, compared by clinical characteristics, DSE results, and b-blocker use. Results Forty-five patients (3.3%) had perioperative cardiac death or nonfatal myocardial infarction. In multivariable analysis, im ...
Cardiac muscle
... sarcoplasmic reticulum that must occur under normal excitation-contraction (EC) coupling to cause contraction. Once the intracellular concentration of calcium increases, calcium ions bind to the protein troponin, which initiates contraction by allowing the contractile proteins, myosin and actin to a ...
... sarcoplasmic reticulum that must occur under normal excitation-contraction (EC) coupling to cause contraction. Once the intracellular concentration of calcium increases, calcium ions bind to the protein troponin, which initiates contraction by allowing the contractile proteins, myosin and actin to a ...
Larger Cell Size in Rabbits With Heart Failure Increases Myocardial
... Background—Patients with heart failure (HF) have an increased QRS duration, usually attributed to decreased conduction velocity (CV) due to ionic remodeling but which may alternatively result from increased heart size or cellular uncoupling. We investigated the relationship between QRS width, heart ...
... Background—Patients with heart failure (HF) have an increased QRS duration, usually attributed to decreased conduction velocity (CV) due to ionic remodeling but which may alternatively result from increased heart size or cellular uncoupling. We investigated the relationship between QRS width, heart ...
Left Bundle Branch Block and Left Ventricular Hypertrophy
... Table 1 summarizes the findings of this study. Thirty-six of the 50 patients had significant arteriosclerotic heart disease. Twenty-three of these 36 had arteriosclerotic heart disease as the only pathologic diagnosis while the additional 13 patients had concomitant hypertension and aortic valvular ...
... Table 1 summarizes the findings of this study. Thirty-six of the 50 patients had significant arteriosclerotic heart disease. Twenty-three of these 36 had arteriosclerotic heart disease as the only pathologic diagnosis while the additional 13 patients had concomitant hypertension and aortic valvular ...
Disruption of the circadian clock within the cardiomyocyte influences
... was used for isolation of both mitochondrial populations. Mice were anesthetized (isoflurane), and the left ventricle was excised and subsequently placed in KME (100 mM KCl, 50 mM MOPS, internal salt, and 0.5 mM EGTA). The IFM were harvested following treatment of skinned fibers with 5 mg/g wet wt t ...
... was used for isolation of both mitochondrial populations. Mice were anesthetized (isoflurane), and the left ventricle was excised and subsequently placed in KME (100 mM KCl, 50 mM MOPS, internal salt, and 0.5 mM EGTA). The IFM were harvested following treatment of skinned fibers with 5 mg/g wet wt t ...
Antianginal Drugs
... allowing a more efficient ventricular contraction). They are not used routinely in heart failure but can be used when: ① symptoms of pulmonary congestion predominate (redistribution of blood volume away from the chest relieves the congestion. This improves exercise tolerance even when cardiac output ...
... allowing a more efficient ventricular contraction). They are not used routinely in heart failure but can be used when: ① symptoms of pulmonary congestion predominate (redistribution of blood volume away from the chest relieves the congestion. This improves exercise tolerance even when cardiac output ...
Constrictive Pericarditis - STA HealthCare Communications
... abnormal filling of ventricles in early diastole which abruptly halts in mid-diastole. Complete filling of the ventricles is limited by non-compliance of the ventricles, which are restricted due to constricting pericardium. This chronic high pressure leads to systemic venous congestion, resulting in ...
... abnormal filling of ventricles in early diastole which abruptly halts in mid-diastole. Complete filling of the ventricles is limited by non-compliance of the ventricles, which are restricted due to constricting pericardium. This chronic high pressure leads to systemic venous congestion, resulting in ...
A 93-Year-Old Woman with an Abnormal
... AV junction, at low levels, digoxin slows AV nodal conduction by vagal stimulation. At toxic levels, it appears to act through its direct effects on the sodium pump to prolong the AV nodal refractory period. This direct effect at toxic levels leads not only to advanced AV nodal block, but it also en ...
... AV junction, at low levels, digoxin slows AV nodal conduction by vagal stimulation. At toxic levels, it appears to act through its direct effects on the sodium pump to prolong the AV nodal refractory period. This direct effect at toxic levels leads not only to advanced AV nodal block, but it also en ...
Paper Accepted* Original Article / Оригинални рад Prognostic value
... data supporting its use, and sST2 and troponin measurements were included in the American College of Cardiology/American Heart Association guidelines for the evaluation of HF [3]. However, the value of any biomarker for risk prediction in AHF, should clearly depend on the degree to which it adds to ...
... data supporting its use, and sST2 and troponin measurements were included in the American College of Cardiology/American Heart Association guidelines for the evaluation of HF [3]. However, the value of any biomarker for risk prediction in AHF, should clearly depend on the degree to which it adds to ...
hap10 - WordPress.com
... P wave corresponds to depolarization of SA node QRS complex corresponds to ventricular depolarization T wave corresponds to ventricular repolarization Atrial repolarization record is masked by the larger QRS complex ...
... P wave corresponds to depolarization of SA node QRS complex corresponds to ventricular depolarization T wave corresponds to ventricular repolarization Atrial repolarization record is masked by the larger QRS complex ...
EXTRA SYSTOLES IN THE FROG HEART
... this experiment also includes a comment on the amplitudes of the ES and PES. The standard teaching is that the ES should be smaller and the PES potentiated (Postextrasystolic Potentiation or PESP) as compared to a normal beat (Fig. 1). The explanation offered for the expected observation is that the ...
... this experiment also includes a comment on the amplitudes of the ES and PES. The standard teaching is that the ES should be smaller and the PES potentiated (Postextrasystolic Potentiation or PESP) as compared to a normal beat (Fig. 1). The explanation offered for the expected observation is that the ...
Developing Electrocardiogram Mathematical Model for
... will be: normal as shown in Figure 5(a) or extrasystolic as shown in Figure 5(b)-(d). In case of normal contraction the excitation is shifted in time towards the end of the period, and in case of extrasystolic contraction there is no such shift. Thus, the fact is modeled, that extrasystolic, out-of- ...
... will be: normal as shown in Figure 5(a) or extrasystolic as shown in Figure 5(b)-(d). In case of normal contraction the excitation is shifted in time towards the end of the period, and in case of extrasystolic contraction there is no such shift. Thus, the fact is modeled, that extrasystolic, out-of- ...
No Slide Title
... AP and contraction • Ca+ triggers the same series of events as seen in skeletal muscle – troponintropomyosin “shift” – BUT – the amount of Ca+ release can directly affect the number of cross-brides formed in cardiac muscle and can directly affect the strength of the contraction! – elevated ECF Ca+ ...
... AP and contraction • Ca+ triggers the same series of events as seen in skeletal muscle – troponintropomyosin “shift” – BUT – the amount of Ca+ release can directly affect the number of cross-brides formed in cardiac muscle and can directly affect the strength of the contraction! – elevated ECF Ca+ ...
INDICATIONS AND USAGE DOSAGE AND ADMINISTRATION
... peginterferon alfa-2a-treated subjects in clinical trials. Anemia associated with ribavirin occurs within 1 to 2 weeks of initiation of therapy. Because the initial drop in hemoglobin may be significant, it is advised that hemoglobin or hematocrit be obtained pretreatment and at week 2 and week 4 of ...
... peginterferon alfa-2a-treated subjects in clinical trials. Anemia associated with ribavirin occurs within 1 to 2 weeks of initiation of therapy. Because the initial drop in hemoglobin may be significant, it is advised that hemoglobin or hematocrit be obtained pretreatment and at week 2 and week 4 of ...
Sudden Death In the Structurally Normal Heart
... Spontaneous type 1 ECG “Asymptomatic” Negative family hx EP study (IIA indication) • Sustained VT with DES at 500 from RVA • No supraventricular arrhythmias induced • Normal AV node and His-Purkinje function ...
... Spontaneous type 1 ECG “Asymptomatic” Negative family hx EP study (IIA indication) • Sustained VT with DES at 500 from RVA • No supraventricular arrhythmias induced • Normal AV node and His-Purkinje function ...
ESC Expert consensus document on angiotensin converting
... present all the relevant evidence on a particular issue in order to help physicians to weigh the benefits and risks of a particular diagnostic or therapeutic procedure. They should be helpful in everyday clinical decision-making. A great number of Guidelines and Expert Consensus Documents have been ...
... present all the relevant evidence on a particular issue in order to help physicians to weigh the benefits and risks of a particular diagnostic or therapeutic procedure. They should be helpful in everyday clinical decision-making. A great number of Guidelines and Expert Consensus Documents have been ...
Expert consensus document on angiotensin converting enzyme
... present all the relevant evidence on a particular issue in order to help physicians to weigh the benefits and risks of a particular diagnostic or therapeutic procedure. They should be helpful in everyday clinical decision-making. A great number of Guidelines and Expert Consensus Documents have been ...
... present all the relevant evidence on a particular issue in order to help physicians to weigh the benefits and risks of a particular diagnostic or therapeutic procedure. They should be helpful in everyday clinical decision-making. A great number of Guidelines and Expert Consensus Documents have been ...
(AV) Block
... There are several important points that should be considered when initiating the pulseless arrest algorithm: • High-quality CPR should be performed until the defibrillator is attached the patient. • Interruptions in chest compressions should be kept to a minimum. • Rapid use of the defibrillator s ...
... There are several important points that should be considered when initiating the pulseless arrest algorithm: • High-quality CPR should be performed until the defibrillator is attached the patient. • Interruptions in chest compressions should be kept to a minimum. • Rapid use of the defibrillator s ...
Physical activity and exercise training in preventive cardiology
... cardiovascular (CV) health. Nowadays, multiple population-based trials have confirmed that there is an inverse correlation between PA and all-cause/CV mortality: even doses as low as 15 min of PA per day appear to reduce CV disease risk and all-cause mortality with the greatest health gains due to t ...
... cardiovascular (CV) health. Nowadays, multiple population-based trials have confirmed that there is an inverse correlation between PA and all-cause/CV mortality: even doses as low as 15 min of PA per day appear to reduce CV disease risk and all-cause mortality with the greatest health gains due to t ...
Advanced Cardiac Life Support 2000
... • Goal: AEDs used by laypersons everywhere • Most effective cardiac intervention • Shown to be cost effective (cost per life year saved) • Response time goal is 3 to 5 minutes – Police – Fire – Casino – Airlines – First responders • Survival rates up to 49% from primary ventricular fibrillation ...
... • Goal: AEDs used by laypersons everywhere • Most effective cardiac intervention • Shown to be cost effective (cost per life year saved) • Response time goal is 3 to 5 minutes – Police – Fire – Casino – Airlines – First responders • Survival rates up to 49% from primary ventricular fibrillation ...
The Effect of Regular Physical Activity on the Left Ventricle Systolic
... comparison with them, our patients had only slight depression of LVEF and not all of them underwent clinical myocardial infarction. The intensity and duration of CR necessary for LV function improvement have not yet been sufficiently evaluated. In the analysis in the work of Piepoli (2004) the data ...
... comparison with them, our patients had only slight depression of LVEF and not all of them underwent clinical myocardial infarction. The intensity and duration of CR necessary for LV function improvement have not yet been sufficiently evaluated. In the analysis in the work of Piepoli (2004) the data ...
Non Invasive Haemodynamic Monitoring
... • Furthermore, this technique is sensitive to the placement of the electrodes on the body, variations in patient body size, and other physical factors that impact on electric conductivity between the electrodes and the skin (eg, temperature and ...
... • Furthermore, this technique is sensitive to the placement of the electrodes on the body, variations in patient body size, and other physical factors that impact on electric conductivity between the electrodes and the skin (eg, temperature and ...
Cardiac contractility modulation
.jpg?width=300)
Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.