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Clinical characteristics of adult uncorrected secundum atrial septal
Clinical characteristics of adult uncorrected secundum atrial septal

... Atrial septal defect (ASD) is the most frequent congenital heart disease in adulthood. Pulmonary hypertension (PH) complicating ASD compels patients seeking medical assistance because of its disabling symptom. Most adult ASD develop PH which render significant morbidity and mortality. The aim of the ...
Pulmonary Arterial Hypertension - The Association of Physicians of
Pulmonary Arterial Hypertension - The Association of Physicians of

... Functional class: New York Heart Association (NYHA) functional class III and IV have lower medial survival than class I and II, i.e. 2.5 years versus 6 years.14 Six-minute work test was found to be and independent predictor of survival leading to use of this test as the primary end point for many pr ...
The Apical First Heart Sound as an Aid in the Diagnosis
The Apical First Heart Sound as an Aid in the Diagnosis

... Splitting of the first hleart sounid was first lescribed by Potai.n'111 in the nineteenth century. He advaneed nio pLysiologic explanation for this finding, althouitgh he believed that the first heart sounlld was produced by closure of the atrioventrieular valves. In 1925, Katz" demnonistrated exper ...
- American Association for Thoracic Surgery
- American Association for Thoracic Surgery

... or a no-HRE control group. The primary end point was the need for blood transfusion. The secondary end point was the incidence of adverse events. The HRE Group required nearly one-third fewer blood units per patient, compared with the control group (0.39 units vs. 1.12 units, respectively). The mean ...
N-terminal pro B-type natriuretic peptide (NT
N-terminal pro B-type natriuretic peptide (NT

... excluding acute heart failure are: NT-proBNP less than 300 ng/L or BNP less than 100 ng/L. If these levels are exceeded, echocardiography is recommended within 48 hours to guide early specialist management. The NICE clinical guideline CG108 (2010) on the management of chronic heart failure in adult ...
Clinical Information
Clinical Information

... signal distortion. If ECG signal distortion is severe it may be necessary to select another lead or reposition the ECG electrodes. Once you have done all things possible to reduce the interference, adjust the current until capture is recognized. Monitoring the externally paced patient Patients who a ...
Editorial
Editorial

... the initial depolarization, a brief repolarization event occurs in human hearts that sets the critically important plateau phase of the AP during which calcium enters the cytosol, leading to contraction; alteration of the plateau predisposes to arrhythmia. The brief repolarization before the plateau ...
Left Atrial Appendage Closure Devices for
Left Atrial Appendage Closure Devices for

... anticoagulation therapy and determined that it does not meet Technology Evaluation Criteria.[5] In addition, there are two RCTs, the PROTECT-AF and the PREVAIL trials, that have evaluated the WATCHMAN™ device. The first RCT is the PROTECT-AF study by Holmes which reported outcomes for 18 months of f ...
Microtubule Involvement in the Adaptation to Altered Mechanical
Microtubule Involvement in the Adaptation to Altered Mechanical

... function in the fetal heart and young infant.15,16 Although the relationship between changes in ventricular load, function, and structure is well documented, we know very little regarding the intracellular and extracellular mechanisms responsible for this adaptation in the developing myocardium. Cha ...
Human ECG Laboratory Experiment By Brittany Baierlein, Alison L
Human ECG Laboratory Experiment By Brittany Baierlein, Alison L

... QRS complex and the waves associated with an ECG. Finally, the lab will serve as a way to learn how to use an ECG to record and calculate heart rate. 1) INTRODUCTION: 1a) The Electrocardiogram: An ECG can be used to record activity during the cardiac process of pumping and returning blood to the bod ...
AHA/ACCF/ESC Scientific Statement
AHA/ACCF/ESC Scientific Statement

... new-onset unexplained cardiomyopathy. These are the most reliable data in the literature20; the complication rates of sheath insertion and biopsy procedure were reported as 2.7% and 3.3%, as noted in Table 1. The death rate associated with EMB is a result of perforation with pericardial tamponade.20 ...
Syncytium in Drosophila melanogaster
Syncytium in Drosophila melanogaster

Perioperative for pdf - St. Joseph Mercy Ann Arbor
Perioperative for pdf - St. Joseph Mercy Ann Arbor

... to cancellation or delay of surgery until the problem has been identified and treated. Examples of unstable coronary syndromes include recent MI with evidence of ischemic risk by clinical symptoms or noninvasive study, unstable or severe angina, and new or poorly controlled ischemia-mediated HF. Man ...
High intensity intermittent exercise improves cardiac
High intensity intermittent exercise improves cardiac

... participant could not commit the time and two failed to comply with MRI procedures, leaving 12 in the HIIT group and 11 in the control group (Fig. 1). Experimental protocol and randomisation Following an initial screening visit, cardiac structure and function, liver and visceral fat, body compositio ...
Pharmacology and the Nursing Process, 4th ed. Lilley/Harrington
Pharmacology and the Nursing Process, 4th ed. Lilley/Harrington

... Used in the intensive care setting as a final effort to treat severe, life-threatening heart failure, often in combination with several other cardiostimulatory medications ...
the heart - Cloudfront.net
the heart - Cloudfront.net

... • Influx of Na+ from the extracellular fluid into cardiac cells initiates a positive feedback cycle that causes the rising phase of the action potential (-90 mV to nearly + 30 mV) by opening voltage-regulated fast Na+ channels • Period of increased Na+ permeability is very brief, because the sodium ...
European experience of the convergent atrial fibrillation procedure
European experience of the convergent atrial fibrillation procedure

... METHODS This is an outcomes data evaluation study performed at 4 European centers in compliance with the Declaration of Helsinki. Local medical ethics committee approval was obtained by each site before study initiation. All patients with a history of persistent or long-standing persistent AF consen ...
Slide 1
Slide 1

... have normal ventricular function, no known mitral valvular disease and no history of thromboembolic event can be considered for cardioversion in the ED Up to 90% of atrial fibrillation episodes are asymptomatic with approximately 20% of such episodes longer than 48 hrs (Select your cardioversion cas ...
Phase-contrast MRI volume flow - a acquisitions Linköping University Post Print
Phase-contrast MRI volume flow - a acquisitions Linköping University Post Print

... Even over shorter periods of time, heart rate varies with anxiety/arousal of the patient. In this study, individual heart rates differed substantially between the different acquisitions, the largest difference in a particular patient ...
Patients with a hypertensive response to exercise have
Patients with a hypertensive response to exercise have

... Journal of the American College of Cardiology © 2004 by the American College of Cardiology Foundation ...
presentation source
presentation source

... catecholamines. The high blood concentration of catecholamines causes the heart rate to accelerate. ...
Controlled Trial of Physical Training in Chronic Heart
Controlled Trial of Physical Training in Chronic Heart

... by the trip to the hospital and most likely to represent daytime and sleeping states. They are not, however, full summaries of waking and sleeping heart rate behavior. Resting ECG recording in the laboratory. During supine rest in a quiet, darkened room, 640 consecutive heartbeats were recorded on a ...
Echocardiological Assessment of Diastolic Dysfunction using the Vevo
Echocardiological Assessment of Diastolic Dysfunction using the Vevo

... Doppler is used to assess diastolic dysfunction at the mitral valve. The sample volume is typically placed at the annulus of this valve to quantify the movement of the tissue in this area. Again this image is acquired from a modified apical four chamber view. The key measurements made from this spec ...
Developmental anatomy of the heart: a tale of
Developmental anatomy of the heart: a tale of

... where the exact staging protocol that has been followed is not known, it is equally important to point that out when reporting on data based on these tissues. As more and more clinical imaging techniques are now being adapted for use in studies on mouse models [e.g., MRI, ultrasound (10)], it is imp ...
- American Journal of Kidney Diseases
- American Journal of Kidney Diseases

... driver of fluid distribution between compartments in the human body, albumin has great appeal as a resuscitative fluid. Albumin was a staple for volume resuscitation until a meta-analysis in 1998 showed that it was associated with increased mortality. Opinions changed again after publication of the SA ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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