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Module 6
Module 6

... quinidine. The QT interval (0.6 seconds) is markedly prolonged for the heart rate (65/min) and the QT interval is greater than one half the R-R ...
AUSCULTATION SKILLS for ATHLETIC TRAINERS
AUSCULTATION SKILLS for ATHLETIC TRAINERS

... UMDNJ-Robert Wood Johnson Medical School New Brunswick, NJ The Athletes Heart (Athletic Heart Syndrome) I. ...
Cardiac risk assessment before the use of stimulant medications in
Cardiac risk assessment before the use of stimulant medications in

... sudden death. ECG screening has been evaluated as a method to prevent sudden cardiac death in athletes in the United States, with an estimated cost of US $44,000 per year of life saved [36]. Japan has per­ formed school-based ECG screening of all children, with an estimated cost of US$8,800 per year ...
Sudden death due to duchenne muscular dystrophy: A case report
Sudden death due to duchenne muscular dystrophy: A case report

... weakness, usually limited to the shoulders and hips, and these women are known as “manifesting carriers.” The genetic fault may have arisen in a previous generation where there may be a known family history. However, in approximately one-third of DMD cases the genetic fault arises in the affected bo ...
2. Model of care for Chronic Cardiac Patients
2. Model of care for Chronic Cardiac Patients

... patient’s clinical status was reviewed, with particular attention to possible remediable exacerbating factors.One-on-one education with the study nurse was initiated at the first clinic visit. A patient diary, for daily weights, medication record, clinical notes and appointments, and education bookl ...
Does the 2-Agonist Clenbuterol Help to Maintain
Does the 2-Agonist Clenbuterol Help to Maintain

... Key Words: cardiomyopathy 䡲 heart-assist device 䡲 heart failure 䡲 inotropic agents 䡲 receptors, adrenergic, beta ...
Catheter Ablation of Ventricular Tachycardia in Patients with Structural
Catheter Ablation of Ventricular Tachycardia in Patients with Structural

... Clinical Results of RF Ablation of VT in Patients with Heart Disease. - Complications of RF Catheter Ablation. ...
Course Book Cardiovascular Disease 2013-2014
Course Book Cardiovascular Disease 2013-2014

... action potential. The action potential is therefore a signal that is propagated through the muscle. In the heart, several sets of cells spontaneously depolarize (automaticity), initiating their own action potential, which may then be propagated through the heart. Spontaneous depolarization is also c ...
Part b
Part b

... (c) Second-degree heart block. (d) Ventricular fibrillation. These chaotic, grossly irregular ECG Some P waves are not conducted deflections are seen in acute through the AV node; hence more heart attack and electrical shock. P than QRS waves are seen. In this tracing, the ratio of P waves to QRS wa ...
Computational modeling of cardiac electrophysiology
Computational modeling of cardiac electrophysiology

... pacemaker cells such as the sinoatrial and the atrioventricular node, and action potentials for nonpacemaker cells such as atrial or ventricular muscle cells. For example, the diagrams in Figure 5 depict the representative action potentials for the atrioventricular node and the non-pacemaker cardiac ...
Caitlin Roscher, 20103525, 2 Ba GEN
Caitlin Roscher, 20103525, 2 Ba GEN

... 3.) To help students better understand and visualize the dynamic changes in stroke volume, cardiac output, and aortic pressure that occur as a consequence of changes in the four determinants of myocardial function. II. Student Preparation for this Laboratory Exercise: It is assumed that students hav ...
Free-Breathing 3 T Magnetic Resonance T2
Free-Breathing 3 T Magnetic Resonance T2

... and healthy tissue after myocardial infarction has been demonstrated (7), and an TR ⴝ repetition time improved performance relative to conventional FSE imaging was reported in both patients with edema after myocardial infarction (8) and acute inflammatory cardiomyopathies (9). The availability of a ...
Diagnosis and Evaluation of Heart Failure
Diagnosis and Evaluation of Heart Failure

... Heart failure is a common clinical syndrome characterized by dyspnea, fatigue, and signs of volume overload, which may include peripheral edema and pulmonary rales. Heart failure has high morbidity and mortality rates, especially in older persons. Many conditions, such as coronary artery disease, hy ...
Brugada Syndrome and Vasovagal Syncope
Brugada Syndrome and Vasovagal Syncope

... episode of venricular tachyarrythmia in the absence of structural heart disease.1-3 Patients with spontaneously or inducible Brugada type-1 morphology are at high risk of polymorphic ventricular tachycardia (and less frequently for monomorphic ventricular or supraventricular tachycardias), which whe ...
Position of the Heart and the
Position of the Heart and the

... UNIPOLAR ELECTROCARDIOGRAPHY ...
Chronic heart failure in adults: management
Chronic heart failure in adults: management

... Heart failure is a complex clinical syndrome of symptoms and signs that suggest the efficiency of the heart as a pump is impaired. It is caused by structural or functional abnormalities of the heart. Some patients have heart failure due to left ventricular systolic dysfunction (LVSD) which is associ ...
Developmental anatomy of the heart
Developmental anatomy of the heart

... where the exact staging protocol that has been followed is not known, it is equally important to point that out when reporting on data based on these tissues. As more and more clinical imaging techniques are now being adapted for use in studies on mouse models [e.g., MRI, ultrasound (10)], it is imp ...
Sudden cardiac death in the young: causes and prevention
Sudden cardiac death in the young: causes and prevention

... Sudden cardiac death (SCD) in the young is a tragic event that can occur in infants, children, adolescents and young adults alike. In a lot of cases, sudden death is the first manifestation of an undetected fatal heart abnormality, with no previous symptoms or warning signs during the victim’s life. ...
Cardiac Imaging: Part 1, MR Pulse Sequences, Imaging Planes, and
Cardiac Imaging: Part 1, MR Pulse Sequences, Imaging Planes, and

... ium can interfere with nulling of blood signal and should be administered after dark blood imaging. However, real-time nongated black blood sequences with gadolinium contrast administration have proven to be effective for evaluating myocardial ischemia [9]. Bright Blood Imaging Bright blood imaging ...
Spatial QRS-T angle predicts cardiac death in a
Spatial QRS-T angle predicts cardiac death in a

... angle in predicting cardiovascular mortality in a large, general hospital-based population. Our findings support the value of repolarization measures13–15 as determined by the spatial QRS-T angle as a tool for risk stratification. Although considered a marker of pathology from the early days of ECG, ...
Full text - Nasjonalt kunnskapssenter for helsetjenesten
Full text - Nasjonalt kunnskapssenter for helsetjenesten

... health states “stable heart failure” and “death”. Other possible health states associated to complications were not modeled. However, the costs associated with the overall implant related complications were included in the evaluation. In addition to presenting the results calculated by the sponsor, ...
Alexander Samoylov: Founding father of Russian electrophysiology
Alexander Samoylov: Founding father of Russian electrophysiology

... that the path of the inhibitory impulse to the efferent neuron is shorter than the path of the excitatory impulse (Pflug. Arch. Bd. 215, 1927). This study was further developed in his last, posthumous publication devoted to the analysis of a single tetanic contraction, which had been first described ...
Stroke Prevention in Patients With Atrial Fibrillation
Stroke Prevention in Patients With Atrial Fibrillation

... may be unable to fully evaluate the available clinical trial data on emerging thromboprophylactic treatments, ...
Spatiotemporal evolution of ventricular fibrillation
Spatiotemporal evolution of ventricular fibrillation

... recording array, each rotor occupied on average 12 6 4 cm2 . According to rough measurements of heart surface area, we estimate that the total number of rotors during fibrillation would be approximately 1–2 for rabbits, 5 for sheep, and 15 for humans (assuming the rotor density is the same in humans ...
Johns Hopkins Medicine: Atrial Fibrillation
Johns Hopkins Medicine: Atrial Fibrillation

... These misfirings can result in what are called premature or ectopic beats—that is, coming from a source other than the SA node. If there is a so-called “run” of premature beats in the atria, the heart rhythm can go into what’s called atrial fibrillation. This fibrillation—the multiple or rapid firin ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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