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Prosthesis–patient mismatch after aortic valve replacement
Prosthesis–patient mismatch after aortic valve replacement

... on the determination of functional status and the occurrence of valve-related complications, physical examination, electrocardiogram, chest radiograph, complete blood count, serum chemistries, and international normalized ratio determinations (when applicable). The total follow-up was 3285 patient-y ...
CHEST Recent Advances in Chest Medicine
CHEST Recent Advances in Chest Medicine

... ventricle also results in paradoxical motion of the septum. This is visualized as a bounce of the septum or movement of the septum toward the left ventricle during ventricular contraction. This paradoxical septal motion results from different rates of rise of intracavitary pressure during ventricula ...
Assessment of wasted myocardial work: a novel method - AJP
Assessment of wasted myocardial work: a novel method - AJP

... segment is wasted by stretching other segments. In the present study, we introduce a novel noninvasive clinical method that quantifies wasted energy as the ratio between work consumed during segmental lengthening (wasted work) divided by work during segmental shortening. The wasted work ratio (WWR) ...
Familial Congenital Heart Disease
Familial Congenital Heart Disease

... cardiac malformations were identical within each family. In only 11 families were the cardiac malformations dissimilar by this method of analysis, in that a septal defect was present in one or more but not in all of the affected members. Thus, this type of classification resulted in more intrafamili ...
Full text (PDF file)
Full text (PDF file)

... A change in cardiac structure inevitably leads to a change in cardiac function, but the complex relationship between altered structure and function are not fully understood. Although structural remodeling serves important adaptive purposes, maladaptive consequences of remodeling are likely to contri ...
Atrial Fibrillation - the University Health Network
Atrial Fibrillation - the University Health Network

...  Rate-control medicines keep the heart from beating too fast during Atrial Fibrillation. These drugs include beta blockers, calcium blockers, and Digoxin. These drugs work by slowing down electrical impulses through the AV node, thereby slowing down the heart rate. This allows the ventricles to pum ...
Sudden cardiac death in forensic medicine – Swiss
Sudden cardiac death in forensic medicine – Swiss

... No exact data exist for Switzerland concerning the incidence of SCD in the young or for the autopsy rate. The presumed values were recently published for the canton of Vaud by Hofer et al. [5]. According to this study, the presumed incidence of SCD in the young (aged 5–39 years) is 1.71/100,000 pers ...
Ventricular Premature Contractions in the Athlete
Ventricular Premature Contractions in the Athlete

... Increased LV mass correlated with less VEA - Supports the benign nature of VEA in trained athlete and the expression of athlete’s heart ...
The Dicrotic Arterial Pulse
The Dicrotic Arterial Pulse

... Dicrotic notch Dicrotic wave Primary myocardial disease Hemodynannic data THE dicrotic arterial pulse is characterized by two pulsations with each cardiac cycle; the second is due to an accentuated dicrotic wave (fig. 1). Paul Wood wrote, ". . . the dicrotic pulse is encountered chiefly in patients ...
Implantation Techniques of Leads for Left Ventricular
Implantation Techniques of Leads for Left Ventricular

... kept and the TORQR is advanced to cannulate the coronary sinus (lower arrow), right panel. The guiding delivery sheath is brought in the roof of the right atrium after which the EP catheter is advanced in the floor of the right atrium and pulled up with counterclockwise torque to direct it posterior ...
pericardial disorders in - The ScholarShip at ECU
pericardial disorders in - The ScholarShip at ECU

... *Percentage represents average of referenced studies. ...
Effects of Sodium Nitroprusside on Left Ventricular Diastolic
Effects of Sodium Nitroprusside on Left Ventricular Diastolic

... excluded. The study group thus obtained consisted of 11 patients, including 2 patients with hypertrophic cardiomyopathy, 5 patients with chronic mitral regurgitation due to rheumatic heart disease, 1 patient with acute mitral regurgitation due to bacterial endocarditis, 2 patients with aortic regurg ...
Short- and mid-term results of resection of discrete subaortic
Short- and mid-term results of resection of discrete subaortic

... Although the aortic valve functions might be affected by more than one factor during follow-up, we consider that early surgery slows the rate of degeneration of the aortic valve and, thus, decreases the need for valvular replacement. Furthermore, surgery is currently associated with low mortality an ...
Left Atrial Appendage: Useless or Priceless?
Left Atrial Appendage: Useless or Priceless?

... removed during maze and mini-maze procedures irrespective of whether the patient has underlying heart disease or not. Is this a good idea? Some researchers think not. A comprehensive study by British researchers concluded, “The removal of the LAA may result in unfavourable hemodynamic and hormonal e ...
Module I E.C.G. RHYTHM INTERPRETATION
Module I E.C.G. RHYTHM INTERPRETATION

... transmission of the impulses throughout the heart in a coordinated manner, producing the rhythmic contraction associated with normal cardiac output. Impulses generated by the SA node travel along specialized tissue known as the conduction pathways. The impulse travels to the AV node where it is dela ...
Post-mortem in sudden unexpected death in the young: Guidelines
Post-mortem in sudden unexpected death in the young: Guidelines

... inherited cardiac disease in more than 40% of cases.1,2 For each of these diagnosed cases, an average of 9-10 high-risk relatives are identified. Increasingly, effective screening and therapy are available, which has the potential to reduce greatly the risk of future sudden deaths in this high risk ...
Neonatal Cardiac Emergencies: Evaluation and Management
Neonatal Cardiac Emergencies: Evaluation and Management

... centre capable of carrying out the required diagnostic and surgical procedures is essential to the survival of these infants. Successful management of pediatric cardiac emergencies requires an accurate diagnosis to institute an appropriate plan of therapy. The diagnosis however is not always straigh ...
Baroreceptor reflex in heart failure
Baroreceptor reflex in heart failure

... membrane function[13,14]. The mechanism of this depression involves increased Na+-K+ ATPase activity. This finding is based on the evidence that a low dose of ouabain partially restores baroreceptor discharge sensitivity when perfused through isolated carotid sinuses of dogs with experimental heart ...
EKG Review Part II
EKG Review Part II

... and a sinus beat lies in the comparison of the P wave. The P wave of the PAC differs from the P wave generated from the SA node. The QRS complex is usually identical to that found in within the sinus rhythm. Indeed, ventricles are depolarized by a PAC as well as a sinus beat. Furthermore, conduction ...
Guidelines on autopsy practice - The Royal College of Pathologists
Guidelines on autopsy practice - The Royal College of Pathologists

... inherited cardiac disease in more than 40% of cases.1,2 For each of these diagnosed cases, an average of 9-10 high-risk relatives are identified. Increasingly, effective screening and therapy are available, which has the potential to reduce greatly the risk of future sudden deaths in this high risk ...
ECG Rhythm Interpretation December 16 & 18
ECG Rhythm Interpretation December 16 & 18

... down the branches to the Purkinje fibers are the normal pacing sites of the heart. In a healthy person, an ECG should demonstrate an organized, sequential electrical impulse from its beginning at the SA node to its conclusion at the Purkinje fibers. Cardiac electrical activity immediately precedes t ...
Arrhythmias in the developing heart
Arrhythmias in the developing heart

... one with supraventricular tachycardia and one with a second-degree AV block – associated with structural heart disease of all 614 foetuses with irregular heart rhythm. On the other hand, there is evidence that foetal arrhythmia may be associated with structural heart disease. Schmidt et al. (1991) r ...
Role of Atrial Fibrillation and Atrioventricular Conduction
Role of Atrial Fibrillation and Atrioventricular Conduction

... interval sequence- and signal analysis of the electrocardiogram of Patient 1 with atrial tibrillation and AV conduction by way of an accessory pathway demonstrate 1) a short refractory period of the bypass tract, and 2) a long/short RR interval ratio of just over 1. This observation provides some in ...
SAED Guide revised Jan 2008 - Grampians Region Health
SAED Guide revised Jan 2008 - Grampians Region Health

... This interval represents the time taken for the impulse to go through the atria, across the AV node and junction and down the Bundle of His. It is measured from the beginning of the P wave to the beginning of the QRS. Normal duration 0.12 – 0.20 seconds.  QRS – This complex follows the P wave, PR i ...
Heart Transplant Powerpoint - Connecticut Society of Medical
Heart Transplant Powerpoint - Connecticut Society of Medical

... • Patients require inotropes in the immediate post op period to assist the heart • As with most heart surgeries post heart transplant also have chest tubes, external pacemaker • Usually extubated within 24 to 48 hours • Post heart TX pts require diuresis post transplant ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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