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The Teleost Heart: A Morphological Approach*
The Teleost Heart: A Morphological Approach*

... the ventricle and the beginning of the dorsal aorta. In most primitive fish, the OFT is formed by two segments: a proximal, muscular, conus arteriosus, and a distal, arterial-like, bulbus arteriosus (Icardo et al. 2002, 2005a; Durán et al. 2008; Grimes and Kirby 2009). The anatomical composition of ...
Is transcatheter aortic valve implantation cost effective in the
Is transcatheter aortic valve implantation cost effective in the

... Treatment visit I ...
Obstructive Sleep Apnea and its Relationship to Cardiac Arrhythmias
Obstructive Sleep Apnea and its Relationship to Cardiac Arrhythmias

... OSA and Cardiac Arrhythmias. Obstructive sleep apnea (OSA) affects approximately 4% of middleaged men and 2% of middle-aged women. Cardiac arrhythmias are common problems in patients with OSA, even though the true prevalence and clinical relevance of cardiac arrhythmias remains to be determined. The ...
Non-invasive assessment of cardiac physiology by tissue Doppler
Non-invasive assessment of cardiac physiology by tissue Doppler

... York Heart Association functional class I; 11 (50%) in class II, and four (20%) in class III. During the examination 19 patients (85%) were in sinus rhythm and three (15%) in atrial fibrillation. ...
Cardiac Resynchronization Therapy (CRT)
Cardiac Resynchronization Therapy (CRT)

... What is recovery like?..............................................................................................................................11 Living with a CRT Device.....................................................................................................................12 How d ...
Anisotropic Reinforcement of Acute Anteroapical Infarcts Improves
Anisotropic Reinforcement of Acute Anteroapical Infarcts Improves

... to develop a complementary therapeutic approach that could improve LV pump function early after a large MI. Normal myocardium deforms in a complex 3-dimensional pattern with each heartbeat,22–24 and healing myocardial infarcts can be highly anisotropic (having different mechan­ ical properties in di ...
Implementation of reperfusion therapy in acute myocardial infarction
Implementation of reperfusion therapy in acute myocardial infarction

... or new left bundle-branch block, and measures to initiate this treatment must be taken without delay. Fibrinolysis has for more than 20 years been the standard treatment preserving left ventricular function and resulting in improved survival.4 Mechanical reperfusion techniques were introduced more t ...
12/07 Atrial Septal Defects
12/07 Atrial Septal Defects

... Multivariate analysis revealed a reduced mortality from all cause in the surgical group (relative risk 0.31; 95% C.I. 0.11-0.85). Ten-year survival rate was 95% in surgical group, 84% in medically treated group. ...
Arrhythmogenic Right Ventricular Dysplasia
Arrhythmogenic Right Ventricular Dysplasia

... Arrhythmogenic right ventricular dysplasia (ARVD) is a disorder in which normal myocardium is replaced by fibrofatty tissue. This disorder usually involves the right ventricle, but the left ventricle and septum also may be affected. Although the exact prevalence of ARVD is unknown, it is thought to ...
EXPERIENCE, INSIGHTS AND TECHNIQUES FOR CARDIAC
EXPERIENCE, INSIGHTS AND TECHNIQUES FOR CARDIAC

Pressure and Volume Changes in the Cardiac
Pressure and Volume Changes in the Cardiac

... in the Heart L.O: to interpret graphs on the cardiac cycle Starter: What animal has the highest blood pressure in the whole wide world? ...
Pulmonary atresia with a ventricular septal defect
Pulmonary atresia with a ventricular septal defect

... my child grows up? Children who have pulmonary atresia with a VSD are always limited to some extent in their physical activities, but specific restrictions on exercise are usually not necessary. Although surgery can give a better quality of life, it is not possible to correct the heart abnormality a ...
Nandrolone and resistance training induce heart remodeling: Role
Nandrolone and resistance training induce heart remodeling: Role

... cardiac effects of nandrolone administration and resistance training in the same experimental protocol. Therefore, the aim of this study was to investigate under highly controlled conditions the isolated and combined effects of high-dose nandrolone administration and resistance training on cardiac f ...
2016 AHA/ACC Clinical Performance and Quality Measures
2016 AHA/ACC Clinical Performance and Quality Measures

... RG, Ezekowitz JA, Fonarow GC, Kantharia BK, Kleinman M, Nichol G, Varosy PD. 2016 AHA/ACC clinical performance and quality measures for prevention of sudden cardiac death: a report of the American College of Cardiology/American Heart Association Task Force on Performance Measures. J Am ...
histology of muscle tissue
histology of muscle tissue

... Cardiac muscle exhibits striations because it also has actin and myosin filaments arranged into sarcomeres. Generally these striations do not appear as well-defined as in skeletal muscle. At the ultrastructural level, some differences in the arrangement of the sarcoplasmic reticulum and T tubules ca ...
Atrioventricular septal defect (AVSD)
Atrioventricular septal defect (AVSD)

improved detection of ventricular ejection time for
improved detection of ventricular ejection time for

... waveform are used to calculate ventricular ejection time, and they are synchronous to first and second heart sounds. Intra-subject variability results in event latency which introduces distortion in ensemble averaged waveform. Visual inspection of ensemble averaged waveform shows the ambiguity in de ...
DOI: 10.1161/CIRCULATIONAHA.108.811877 published online Mar
DOI: 10.1161/CIRCULATIONAHA.108.811877 published online Mar

... Background—Atrial fibrillation (AF) is associated with diffuse left atrial fibrosis and a reduction in endocardial voltage. These changes are indicators of AF severity and appear to be predictors of treatment outcome. In this study, we report the utility of delayed-enhancement magnetic resonance ima ...
Isolated congenital absence of coronary sinus - Heart
Isolated congenital absence of coronary sinus - Heart

... the interventricular septum) efflux into this structure (Hood, 1968). In the posterior atrioventricular groove the coronary sinus receives the great cardiac vein which drains the anterolateral aspect of the heart via anterior interventricular and left marginal (diagonal) veins. The coronary sinus is ...
Relevance of assessing quadriceps endurance in patients with COPD C. Coronell
Relevance of assessing quadriceps endurance in patients with COPD C. Coronell

... exercise and daily physical activity (PA)) [3–6]. Impairment of their ventilatory function represents the main limiting factor for exercise capacity in most patients. However, other extrapulmonary factors also play a significant role in limiting exercise. MALTAIS et al. [7] showed that peripheral mu ...
DOI: 10.1161/CIRCULATIONAHA.108.811877 published online Mar
DOI: 10.1161/CIRCULATIONAHA.108.811877 published online Mar

... Background—Atrial fibrillation (AF) is associated with diffuse left atrial fibrosis and a reduction in endocardial voltage. These changes are indicators of AF severity and appear to be predictors of treatment outcome. In this study, we report the utility of delayed-enhancement magnetic resonance ima ...
Right Ventricular Ejection Fraction During Exercise in Normal
Right Ventricular Ejection Fraction During Exercise in Normal

... (0.42 ± 0.06 to 0.58 ± 0.08, p = 0.001) and was unchanged or fell in 12 of 13 patients with right coronary artery stenosis (0.50 + 0.09 to 0.45 i 0.10, p = NS). We conclude that (1) in normal subjects RVEF increases during upright exercise and (2) although RVEF at rest is not necessarily affected by ...
NT-proBNP and the diagnosis of exercise-induced myocardial ischaemia 264
NT-proBNP and the diagnosis of exercise-induced myocardial ischaemia 264

... NT-proBNP in the evaluation of exercise-induced myocardial ischaemia in an unselected population. This study population was unselected and included subjects with ejection fractions less than 45%. In this population there was no relationship between delta-NT-proBNP, resting NTproBNP or post-effort NT ...
Performance Measures ACC/AHA 2016 Prevention of Sudden
Performance Measures ACC/AHA 2016 Prevention of Sudden

... QM-4: Improvement in 911 call and/or AED use in resuscitating cardiac arrest victims in public locations ...
The implications of genetic mutations in the sodium channel gene (SCN5A) REVIEW
The implications of genetic mutations in the sodium channel gene (SCN5A) REVIEW

... both diseases exhibit very different clinical ECG features but show coincidences that emanate from their common genetic root. It is not yet clear why the ECG pattern of affected individuals with BS vary from day to day and why most affected persons are males. Sex and hormonal differences in ion channel ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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