• Study Resource
  • Explore
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
valves
valves

... The Pulmonary and Systemic Circuits • Heart is transport system; two side-by-side pumps – Right side receives oxygen-poor blood from tissues • Pumps to lungs to get rid of CO2, pick up O2, via pulmonary circuit ...
Cardiac Anatomy for Radiology
Cardiac Anatomy for Radiology

... addition, they may insert directly onto the septal wall. This feature is absent in the ? valve of the left ventricle. CARDIAC CHAMBERS: LEFT ATRIUM The left atrium is characterized by one to four entries for the pulmonary veins. The foraman ovale can be seen at the septal wall. It persists a left at ...
Papillary fibroelastoma of the pulmonary valve
Papillary fibroelastoma of the pulmonary valve

... delineate cardiac masses [1, 12, 14]. Over the last 10 years, the development of newer pulse sequences and applications in new clinical areas has enabled cardiovascular magnetic resonance (CMR) to emerge as a powerful tool for the physician to both diagnose and guide treatment of various cardiac pat ...
Pediatric Cardiomyopathies
Pediatric Cardiomyopathies

... Cardiomyopathy is a chronic disease of the heart muscle (myocardium), in which the muscle is abnormally enlarged, thickened, and/or stiffened. The weakened heart muscle loses the ability to pump blood effectively, resulting in irregular heartbeats (arrhythmias) and possibly even heart failure. Cardi ...
Electrocardiography - Frank`s Hospital Workshop
Electrocardiography - Frank`s Hospital Workshop

... leads. Each of these segments is short, perhaps 1-3 heart beats only, depending on the heart rate and it can be difficult to analyse any heart rhythm that shows changes between heart beats. To help with the analysis it is common to print one or two "rhythm strips" as well. This will usually be lead ...
Comparison of estimations versus measured resting oxygen
Comparison of estimations versus measured resting oxygen

... represents the final stage of several diseases of the heart and is commonly defined as a reduction in the heart’s ability to circulate blood. Cardiac output during right heart catheterization is an important variable used in patient selection for advanced therapies, such as cardiac transplantation a ...
No Slide Title
No Slide Title

... Patients routinely taking NSAIDs (except for aspirin), both nonselective as well as COX-2 selective agents, before STEMI should have those agents discontinued at the time of presentation with STEMI because of the increased risk of mortality, reinfarction, hypertension, heart failure, and myocardial ...
Articles Primary prevention of cardiovascular disease with
Articles Primary prevention of cardiovascular disease with

... Patients in both groups who had total cholesterol concentrations above 6·98 mmol/L, even after alterations to the assigned treatment, could be switched to other aggressive treatments, including statin therapy. An independent data centre monitored the total cholesterol concentrations of all patients ...
Ratio of end-systolic stress to end-systolic volume: is it a
Ratio of end-systolic stress to end-systolic volume: is it a

... functioning sarcomeres in eccentric hypertrophy could result in a low stress/volume ratio (because volume had increased) without necessarily indicating a depression in contractile function . Although this effect may potentially limit the usefulness of the ratio in mild eccentric hypertrophy, it is a ...
Difference between the left and right ventricular
Difference between the left and right ventricular

... Mandorla S, et al in their study on fetal heart by real-time-directed M-mode ultrasound from the 19th gestation week until term opined that left ventricular, right ventricular, left atrial and right atrial chamber size, interventricular septum thickness, right and left wall thickness, aortic and pul ...
quantification of regional myocardial function following acute
quantification of regional myocardial function following acute

... Objectives: The rapid diagnosis and early risk stratification of patients presenting with acute myocardial infarction (AMI) is important. In experimental setting ultrasonic strain rate (SR) and strain (S) have been shown to identify changes in deformation predictive of ischemia. We sought to evaluat ...
LEFT VENTRICULAR EJECTION FRACTION: A RETROSPECTIVE
LEFT VENTRICULAR EJECTION FRACTION: A RETROSPECTIVE

... troponin I release ≥ 1,0 μg/L between the tests or shortly before the first test and also atrial fibrillation/atrial flutter, if present at only one of the tests, were considered to be relevant LVEF changing events and these patients were excluded. Percutaneous ...
Coagulation activity is increased in the left atrium of patients
Coagulation activity is increased in the left atrium of patients

... atrium of the patients, these levels significantly exceeded those in the peripheral blood or the right atrium. There was a significantly positive relation between the plasma levels of fibrinopeptide A and thrombin-antithrombin III complex in the left atrium of the patients (Fig. 4). Fibrinolytie sta ...
Multi-Ethnic Study of Atherosclerosis (MESA) remodelling in a
Multi-Ethnic Study of Atherosclerosis (MESA) remodelling in a

... (22%) reported no intentional exercise. We therefore selected cut-points that approximately divided participants into quintiles as 0, 1–89, 90–187, 188–364 and greater than 364 METmin/day for intentional exercise. Quintiles for moderate and vigorous physical activity were 0–239, 240–455, 456–744, 74 ...
The outcomes of operations for 539 patients with Ebstein anomaly
The outcomes of operations for 539 patients with Ebstein anomaly

... Mayo Clinic, 182 patients had tricuspid valve repair, and 337 had tricuspid valve replacement. The 30-day mortality was 5.9% for the entire cohort (2.7% after 2001). Late survival was 84.7% at 10 years and 71.2% at 20 years. In a multivariate analysis of overall mortality for the patients’ first ope ...
Myosin Types and Fiber Types in Cardiac Muscle. III. Nodal
Myosin Types and Fiber Types in Cardiac Muscle. III. Nodal

... previously reported (15) and confirmed in the present study, a very minor population of bovine atrial myoeytes is stained by anti-bV but not by anti-hA, and thus appears to contain exclusively /3-type MHC. These cells, which are generally larger in size than ordinary atrial muscle cells, are specifi ...
High prevalence of acute myocardial damage in a hospital necropsy
High prevalence of acute myocardial damage in a hospital necropsy

Sudden Cardiac Death After Non–ST
Sudden Cardiac Death After Non–ST

... index event. Race or ethnicity was self-identified among several options defined according to the trial and included in the analysis in view of its potential role in SCD. Because the aim of this analysis was to evaluate SCD, patients receiving an implantable cardioverter defibrillator (ICD) after ra ...
Non-invasive assessment of cardiac physiology by
Non-invasive assessment of cardiac physiology by

... York Heart Association functional class I; 11 (50%) in class II, and four (20%) in class III. During the examination 19 patients (85%) were in sinus rhythm and three (15%) in atrial fibrillation. ...
Publication  - American Heart Association
Publication - American Heart Association

... of atrial fibrillation was 5.0% per patient-year in patients treated with Corlanor and 3.9% per patient-year in patients treated with placebo [see Clinical Studies (14)]. Regularly monitor cardiac rhythm. Discontinue Corlanor if atrial fibrillation develops. 5.3 Bradycardia and Conduction Disturbanc ...
Pharmacologic prophylaxis for atrial fibrillation following cardiac
Pharmacologic prophylaxis for atrial fibrillation following cardiac

... Atrial Fibrillation (AF) is the most common arrhythmia occurring after cardiac surgery. Its incidence varies depending on type of surgery. Postoperative AF may cause hemodynamic deterioration, predispose to stroke and increase mortality. Effective treatment for prophylaxis of postoperative AF is vit ...
1 - Europace
1 - Europace

... Twenty minutes after the successful AFL ablation, the baseline intracardiac conduction intervals including the sinus rhythm cycle length, atrio-His (AH) and His-ventricle (HV) intervals were measured during sinus rhythm. The conduction time along the TA was measured from the distal bipole 1 – 2 to p ...
Exercise at the Extremes
Exercise at the Extremes

... Morris et al. (13) also reported a lower incidence of coronary heart disease among English postmen compared with telephone operators working at the same company. These data were the first to illustrate an association between habitual physical activity and cardiovascular health. Many subsequent epidem ...
JE Muller, PL Ludmer, SN Willich, GH Tofler, G Aylmer, I
JE Muller, PL Ludmer, SN Willich, GH Tofler, G Aylmer, I

... ALTHOUGH sudden cardiac death afflicts over 400,000 individuals each year in the United States alone and accounts for approximately 50% of all deaths from coronary artery disease,l1 the mechanisms triggering this common catastrophic event remain obscure. Attempts to identify precipitating mechanisms ...
Induction of cardiac muscle differentiation in isolated
Induction of cardiac muscle differentiation in isolated

... similar cDNA fragment was also isolated by the same RTPCR strategy from embryonic heart RNA and sequencing confirmed that this was identical to the PCR fragment derived from adult heart RNA. The predicted amino acid sequence shows 81% identity to the corresponding carboxy terminal region of other ve ...
< 1 ... 133 134 135 136 137 138 139 140 141 ... 680 >

Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
  • studyres.com © 2025
  • DMCA
  • Privacy
  • Terms
  • Report