Reduced Ventricular Proarrhythmic Potential of the Novel Combined
... repolarization duration (BVR of the QT interval) also remained unaltered. In contrast, the selective IKr blocker dofetilide prolonged the QT interval, increased BVR, and induced TdP in the majority of animals tested.7 AZD1305 has been shown to depress excitability and suppress delayedafterdepolariza ...
... repolarization duration (BVR of the QT interval) also remained unaltered. In contrast, the selective IKr blocker dofetilide prolonged the QT interval, increased BVR, and induced TdP in the majority of animals tested.7 AZD1305 has been shown to depress excitability and suppress delayedafterdepolariza ...
The Failing Fontan Transplant and VAD Options
... Patient (12 year old, 35 kg, with dysfunction and PLE) comes into ED with 1 week history of difficulty breathing, Cr has doubled, he complains of headache and is vomiting. He is intubated with good respiratory response and now with poor UOP and escalating inotropes? Listed for transplant If you deci ...
... Patient (12 year old, 35 kg, with dysfunction and PLE) comes into ED with 1 week history of difficulty breathing, Cr has doubled, he complains of headache and is vomiting. He is intubated with good respiratory response and now with poor UOP and escalating inotropes? Listed for transplant If you deci ...
View Slides
... • Median F/U = 4.2 yrs (range, 4 d - 16 yrs) – 17 pts: upgraded to BiVP • Median time from initial univentricular pacer insertion to BiVP upgrade = 3 yrs (range, 3 mths - 22 yrs) • Median time from upgrade to demonstrated improvement in ventricular function (6 pts) = 8 wks (range, 2 – 20 wks) ...
... • Median F/U = 4.2 yrs (range, 4 d - 16 yrs) – 17 pts: upgraded to BiVP • Median time from initial univentricular pacer insertion to BiVP upgrade = 3 yrs (range, 3 mths - 22 yrs) • Median time from upgrade to demonstrated improvement in ventricular function (6 pts) = 8 wks (range, 2 – 20 wks) ...
Isolated Cat Trabeculae in a Simulated Feline Heart and Arterial
... changed the polarity of the electrodes every impulse. We have used for this study muscles with cross-sectional areas less than 0.06 mm2 (Table 1). The following arguments can be put forward to support the idea that the performance of such small muscles under these conditions is not limited by diffus ...
... changed the polarity of the electrodes every impulse. We have used for this study muscles with cross-sectional areas less than 0.06 mm2 (Table 1). The following arguments can be put forward to support the idea that the performance of such small muscles under these conditions is not limited by diffus ...
COMPLICATIONS OF AF ABLATION AFA Booklet
... patients who have undergone ablation in their hospital. Many hospitals will also publish their results and complication rates on the Internet. Data from individual hospitals may sometimes be inaccurate for the following reasons. a) Small numbers: Many of the most serious complications occur rarely, ...
... patients who have undergone ablation in their hospital. Many hospitals will also publish their results and complication rates on the Internet. Data from individual hospitals may sometimes be inaccurate for the following reasons. a) Small numbers: Many of the most serious complications occur rarely, ...
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
... Myocardial infarction is the leading cause of death in both men and women all over the world. Acute myocardial infarction generally occurs when there is an abrupt decrease in coronary blood flow, following a rapid thrombotic occlusion of coronary artery which is previously narrowed by atherosclerosi ...
... Myocardial infarction is the leading cause of death in both men and women all over the world. Acute myocardial infarction generally occurs when there is an abrupt decrease in coronary blood flow, following a rapid thrombotic occlusion of coronary artery which is previously narrowed by atherosclerosi ...
Impact of Pacing on Systemic Ventricular Function in L
... • Median F/U = 4.2 yrs (range, 4 d - 16 yrs) – 17 pts: upgraded to BiVP • Median time from initial univentricular pacer insertion to BiVP upgrade = 3 yrs (range, 3 mths - 22 yrs) • Median time from upgrade to demonstrated improvement in ventricular function (6 pts) = 8 wks (range, 2 – 20 wks) ...
... • Median F/U = 4.2 yrs (range, 4 d - 16 yrs) – 17 pts: upgraded to BiVP • Median time from initial univentricular pacer insertion to BiVP upgrade = 3 yrs (range, 3 mths - 22 yrs) • Median time from upgrade to demonstrated improvement in ventricular function (6 pts) = 8 wks (range, 2 – 20 wks) ...
639 Arrhythmias - SA & Atrial
... • PACs may not activate the myocardium if it is still refractory (non-conducted PACs – pause) • PACs may be benign: caused by stress, alcohol, caffeine, and tobacco • PACs may also be caused by ischemia, acute MI’s, d electrolytes, atrial hypertrophy • PACs may also precede PSVT • Post-extrasystolic ...
... • PACs may not activate the myocardium if it is still refractory (non-conducted PACs – pause) • PACs may be benign: caused by stress, alcohol, caffeine, and tobacco • PACs may also be caused by ischemia, acute MI’s, d electrolytes, atrial hypertrophy • PACs may also precede PSVT • Post-extrasystolic ...
The Roles of Thiamine in Myocardial Infarction
... 2012]. A direct renin inhibitor (DRI), aliskiren, when combined with ACE inhibitors (ACEIs) or angiotensin II type 1 receptor blockers (ARBs), improved the extent of myocardial salvage after AMI compared with an ACEI or ARB alone and was associated with a decrease in circulating CD14+CD16- monocyte ...
... 2012]. A direct renin inhibitor (DRI), aliskiren, when combined with ACE inhibitors (ACEIs) or angiotensin II type 1 receptor blockers (ARBs), improved the extent of myocardial salvage after AMI compared with an ACEI or ARB alone and was associated with a decrease in circulating CD14+CD16- monocyte ...
For Peer Review
... triathletes, and exercised 12±3 hours/week (mean±SD). The subjects in the patient group were ...
... triathletes, and exercised 12±3 hours/week (mean±SD). The subjects in the patient group were ...
Atrial transport function in coronary artery disease: Relation
... premature beat. Furthermore , patients were excluded if the various phases of filling during diastole could not be delineated (see later). This invariably necessitated eliminating patients who had a heart rate of 90 beats/min or greater during the time of the left ventricular angiogram. The electroc ...
... premature beat. Furthermore , patients were excluded if the various phases of filling during diastole could not be delineated (see later). This invariably necessitated eliminating patients who had a heart rate of 90 beats/min or greater during the time of the left ventricular angiogram. The electroc ...
Three-Dimensional Transthoracic Echocardiography
... Substantial tricuspid regurgitation due to tricuspid leaflet dysfunction caused by ICD leads has been noted in the medical literature,1-4 although its true prevalence is not well established. The mechanisms of devicerelated tricuspid regurgitation include leaflet perforation or laceration, interfere ...
... Substantial tricuspid regurgitation due to tricuspid leaflet dysfunction caused by ICD leads has been noted in the medical literature,1-4 although its true prevalence is not well established. The mechanisms of devicerelated tricuspid regurgitation include leaflet perforation or laceration, interfere ...
Europace Advance Access published November 19, 2010
... Patients were eligible if they had recurrent unexplained syncope or pre-syncope, estimated after the event and not separated in the analysis. The term ‘unexplained’ was not defined in the protocol but the application of the term to a patient and the subsequent decision to implant an ILR and the prog ...
... Patients were eligible if they had recurrent unexplained syncope or pre-syncope, estimated after the event and not separated in the analysis. The term ‘unexplained’ was not defined in the protocol but the application of the term to a patient and the subsequent decision to implant an ILR and the prog ...
Pharmacologic and Non-Pharmacologic Treatment of Chronic Atrial
... result, it is advised to keep the patients receiving ibutilide under monitoring for at least 24 hours after the infusion of this drug24. Dofetilide is another class III antiarrhythmic drug that can be used for maintaining sinus rhythm in congestive heart failure patients with AF. The DIAMOND CHF tri ...
... result, it is advised to keep the patients receiving ibutilide under monitoring for at least 24 hours after the infusion of this drug24. Dofetilide is another class III antiarrhythmic drug that can be used for maintaining sinus rhythm in congestive heart failure patients with AF. The DIAMOND CHF tri ...
Hypertrophy of Neurons Within Cardiac Ganglia in Human, Canine
... normotensive controls.11,12 Chronic administration of nerve growth factor to newborn Wistar-Kyoto rats leads to hypertrophy and hyperplasia of cardiac sympathetic neurons and cardiac catecholamine content that exceeds levels found in spontaneously hypertensive rats.25 Hypertrophy of the bladder or c ...
... normotensive controls.11,12 Chronic administration of nerve growth factor to newborn Wistar-Kyoto rats leads to hypertrophy and hyperplasia of cardiac sympathetic neurons and cardiac catecholamine content that exceeds levels found in spontaneously hypertensive rats.25 Hypertrophy of the bladder or c ...
Percutaneous Left-Atrial Appendage Closure Devices
... hemorrhagic), cardiovascular or unexplained death, or systemic embolism. There was also a primary safety outcome, which was a composite endpoint of excessive bleeding (intracranial or gastrointestinal [GI] bleeding) and procedure-related complications (pericardial effusion, device embolization, or p ...
... hemorrhagic), cardiovascular or unexplained death, or systemic embolism. There was also a primary safety outcome, which was a composite endpoint of excessive bleeding (intracranial or gastrointestinal [GI] bleeding) and procedure-related complications (pericardial effusion, device embolization, or p ...
Volume and Oxygen Consumption in Man
... dogs' had indicated a high individual variability of response of cardiac dimensions to exercise, the 20 patients were divided into three groups according to change in enddiastolic volume, to see if different patterns of response could be recognized.* Seven patients showed less than 10 per cent chang ...
... dogs' had indicated a high individual variability of response of cardiac dimensions to exercise, the 20 patients were divided into three groups according to change in enddiastolic volume, to see if different patterns of response could be recognized.* Seven patients showed less than 10 per cent chang ...
EXPERIMENTAL & CLINICAL CARDIOLOGY
... beeen described [11,12,13]. Gadolinium is used in MRI as a contrast medium for myocardial visualisation. Gadolinium is picked-up and released by healthy myocardium quickly. In fibrotic myocardium the contrast stays in longer time and is released slowly. This phenomenon is called late gadolinium enha ...
... beeen described [11,12,13]. Gadolinium is used in MRI as a contrast medium for myocardial visualisation. Gadolinium is picked-up and released by healthy myocardium quickly. In fibrotic myocardium the contrast stays in longer time and is released slowly. This phenomenon is called late gadolinium enha ...
DOI: 10.1161/CIRCULATIONAHA.106.661983 published online Jul
... eart failure is a common cardiovascular syndrome that may occur in conjunction with either normal or abnormal left ventricular (LV) ejection fraction (EF). Patients with reduced EF have predominantly systolic dysfunction, whereas those with heart failure symptoms despite normal EF (HFNEF) are though ...
... eart failure is a common cardiovascular syndrome that may occur in conjunction with either normal or abnormal left ventricular (LV) ejection fraction (EF). Patients with reduced EF have predominantly systolic dysfunction, whereas those with heart failure symptoms despite normal EF (HFNEF) are though ...
Advances in congestive heart failure management - Area
... and NT-proBNP, these peptides are increasingly used for diagnostic and prognostic purposes. Objective: To review studies evaluating the diagnostic and prognostic value of BNP and NT-proBNP, with special emphasis on their performance as indicators of acute heart failure in the ...
... and NT-proBNP, these peptides are increasingly used for diagnostic and prognostic purposes. Objective: To review studies evaluating the diagnostic and prognostic value of BNP and NT-proBNP, with special emphasis on their performance as indicators of acute heart failure in the ...
S1936878X15002648_mmc1 - JACC: Cardiovascular Imaging
... predicted a between-group difference in mean LVESVI of 4.65 ml/m2 equivalent to three eighths of a common standard deviation (or an effect size of 0.375). We also estimated that at least 30 MACE events would occur based on a conservative estimate of the event rate (1012%) at 18 months. Statistical a ...
... predicted a between-group difference in mean LVESVI of 4.65 ml/m2 equivalent to three eighths of a common standard deviation (or an effect size of 0.375). We also estimated that at least 30 MACE events would occur based on a conservative estimate of the event rate (1012%) at 18 months. Statistical a ...
Redalyc.Treatment of Chronic Atrial Fibrillation During Surgery for
... In the postoperative six months follow-up, 18 (90%) patients continued with regular atrial rhythm, one (5%) patient returned to atrial fibrillation and one patient presented with sinus bradycardia, requiring endocardial pacemaker implantation (5%). During hospitalization and 12 weeks after surgery, ...
... In the postoperative six months follow-up, 18 (90%) patients continued with regular atrial rhythm, one (5%) patient returned to atrial fibrillation and one patient presented with sinus bradycardia, requiring endocardial pacemaker implantation (5%). During hospitalization and 12 weeks after surgery, ...
English
... literature suggested, the possibility of a unique peculiarity in rheumatic patients as the QT interval duration, possibly an innate tendency toward this prolongation, which would later trigger acute rheumatic disease in the heart, in the presence of an immune mechanism. One example of this behavior ...
... literature suggested, the possibility of a unique peculiarity in rheumatic patients as the QT interval duration, possibly an innate tendency toward this prolongation, which would later trigger acute rheumatic disease in the heart, in the presence of an immune mechanism. One example of this behavior ...
The Diastolic Murmur - STA HealthCare Communications
... guess? It would certainly seem so, but considering that rheumatic valve pathology was the leading cause of heart disease in his day, and that atrial fibrillation (AF), also known as pulsus mitrale, was commonly found in those with significant mitral stenosis, it was more likely an educated guess. I ...
... guess? It would certainly seem so, but considering that rheumatic valve pathology was the leading cause of heart disease in his day, and that atrial fibrillation (AF), also known as pulsus mitrale, was commonly found in those with significant mitral stenosis, it was more likely an educated guess. I ...
Cardiac contractility modulation
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Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.