Successful radiofrequency catheter ablation therapy of an
... secondary cardiomyopathy appear. Complaints related to dilated cardiomyopathy are observed in over 50% of cases. Tachycardia rates are usually between 120-300 bpm1-4. Our patient had only symptoms of palpitation and chest pain, but not cardiomyopathy. In children, abnormal focus is more frequently l ...
... secondary cardiomyopathy appear. Complaints related to dilated cardiomyopathy are observed in over 50% of cases. Tachycardia rates are usually between 120-300 bpm1-4. Our patient had only symptoms of palpitation and chest pain, but not cardiomyopathy. In children, abnormal focus is more frequently l ...
CONSTRICTIVE PERICARDITIS
... fraction is usually normal or increased, and both isovolumic and ejection phase indices of contractile function (e.g., peak dP /dt) are preserved (10) , (12) . The important exception to this is patients with extensive coexisting myocardial fibrosis, which is a complication of radiation-induced peri ...
... fraction is usually normal or increased, and both isovolumic and ejection phase indices of contractile function (e.g., peak dP /dt) are preserved (10) , (12) . The important exception to this is patients with extensive coexisting myocardial fibrosis, which is a complication of radiation-induced peri ...
Induction of cardiac muscle differentiation in isolated
... similar cDNA fragment was also isolated by the same RTPCR strategy from embryonic heart RNA and sequencing confirmed that this was identical to the PCR fragment derived from adult heart RNA. The predicted amino acid sequence shows 81% identity to the corresponding carboxy terminal region of other ve ...
... similar cDNA fragment was also isolated by the same RTPCR strategy from embryonic heart RNA and sequencing confirmed that this was identical to the PCR fragment derived from adult heart RNA. The predicted amino acid sequence shows 81% identity to the corresponding carboxy terminal region of other ve ...
Syncope
... electroencephalogram (EEG), brain CT, brain magnetic resonance imaging, and carotid Doppler ultrasound, are frequently obtained in patients with syncope. In one review of 649 patients, 53 percent had at least one neurologic test. However, such testing was rarely useful. ...
... electroencephalogram (EEG), brain CT, brain magnetic resonance imaging, and carotid Doppler ultrasound, are frequently obtained in patients with syncope. In one review of 649 patients, 53 percent had at least one neurologic test. However, such testing was rarely useful. ...
Incidence and Predictors of Very Late (>4 Years) Major Cardiac
... Objectives Our aim was to access the incidence of late major adverse cardiac events (MACE) and stent thrombosis (ST) in nonselected, complex patients followed for a period ⱖ4 years. Background Despite the efficacy of drug-eluting stents (DES) in reducing repeated target lesion revascularization, conc ...
... Objectives Our aim was to access the incidence of late major adverse cardiac events (MACE) and stent thrombosis (ST) in nonselected, complex patients followed for a period ⱖ4 years. Background Despite the efficacy of drug-eluting stents (DES) in reducing repeated target lesion revascularization, conc ...
a study on the echocardiography of the mitral valve in normal
... regurgitation, and it can lead to symptoms and complications.Regurgitation doesn’t occur in all cases of MVP. In fact, the majority of people with MVP don’t have regurgitation and never have any symptoms or complications. In these people, even though the valve flaps prolapse, the valve is still able ...
... regurgitation, and it can lead to symptoms and complications.Regurgitation doesn’t occur in all cases of MVP. In fact, the majority of people with MVP don’t have regurgitation and never have any symptoms or complications. In these people, even though the valve flaps prolapse, the valve is still able ...
The little brain on the heart
... The cardiac neuronal hierarchy can be represented as a massively parallel and, for the most part, stochastic control system such that stable cardiac control occurs in the absence of obvious cause and effect (ie, it displays emergent properties). This hierarchy displays robust external behavior while ...
... The cardiac neuronal hierarchy can be represented as a massively parallel and, for the most part, stochastic control system such that stable cardiac control occurs in the absence of obvious cause and effect (ie, it displays emergent properties). This hierarchy displays robust external behavior while ...
The formation and function of the cardiac conduction system
... (Dominguez et al., 2012). Genetic lineage tracing has revealed that the AVC is derived from Tbx2+ cells of the IFT of the early tubular heart (Aanhaanen et al., 2009). Although the precise cellular origin of AVN myocytes has been a topic of debate, the current view is that the embryonic AVC contains ...
... (Dominguez et al., 2012). Genetic lineage tracing has revealed that the AVC is derived from Tbx2+ cells of the IFT of the early tubular heart (Aanhaanen et al., 2009). Although the precise cellular origin of AVN myocytes has been a topic of debate, the current view is that the embryonic AVC contains ...
Embryology - Conotruncal development
... Inversion of conotruncus- 2 stages Stage1 – Inversion of ostium bulbi at same time of looping Stage 2- Rotation of truncus which occurs after the formation of septum aortopulmonale. Ostium bulbar rotation causes the anatomic concordance between the left ventricle and the proximal aortic conus T ...
... Inversion of conotruncus- 2 stages Stage1 – Inversion of ostium bulbi at same time of looping Stage 2- Rotation of truncus which occurs after the formation of septum aortopulmonale. Ostium bulbar rotation causes the anatomic concordance between the left ventricle and the proximal aortic conus T ...
Flecainide Therapy Reduces Exercise
... is, flecainide directly targets the molecular defect responsible for the arrhythmogenic Ca2⫹ waves that trigger CPVT in vivo) (24). In preliminary work, flecainide also appeared to be effective in 2 highly symptomatic CPVT patients (23). Here we collate the data from every CPVT patient started on fl ...
... is, flecainide directly targets the molecular defect responsible for the arrhythmogenic Ca2⫹ waves that trigger CPVT in vivo) (24). In preliminary work, flecainide also appeared to be effective in 2 highly symptomatic CPVT patients (23). Here we collate the data from every CPVT patient started on fl ...
Reduced Ventricular Proarrhythmic Potential of the Novel Combined
... repolarization duration (BVR of the QT interval) also remained unaltered. In contrast, the selective IKr blocker dofetilide prolonged the QT interval, increased BVR, and induced TdP in the majority of animals tested.7 AZD1305 has been shown to depress excitability and suppress delayedafterdepolariza ...
... repolarization duration (BVR of the QT interval) also remained unaltered. In contrast, the selective IKr blocker dofetilide prolonged the QT interval, increased BVR, and induced TdP in the majority of animals tested.7 AZD1305 has been shown to depress excitability and suppress delayedafterdepolariza ...
LRRC10 is required to maintain cardiac function in - AJP
... CARDIOMYOCYTE HYPERTROPHY in response to extracellular stimuli, such as neurohumoral or growth factor stimulation of membrane-bound receptors (13, 23, 44), or in response to mechanical stretch or strain that is sensed by mechanosensory machinery embedded in the Z-disc cytoskeleton, and sarcolemma (2 ...
... CARDIOMYOCYTE HYPERTROPHY in response to extracellular stimuli, such as neurohumoral or growth factor stimulation of membrane-bound receptors (13, 23, 44), or in response to mechanical stretch or strain that is sensed by mechanosensory machinery embedded in the Z-disc cytoskeleton, and sarcolemma (2 ...
Forearm Blood Flow In Individuals With CHF And Age
... group. Participants were healthy with no history of cardiovascular disease or other limiting noncardiac disorders. None was taking medication that had an inotropic or chronotropic effect. All volunteers were of similar age to the patient group and lead a sedentary lifestyle (did not perform structur ...
... group. Participants were healthy with no history of cardiovascular disease or other limiting noncardiac disorders. None was taking medication that had an inotropic or chronotropic effect. All volunteers were of similar age to the patient group and lead a sedentary lifestyle (did not perform structur ...
Comorbidities and Physical and Cognitive Impairments in Elderly
... factors, pathophysiology, clinical course, and response to HF therapies 3. Elderly patients with HF are more likely to have hypertensive cardiomyopathy and diastolic dysfunction while middle age adults with HF are more likely to have ischemic cardiomyopathy and systolic dysfunction 6. Management of ...
... factors, pathophysiology, clinical course, and response to HF therapies 3. Elderly patients with HF are more likely to have hypertensive cardiomyopathy and diastolic dysfunction while middle age adults with HF are more likely to have ischemic cardiomyopathy and systolic dysfunction 6. Management of ...
cardiogenic shock-management - The Association of Physicians of
... The incidence of cardiogenic shock in community studies has not decreased significantly over time. Despite decreasing mortality rates associated with increasing utilisation of revascularisation, shock remains the leading cause of death for patients hospitalised with acute myocardial infarction (MI). ...
... The incidence of cardiogenic shock in community studies has not decreased significantly over time. Despite decreasing mortality rates associated with increasing utilisation of revascularisation, shock remains the leading cause of death for patients hospitalised with acute myocardial infarction (MI). ...
Strain Rate Acceleration Yields a Better Index for Evaluating Left
... was performed with software (EchoPac, GE Medical Systems) installed on a computer (G4, Macintosh, Apple, Cuppertino, Calif). The start and end points of IVCT were carefully selected on the electrocardiogram (the first frame after R wave) and confirmed by visualization of mitral valve closure and sub ...
... was performed with software (EchoPac, GE Medical Systems) installed on a computer (G4, Macintosh, Apple, Cuppertino, Calif). The start and end points of IVCT were carefully selected on the electrocardiogram (the first frame after R wave) and confirmed by visualization of mitral valve closure and sub ...
Editor`s Perspective - Circulation: Arrhythmia and Electrophysiology
... Although it is essentially impossible to ablate midseptal accessory pathways without risk to the AV node, anterior septal pathways, while often challenging, do give the operator clear options for high success rates and lower risk for injury to the compact AV node. Because the compact AV node is a mi ...
... Although it is essentially impossible to ablate midseptal accessory pathways without risk to the AV node, anterior septal pathways, while often challenging, do give the operator clear options for high success rates and lower risk for injury to the compact AV node. Because the compact AV node is a mi ...
Arrhythmogenic right ventricular dysplasia/cardiomyopathy versus
... form of dilated cardiomyopathy first described in 1982 [1]. It primarily affects the right ventricular myocardium with fat and/or fibrous tissue replacement of the muscle [2, 3]. The clinical manifestation of the disease varies significantly, from total absence of clinical symptoms which is most com ...
... form of dilated cardiomyopathy first described in 1982 [1]. It primarily affects the right ventricular myocardium with fat and/or fibrous tissue replacement of the muscle [2, 3]. The clinical manifestation of the disease varies significantly, from total absence of clinical symptoms which is most com ...
The Failing Fontan Transplant and VAD Options
... Patient (12 year old, 35 kg, with dysfunction and PLE) comes into ED with 1 week history of difficulty breathing, Cr has doubled, he complains of headache and is vomiting. He is intubated with good respiratory response and now with poor UOP and escalating inotropes? Listed for transplant If you deci ...
... Patient (12 year old, 35 kg, with dysfunction and PLE) comes into ED with 1 week history of difficulty breathing, Cr has doubled, he complains of headache and is vomiting. He is intubated with good respiratory response and now with poor UOP and escalating inotropes? Listed for transplant If you deci ...
6 ACE inhibitors and angio- tensin receptor blockers
... Where do angiotensin receptor blockers fit in? Angiotensin receptor blockers work in a similar way to ACE inhibitors but at a different level in the RAAS (see Fig. 1 above). Unlike ACE inhibitors, they do not stop angiotensin II from developing but they do stop it from ...
... Where do angiotensin receptor blockers fit in? Angiotensin receptor blockers work in a similar way to ACE inhibitors but at a different level in the RAAS (see Fig. 1 above). Unlike ACE inhibitors, they do not stop angiotensin II from developing but they do stop it from ...
Effects of Aging on the Cardiovascular System
... mass does not increase with age if subjects with underlying heart disease are excluded.25 However, there is general agreement that left ventricular wall thickness increases progressively with age.7,24 Age-related changes in cardiac structure are apparent not just macroscopically, but at the level of ...
... mass does not increase with age if subjects with underlying heart disease are excluded.25 However, there is general agreement that left ventricular wall thickness increases progressively with age.7,24 Age-related changes in cardiac structure are apparent not just macroscopically, but at the level of ...
Cardiac contractility modulation
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Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.