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PEDIATRIC CARDIOLOgy - Children`s Hospital of Pittsburgh
PEDIATRIC CARDIOLOgy - Children`s Hospital of Pittsburgh

... he Division of Pediatric Cardiology provides comprehensive clinical services to children and adults with congenital heart disease as well as to children with acquired heart disease. This clinical program includes ambulatory diagnostic services at 15 locations: the Children’s Hospital of Pittsburgh o ...
lar - Circulation
lar - Circulation

... (smallest dose causing a measurable increase of mechanical efficiency in the failing heart) for the three substances. Their conclusions were not confirmed by Cattell and Gold,2 who carried out somewhat similar assays on the isolated papillary muscle, or by Farah and Maresh,3 who used the heart-lung ...
Original Contributions
Original Contributions

... blood flow were continuously recorded on an eightchannel recorder (Gould, Cleveland, Ohio). The above indexes were measured three times at 10minute intervals while the pig was in a quiescent state. Once it was determined that significant differences did not exist among the three measurements (repeat ...
Low-Volume, High-Intensity Interval Training in Patients with CAD
Low-Volume, High-Intensity Interval Training in Patients with CAD

... coronary artery bypass graft surgery; and positive exercise stress test determined by a positive nuclear scan or symptoms of chest discomfort accompanied by ECG changes of 91 mm horizontal or down sloping ST-segment depression. Twenty-seven men and three women with documented CAD were recruited from ...
16 Myocardial Disease
16 Myocardial Disease

... increased venous return. This is dependent on constriction in non-exercising venous capacitance beds, which compensates for the vasodilation occurring in exercising muscle. The importance of this mechanism may be greater with HCM and diastolic dysfunction, which precludes adequate ventricular fillin ...
Assessment of Regional Left Ventricular Wall Motion Abnormalities
Assessment of Regional Left Ventricular Wall Motion Abnormalities

... Purpose:The aim of this study was to evaluate the accuracy of dual-source computed tomography(DSCT) for assessment of regional left ventricular(LV)wall motion abnormalities and global LV function, using left ventriculography(LVG)as a gold standard. Methods: Forty-three patients(25 men;mean age, 64.4 ...
Atrioventricular N odal Response to Retrograde Activation in Atrial
Atrioventricular N odal Response to Retrograde Activation in Atrial

... atrioventricular node simultaneous with, or just before an atrial impulse can facilitate subsequent anterograde conduction. However, a spontaneous or programmed ventricular extrasystole during atrial fibrillation is generally followed by a compensatory pause indicating subsequent delayed anterograde ...
Functional assessment of the fetal heart: a review
Functional assessment of the fetal heart: a review

... a broad consensus that the fetal heart (in both the human and lamb model) exhibits right-sided dominance, with the majority (52–65%)2 – 5 of cardiac output (CO) going through the right ventricle (RV). Of the right ventricular output the majority (756 –90% )4 – 6 is shunted through the ductus arterio ...
Journal of Exercise Physiologyonline
Journal of Exercise Physiologyonline

... Physiological benefits gained from exercise training rely primarily on the intensity of the training stimulus. The prescribed intensity fraction can be alternatively applied using an absolute or relative approach. Absolute intensity is to prescribe a workload, such as 80 Watts on a cycle ergometer o ...
SAM Cardiology - КАРДИОЛОГИЯ - kasatka
SAM Cardiology - КАРДИОЛОГИЯ - kasatka

... A. 3rd degree heart block B. atrioventricular dissociation C. myocardial inforction D. pericardial effusion E. 2nd degree heart block Answer: D 24. cardiovascular disease most likely affects what valve? A. aortic B. pulmonic C. tricupsid D. mitral E. all of the above Answer: D 25. deep s-wave is le ...
Original Article - Arquivos Brasileiros de Cardiologia
Original Article - Arquivos Brasileiros de Cardiologia

... cardiovascular events at 4 years in patients who underwent unprotected left main angioplasty and 2) evaluate the long‑term outcome according to the SYNTAX score 2-recommended revascularization strategy.  Methods: We retrospectively studied 132 patients from a single-centre registry who underwent unp ...
Post-exercise heart rate recovery: an index of cardiovascular fitness
Post-exercise heart rate recovery: an index of cardiovascular fitness

... among factors like exercise intensity (14, 17), cardiac autonomic modulation, and the level of physical fitness (18, 19, 20). Investigations aiming to quantify HRR have calculated time constants by fitting HR decay data to several mathematical models (21, 22, 23). Alternatively, most investigators h ...
2.02.507 Coronary Angiography for Known or Suspected Coronary
2.02.507 Coronary Angiography for Known or Suspected Coronary

... for patients with stable angina only when symptoms are not satisfactorily controlled with optimal medical treatment. Specialty society guidelines recommend cardiac angiography for risk assessment in patients with stable ischemic heart disease when clinical characteristics and noninvasive testing res ...
Relation Between Body Fat–Corrected ECG Voltage
Relation Between Body Fat–Corrected ECG Voltage

... cells but also increases in such interstitial substances as fibroblasts and collagen play a part in increases of LVM. Therefore, LVM as demonstrated by echocardiography and MRI provides a good opportunity to examine not only cardiac muscle cells but total interstitial substances as well. However, wi ...
Nano-imaging of the beating mouse heart in vivo
Nano-imaging of the beating mouse heart in vivo

... rat cardiomyocytes), which is greater than the precision value of 40 nm for SL displacement under the experimental setting (see Fig. 2 A). It should likewise be pointed out that the image was defocused in systole because of the movement of the myocyte along the Z-axis (Fig. 4 B). Fig. 4 C shows the ...
Transesophageal echocardiography in the OR and ICU
Transesophageal echocardiography in the OR and ICU

... (RWMA). TEE can be used to evaluate the extension of the ischemic area via examination of the myocardial segmental kinesis using a segmental model of the LV in which 16 or 17 segments are recognized.18 This imaging technique can also be used to assess cardiac function and any associated complication ...
SessionProgramme 14 April - Scientific Events
SessionProgramme 14 April - Scientific Events

... moderated and chaired by two experts in the topic presented. All abstracts presentation, slides and e-Poster will be available on the e-library stations located next to the Agora. These can be consulted by the visiting audience and to continue discussions on your research after presentation ...
Hypokalemia - IRCG - International Renal Care Group
Hypokalemia - IRCG - International Renal Care Group

... Failure to follow serum potassium and other electrolyte concentrations during or after therapy Treating a patient based on a falsely low serum potassium value due to sampling or ...
Transcatheter aortic valve implantation
Transcatheter aortic valve implantation

... Scotland)). Repeat hospitalisation due to AS TAVI group and 26.8% in the AVR group, a nonstatistically significant difference of -2.6 percentage or complications of the valve procedure was also significantly lower in the TAVI group at points (95% CI -9.3 to 4.1; p=0.44). The upper 1 year (22.3% vers ...
transfer of the heart pacemaker during juvenile development in the
transfer of the heart pacemaker during juvenile development in the

... Fig. 2. Light micrographs (A,D) and electron micrographs (B,C) of early juvenile and adult Ligia exotica hearts. (A,B,C) Juveniles just after hatching, (D) an adult 34 mm in body length. (A) Cross section of the heart and the surrounding tissues through the central region of the heart. The heart tub ...
EFFECTS OF CARDIAC VAGOTOMY ON HEART RATE
EFFECTS OF CARDIAC VAGOTOMY ON HEART RATE

... reactivity to shock was moderate a t the beginning of each session, it increased gradually towards its end. The most important results were the following: (i) The deceleratory response appeared already during the first half of session 1. Its evolution can be observed in Fig. 1. In the initial 20 ses ...
Transcatheter Aortic-Valve Implantation for Aortic
Transcatheter Aortic-Valve Implantation for Aortic

... patient selection decisions and approved the classification of patients as unsuitable for surgery. A total of 3,105 patients were screened for aortic-valve surgery, and 12% of these were eventually included in the cohort of patients deemed unsuitable for surgery. A total of 358 patients were randomi ...
Sudeen Cardiac Arrest Monograph
Sudeen Cardiac Arrest Monograph

... the heart. • Other abnormalities in metabolism can disrupt the normal electrical processes of the heart to cause life-threatening ventricular arrhythmias. • Some individuals can have inherited abnormalities that are not manifest until triggered by an external event. For example, autonomic modulation ...
The striated muscles in pulmonary arterial hypertension: adaptations
The striated muscles in pulmonary arterial hypertension: adaptations

... patients as well as animal models of pulmonary hypertension (PH) [8, 9, 49, 51–54]. In addition, in PH rats, no change in force-generating capacity was found, while in PAH patients, maximal tension was reduced [8, 49, 55]. Differences between experimental and patient data may be explained by differe ...
Syncope in patients with structural heart disease
Syncope in patients with structural heart disease

... Syncope is a common condition and the differential diagnosis is extensive. It has been reported that the frequency of syncope amongst users of emergency departments in Europe is approximately 1% [1, 2]. The causes of syncope are frequently benign, but can occasionally be due to a potentially life-th ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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