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ACC/AHA Guidelines for Ambulatory - Doctors
ACC/AHA Guidelines for Ambulatory - Doctors

... in clinical decision making by describing a range of generally acceptable approaches for the diagnosis, management, or prevention of specific diseases or conditions. These guidelines attempt to define practices that meet the needs of most patients in most circumstances. The ultimate judgment regardi ...
VIP
VIP

... • Immediate ventricular support at the appropriate AV delay • Provide necessary pacing with optimized AV delay • To pace (with QuickOpt) or not to pace (with VIP) ...
PDF
PDF

... The properties of the early chick embryonic heart cardiac jelly were studied. The cells of the heart were removed by sequential treatments with calcium magnesium-free medium; the same medium containing 5 mM EDTA; and aqueous 0 1 % deoxycholate. The transparent, naked cardiac jelly retained the origi ...
Functional and Structural Differences in Atria Versus Ventricles in
Functional and Structural Differences in Atria Versus Ventricles in

... Across vertebrates, the fish heart is structurally relatively simple. The heart of teleosts is unique in structure, composed of four chambers in series: venous sinus, atrium, ventricle and bulbus arteriosus. The two chambers acting as pumps are the atrium and ventricle, a simplified ver‐ sion of tha ...
Computational modeling of acute myocardial
Computational modeling of acute myocardial

... Myocardial infarction, commonly known as heart attack, is caused by reduced blood supply and damages the heart muscle because of a lack of oxygen. Myocardial infarction initiates a cascade of biochemical and mechanical events. In the early stages, cardiomyocytes death, wall thinning, collagen degrad ...
Pulmonary arterial compliance and exercise capacity after pulmonary endarterectomy
Pulmonary arterial compliance and exercise capacity after pulmonary endarterectomy

... From April 1994 to October 2012, 433 patients diagnosed with CTEPH, according to published standardised protocols [1, 2], underwent PEA at our institution (Fondazione IRCCS Policlinico San Matteo, Pavia, Italy). The present study is a retrospective evaluation of the cohort of 296 patients in whom at ...
Link
Link

... that can be deployed to close extra openings or vessels in the heart. 13 An electrophysiology laboratory is designed to perform diagnostic, therapeutic, and interventional electrophysiology-based procedures in pediatric and congenital patients such as pacemaker, internal cardiac defibrillator, loop ...
Full Text
Full Text

... genes (troponin or XNKx2-5) as molecular markers (Drysdale et al., 1994; Tonissen et al., 1994; Patterson et al., 1998), that the Spemann organizer forms heart structures in 100% of the cases after Suramin treatment (Fig. 2). In an attempt to show that such heart tissue could function normally in vi ...
PDF file - Via Medica Journals
PDF file - Via Medica Journals

... comparable to a younger population with up to 80% or more of patients maintaining sinus rhythm at 12 months follow-up. We compared the results of 15 consecutive patients ≥ 70 years old with symptomatic paroxysmal atrial fibrillation who underwent catheter ablation of AF at our institution to 45 rand ...
Canadian Heart Rhythm Society and CAR Consensus Statement on
Canadian Heart Rhythm Society and CAR Consensus Statement on

... negatively with the metallic components of CIEDs. However, as CIED technology has advanced, newer MRI conditional devices have been developed that are now in clinical use and these systems have had demonstrated safety in the MRI environment. Despite the supportive data of such CIED systems, physicia ...
- European Medical Journal
- European Medical Journal

... was obtained within 1 month after primary PCI, and a follow-up measurement taken within 1 year after the index event. After multivariate analysis, the presence of a CTO in a non-IRA was an independent predictor for further deterioration of LVEF (OR 3.5, 95% CI: 1.6-7.8, p<0.01). In contrast, MVD wit ...
Non-Invasive Transcutaneous Pacing
Non-Invasive Transcutaneous Pacing

... indication of the ECG and the pulse marker. Skeletal muscle contraction is not an indication that capture has been established, nor is electrical capture alone an indication of effective cardiac perfusion. The patient may be suffering from pulseless electrical activity (PEA), previously referred to ...
Electrocardiographic imaging of cardiac resynchronization therapy
Electrocardiographic imaging of cardiac resynchronization therapy

... them to the corresponding locations determined from computed tomographic (CT) images. Average accuracy within 10.2 ⫾ 5.1 mm was achieved in locating the pacing sites. With this level of accuracy and extensive validation, ECGI provides a unique tool for noninvasive evaluation of electrophysiologic ph ...
Percutaneous closure of multiple atrial septal defects and patent
Percutaneous closure of multiple atrial septal defects and patent

... have multiple fenestrations and are often considered unsuitable for device closure.[5] In less common cases with multiple or complex, fenestrated defects, a single device can be placed through one defect so that it overlaps and closes a second defect. In our case, we were able to close three defects ...
CHANGES IN AUTONOMIC TONE RESULTING FROM CIRCUMFERENTIAL PULMONARY VEIN ISOLATION by GEOFFREY SEABORN
CHANGES IN AUTONOMIC TONE RESULTING FROM CIRCUMFERENTIAL PULMONARY VEIN ISOLATION by GEOFFREY SEABORN

... reflects autonomic control of heart rate. In general, normal HRV, and therefore normal ANS activity, is associated with good cardiovascular health, whereas reduced HRV is associated with poor prognosis and susceptibility to a number of conditions, such as mortality after myocardial infarction [48], ...
Progressive Dystrophic Pathology in Diaphragm and Impairment of
Progressive Dystrophic Pathology in Diaphragm and Impairment of

... Progressive Dystrophic Pathology in Diaphragm and Impairment of Cardiac Function in FKRP Mutant Mice ...
Cardiovascular II Part 2
Cardiovascular II Part 2

... coronary artery but produce a narrowing that restricts blood flow. – In times of increased oxygen demand, such as with exercise, the restricted blood flow may produce ischemia in cells supplied by that artery. – This produces the pain of angina. ...
S0735109712021377_mmc1
S0735109712021377_mmc1

... Minnesota) to map the atria with a wide field of view. Insertion of the basket or its exchange with other catheters through an existing sheath typically required <1 minute, and subsequent positioning for optimal electrode contact (1) <5 minutes. Figure 1 of the main text illustrates such a case in a ...
Ventricular Tachycardia Rate and Morphology Determine Energy
Ventricular Tachycardia Rate and Morphology Determine Energy

... Background. The electrical current and energy required to terminate ventricular tachyarrhythmias are known to vary by arrhythmia: Ventricular tachycardia (VT) is generally considered to require less energy than ventricular fibrillation (VF). The hypothesis of our study was that current requirements ...
Mechanical Properties of the Myocardium in the Ischemic Heart
Mechanical Properties of the Myocardium in the Ischemic Heart

... The biomechanical “machine” that keeps the human body going is the heart; this organ is responsible for blood and oxygen supply to the rest of the body. Unhealthy diet and heart diseases can cause damage to the heart. This damage may be irreversible even with all the advances in science and technolo ...
Ventricular Arrhythmias in the Absence of Structural Heart Disease
Ventricular Arrhythmias in the Absence of Structural Heart Disease

... molecular level and predispose them to arrhythmias. Another fascinating area, idiopathic ventricular fibrillation and early repolarization syndrome, are undergoing research for a genetic basis. (J Am Coll Cardiol 2012;59:1733–44) © 2012 by the American College of Cardiology Foundation ...
Role of Structural Barriers in the Mechanism of Alternans
Role of Structural Barriers in the Mechanism of Alternans

... Background: Previously, using an animal model of T wave alternans in structurally normal myocardium, we demonstrated that action potential duration (APD) can alternate with opposite phase between neighboring cells (i.e. discordant alternans) causing spatial dispersions of repolarization which form t ...
Appropriate Use Criteria for ICD/CRT Online Appendix Guideline
Appropriate Use Criteria for ICD/CRT Online Appendix Guideline

... prevention of sudden cardiac death: a report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Develop Guidelines for Management of Patients With Ventricular Arrhythmias and the P ...
it`s all about compressions― and defibrillation!
it`s all about compressions― and defibrillation!

... ƒ Chest compressions were too shallow (< 38 mm or 1.5”) 37.4% of the time. ƒ Ventilation rates were too high; during 60.9% of the 30-second segments ventilations were performed at a rate of > 20/min. ƒ The no flow fraction (NFF) yielded a mean of 0.24 with 40.3% of the segments having a NFF of > 0.2 ...
Effect of oral administration of pimobendan in cats with heart failure
Effect of oral administration of pimobendan in cats with heart failure

... ed median survival time of 13 days with conventional treatment.a The objective of the study reported here was to determine the effect of PO administration of pimobendan on clinical and echocardiographic variables and survival time in cats with HF characterized by ventricular systolic dysfunction. Ma ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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