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Effect of dual-chamber pacing on systolic and diastolic
Effect of dual-chamber pacing on systolic and diastolic

... from the let, ventricular inflow region and the ascending aorta (2,14-16). Transseptal catheterization was thus performed on all patients with a Brockenbrough needle and an 8F Mullins sheath. The sheath was initially placed in the inflow region of the left ventricle, and 21; and 3F high fidelity man ...
Ventricular Septal Rupture After Acute Myocardial Infarction
Ventricular Septal Rupture After Acute Myocardial Infarction

... branches of the left anterior descending coronary artery, the posterior descending branch of the right coronary artery, or the circumflex artery when it is dominant. VSR has equal frequency in anterior and non-anterior infarctions.7 Anterior MI is associated with rupture of the apical septum, in inf ...
Transoesophageal Echocardiography and Left Ventricular Function
Transoesophageal Echocardiography and Left Ventricular Function

... A volume-based representation of ejection fraction can be obtained by estimating end-systolic and end-diastolic volumes through two-dimensional quantitative methods, with the aid of a computer program. The resulting left ventricular volumes are inferred and yield an estimated ejection fraction. Volu ...
SUDDEN CARDIAC DEATH IN YOUNG PEOPLE – FORENSIC
SUDDEN CARDIAC DEATH IN YOUNG PEOPLE – FORENSIC

... deaths, in which case the type and cause of death will be determined only after forensic autopsy and laboratory complex thanatological examinations (microscope, toxicological, serological, etc.) whose results must be correlated with survey data. In the category of sudden death (death suspected to be ...
Contribuição Internacional
Contribuição Internacional

... morning BP surge from the low nighttime levels to higher daytime levels continues for 4-6 hours after awakening3,4 and is characterized by an increase in systolic BP of approximately 3 mmHg per hour and in diastolic BP of 2 mmHg per hour1. In some cases, there may be a slight overshoot in BP, result ...
Positive jugular pulse
Positive jugular pulse

... factors, e.g. decreased amplitude because of reduced venous return as well as from reduced contractile power of the myocardium. Reflex acceleration of the heart occurs in painful conditions, e.g. spasmodic colic, as well as in febrile diseases. In toxaemic and septicaemic conditions all the circulat ...
hypertrophic cardiomyopathy - American Heart Association
hypertrophic cardiomyopathy - American Heart Association

... of the heart) looking for abnormally thick walls predominantly in the left pumping chamber (left ventricle). In addition, the extent of obstruction or muscular narrowing through the outlet of the left ventricle to the aorta (main vessel which carries blood to the body) will be assessed. This diagnos ...
Atrioventricular node fetal dispersion and His bundle
Atrioventricular node fetal dispersion and His bundle

... Ischemic heart disease is the most frequent cause of sudden death in adults (1,2), whereas hypertrophic cardiomyopathy, myocarditis, anomalous origin of coronary arteries, aortic stenosis, Fallot tetralogy, pulmonary hypertension and others are more frequent in children and teenagers (3– 6). However ...
Metastatic Cancer to the Heart
Metastatic Cancer to the Heart

... eonduction system by infiltration of cancer. In the latter instance, the arrhythnmias or rate changes provide important clues for antemortem diagnosis. Doane and Pressman44 stated that whenever the right heart is involved, the intervenltricular septum is likely to share in the process and the conduc ...
Sutureless aortic valve replacement in patients with severe aortic
Sutureless aortic valve replacement in patients with severe aortic

... There were no intra-procedural deaths. Five patients (2%) died during the hospital stay; however, none were considered to be valve-related. Twenty patients died during followup but it was not specified how many deaths were valve-related. Nine patients (4%) experienced peri-operative PVL, seven of w ...
Catheter ablation of typiCal atrial flutter
Catheter ablation of typiCal atrial flutter

... leads (II, III and aVF) (figure 1) whereas CW AFL shows a positive polarity (figure 2). An additional criteria is to measure the ratio between the voltage in aVF and lead I: aVF/ lead I ratio of the flutter waves >2.5 is diagnostic for CCW (2). The diagnosis of CCW AFL with 2:1 AV conduction can be ...
ecg interpretation part 1: understanding mean electrical axis
ecg interpretation part 1: understanding mean electrical axis

... Hypertrophy of the left ventricle often occurs after myocardial infarction (MI) of this ventricle as a result of the remodeling process or lesions of the mitral or aortic valves. It can also occur due to MI in the right ventricle; however, this is less common. Right-sided ventricular hypertrophy oft ...
ECG basics
ECG basics

... in a pocket or pouch. Telemetry monitoring is especially useful for detecting arrhythmias that occur at rest or during sleep, exercise, or stressful situations. Most systems, however, can monitor only heart rate and rhythm. ...
Title: Persufflation (Gaseous Oxygen Perfusion) as a Method of
Title: Persufflation (Gaseous Oxygen Perfusion) as a Method of

... setting of prolonged cold ischemia time (CIT). For example, strong evidence now exists and supports the use of hypothermic machine perfusion (HMP) during kidney preservation [1-5], and excellent results were recently attained in the first human clinical trials using HMP during liver preservation [6] ...
VA-ECMO in Cardiogenic Shock in Adults
VA-ECMO in Cardiogenic Shock in Adults

... Another factor contributing to the wide acceptance of ECMO technology is progress in other areas of mechanical circulatory support, particularly left ventricular assist devices (LVADs). With the ability to maintain adequate hemodynamics in patients using an LVADs for several years, it became possibl ...
Paradoxical effect of respiration on ventricular rate in atrial fibrillation
Paradoxical effect of respiration on ventricular rate in atrial fibrillation

... In atrial fibrillation ventricular rate increases with atropine and exercise [3], and a possible mechanism is withdrawal of vagal tone which may be responsible for the maintenance of a submaximal ventricular rate at rest. In sinus rhythm resting vagal tone fluctuates in phase with respiration, resul ...
GREEN Form - AHP Diet Drug Settlement
GREEN Form - AHP Diet Drug Settlement

... H. Feigenbaum, Echocardiography 68-133 (5th ed. 1994). A. E. Weyman, Principles and Practice of Echocardiography 75-97 (2d ed. 1994). J. P. Singh, et al., Prevalence and Clinical Determinants of Mitral, Tricuspid and Aortic Regurgitation (The Framingham Heart Study), 83 Am. J. Cardiol. ...
Anomalies of cardiac venous drainage associated with
Anomalies of cardiac venous drainage associated with

... Abnormalities of the anatomy of the great veins and coronary sinus could result in anomalies of the left pacemaking area close to the coronary sinus. Chiang et al. found major coronary sinus abnormalities in 4·7% of patients with accessory pathways, and found that they are often anatomically related ...
- Wiley Online Library
- Wiley Online Library

... were included: (i) population: pediatric patients undergoing CHD surgery; (ii) intervention: dexmedetomidine; (iii) comparison: other anesthetics or placebo; (iv) outcome parameters: blood pressure, heart rate, duration of ventilation, ICU and hospital stays, requirement for postoperative fentanyl a ...
Effect of Age and Sex on QRS Axis Deviation of Healthy
Effect of Age and Sex on QRS Axis Deviation of Healthy

... by a myriad of changes in body systems. Health and lifestyle factors together with the genetic make-up of an individual determine the response to these changes. In India, the absolute size of the aged population is considerable. The projected figures (for >65 years) for the year 2000 and 2010 are 8% ...
Review Article Magnetic Resonance Imaging Conditional
Review Article Magnetic Resonance Imaging Conditional

... we are not aware of any reports of this effect in humans. 2. Heating: this is of most concern at the lead tip, due to resistive heating at the leadmyocardium interface induced by both the radiofrequency (RF) current and gradient magnetic field. Temperature rises have been measured both in vitro and ...
The right ventricle following prolonged endurance exercise: are we
The right ventricle following prolonged endurance exercise: are we

... duration. A majority of research has focused on the left ventricle (LV) and common comorbidities such as coronary vessel disease.2–4 The right ventricle has been largely overlooked. Early studies into the phenomenon of ‘cardiac fatigue’ showed that LV ejection fraction (LVEF) and diastolic filling pa ...
A case of isolated ventricular septal rupture caused by
A case of isolated ventricular septal rupture caused by

Dynamics of oxygen uptake during exercise in adults
Dynamics of oxygen uptake during exercise in adults

... All subjects performed exercise on an upright electromagnetically braked cycle ergometer. During the tests, the subjects breathed through a mouthpiece connected to a turbine volume transducer (Alpha Technologies). The volume transducer has a linear response of -+- 2% throughout a range of flow rates ...
Late presentation of ALCAPA syndrome in an elderly Asian lady
Late presentation of ALCAPA syndrome in an elderly Asian lady

... ventricle at higher risk of flow ischemia with ventricular systolic dysfunction and possibly ischemic mitral regurgitation causing congestive heart failure usually within the first year of life. The affected infants have non-specific colicky like crying bouts, failure to thrive, feeding difficulties ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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