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Atrial Fibrillation - St. Joseph`s Healthcare Hamilton
Atrial Fibrillation - St. Joseph`s Healthcare Hamilton

... from many different areas within the atria or upper chambers, especially the pulmonary veins. These signals are disorganized and rapid. This causes your heart to beat fast and unevenly. Atrial fibrillation is also called AF or A fib. There are 3 types of atrial fibrillation: • Paroxysmal: This is an ...
- Wiley Online Library
- Wiley Online Library

... subjects, two dipoles could be observed in most of the cases in the latter half of the QRS wave.15 In the present study, we analyzed only the dipole on the left because only one dipole could be observed in most patients with left ventricular overload.The direction of inscription of the normal QRS lo ...
PhD thesis
PhD thesis

... Besides multicenter randomized clinical trials, multi- and single-center registries are also important sources for providing real-world information on CRT. It is well-known, that patients with NYHA class IV and inotropes, those with severe renal dysfunction, or on dialysis, those who are having coe ...
Which is Important for Patients with ST
Which is Important for Patients with ST

... that D2B time of STEMI patients including cardiogenic shock in 9.9 of 8771 patients markedly decreased from 103 min in 2003 to 76 min in 2008 and the achievement rate of D2B time ≤90 min also markedly increased from 28.5% to 62.7, however, no improved presentation time was found and in-hospital mort ...
Exercise training reverses exertional oscillatory ventilation in heart failure patients `
Exercise training reverses exertional oscillatory ventilation in heart failure patients `

... ABSTRACT: Exertional oscillatory ventilation (EOV) is an ominous prognostic sign in chronic heart failure (CHF), but little is known about the success of specific therapeutic interventions. Our aim was to study the impact of an exercise training on exercise capacity and cardiopulmonary adaptation in ...
Table 1
Table 1

... ANALYSIS. Data ...
A Novel Method for Cine-CMR Automated Assessment of Left
A Novel Method for Cine-CMR Automated Assessment of Left

... set manually on the LV cavity, and the following automation is applied: 1) LV region grows iteratively with successively lower thresholds until breaching myocardium and effusion. 2) Myocardial breaching point allows determination of myocardial signal intensity (SI) for precise LV-myocardial border d ...
Drug-induced Torsades de Pointes in patients aged 80 years or more
Drug-induced Torsades de Pointes in patients aged 80 years or more

Occurrence and predictors of left ventricular systolic dysfunction at
Occurrence and predictors of left ventricular systolic dysfunction at

... Background: Post-ST-segment elevation myocardial infarction (STEMI) left ventricular systolic dysfunction (LVSD) has been identified as an important marker of poor prognosis. Aim: To assess the prevalence and course of LVSD at hospital discharge and in long-term follow-up in STEMI patients treated w ...
Use of quinine and mortality-risk in patients with heart failure—a
Use of quinine and mortality-risk in patients with heart failure—a

... 2009),14 the indication for quinine in this study population was most likely leg cramps, which is, apart from malaria, the only labeled indication for quinine in Denmark. As the effect of quinine on leg cramps has been shown to be sustained for at least two weeks after treatment cessation, and to av ...
A Randomized Comparison of Atrial and Dual
A Randomized Comparison of Atrial and Dual

complete auriculo-ventricular dissociation with high ventricular rate
complete auriculo-ventricular dissociation with high ventricular rate

... and during attacks of dissociation the ventricles usually, although not invariably, beat more rapidly than the auricles; most reported examples which he quotes had auricular rates exceeding the ventricular. His observations led him to conclude that the occurrence of dissociation is favoured, on the ...
A new concept of the contraction–extension
A new concept of the contraction–extension

... Objectives: Using newly developed ultrasonic technology, we attempted to disclose the characteristics of the left ventricular (LV) contraction–extension (C–E) property, which has an important relationship to LV function. Methods: Strain rate (SR) distribution within the posterior wall and interventr ...
Randomized, Double-Blind Placebo-Controlled Trial of
Randomized, Double-Blind Placebo-Controlled Trial of

... can inhibit platelet aggregation and human vitronectin receptor expression [10], which are important predisposing mechanisms of coronary thrombosis after AMI. Coenzyme Q is a naturally occurring vitamin-like agent that is normally present in cardiac cells and functions as an electron carrier in oxid ...
331 ANATOMIC AND HISTOLOGIC REVIEW OF THE CORONARY
331 ANATOMIC AND HISTOLOGIC REVIEW OF THE CORONARY

... continuous anatomically and electrically with the myocardial muscular bundle described herein (atriocoronary sinus bundle), that links the base of the left atrial appendage to the myocardial musculature of the CS. Therefore, the Bachmann’s bundle, from the left atrium through the atrio-coronary sinu ...
Chapter 7
Chapter 7

... In this most common congenital defect there is a hole in the septum that separates the right and left ventricles (Fig. 7.2). As a result, blood is short-circuited back into the lungs, putting a burden on both heart and lungs. About 30 percent to 50 percent of these holes, especially the smaller ones ...
Use of Sildenafil for Safe Improvement of Erectile Function
Use of Sildenafil for Safe Improvement of Erectile Function

... function. 7 A serious relation exists between sexual function and the results of the 6-minute walk (r = 0.32) or New York Heart Association (NYHA) functional class (r = 0.21).7 This strong association can be explained because, in addition to vascular disease, patients with CHF have other predisposin ...
Antepartum non-invasive evaluation of opening and closing timings
Antepartum non-invasive evaluation of opening and closing timings

... Maternal risk factors and a large number of intrapartum causes lead to fetal hypoxia. Diagnostics of a distressed unborn baby are mainly aimed at detection of occurrence of intrauterine hypoxia. Consequences resulting from fetal hypoxia appear in its heart activity [6]. In perinatal medicine, non-in ...
Ultrasonographic and Biochemical Markers of Human
Ultrasonographic and Biochemical Markers of Human

... in placental insufficiency.1 It is a protective mechanism maintaining oxygen supply to the most vital fetal organs, the heart and brain. In addition, redistribution of fetal cardiac output in favor of the left ventricle has been described in these complicated pregnancies.2 In placental insufficiency ...
Cardiac System - Nursing Education Consultants
Cardiac System - Nursing Education Consultants

... cardiac output by increasing the stretch of the myocardial muscle fibers, thus increasing the contractility (Starling’s law). In a healthy heart, this is the mechanism that functions when there is a need for increased cardiac output, as in exercise. The increase in the stretch of the myocardial fibe ...
Pathophysiology of right ventricular failure
Pathophysiology of right ventricular failure

... failure may be an independent risk factor for morbidity and mortality in patients with left heart failure (6). RV failure is still a leading cause of death and morbidity early after cardiac transplant (7) and following several other cardiothoracic procedures (8). Primary pulmonary hypertension, whil ...
Early mitral deceleration and left atrial stiffness - AJP
Early mitral deceleration and left atrial stiffness - AJP

... measurements of the mitral valve flow velocity were then obtained using a pulse repetition rate of 4.5 kHz, with the Doppler beam aligned perpendicular to and bisecting the plane of the mitral anulus and with the 3-mm-wide sample volume placed at the level of the anulus, together with synchronized L ...
Thoraco-Omphalopagus conjoined 284
Thoraco-Omphalopagus conjoined 284

... was observed in only three cases of all 1262 twins. The present case had a triple-outlet connection from the left ventricle; two aorta and one pulmonary artery were visualized as connecting the left ventricle. Spitz et al. (2) classified management of 17 conjoined twins in three distinct categories. ...
Value of an Exercise Workload ≥10 Metabolic Equivalents
Value of an Exercise Workload ≥10 Metabolic Equivalents

... has increased, whereas the number of myocardial perfusion imaging studies has decreased.1 One possible explanation for this finding is concern about radiation. Although ExE may evaluate functional capacity and ischemia in a single test, the relationship between these 2 variables is controversial bec ...
Progressive Left Ventricular Dysfunction and
Progressive Left Ventricular Dysfunction and

... output were measured after baseline resting parameters had been obtained and during steady-state conditions after 4 minutes at an exercise level of 50 W. In addition, 4 weeks after admission, coronary angiography and biplane cineangiography were performed in all patients. No attempt was made to cont ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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