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Ch_21_lecture_presentation
Ch_21_lecture_presentation

... • Has the thickest wall • Needed for strong contractions to pump blood throughout the entire systemic circuit • Compare to the right ventricle, which has a thin wall since it only pumps blood through the pulmonary circuit ...
Cardiogenic Shock
Cardiogenic Shock

... advances in treating this condition, nearly 50% of patients with cardiogenic shock still do not survive to hospital discharge. In a strict sense, cardiogenic shock develops as a result of the failure of the heart in its function as a pump, resulting in inadequate cardiac output. This failure is most ...
Prolongation of the QTc interval in patients with cirrhosis
Prolongation of the QTc interval in patients with cirrhosis

... by Child-Pugh score. Other variables (prothrombin time, serum albumin, serum bilirubin, hemoglobin, serum sodium, mean arterial pressure and plasma renin, plasma aldosterone and plasma atrial natriuretic factor) were not independently related with QT prolongation7. The QTc prolongation may reflect e ...
Supraventricular arrhythmias
Supraventricular arrhythmias

... episode of syncope. While working in the intensive care unit, she developed tachycardia and then lost consciousness. She admits to having a stressful day and having had more caffeine than normal. She has had brief episodes of tachypalpitations in the past but no prior syncope. • Physical examination ...
Survival in elderly patients with severe aortic stenosis
Survival in elderly patients with severe aortic stenosis

... trend towards increased mortality, which was not statistically significant. AVR was a strong independent predictor of improved survival. There is a paucity of studies in the literature comparing survival with and without AVR for severe aortic stenosis in those aged 80 years. Gilbert et al. [11] rep ...
Full paper
Full paper

... Background. Myocardial blush grade (MBG) is routinely used to assess the effectiveness of myocardial reperfusion in patients with acute myocardial infarction. Impaired MBG has been found to be an independent predictor of outcome after reperfusion therapy. Objectives. To assess the impact of myocardi ...
comparison of blood pool gated spect with three diffe
comparison of blood pool gated spect with three diffe

... Purpose: To compare several gated myocardial perfusion SPECT (gMPS) programs with blood pool gated SPECT (BPGS) for the evaluation of left ventricular (LV) functional parameters and further investigate the effect of heart size in a population with low coronary artery disease (CAD) risk. Materials an ...
Transcatheter Closure of Atrial Septal Defects in Adolescents and
Transcatheter Closure of Atrial Septal Defects in Adolescents and

... carried out under general anaesthesia whereas in adults, they were done with local anaesthesia and sedation. All patients underwent cardiac catheterization of the right and the left heart. The sheaths were introduced into the right femoral artery, right femoral vein, and left femoral vein. Pressure ...
Adult Heart Murmurs
Adult Heart Murmurs

... You are seeing a 62 year old man with an apparently new systolic murmur. Which of the following would NOT be an indication for immediate echocardiography? A. Systolic murmur with new chest pain and dyspnea B. Asymptomatic patient with a 2/6 systolic murmur C. Asymptomatic patient with a 4/6 systolic ...
and idiopathic hypertrophic subaortic stenosis - Heart
and idiopathic hypertrophic subaortic stenosis - Heart

... in 25 patients with idiopathic hypertrophic subaortic stenosis. The results were compared with the peak systolic pressure gradient across the aortic valve or the subaortic stenosis. It was shown that the Q-Mi interval was pathologically long in patients with idiopathic hypertrophic subaortic stenosi ...
Electrocardiographic Evidence for Left Ventricular Hypertrophy
Electrocardiographic Evidence for Left Ventricular Hypertrophy

... wall and the interventricular septum. The papillary muscles and trabeculae are thickened and may reduce the luminal against the anterior leaflets of the mitral valve. This leaflet dimensions of the chambers. In the hypertrophied myocaroften shows endocardial thickening. The obstructive syndium the c ...
Rapid-response extracorporeal membrane oxygenation to support
Rapid-response extracorporeal membrane oxygenation to support

... (11), or did not predict survival. (4,6,10) Kane et al also showed that although the duration of CPR was reduced in on-going years, the survival rates in their centre did not improve. (4) Morris et al. reported that three from 6 patients who were resuscitated for more than 60 minutes survived with g ...
Evaluation of arrhythmias in the late hospital phase - Heart
Evaluation of arrhythmias in the late hospital phase - Heart

... not confined only to the time in the coronary care unit (Table i) but are prevalent throughout the stay in hospital (Table 2). This investigation should not be interpreted as conflicting with earlier reports which have established that lethal arrhythmias are most frequent in the initial 24 hours aft ...
A Patient Guide To Electrophysiology Study And Catheter Ablation
A Patient Guide To Electrophysiology Study And Catheter Ablation

... Because of the presence of these arrhythmias, patients are referred for further evaluation and treatment recommendations. Most patients undergo an electrophysiology (EP) study or electrical catheter testing to determine the location of the extra connection, study the cause of the clinical rhythm pro ...
DOI: 10.1161/CIRCULATIONAHA.106.653964 published online Mar
DOI: 10.1161/CIRCULATIONAHA.106.653964 published online Mar

... concentrations in patients on diuretics treated with or without angiotensin-converting enzyme inhibitor/angiotensin II receptor blockers were associated with increased mortality and rehospitalization rates.5– 8 Nevertheless, these studies were restricted to patients in New York Heart Association (NY ...
Summer 2015, Vol. 01, No. 1 - Cardiothoracic Surgery
Summer 2015, Vol. 01, No. 1 - Cardiothoracic Surgery

... recently, the use of surgical robotics has allowed far greater sophistication in performing these procedures and may have advantages in improving lymph node removal (a vital part of surgery for lung cancer), allowing for minimally invasive parenchymal-sparing resections (segmentectomy), and further ...
pulmonary vascular disease in patients with congenital
pulmonary vascular disease in patients with congenital

... Echocardiography is useful for managing PHTN. Echocardiographic findings indicative of the severity of PHTN and the response to therapies include: estimation of RV systolic pressure based on the velocity of the tricuspid regurgitant jet; the amount of tricuspid regurgitation; the position of the int ...
Heart Murmurs in Cats - Kingsbrook Animal Hospital
Heart Murmurs in Cats - Kingsbrook Animal Hospital

Title of Presentation
Title of Presentation

... • May improve CO in some patient and hence increase effective renal perfusion • ACEI may lower BP to the point where effective renal perfusion is impaired • With chronic renal disease, there is hyperfiltration in the remaining nephrons. ACEI decreases efferent arteriole constriction and hence decrea ...
Current and Novel Devices in Structural Heart Disease
Current and Novel Devices in Structural Heart Disease

... due to the longer stent design (55 mm) reaching further down the left ventricular outflow tract and the self-expanding nature of the valve, which exerts pressure on the conducting tissue within the septal wall. Careful valve positioning has resulted in a lower need for permanent pacemaker implantati ...
ECG Notes
ECG Notes

... rarely causes significant bradycardia, or progresses to higher degree block Mobitz II = fixed PR & RR intervals (long) with regular dropped beats caused by disease below the AV node, ie. the bundle of His may be associated with anterior AMI ventricular rates can be quite slow, with dyspnoea, syncope ...
jellyfish, and turtles
jellyfish, and turtles

... The accepted explanation was that ganglia were necessary to trigger the heart beat, and these had been demonstrated in the basal portion of the ventricle but not in the apex. Foster found that a weak interrupted current applied to the isolated apex produced a series of beats "separated from each oth ...
Naming of the Waves in the ECG, With a Brief Account
Naming of the Waves in the ECG, With a Brief Account

... thinking about Descartes’ use of the letter P to designate a point on a curve. As will be shown, this eventually led to the use of PQRST to designate the waves in the ECG. Waller, however, refused to use the new labels.3 The ECG recorded by Einthoven with an even more refined Lippmann capillary elec ...
Syncope and The Older Patient
Syncope and The Older Patient

Frequency dependent effect of selective biphasic left vagus nerve
Frequency dependent effect of selective biphasic left vagus nerve

... function. The ability to selectively stimulate certain superficial compartments of peripheral nerves has been demonstrated previously. The aim of the present study was to find a clinically acceptable selective biphasic vagus nerve stimulation technique, which could allow gradual regulation of heart ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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