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Patients with atrial fibrillation and low risk of stroke: do they really
Patients with atrial fibrillation and low risk of stroke: do they really

... stratification is to identify low-risk patients.13 If the risk is low, the patient does not require anticoagulation. According to the 2012 ESC guidelines, in patients with nonvalvular AF with a CHA2DS2-VASc score of 0 or in patients younger than 65 years with lone AF regardless of sex should not rec ...
Randomized, prospective trial of oxygen, continuous positive airway
Randomized, prospective trial of oxygen, continuous positive airway

... p values were calculated about the mean doses of the drugs; fdoses are the mean of the higher doses used during the protocol. ...
Anomalous origin of the right coronary artery from the pulmonary trunk
Anomalous origin of the right coronary artery from the pulmonary trunk

... chest heaviness had lasted for about a year. Cardiac and chest auscultation were unremarkable. The patient’s cardiovascular risk factors included treated hypertension. There was no family history of coronary artery disease. The patient’s ECG demonstrated sinus bradycardia with no ST-segment changes ...
CRT Device - St. Jude Medical
CRT Device - St. Jude Medical

... working on automobile ignition systems also will not damage CRT devices; however, there is a possibility that they may briefly interfere with proper device operation. Some medical equipment also may interfere with the function of the CRT device. If you become lightheaded or feel palpitations (rapid, ...
Calibrated integrated backscatter and
Calibrated integrated backscatter and

... between cIB and fibrosis in patients with less extensive fibrosis. We have shown that left ventricular functional abnormalities of the metabolic syndrome and type 2 diabetes are not associated with increased myocardial fibrosis.8 In addition, factors other than fibrosis may influence cIB.9–16 cIB increas ...
AHA Scientific Statement
AHA Scientific Statement

... The American Heart Association makes every effort to avoid any actual or potential conflicts of interest that may arise as a result of an outside relationship or a personal, professional, or business interest of a member of the writing panel. Specifically, all members of the writing group are requir ...
Validation of echocardiographic methods for assessing left
Validation of echocardiographic methods for assessing left

... time constant of isovolumic relaxation (r ⫽ 0.68 and 0.48) and inversely with peak rate of rise of LV pressure (⫹dP/dt; r ⫽ ⫺0.68 and ⫺0.50), peak rate of decline in LV pressure (r ⫽ ⫺0.57 and ⫺0.44), LV developed pressure (r ⫽ ⫺0.58 and ⫺0.42), area fractional shortening (r ⫽ ⫺0.85 and ⫺0.53), and ...
Jostein Grimsmo and Ulrik Wisløff Øivind Rognmo, Trine
Jostein Grimsmo and Ulrik Wisløff Øivind Rognmo, Trine

... The high-intensity interval training sessions were performed as described earlier 17 and typically consisted of warm-up for a minimum of 10 minutes at 60% to 70% of HRpeak before working four 4-minute intervals at 85% to 95% of HRpeak. Each interval was separated by active pauses at 50% to 70% of HR ...
Skin autofluorescence is elevated in acute myocardial infarction and
Skin autofluorescence is elevated in acute myocardial infarction and

... between-group differences in skin AF remained significant after correction for diabetes, smoking, cholesterol, and serum creatinine (F=5.2, η2=0.035, p=0.024 for STEMI compared with sCAD and F=8.9, η2=0.079, p=0.004 for STEMI compared with controls). Skin AF and markers for glycaemic and inflammator ...
262 Cardiovascular System - Jordan University of Science and
262 Cardiovascular System - Jordan University of Science and

... Describe different types of arrhythmia and the ECG appearance in each type. Atrial fibrillation, atrial flutter, supra ventricular tachycardia, ventricular tachycardia and ventricular fibrillation. Discuss different types of conduction block. Incomplete (first and second degree) and complete heart b ...
262 Cardiovascular System - Jordan University of Science and
262 Cardiovascular System - Jordan University of Science and

... Describe different types of arrhythmia and the ECG appearance in each type. Atrial fibrillation, atrial flutter, supra ventricular tachycardia, ventricular tachycardia and ventricular fibrillation. Discuss different types of conduction block. Incomplete (first and second degree) and complete heart b ...
Implications of Coronary Artery Disease in Heart Failure With
Implications of Coronary Artery Disease in Heart Failure With

... Approximately one-half of all patients with heart failure (HF) have heart failure with preserved ejection fraction (HFpEF) (1). In contrast to heart failure with reduced ejection fraction (HFrEF), there is no proven effective treatment for HFpEF (2). Accordingly, current studies and guidelines endor ...
ECG Signal Analysis Using Wavelet Transforms
ECG Signal Analysis Using Wavelet Transforms

... normal negativity in a process called depolarization, which is the fundamental electrical activity of the heart. This depolarization is propagated from cell to cell, producing a wave of depolarization that can be transmitted across the entire heart. This wave of depolarization produces a flow of ele ...
Cryptogenic Stroke
Cryptogenic Stroke

... Foramen Ovale for Secondary Stroke Prevention: 2010  No device for PFO closure after cryptogenic stroke has been approved by the FDA.  Randomized controlled trials offer the best means for assessing the safety and efficacy of percutaneous device closure relative to anti-thrombotic meds.  Enrollme ...
1 - JACC: Heart Failure
1 - JACC: Heart Failure

... on severity of illness: United Network for Organ Sharing (UNOS) status 1A for high-risk ...
Mechanisms of Acute Mitral Regurgitation in Patients
Mechanisms of Acute Mitral Regurgitation in Patients

... examinations with an iE-33 system (Philips Medical Systems; Andover, MA) within 24 hours of admission. Follow-up echocardiography was performed within 4 weeks (range, 1 to 4 weeks) after initial presentation. The LV wall motion score index (WMSI) was calculated on the basis of a 16-segment model rec ...
Relation between QT duration and maximal wall thickness in familial
Relation between QT duration and maximal wall thickness in familial

cristiana maria mendes de sousa paulo ortigão soares
cristiana maria mendes de sousa paulo ortigão soares

... systolic dysfunction were alive five years after the diagnosis. Patients with heart failure without left ventricular systolic dysfunction, patients with asymptomatic left ventricular systolic dysfunction and the general population had 5-year survival rates of 62%, 69% and 93%, respectively.26 There ...
The Use of Central Venous Pressure in Critically Ill Patients
The Use of Central Venous Pressure in Critically Ill Patients

... devices, and is therefore the value for zeroing measuring devices, whether the device is a column of mercury or water or a transducer. However, it is the transmural pressure, which is the difference in pressure between inside and outside the elastic structure, that determines the distension of the s ...
Patients With Syndrome X Have Normal Transmural Myocardial
Patients With Syndrome X Have Normal Transmural Myocardial

... frames) had regional or circumferential areas of hypoenhancement lasting ⬎5 frames on visual analysis of stress perfusion images, but similar areas of hypoenhancement were seen on their resting scans and, therefore, considered to be artifacts. Overall, 10 (55%) patients with syndrome X and 4 (29%) c ...
PDF - Circulation
PDF - Circulation

... heart. Sensitivity of the carotid sinus is increased in a variety of conditions, particularly in myocardial infarction,' congestive heart failure,2 and arteriosclerotic hypertensive vascular disease.3 Digitalis in excess also causes sinus bradyeardia or arrest, in addition to the more familiar effec ...
Formation of the Ventricles
Formation of the Ventricles

... Knockout studies in mice have shown that several cardiac transcription factors are essential for appropriate looping morphogenesis and their loss of function tends also to be characterized by a single, common, hypoplastic ventricular chamber. In mouse embryos lacking the early cardiac homeobox gene ...
Diagnosis of Cardiac Tamponade.
Diagnosis of Cardiac Tamponade.

... vein distention may be obvious clinically, but the measured CVP is more reliable than the presence of venous distention. The CVP reading should take into account positive-pressure ventilation and the effects of a Valsalva maneuver. Most patients with significant tamponade will have a CVP of greater ...
Retinoids and Cardiac Development
Retinoids and Cardiac Development

... early embryonic lethality [43,44,49]. Problems in SHF deployment can in addition compromise outflow tract development resulting in a spectrum of CHD. These defects are essentially anomalies in patterning and septation of the great arteries, and ventricular and atrial septal defects (see [9,50]). Suc ...
A mathematical model of left ventricular contraction and
A mathematical model of left ventricular contraction and

... It is important to note that, although the causes differ, the clinical features and neurohumoral changes are indistinguishable between HFpEF and HFrEF, suggesting a mechanistic association. The processes involved on heart failure have been investigated for many decades but despite this the underlyin ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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