cardiac toxicology - The University of North Carolina at Chapel Hill
... • The mechanism of cardiomyopathy from AZT is not completely understood, but suggested to be related to depletion mtDNA replication, resulting in impaired synthesis of mitochondrial enzymes that generate ATP - The enzyme responsible for mtDNA replication is DNA polymerase gamma, and it was found to ...
... • The mechanism of cardiomyopathy from AZT is not completely understood, but suggested to be related to depletion mtDNA replication, resulting in impaired synthesis of mitochondrial enzymes that generate ATP - The enzyme responsible for mtDNA replication is DNA polymerase gamma, and it was found to ...
The Rate of Change of Left Ventricular Volume in Man
... The rate of left ventricular volume change (dV/dt) is by definition left ventricular ejection during systole and filling rate during diastole, and in the absence of valvular regurgitation or intracardiac shunts, is equal to systolic aortic valve flow and diastolic mitral valve flow respectively. A c ...
... The rate of left ventricular volume change (dV/dt) is by definition left ventricular ejection during systole and filling rate during diastole, and in the absence of valvular regurgitation or intracardiac shunts, is equal to systolic aortic valve flow and diastolic mitral valve flow respectively. A c ...
Association of prolapse of posterior cusp of mitral - Heart
... The ii patients were aged from 4 to 57 years; 3 were male and 8 female. Electrocardiograms, chest radiographs, and phonocardiograms were obtained in all patients and cardiac catheterization -and left ventricular angiography were performed. The findings at operation were available in 5 patients. ...
... The ii patients were aged from 4 to 57 years; 3 were male and 8 female. Electrocardiograms, chest radiographs, and phonocardiograms were obtained in all patients and cardiac catheterization -and left ventricular angiography were performed. The findings at operation were available in 5 patients. ...
BRS Physiology Cases and Problems 2nd Edition
... 1. Orthostatic hypotension is the phenomenon whereby arterial pressure decreases when one stands up. When a person suddenly moves from a supine (lying) position to a standing position, blood pools in the veins of the legs. (Because the capacitance, or compliance, of the veins is high, they can hold ...
... 1. Orthostatic hypotension is the phenomenon whereby arterial pressure decreases when one stands up. When a person suddenly moves from a supine (lying) position to a standing position, blood pools in the veins of the legs. (Because the capacitance, or compliance, of the veins is high, they can hold ...
TEXAS CHILDREN`S HOSPITAL PEDIATRIC TRANSTHORACIC
... All initial echocardiograms at Texas Children’s Hospital are complete studies. A limited follow up study is generally only performed when the patient has recently undergone a complete echocardiogram and there is no reason to suspect any changes outside the area of interest. ...
... All initial echocardiograms at Texas Children’s Hospital are complete studies. A limited follow up study is generally only performed when the patient has recently undergone a complete echocardiogram and there is no reason to suspect any changes outside the area of interest. ...
Severe Aortic Stenosis and Transcatheter Aortic Valve Replacement
... option. In certain cases, TAVR may not be an option because of co-existing medical conditions or disease processes that would prevent you from experiencing the expected treatment benefit or because the risks outweigh the benefits. For those who are candidates for TAVR, this therapy may provide relie ...
... option. In certain cases, TAVR may not be an option because of co-existing medical conditions or disease processes that would prevent you from experiencing the expected treatment benefit or because the risks outweigh the benefits. For those who are candidates for TAVR, this therapy may provide relie ...
Myocardial Infarction
... Helps prevent occlusion of the coronary arteries, reducing the incidence of ischemic events Used in treating patients with USA Usually administered in combination with angioplasty with or without PCI Given in combination with heparin or ASA to prevent clotting before and during invasive hear ...
... Helps prevent occlusion of the coronary arteries, reducing the incidence of ischemic events Used in treating patients with USA Usually administered in combination with angioplasty with or without PCI Given in combination with heparin or ASA to prevent clotting before and during invasive hear ...
EKG ase Presentations
... • What should you do at this time? a. Synchronized cardioversion b. Treat the patient with metoprolol c. Treat the patient with IV Digoxin d. Massage his carotid arteries e. Treat the patient with IV Adenosine ...
... • What should you do at this time? a. Synchronized cardioversion b. Treat the patient with metoprolol c. Treat the patient with IV Digoxin d. Massage his carotid arteries e. Treat the patient with IV Adenosine ...
Chapter 14 Heart The main function of the heart is to circulate blood
... Heart works harder to accommodate the increased heart rate and stroke volume required for the expanded blood volume. Left ventricle increases in both wall thickness and mass. Heart shifts to more horizontal position. Uterus enlarges and the diaphragm moves upward. Older Adults Heart size may decreas ...
... Heart works harder to accommodate the increased heart rate and stroke volume required for the expanded blood volume. Left ventricle increases in both wall thickness and mass. Heart shifts to more horizontal position. Uterus enlarges and the diaphragm moves upward. Older Adults Heart size may decreas ...
Can the block help the beat? Beta blockers for ventricular fibrillation.
... 1. High-frequency and asynchronous contraction of the ventricles resulting in no cardiac output or blood pressure 2. Almost always fatal i. Approximately 92% of out-of-hospital cardiac arrest die ii. Tends to deteriorate into asystole over time 3. Most common arrhythmia in cardiac arrest 4. The init ...
... 1. High-frequency and asynchronous contraction of the ventricles resulting in no cardiac output or blood pressure 2. Almost always fatal i. Approximately 92% of out-of-hospital cardiac arrest die ii. Tends to deteriorate into asystole over time 3. Most common arrhythmia in cardiac arrest 4. The init ...
EP Study Protocol
... These parameters may be influenced by the effect of antiarrhythmic drugs already given to prevent/diminish cardiac arrhythmias. It is not always possible to interrupt this treatment to have a baseline study. Therefore the antiarrhythmic treatment(s) have to be indicated at the date of EPS. 1) Basic ...
... These parameters may be influenced by the effect of antiarrhythmic drugs already given to prevent/diminish cardiac arrhythmias. It is not always possible to interrupt this treatment to have a baseline study. Therefore the antiarrhythmic treatment(s) have to be indicated at the date of EPS. 1) Basic ...
Atrial fibrillation
... The term ventricular arrhythmia refers to any cardiac rhythm in which both the pacemaker site and conduction path are confined to the ventricles Arrhythmias arising from the ventricles are less common than SVTs and are more likely to be found in people with heart disease ...
... The term ventricular arrhythmia refers to any cardiac rhythm in which both the pacemaker site and conduction path are confined to the ventricles Arrhythmias arising from the ventricles are less common than SVTs and are more likely to be found in people with heart disease ...
Noninvasive Cardiac Output
... Goal-directed therapy is a technique to guide administration of fluid and drugs to achieve certain hemodynamic goals. Protocols based on goal-directed therapy have been proven to reduce morbidity and mortality rates for critical patients specially who are suffering from severe sepsis, septic shock a ...
... Goal-directed therapy is a technique to guide administration of fluid and drugs to achieve certain hemodynamic goals. Protocols based on goal-directed therapy have been proven to reduce morbidity and mortality rates for critical patients specially who are suffering from severe sepsis, septic shock a ...
MR-Imaging in diagnosis and follow-up post corrective
... • In this educational exhibit we will review the use of MR imaging in the diagnosis of the different forms of congenital heart disease in pediatric patients. • An overview of common forms of CHD along with treatment procedures will be given. • Special interest is taken on technical issues and partic ...
... • In this educational exhibit we will review the use of MR imaging in the diagnosis of the different forms of congenital heart disease in pediatric patients. • An overview of common forms of CHD along with treatment procedures will be given. • Special interest is taken on technical issues and partic ...
Implantation of Aortic Stentless Bioprosthesis: Case Series
... Aim. To present our preliminary results with stentless aortic valve bioprostheses. Methods. From November 2001 to February 2002, 15 patients (8 men and 7 women) underwent aortic valve replacement with aortic stentless bioprosthesis. The patients’ age ranged from 50 to 79 years (mean±SD, 63.3±5.7 yea ...
... Aim. To present our preliminary results with stentless aortic valve bioprostheses. Methods. From November 2001 to February 2002, 15 patients (8 men and 7 women) underwent aortic valve replacement with aortic stentless bioprosthesis. The patients’ age ranged from 50 to 79 years (mean±SD, 63.3±5.7 yea ...
Ventricular Intrinsic PreferenceTM Feature Reduces Heart Failure
... Reduced combined heart failure hospitalization and cardiac death Reduced cost burden associated with HF hospitalization ...
... Reduced combined heart failure hospitalization and cardiac death Reduced cost burden associated with HF hospitalization ...
Tetralogy of Fallot (TOF) - University of Maryland School of Medicine
... Tetralogy of Fallot (TOF) is a congenital heart defect. TOF is described as 4 abnormalities that occur together. One is that there is a large hole in the wall of muscle (septum) that divides the 2 bottom pumping chambers (ventricles) of the heart. That hole is called a ventricular septal defect (VSD ...
... Tetralogy of Fallot (TOF) is a congenital heart defect. TOF is described as 4 abnormalities that occur together. One is that there is a large hole in the wall of muscle (septum) that divides the 2 bottom pumping chambers (ventricles) of the heart. That hole is called a ventricular septal defect (VSD ...
in cardiac cells.
... blocked at the AV junction, therefore, the atria and the ventricles beat independently from each other. This arrhythmia is dangerous because it significantly decreases cardiac output, and could lead to asystole. Possible causes: acute inferior and anterior myocardic infraction, coronary heart diseas ...
... blocked at the AV junction, therefore, the atria and the ventricles beat independently from each other. This arrhythmia is dangerous because it significantly decreases cardiac output, and could lead to asystole. Possible causes: acute inferior and anterior myocardic infraction, coronary heart diseas ...
Atrial_Flutter
... Atrial flutter occurs when the atria are stimulated to contract at 200-350 beats per minute usually because electrical impulses are traveling in a circular fashion around and around the atria. Often the impulses are traveling around an obstacle like the mitral valve, tricuspid valve or the openings ...
... Atrial flutter occurs when the atria are stimulated to contract at 200-350 beats per minute usually because electrical impulses are traveling in a circular fashion around and around the atria. Often the impulses are traveling around an obstacle like the mitral valve, tricuspid valve or the openings ...
04_Symptoms and syndromes based on the data of auscultation of a
... • I heart sound: -the valve component, i.e. vibrations of the cusps of the atrioventricula valves during the isometric contraction phase -the muscular one due to the myocardial isometric contraction -the vascular one. This is due to vibrations of the nearest portions of the aorta and the pulmonary ...
... • I heart sound: -the valve component, i.e. vibrations of the cusps of the atrioventricula valves during the isometric contraction phase -the muscular one due to the myocardial isometric contraction -the vascular one. This is due to vibrations of the nearest portions of the aorta and the pulmonary ...
Hypertrophic cardiomyopathy
Hypertrophic cardiomyopathy (HCM) is a primary disease of the myocardium (the muscle of the heart) in which a portion of the myocardium is hypertrophied (thickened) without any obvious cause, creating functional impairment of the cardiac muscle. It is a leading cause of sudden cardiac death in young athletes.The occurrence of hypertrophic cardiomyopathy is a significant cause of sudden unexpected cardiac death in any age group and as a cause of disabling cardiac symptoms. Younger people are likely to have a more severe form of hypertrophic cardiomyopathy.HCM is frequently asymptomatic until sudden cardiac death, and for this reason some suggest routinely screening certain populations for this disease.A cardiomyopathy is a disease that affects the muscle of the heart. With HCM, the myocytes (cardiac contractile cells) in the heart increase in size, which results in the thickening of the heart muscle. In addition, the normal alignment of muscle cells is disrupted, a phenomenon known as myocardial disarray. HCM also causes disruptions of the electrical functions of the heart. HCM is most commonly due to a mutation in one of nine sarcomeric genes that results in a mutated protein in the sarcomere, the primary component of the myocyte (the muscle cell of the heart). These are predominantly single-point missense mutations in the genes for beta-myosin heavy chain (MHC), myosin-binding protein C, cardiac troponinT, or tropomyosin. These mutations cause myofibril and myocyte structural abnormalities and possible deficiencies in force generation. Not to be confused with dilated cardiomyopathy or any other cardiomyopathy.While most literature so far focuses on European, American, and Japanese populations, HCM appears in all ethnic groups. The prevalence of HCM is about 0.2% to 0.5% of the general population.