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Downloaded from by guest on September 30, 2014
Downloaded from by guest on September 30, 2014

... patients with dilated cardiomyopathy we have described, pacemaker therapy can be further refined. It is perhaps a measure of the magnitude of the activation disturbance that even so unsophisticated a measure as pacing from the right ventricular apex leads to functional improvement. It is most unlike ...
Reversible Mitral Regurgitation as a Complication of
Reversible Mitral Regurgitation as a Complication of

... Page 1 of 6 ...
Right ventricular failure in congenital heart disease
Right ventricular failure in congenital heart disease

... is especially important in RV failure because atrial fibrillation and atrioventricular block may have profound hemodynamic effects18). In patients with RV dysfunction and valvular heart disease or CHD, corrective surgery or percutaneous interven­tion should be considered in suitable candidates18,39, ...
Pericardium 2 - Brown University
Pericardium 2 - Brown University

... 2. Trauma causing bleeding in pericardial space. 3. Noninfectious conditions such as: a. increase in pulmonary hydrostatic pressure e.g. congestive heart failure. b. increase in capillary permeability e.g. hypothyroidism c. decrease in plasma oncotic pressure e.g. cirrhosis. 4. Decreased drainage of ...
Assessment of Systolic and Diastolic Cardiac Function beyond
Assessment of Systolic and Diastolic Cardiac Function beyond

... that the functional systolic and diastolic reserve is decreased even in the early, subclinical stages of cardiac dysfunction that exists for example in hypertensive disease and that the decrease seems to be related to the number of the associated cardiovascular risk factors. Conclusion: thus, better ...
When Oxygen Goes Bad or How Not to Kill a Small Child with O2
When Oxygen Goes Bad or How Not to Kill a Small Child with O2

... Oxygenated Blood from the umbilical vein enters the RA Some mixes with systemic blood and is ejected by the RV into the PA ...
Right Atrium: sinus venarum: thin-walled posterior part, where vena
Right Atrium: sinus venarum: thin-walled posterior part, where vena

... through the right fibrous trigone into the muscular part of the interventricular septum; it divides into right and left branches to supply the ventricles; also known as: bundle of His atrioventricular node is located in the wall of the right atrium above the opening of the coronary sinus and the sep ...
Arrhythmogenic Right Ventricular
Arrhythmogenic Right Ventricular

... Risk stratification is imperfect. Patients who have documented or even borderline criteria for ARVC are usually treated with ICD’s. In the North American ARVC Registry 77% of newly diagnosed probands or affected family members received this therapy.19 Although it is well documented from other studie ...
A retrospective study of tetralogy of Fallot in dogs
A retrospective study of tetralogy of Fallot in dogs

... The anatomic features of tetralogy of Fallot (ToF) were first described by the Danish anatomist Nils Stensen in 1673, but in 1888 the French doctor Etienne Fallot gave a detailed anatomical and clinical description of this heart defect (1). ToF is a complex congenital heart disease that consists of ...
Lecture 13 Coronary Circulation, Ischemic Heart Disease
Lecture 13 Coronary Circulation, Ischemic Heart Disease

... b. since subendocaridal muscle has the longest period of low flow during the cardiac cycle most myocardial infarctions are subendocardial D. Causes of death following acute coronary occlusion 1. Decrease cardiac output - Cardiac shock a. greater than 40 % loss of muscle almost always causes death b. ...
chapter 5 sudden and unexpected death
chapter 5 sudden and unexpected death

... This condition may lead to sudden cardiac death from left ventricular hypertrophy. In hypertension, the heart may increase to 600 g or more and the muscle mass thus outgrows it coronary supply, even if the coronary arteries are healthy. Atheroma is often associated with hypertension, so that the enl ...
the normal sounds
the normal sounds

... Most prominent on expiration Indicates narrowing of bronchi by secretions or by constriction of the bronchi in asthma The severity of the wheeze is NOT an indicator of the severity of the disease. ...
Michael P. Mallin and Christine Butts
Michael P. Mallin and Christine Butts

... of the right and left ventricles at end-diastole. A right-to-left ventricular area ratio of greater than 0.66 has been shown to be 85% specific for PE.11 Another finding is described as retained apical function in the setting of right ventricular free wall hypokinesis. This is called the McConnell s ...
Transcatheter Heart Valves
Transcatheter Heart Valves

... Individual has been identified by the heart team to have high or greater risk for open surgical therapy with a Society of Thoracic Surgeons operative risk score equal to or greater than 8% or at a 15% or greater risk of operative mortality at 30 days Request is for a transcatheter pulmonary valve (T ...
Heart Failure
Heart Failure

... The extent of hypertrophy varies for different underlying causes. Heart weight usually ranges from 350 to 600 gm (up to approximately two times normal) in pulmonary hypertension and ischemic heart disease; from 400 to 800 gm (up to two to three times normal) in systemic hypertension, aortic stenosis ...
Transcatheter Heart Valves Procedures
Transcatheter Heart Valves Procedures

... Individual has been identified by the heart team to have high or greater risk for open surgical therapy with a Society of Thoracic Surgeons operative risk score equal to or greater than 8% or at a 15% or greater risk of operative mortality at 30 days Request is for a transcatheter pulmonary valve (T ...
Transcatheter Heart Valves Procedures
Transcatheter Heart Valves Procedures

... Individual has been identified by the heart team to have high or greater risk for open surgical therapy with a Society of Thoracic Surgeons operative risk score equal to or greater than 8% or at a 15% or greater risk of operative mortality at 30 days Request is for a transcatheter pulmonary valve (T ...
CYCLE III:
CYCLE III:

... 2. Examination of the arterial pulse in various regions. Examination can be easily performed over the common carotid artery, temporal artery, subclavian artery, femoral artery, popliteal artery, tibial posterior artery, dorsal artery of the foot, etc. Arterial pressure – results from the extension o ...
Hypertension, Left Ventricular Hypertrophy and Sudden Cardiac
Hypertension, Left Ventricular Hypertrophy and Sudden Cardiac

... the left ventricular mass (LVM), left ventricular volume, thickness of the left ventricular posterior wall (LVW) or interventricular wall (IVW). LVM and LVW thickness increase with body weight, obesity,2 valvular heart disease, chronic elevations in systolic blood pressure,8 history of cardiovascula ...
Salvage One and One-Half Ventricular Repair and Resection of
Salvage One and One-Half Ventricular Repair and Resection of

... amount of myocardial and great vessel involvement.5 The basic premise for the treatment of primary malignant cardiac tumours has not changed during the history of cardiac surgery. Resection is the only available form of curative therapy, debulking the tumour mass and relieving the pathway obstructio ...
Applied Anatomy of the Heart (syllabus and ICARS lecture - Wk 1-2
Applied Anatomy of the Heart (syllabus and ICARS lecture - Wk 1-2

... Pull: Pneumothorax or fibrosis can pull the heart across Sternal Thrust Right Ventricular Hypertrophy 2. The degree of anastomosis of the coronary arteries and the effects of sudden vs gradual occlusion. Anastomoses of the coronary arteries are only potential anastomoses. Gradual coronary artery dis ...
Pathophysiology of Heart Failure
Pathophysiology of Heart Failure

... which is a measure of left ventricular chamber contractility and the EDPVR which is a measure of ventricular filling. 3. The ESPVR is a measure of chamber contractility, which is determined both by its slope and it relative position on the pressure volume plane. For example, one can increase of decr ...
Congenital Corrected Transposition of the Great Vessels in a 58
Congenital Corrected Transposition of the Great Vessels in a 58

... and associates' in 1981 to differentiate from surgically corrected transposition of the great vessels which can be accomplished after a Mustard procedure. The true incidence of congenital corrected transposition of the great vessels is not known. Fontana and Edwards* reported this condition to occur ...
5.9.2006 Dear Mrs Selz, I hereby include a summary taken from my
5.9.2006 Dear Mrs Selz, I hereby include a summary taken from my

... preload parameter, LVEDP, being thus pertinent in following preload changes post MI. Finally, chamber remodeling post MI can successfully be followed due to the fact that ESV and EDV both correlate to MPI and LVFS/MPI. Paper 3: We studied hemodynamics, arterial function, cardiac function and ventric ...
Slide 1
Slide 1

... Mutations in several genes encoding ion channels, especially SCN5A, have emerged as the basis for a variety of inherited cardiac arrhythmias. ...
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Hypertrophic cardiomyopathy



Hypertrophic cardiomyopathy (HCM) is a primary disease of the myocardium (the muscle of the heart) in which a portion of the myocardium is hypertrophied (thickened) without any obvious cause, creating functional impairment of the cardiac muscle. It is a leading cause of sudden cardiac death in young athletes.The occurrence of hypertrophic cardiomyopathy is a significant cause of sudden unexpected cardiac death in any age group and as a cause of disabling cardiac symptoms. Younger people are likely to have a more severe form of hypertrophic cardiomyopathy.HCM is frequently asymptomatic until sudden cardiac death, and for this reason some suggest routinely screening certain populations for this disease.A cardiomyopathy is a disease that affects the muscle of the heart. With HCM, the myocytes (cardiac contractile cells) in the heart increase in size, which results in the thickening of the heart muscle. In addition, the normal alignment of muscle cells is disrupted, a phenomenon known as myocardial disarray. HCM also causes disruptions of the electrical functions of the heart. HCM is most commonly due to a mutation in one of nine sarcomeric genes that results in a mutated protein in the sarcomere, the primary component of the myocyte (the muscle cell of the heart). These are predominantly single-point missense mutations in the genes for beta-myosin heavy chain (MHC), myosin-binding protein C, cardiac troponinT, or tropomyosin. These mutations cause myofibril and myocyte structural abnormalities and possible deficiencies in force generation. Not to be confused with dilated cardiomyopathy or any other cardiomyopathy.While most literature so far focuses on European, American, and Japanese populations, HCM appears in all ethnic groups. The prevalence of HCM is about 0.2% to 0.5% of the general population.
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