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Comparative Ultrastructural Morphometry Of The Relationship
Comparative Ultrastructural Morphometry Of The Relationship

... falls to about 30 beats/min in hibernation [6]. In the grey seal in which T-tubules are also wide (450 nm) [14], the heart rate drops from 120 beats/min to 4 beats/min during diving [15]. T-tubules as invaginations of the sarcolemma increase surface area of cell membrane available in myocyte for met ...
The isovolumic relaxation to early rapid filling relation: kinematic
The isovolumic relaxation to early rapid filling relation: kinematic

... Doppler mode (Appendix). Echocardiographic data acquisition is performed in accordance with American ...
Biomarkers of Heart Failure in Myocarditis and Dilated
Biomarkers of Heart Failure in Myocarditis and Dilated

... new high-sensitivity detection methods for troponins, very minor changes in cardiac damage can be detected. Although troponins released to the circulation do not identify the type of heart damage, their levels may indicate the severity of damage (Figure 2) (Miller et al., 2007). A number of studies ...
Pulmonary atresia with intact ventricular septum
Pulmonary atresia with intact ventricular septum

... nection between the superior caval vein and the right pulmonary artery. In 1971, the French surgeons Fontan and Baudet (1971) described the atriopulmonary connection with the purpose of draining all the caval blood directly to the pulmonary circulation, without passing through the right ventricle. ...
Eur Heart J-2005--1115-40
Eur Heart J-2005--1115-40

... rest or during exertion, or ankle swelling and objective evidence of cardiac dysfunction at rest (Table 1 ). The distinctions between cardiac dysfunction, persistent heart failure, heart failure that has been rendered asymptomatic by therapy, and transient heart failure are outlined in Figure 1. A c ...
Parasympathetic control of the heart. I. An interventriculo
Parasympathetic control of the heart. I. An interventriculo

... the ready differentiation of neuronal cytoplasm, nuclei, and axons from other tissue elements within the heart. Nuclear labeling of retrogradely labeled neurons with diamidino yellow was also readily observed with this optical system but was confirmed by using a UV optical filter that visualizes dia ...
Regarding the action of hydrate soda, hydrate of ammonia, and
Regarding the action of hydrate soda, hydrate of ammonia, and

... ammonia. The effects of hydrate of potash are well seen in Figs. 4 and 5. A small quantity of potash, like soda and ammonia, prolongs each contraction and makes its summit rounder (see Fig. 5, B). As soon, however, as the potash induces the spasmodic condition, the rhythmic contractions lessen in he ...
Diagnosis and Management of Cardiac Sarcoidosis
Diagnosis and Management of Cardiac Sarcoidosis

... congestive heart failure, ventricular arrhythmias, and AV block, and it may be difficult to distinguish this from giant cell myocarditis or myocarditis of another origin. In a comparison of 42 patients with cardiac sarcoidosis to 73 patients with idiopathic giant cell myocarditis, 31% of patients wi ...
Minimizing Ventricular Pacing to Reduce Atrial Fibrillation in Sinus
Minimizing Ventricular Pacing to Reduce Atrial Fibrillation in Sinus

... with symptomatic bradycardia due to sinus-node disease has yet to be defined. Atrial pacing is associated with a reduced incidence of atrial fibrillation, as compared with ventricular pacing,1 but atrioventricular block may occur even in carefully selected patients.2,3 Conventional dual-chamber paci ...
Effect of Annular Shape on Leaflet Curvature in
Effect of Annular Shape on Leaflet Curvature in

... curvature. Leaflet billowing introduces the most obvious form of leaflet curvature. The saddle shape of the mitral annulus imparts a more subtle form of leaflet curvature. This study explores the relative contributions of leaflet billowing and annular shape on leaflet curvature and stress distributi ...
Pacemakers and ICDs-2012 - UCSF Department of Anesthesia and
Pacemakers and ICDs-2012 - UCSF Department of Anesthesia and

... is also associated with ventricular tachyarrhythmias, but to a far lesser degree. Recently, genomewide association studies have identified a single nucleotide polymorphism in the MYH6 gene on chromosome 14q11. Carriers have a 50% increased risk of developing SSS as compared to noncarriers who have o ...
Relationship between Sympathetic Overactivity and Left Ventricular
Relationship between Sympathetic Overactivity and Left Ventricular

... (RAAS) plays a direct role in LVH. LV mass increases significantly in primary aldosteronism and renovascular hypertension compared with essential hypertension.15 There is also a positive correlation between plasma aldosterone levels and LVH, independent of BP levels.16 Some RAAS blockers have been p ...
Termination and Inhibition of Recurrent Tachyeardias
Termination and Inhibition of Recurrent Tachyeardias

... daily episodes of SVT and secondary angina despite vigorous antiarrhythmic medication. Demand ventricular pacing at a rate of 88 beats per minute prevented the recurrence of SVT during the seven month follow-up. A third patient with an old myocardial infaretion had frequent biweekly episodes of vent ...
Implantable Cardioverter
Implantable Cardioverter

... computer like device that is about the size of a Mason jar lid.  One or two lead wires will connect the heart muscle ...
Full Pages - IMIB-CHD
Full Pages - IMIB-CHD

... Double  outlet  right  ventricle  (DORV)  encompasses  a  wide  spectrum  of  anatomic  malformations  that  are   characterized  by  origin  of  both  arterial  trunks  from  the  right  ventricle.  Because  of  the  extreme   heterogeneity ...
Fiber Types and Myosin Types in Human Atrial and Ventricular
Fiber Types and Myosin Types in Human Atrial and Ventricular

... of myosin exist in the human atrium, each myosin form being histochemically related to either a- or /3-like ventricular myosin heavy chains. In contrast, there was no direct correspondence between the two experimental approaches in human ventricles, and it is postulated that at least three distinct ...
Sarcospan Regulates Cardiac Isoproterenol Response and
Sarcospan Regulates Cardiac Isoproterenol Response and

... muscle function and increases susceptibility to arrhythmias.32,33 Under pathological conditions, integrins colocalize to the borders of cardiac fibrosis.34,35 Sarcospan (SSPN) is a tetraspanin-like protein that facilitates protein interactions between transmembrane proteins, and associates with the 3 ...
Delaying shock for cardiopulmonary resuscitation
Delaying shock for cardiopulmonary resuscitation

... until arrival of EMS with defibrillator capability. Of note, the times reported in Seattle were after the improvements made in EMS aimed at decreasing response times. The time response difference of 2–3 minutes for the onsite providers vs the 7–8 minutes for EMS services, and the differences in outc ...
Quantitative Imaging of Diastolic Function using Cardiac Magnetic
Quantitative Imaging of Diastolic Function using Cardiac Magnetic

... to reveal that measured changes in left ventricular volume during this interval reflect changes in myocardial strain and are balanced by the inward bowing of the mitral valve leaflets which maintains the isovolumic condition. Next, aspects of the filling portion of the cardiac cycle were studied inc ...
Differences in Sarcoplasmic Reticulum Ca2+ Leak Characteristics
Differences in Sarcoplasmic Reticulum Ca2+ Leak Characteristics

... that of GAPDH. PKA and CaMKII Activity Assay The activities of PKA and CaMKII were measured with the cAMP-Dependent Protein Kinase (PKA) Assay System and Calcium/CalmodulinDependent Protein Kinase (CaMKII) Assay System, respectively (Promega, Madison, WI, USA) (10). The SR vesicles were centrifuged ...
Inhibition of histone deacetylase on ventricular remodeling in
Inhibition of histone deacetylase on ventricular remodeling in

... Cardiac remodeling has been associated with myocardial hypertrophy and left ventricular (LV) dilation following myocardial infarction (MI) (39). Although traditionally considered an adaptive response to pathological signaling, cardiac hypertrophy has generally been thought to induce reactivation of ...
Impact of myocardial fibrosis on left ventricular diastolic function in
Impact of myocardial fibrosis on left ventricular diastolic function in

... All patients underwent a complete physical exam, blood sample testing, 12-lead ECG recording, transthoracic Doppler echocardiography, spirometry, a standard chest X-ray and, when considered appropriate, a high resolution computer tomography (CT) for pulmonary fibrosis identification. Subsequently, t ...
cardiac imaging guidelines - Chapter Affairs Extranet
cardiac imaging guidelines - Chapter Affairs Extranet

... CD-1.8 Non-imaging Heart Function and Cardiac Shunt Imaging  Procedures reported with CPT®78414 and CPT®78428 are essentially obsolete and should not be performed in lieu of other preferred modalities.  Echocardiogram is the preferred method for cardiac shunt detection rather than the cardiac shun ...
Pseudo-postpacing interval of diastolic potential after entrainment
Pseudo-postpacing interval of diastolic potential after entrainment

... suggesting that pacing in Fig. 2 captured a remote bystander pathway (Fig. 5c) [7]. Consequently, the PPI of the DP in Fig. 2 corresponds to the interval between the pacing site in the remote bystander pathway and the DP recorded in the critical isthmus (pseudo-PPI) (Fig. 5c). Furthermore, that the ...
Value of acceleration flow signals proximal to the leaking
Value of acceleration flow signals proximal to the leaking

... 600 Hz) were always used. For each examination, care was taken to use an optimal gain setting, which was defined as the maximal gain level possible without introduction of signals outside of flow areas or onto tissue from an adjoining chamber. Parasternal long-axis, parasternal short-axis and apical ...
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Hypertrophic cardiomyopathy



Hypertrophic cardiomyopathy (HCM) is a primary disease of the myocardium (the muscle of the heart) in which a portion of the myocardium is hypertrophied (thickened) without any obvious cause, creating functional impairment of the cardiac muscle. It is a leading cause of sudden cardiac death in young athletes.The occurrence of hypertrophic cardiomyopathy is a significant cause of sudden unexpected cardiac death in any age group and as a cause of disabling cardiac symptoms. Younger people are likely to have a more severe form of hypertrophic cardiomyopathy.HCM is frequently asymptomatic until sudden cardiac death, and for this reason some suggest routinely screening certain populations for this disease.A cardiomyopathy is a disease that affects the muscle of the heart. With HCM, the myocytes (cardiac contractile cells) in the heart increase in size, which results in the thickening of the heart muscle. In addition, the normal alignment of muscle cells is disrupted, a phenomenon known as myocardial disarray. HCM also causes disruptions of the electrical functions of the heart. HCM is most commonly due to a mutation in one of nine sarcomeric genes that results in a mutated protein in the sarcomere, the primary component of the myocyte (the muscle cell of the heart). These are predominantly single-point missense mutations in the genes for beta-myosin heavy chain (MHC), myosin-binding protein C, cardiac troponinT, or tropomyosin. These mutations cause myofibril and myocyte structural abnormalities and possible deficiencies in force generation. Not to be confused with dilated cardiomyopathy or any other cardiomyopathy.While most literature so far focuses on European, American, and Japanese populations, HCM appears in all ethnic groups. The prevalence of HCM is about 0.2% to 0.5% of the general population.
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