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images/Long term effects of RV pacing.pps
images/Long term effects of RV pacing.pps

... Bradycardia pacing operation in dualchamber ICDs should be optimized for individual patients. -RV pacing in patients with LV dysfunction and no bradycardia indication for pacing can be harmful. -Programming of dual chamber devices to backup ventricular pacing is justified in this patient ...
chronic congestive heart failure.
chronic congestive heart failure.

... Physiological studies of experimental animals. left ventricles of normal dogs. Myosin from sepaThe results are presented in Table I. The 11 dogs rate right and left ventricles of dogs with right with tricuspid insufficiency and pulmonic stenosis heart failure secondary to tricuspid insufficiency sho ...
The role of NT-proBNP in the diagnostics of isolated diastolic
The role of NT-proBNP in the diagnostics of isolated diastolic

... function is attributed to diastolic dysfunction. More than one-third of patients presenting with symptoms and signs of congestive heart failure (CHF) have isolated diastolic dysfunction, which is associated with a poor prognosis.1,2 Clinical examination cannot distinguish between systolic and diasto ...
Transcatheter pulmonary valve replacement
Transcatheter pulmonary valve replacement

... future science group ...
Dextrocardia and asplenia in situs inversus totalis in a baby: a case
Dextrocardia and asplenia in situs inversus totalis in a baby: a case

... repeated sinus and pulmonary infections [7,9]. Frequent pulmonary infections often result in bronchiectasis, which predominantly affects the lower lungs. Typically, persons having situs inversus with dextrocardia without other congenital anomaly have a normal life expectancy and have a similar risk ...
Early repolarization in the inferolateral leads of the
Early repolarization in the inferolateral leads of the

... pointed to an associated locus in KCND3 (Kv4.3) gene, which encodes a subunit of the Ito channel, but the association did not reach genome-wide significance and could not be replicated in all study populations. In conclusion, the results of these studies demonstrated that the ER ECG pattern with hor ...
ECG Interpretation
ECG Interpretation

... When the dominant pacemaker tissue (usually the SA node) fails to discharge for a long period, pacemaker tissue with a slower intrinsic rate (junctional or ventricular) may then discharge, i.e. they ‘escape’ the control of the SA node. This is commonly seen in association with bradyarrhythmias (e.g. ...
Alternate Pacing Sites in the Atria and the Right Ventricle
Alternate Pacing Sites in the Atria and the Right Ventricle

... ore than forty years have passed since the first implantation of a pacemaker with a lead in the apex of the right ventricle. 1 Since then, for many years, whenever a pacemaker was needed pacing was from the right ventricular apex in almost all cases. The reason for choosing this site was that it ens ...
Innocent Cardiac Murmur in Puppies: Prevalence, Correlation with
Innocent Cardiac Murmur in Puppies: Prevalence, Correlation with

... cardiac auscultation when the hematocrit results were not yet available. As the auscultation and the focused echocardiogram were performed by the same person, this part of the investigation was not blind. The puppies were examined in right lateral recumbency without sedation with manual restraint. S ...
A caudorostral wave of RALDH2 conveys anteroposterior
A caudorostral wave of RALDH2 conveys anteroposterior

... were fed into Scion to obtain grayscale images that were calibrated to give distances in µm. Grayscale images were submitted to density slicing which segments images on the basis of gray level. By manipulating upper and lower threshold levels in the look up tables, pixels representing low levels of ...
Atsuyoshi Takao
Atsuyoshi Takao

... the syndrome,4 and microdeletion of this region was confirmed in 1991 and 1992.5,6 Conotruncal anomaly face syndrome had first been reported in 1976.7 In the early 1970s, Atsuyoshi Takao had begun to recognize a characteristic facial appearance, with a flat nasal bridge, a small mouth, a nasal voic ...
Digitalis Toxicity: A Fading but Crucial Complication to Recognize REVIEW
Digitalis Toxicity: A Fading but Crucial Complication to Recognize REVIEW

... Multiple arrhythmias have been documented due to the complex pharmacologic effects of digitalis toxicity, with ventricular extrasystoles being a common manifestation.22,23 A mechanistic classification of arrhythmias related to digitalis toxicity was devised by Fisch and Knoebel in 198523 (Table). Th ...
Digitalis Toxicity: A Fading but Crucial Complication to Recognize
Digitalis Toxicity: A Fading but Crucial Complication to Recognize

... Multiple arrhythmias have been documented due to the complex pharmacologic effects of digitalis toxicity, with ventricular extrasystoles being a common manifestation.22,23 A mechanistic classification of arrhythmias related to digitalis toxicity was devised by Fisch and Knoebel in 198523 (Table). Th ...
Average T-wave alternans activity in ambulatory ECG records
Average T-wave alternans activity in ambulatory ECG records

... ECGs were analyzed in segments of 128 beats with a 50% overlap between adjacent segments. Each segment was included in automatic TWA analysis if (1) the difference between the maximum and the minimum instantaneous heart rate (HR) during the segment was ⱕ20 beats/min and (2) at least 80% of the beats ...
A Matter of the Heart: The African Clawed Frog Xenopus as a Model
A Matter of the Heart: The African Clawed Frog Xenopus as a Model

... have several benefits (reviewed in [13–15]) that include tissue-specific loss-of-function studies with dose-response effects. MOs can target multiple gene products allowing examination of functional gene redundancy. Additionally, multiple knockdowns by combinational MO injections combined with corre ...
Two components of delayed rectifier K+ current in heart: molecular
Two components of delayed rectifier K+ current in heart: molecular

... at high stimulation rates in guinea pig and rabbit ventricular myocytes[9]. After thirty 200-ms depolarization pulses to +30 mV applied at 3.0 Hz to mimic high frequency ventricular excitation, IKs tail in guinea pig was markedly augmented (from 2.3 pA/pF to 3.5 pA/pF), whereas the current amplitude ...
Syncope - OSU CCME account - The Ohio State University
Syncope - OSU CCME account - The Ohio State University

... 9 Class IA ...Quinidine, Procainamide, Disopyramide 9 Class III…Sotalol, Ibutilide, Dofetilide, Amiodarone, (NAPA) ...
Measurement of cardiac output during exercise in patients with
Measurement of cardiac output during exercise in patients with

... kinds of medicines exist. Examples are Angiotensin-converting enzyme (ACE) inhibitors. These are primarily used for the treatment of hypertension. Usually ACE inhibitors are used in combination with diuretics to reduce fluid retentions Another example are β-blockers, also used for treating hypertens ...
Slides
Slides

... Glen S. Van Arsdell, Mda(by invitation), William G. Williams, MDa, Christine Boutin, MDb(by invitation), George A. Trusler, MDa,John G. Coles, MDa, Ivan M. Rebeyka, Mda (by invitation), Robert M. Freedom, MDb, c(by invitation) Toronto, Ontario, Canada ...
Cardiac Resynchronization in Heart
Cardiac Resynchronization in Heart

... prevalence of this disease continues to increase due to an aging population which, in part, is related to the use of new pharmacologic, i.e. thrombolytic therapy, angiotensinconverting enzyme inhibitors, beta-blockers, spironolactone, etc., and nonpharmacologic therapies. However, despite these adva ...
syncope: diagnosis and treatment – marc kraus
syncope: diagnosis and treatment – marc kraus

... However, vasodepressor syncope (ie carotid-sinus hypersensitivity) is defined as a pure vasodepressor (vasodilation) reaction. Numerous terms have been used to identify neurally mediated syncope. These include neurocardiogenic syncope, vasodepressor syncope, vasovagal syncope, situational syncope, a ...
PDF - Romanian Journal of Cardiology
PDF - Romanian Journal of Cardiology

... sex19. Although PAP is considered the main cause of PA dilation, the influence of other factors, such as time and flow, is less known. A recent study has shown that in patients treated for PH, the PA has continued to dilate, irrespective of changes in mean PAP, even in patients whose PAP has decreas ...
The thesis
The thesis

... Mechanical functions of the PF relate to its viscous nature and that it is situated in a subatmospheric pressure condition. PF - due to its viscous characteristics - reduces the friction between the surface of the heart and the pericardium, thereby ensuring the smooth movement of the heart during ev ...
The Artificial Pacemaker . . . . . . A Pure Success Story!?
The Artificial Pacemaker . . . . . . A Pure Success Story!?

... In a normal functioning heart, the pumping action is synchronized by the pacemaker region of the heart which is located in the right atrium. This is some kind of natural pacemaker that has the ability to create electrical energy. The created impulse is transferred to the atria, causing them to contr ...
Slow and Long-Lasting Modulation of
Slow and Long-Lasting Modulation of

... sequence, we studied the effect of ectopic pacing on the distribution of action potential durations (APDs) in nine isolated Langendorif-perfused rabbit hearts. A contact electrode probe was used to map right and left ventricular-epicardial monophasic action potentials during three consecutive change ...
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Hypertrophic cardiomyopathy



Hypertrophic cardiomyopathy (HCM) is a primary disease of the myocardium (the muscle of the heart) in which a portion of the myocardium is hypertrophied (thickened) without any obvious cause, creating functional impairment of the cardiac muscle. It is a leading cause of sudden cardiac death in young athletes.The occurrence of hypertrophic cardiomyopathy is a significant cause of sudden unexpected cardiac death in any age group and as a cause of disabling cardiac symptoms. Younger people are likely to have a more severe form of hypertrophic cardiomyopathy.HCM is frequently asymptomatic until sudden cardiac death, and for this reason some suggest routinely screening certain populations for this disease.A cardiomyopathy is a disease that affects the muscle of the heart. With HCM, the myocytes (cardiac contractile cells) in the heart increase in size, which results in the thickening of the heart muscle. In addition, the normal alignment of muscle cells is disrupted, a phenomenon known as myocardial disarray. HCM also causes disruptions of the electrical functions of the heart. HCM is most commonly due to a mutation in one of nine sarcomeric genes that results in a mutated protein in the sarcomere, the primary component of the myocyte (the muscle cell of the heart). These are predominantly single-point missense mutations in the genes for beta-myosin heavy chain (MHC), myosin-binding protein C, cardiac troponinT, or tropomyosin. These mutations cause myofibril and myocyte structural abnormalities and possible deficiencies in force generation. Not to be confused with dilated cardiomyopathy or any other cardiomyopathy.While most literature so far focuses on European, American, and Japanese populations, HCM appears in all ethnic groups. The prevalence of HCM is about 0.2% to 0.5% of the general population.
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