Arresting the Development of Addiction
... JPET Fast Forward. Published on March 16, 2017 as DOI: 10.1124/jpet.117.240622 This article has not been copyedited and formatted. The final version may differ from this version. ...
... JPET Fast Forward. Published on March 16, 2017 as DOI: 10.1124/jpet.117.240622 This article has not been copyedited and formatted. The final version may differ from this version. ...
9-Sensation of Smell..
... though they involve different receptors and receptive processes. (??overlap in central processing). ...
... though they involve different receptors and receptive processes. (??overlap in central processing). ...
Signaling by truncated Dab1 protein - Development
... phosphotyrosine-dependent signal to regulate cell movement. In addition, Dab1 protein levels decrease in response to reelin signaling (Howell et al., 1999a; Rice et al., 1998). This decrease is partly independent of Dab1 tyrosine phosphorylation (Howell et al., 2000), suggesting that some other chan ...
... phosphotyrosine-dependent signal to regulate cell movement. In addition, Dab1 protein levels decrease in response to reelin signaling (Howell et al., 1999a; Rice et al., 1998). This decrease is partly independent of Dab1 tyrosine phosphorylation (Howell et al., 2000), suggesting that some other chan ...
Immunocytochemical Distribution of the
... were utilized for light microscopy. Housing and experimental procedures were conducted in accordance with United States Department of Agriculture and National Institutes of Health guidelines and with approval of the University of Pittsburgh’s Institutional Animal Care and Use Committee. Monkeys were ...
... were utilized for light microscopy. Housing and experimental procedures were conducted in accordance with United States Department of Agriculture and National Institutes of Health guidelines and with approval of the University of Pittsburgh’s Institutional Animal Care and Use Committee. Monkeys were ...
On the role of primary motor cortex in arm movement
... Population analysis. Our goal is to explain average population (or subpopulation) responses rather than individual response types (Kalaska et al., 1989). Because of the redundancy in the M1-tomuscle mapping, the same pattern of muscle activity can be generated with an infinite family of M1 activatio ...
... Population analysis. Our goal is to explain average population (or subpopulation) responses rather than individual response types (Kalaska et al., 1989). Because of the redundancy in the M1-tomuscle mapping, the same pattern of muscle activity can be generated with an infinite family of M1 activatio ...
Morphological Identification of Cell Death in Dorsal Root Ganglion
... peripheral axotomy than motor neurons, probably because they depend more on neurotrophic molecules released by peripheral target organs [15]. Our study showed that direct reconnection of the proximal nerve stump with its distal stump will reduce the sensory neuronal loss from 42% to 23.7%. In the pr ...
... peripheral axotomy than motor neurons, probably because they depend more on neurotrophic molecules released by peripheral target organs [15]. Our study showed that direct reconnection of the proximal nerve stump with its distal stump will reduce the sensory neuronal loss from 42% to 23.7%. In the pr ...
LYRICA (pregabalin) eLearning System
... as the skin and eyes, and sends it to the brain and spinal cord • motor (efferent) system: carries signals from the brain and spinal cord to muscles, glands, blood vessels, and other organs • association (interneurons): relay signals between neurons; they are especially prevalent in the gray matter ...
... as the skin and eyes, and sends it to the brain and spinal cord • motor (efferent) system: carries signals from the brain and spinal cord to muscles, glands, blood vessels, and other organs • association (interneurons): relay signals between neurons; they are especially prevalent in the gray matter ...
Axonal Membranes and Their Domains: Assembly and Function of
... Neurons are polarized cells made up of structurally and functionally distinct processes, dendrites and axons, which direct the flow of information throughout the nervous system. The dendrites are often composed of multiple branches and dendritic spines that receive signals from upstream synaptic inp ...
... Neurons are polarized cells made up of structurally and functionally distinct processes, dendrites and axons, which direct the flow of information throughout the nervous system. The dendrites are often composed of multiple branches and dendritic spines that receive signals from upstream synaptic inp ...
behavior?
... houses small storage pouches or synaptic vesicles. These vesicles contain neurotransmitters, the chemical Receptor sites messengers that carry signals across the synapse. A synapse is the juncPostsynaptic tion between two neurons where (receiving) neuron the axon bulb of one neuron comes into proxim ...
... houses small storage pouches or synaptic vesicles. These vesicles contain neurotransmitters, the chemical Receptor sites messengers that carry signals across the synapse. A synapse is the juncPostsynaptic tion between two neurons where (receiving) neuron the axon bulb of one neuron comes into proxim ...
Structural changes of the human superior cervical
... Since SCG is the main source of sympathetic innervation of the cerebral arteries, we proposed a hypothesis that a stroke damaging the integrity of cerebral arteries and the structure of perivascular nervous plexus may cause distal axonal damage and indirectly contribute to defects in axonal transpor ...
... Since SCG is the main source of sympathetic innervation of the cerebral arteries, we proposed a hypothesis that a stroke damaging the integrity of cerebral arteries and the structure of perivascular nervous plexus may cause distal axonal damage and indirectly contribute to defects in axonal transpor ...
Nerve activates contraction
... Functional Properties of Neurons Two major functional properties of neurons resulting in electrochemical event Irritability - ability to respond to stimuli & convert it into a nerve impulse Conductivity – ability to transmit an impulse to other neurons, muscles, or glands Copyright © 2003 Pearson E ...
... Functional Properties of Neurons Two major functional properties of neurons resulting in electrochemical event Irritability - ability to respond to stimuli & convert it into a nerve impulse Conductivity – ability to transmit an impulse to other neurons, muscles, or glands Copyright © 2003 Pearson E ...
Nerve activates contraction
... Functional Properties of Neurons Two major functional properties of neurons resulting in electrochemical event Irritability - ability to respond to stimuli & convert it into a nerve impulse Conductivity – ability to transmit an impulse to other neurons, muscles, or glands Copyright © 2003 Pearson E ...
... Functional Properties of Neurons Two major functional properties of neurons resulting in electrochemical event Irritability - ability to respond to stimuli & convert it into a nerve impulse Conductivity – ability to transmit an impulse to other neurons, muscles, or glands Copyright © 2003 Pearson E ...
Visual pathway class..
... • We do not have a descriptive or mechanistic model that predicts response properties of downstream visual areas, or behavior. • A descriptive model would vastly transform technology: the primate visual system is far superior to anything that engineers can build. • A mechanistic model is the ultimat ...
... • We do not have a descriptive or mechanistic model that predicts response properties of downstream visual areas, or behavior. • A descriptive model would vastly transform technology: the primate visual system is far superior to anything that engineers can build. • A mechanistic model is the ultimat ...
The Nervous System
... Functional Properties of Neurons Two major functional properties of neurons resulting in electrochemical event Irritability - ability to respond to stimuli & convert it into a nerve impulse Conductivity – ability to transmit an impulse to other neurons, muscles, or glands Copyright © 2003 Pearson E ...
... Functional Properties of Neurons Two major functional properties of neurons resulting in electrochemical event Irritability - ability to respond to stimuli & convert it into a nerve impulse Conductivity – ability to transmit an impulse to other neurons, muscles, or glands Copyright © 2003 Pearson E ...
PhD Thesis - Laboratory of Cerebral Cortex Development
... The process leading the anterior neural plate to the specification of pallial and subpallial territories implies the determination and the specification of telencephalic identities along the R-C and D-V axis. At E7 the early R-C patterning of the anterior neural tissue (anterior neural induction) i ...
... The process leading the anterior neural plate to the specification of pallial and subpallial territories implies the determination and the specification of telencephalic identities along the R-C and D-V axis. At E7 the early R-C patterning of the anterior neural tissue (anterior neural induction) i ...
A lineage-related reciprocal inhibition circuitry for sensory
... in b. (b) CX neuropils are interconnected by projections from columnar neurons and tangential neurons (FB-EB neurons and EB-ring neurons). Histological, immunocytochemical, and clonal analyses demonstrate that columnar projection neurons connect all CX substructures and are subdivided into modules e ...
... in b. (b) CX neuropils are interconnected by projections from columnar neurons and tangential neurons (FB-EB neurons and EB-ring neurons). Histological, immunocytochemical, and clonal analyses demonstrate that columnar projection neurons connect all CX substructures and are subdivided into modules e ...
PDF
... Fig. 1. Loss of sad-1 and nab-1 functions lead to polarity defects in various neurons. (A) L1-stage sad-1 and nab-1 animals have DD polarity defects. Arrowheads indicate the ectopic dorsal SNB-1::GFP (juIs1) or UNC-49B::GFP (oxIs22) signal. A schematic diagram of the normal connectivity of DD neuron ...
... Fig. 1. Loss of sad-1 and nab-1 functions lead to polarity defects in various neurons. (A) L1-stage sad-1 and nab-1 animals have DD polarity defects. Arrowheads indicate the ectopic dorsal SNB-1::GFP (juIs1) or UNC-49B::GFP (oxIs22) signal. A schematic diagram of the normal connectivity of DD neuron ...
Antagonists and agonists at the glycine site of the NMDA receptor for
... suffering from FMS changes in the CSF were investigated, indicating that besides an increase in substance P and arginine as a precursor to NO, metabolic changes such as glutamine and asparagine increase were also observed and therefore reflect increased excitatory amino acid (EAA) release [39]. The ...
... suffering from FMS changes in the CSF were investigated, indicating that besides an increase in substance P and arginine as a precursor to NO, metabolic changes such as glutamine and asparagine increase were also observed and therefore reflect increased excitatory amino acid (EAA) release [39]. The ...
RESOURCE - Synthetic Neurobiology Group
... Cell type–specific expression of optogenetic molecules allows temporally precise manipulation of targeted neuronal activity. Here we present a toolbox of four knock-in mouse lines engineered for strong, Cre-dependent expression of channelrhodopsins ChR2-tdTomato and ChR2-EYFP, halorhodopsin eNpHR3.0 ...
... Cell type–specific expression of optogenetic molecules allows temporally precise manipulation of targeted neuronal activity. Here we present a toolbox of four knock-in mouse lines engineered for strong, Cre-dependent expression of channelrhodopsins ChR2-tdTomato and ChR2-EYFP, halorhodopsin eNpHR3.0 ...
Targeting of Rough Endoplasmic Reticulum Membrane Proteins and
... proteins within the ER might be. Nor is it known how general the phenomenon is between cell types: are RER membrane proteins targeted to a subregion of the ER membrane only in liver and a few other cell types, or is their localization a general feature of all cells? It is also not clear whether RER ...
... proteins within the ER might be. Nor is it known how general the phenomenon is between cell types: are RER membrane proteins targeted to a subregion of the ER membrane only in liver and a few other cell types, or is their localization a general feature of all cells? It is also not clear whether RER ...
Specification of Cerebral Cortical Areas
... neurons in the mouse cortex form interrupted radial columns (22). This finding confirms the basic postulate of the radial unit hypothesis, including the polyclonal nature of proliferative units. Similar recombinant retrovirus studies, as well as labeling of clones with fluorescent dyes, carried out ...
... neurons in the mouse cortex form interrupted radial columns (22). This finding confirms the basic postulate of the radial unit hypothesis, including the polyclonal nature of proliferative units. Similar recombinant retrovirus studies, as well as labeling of clones with fluorescent dyes, carried out ...
Rearrangement of microtubule polarity orientation during conversion
... plus ends distal and half their minus ends distal. Various signaling molecules are implicated in the early events of neuronal polarization that determines the neurite fate, axons vs. dendrites [Arimura and Kaibuchi, 2005], but little is known of how these molecules affect microtubule polarity orient ...
... plus ends distal and half their minus ends distal. Various signaling molecules are implicated in the early events of neuronal polarization that determines the neurite fate, axons vs. dendrites [Arimura and Kaibuchi, 2005], but little is known of how these molecules affect microtubule polarity orient ...
Spinal Cord
... o Note that in the posterior column system the somatotopic organization in the cord is: leg is medial and arm is lateral. The opposite is true for the anterolateral system: the leg is lateral or dorsolateral and arm is medial. Spinocerebellar Tracts: Dorsal and Ventral Spinocerebellar Tracts loca ...
... o Note that in the posterior column system the somatotopic organization in the cord is: leg is medial and arm is lateral. The opposite is true for the anterolateral system: the leg is lateral or dorsolateral and arm is medial. Spinocerebellar Tracts: Dorsal and Ventral Spinocerebellar Tracts loca ...
Hypocretinergic Neurons are Primarily involved in Activation
... trigeminal motoneurons.28 Hypocretinergic terminals have also been found in the ventral horn where motoneuron cell bodies are located;29 moreover, the direct application of hypocretin onto intracellularly recorded lumbar motoneurons results in depolarization of their membrane potential, a decrease i ...
... trigeminal motoneurons.28 Hypocretinergic terminals have also been found in the ventral horn where motoneuron cell bodies are located;29 moreover, the direct application of hypocretin onto intracellularly recorded lumbar motoneurons results in depolarization of their membrane potential, a decrease i ...
Review Article Long-Term Memory Search across the
... the calcium-dependent kinase CAMKII and are able to spread laterally tens of microns away from the original LTP site [67–69]. Importantly, LTP may be induced by diffusing enzymes even in certain silent spines [66]. The entire dendritic branch is then able to memorize the stimulus direction for short ...
... the calcium-dependent kinase CAMKII and are able to spread laterally tens of microns away from the original LTP site [67–69]. Importantly, LTP may be induced by diffusing enzymes even in certain silent spines [66]. The entire dendritic branch is then able to memorize the stimulus direction for short ...