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Summary Team members: Weiqian Yan, Kanchan Khurad, and Yi
Summary Team members: Weiqian Yan, Kanchan Khurad, and Yi

... The paper, A Monte Carlo Algorithm for Fast Projective Clustering, proposes 2 novel approaches to approximate optimal clusters in high dimensional data space. As research has proven, existing clustering methods that work well in low dimensional spaces don’t work well in high dimensional space due to ...
PPT
PPT

Estimates of DNA and Protein Sequence Divergence: An
Estimates of DNA and Protein Sequence Divergence: An

... is that the relative mutation rates between bases are constant. There is, however, evidence that this is not true and that, generally, transitions occur more frequently than transversions (Topal and Fresco 1976; Vogel and Kopun 1977; Fitch 1980; Gojobori et al. 19826). Several authors (e.g., Kimura ...
Why Compare sequences?
Why Compare sequences?

Sequencing project for Bi1x
Sequencing project for Bi1x

... Part IV: Phylogenetic analysis 1. Phylogenetic analysis. We would like to generate a Neighbor Joining tree for each of your 16S sequences and its nearest neighbors. This will allow you to visualize the evolutionary distance between each of your sequences and their nearest neighbors. We will also cal ...
MATHEMATICAL PROGRAMMING FOR DATA MINING
MATHEMATICAL PROGRAMMING FOR DATA MINING

Math 183 - Statistical Methods
Math 183 - Statistical Methods

Innovative Database Models and Advanced Tools in Bioinformatics
Innovative Database Models and Advanced Tools in Bioinformatics

Molecular evolution of swine vesicular disease virus
Molecular evolution of swine vesicular disease virus

... A panel of 42 SVDV isolates was assembled to be chronologically and geographically representative of isolates held at the World Reference Laboratory for Foot-and-Mouth Disease and a smaller panel of seven CV-B5 isolates was also put together for comparative analysis (Tables 1 and 2). Infected cell R ...
Immediate Applications of Biotech in Tree Breeding
Immediate Applications of Biotech in Tree Breeding

DYNAMIC BLOCK ALLOCATION FOR BIOLOGICAL SEQUENCES
DYNAMIC BLOCK ALLOCATION FOR BIOLOGICAL SEQUENCES

... blocks in accordance with t variable. Variable r is a multiple of a, thus the difference L – t will ensure a number divisible at least by three integers. The maximum length of a data block is declared through m variable (m = 10). To find the optimal length for data blocks, we must find an integer m ...
Fast Root Cause Analysis on Distributed Systems by Composing
Fast Root Cause Analysis on Distributed Systems by Composing

... threshold approach. Moreover, the system with Bayesian reasoning is able to provide early alerts before the fault actually occurs, whereas many faults do not develop gradually over time, rather they occur instantaneously. This is not the only reason, why threshold approach is not an accurate way for ...
lab6
lab6

... • The -dna switch is absent, so MEME assumes the input file as protein sequences. • Each motif is assumed to occur in each of the sequences because the OOPS model is specified. • Specifying -maxw 20 makes MEME run faster since it does not have to consider motifs longer than 20. ...
Compressed suffix tree—a basis for genome
Compressed suffix tree—a basis for genome

1-7
1-7

Binary Variables (1) Binary Variables (2) Binomial Distribution
Binary Variables (1) Binary Variables (2) Binomial Distribution

... requires storing and computing with the entire data set. Parametric models, once fitted, are much more efficient in terms of storage and computation. ...
Protein Sequence Alignment and Database Searching
Protein Sequence Alignment and Database Searching

... Allow multiple hits to the same sequence Based on statistics of ungapped sequence alignments The statistics allow the probability of obtaining an ungapped alignment MSP - Maximal Segment Pair above cut-off All world (k > 3) score grater than T Extend the score both side Use dynamic programmin ...
Neuro-Fuzzy System Optimized Based Quantum Differential
Neuro-Fuzzy System Optimized Based Quantum Differential

... results [5]. The proposed model in this research improves the prediction accuracy by Double Chains Quantum Differential Evolution algorithm (DCQDE), using QDE to optimize the value of radii used in subtractive clustering fuzzy inference system which is trained by Neural Network in ANFIS Model.Accord ...
A Bayesian Framework for SNP Identification
A Bayesian Framework for SNP Identification

MyTaxa: an advanced taxonomic classifier for genomic and
MyTaxa: an advanced taxonomic classifier for genomic and

week 14 Datamining print PPT95
week 14 Datamining print PPT95

... – Each tuple/sample is assumed to belong to a predefined class based on its attribute values – The class is determined by the class label attribute – The set of tuples used for model construction: training set – The model is represented as classification rules, decision trees, or mathematical formul ...
slides-chapter2
slides-chapter2

... The k-nearest neighbors algorithm (k-NN) is a method for classifying objects based on closest training examples in the feature space. ...
Visualization of Biological Sequence Similarity Search
Visualization of Biological Sequence Similarity Search

... Figure 2 is AV output for the same report. The graphical view condenses 800 pages of text into one screen of information. The left hand side is a 3D view, while the right hand side is a 2D projection. The positions and relative lengths of the alignments provide a quick summary of where alignments ar ...
Lecture 10 - University of New England
Lecture 10 - University of New England

Finding, Fitting.. What’s New?
Finding, Fitting.. What’s New?

... Probability that the 2-Track (“vertex”) solution is best. ...
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Computational phylogenetics

Computational phylogenetics is the application of computational algorithms, methods, and programs to phylogenetic analyses. The goal is to assemble a phylogenetic tree representing a hypothesis about the evolutionary ancestry of a set of genes, species, or other taxa. For example, these techniques have been used to explore the family tree of hominid species and the relationships between specific genes shared by many types of organisms. Traditional phylogenetics relies on morphological data obtained by measuring and quantifying the phenotypic properties of representative organisms, while the more recent field of molecular phylogenetics uses nucleotide sequences encoding genes or amino acid sequences encoding proteins as the basis for classification. Many forms of molecular phylogenetics are closely related to and make extensive use of sequence alignment in constructing and refining phylogenetic trees, which are used to classify the evolutionary relationships between homologous genes represented in the genomes of divergent species. The phylogenetic trees constructed by computational methods are unlikely to perfectly reproduce the evolutionary tree that represents the historical relationships between the species being analyzed. The historical species tree may also differ from the historical tree of an individual homologous gene shared by those species.Producing a phylogenetic tree requires a measure of homology among the characteristics shared by the taxa being compared. In morphological studies, this requires explicit decisions about which physical characteristics to measure and how to use them to encode distinct states corresponding to the input taxa. In molecular studies, a primary problem is in producing a multiple sequence alignment (MSA) between the genes or amino acid sequences of interest. Progressive sequence alignment methods produce a phylogenetic tree by necessity because they incorporate new sequences into the calculated alignment in order of genetic distance.
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