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Structural and functional differences between two homologous
Structural and functional differences between two homologous

The song of lipids and proteins: dynamic lipid
The song of lipids and proteins: dynamic lipid

Physiology 441 - West Virginia University
Physiology 441 - West Virginia University

... concentrated, creating a gradient favoring entrance into the blood • However, tubular cell membranes not very permeable and only ~50% of the filtered urea is passively reabsorbed • BUN- measured as a crude assessment of kidney function ...
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... 10.0 dextrose, 26.0 NaHCO3, 1.25 NaH2PO4, 2 CaCl2] oxygenated by bubbling 95% O2/5% CO2 through the solution. Whole-cell patch-clamp recordings were conducted in horizontal brain slices. To control for slice health, the brain was mounted on either its ventral surface (top-down cut) or dorsal surface ...
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... the more permeable the membrane will be. (In other words, nonpolar / hydrophobic particles will diffuse more easily through the nonpolar tail region of the membrane.) o Smaller particles will typically diffuse more rapidly than larger particles o O2, H2O, CO2, N2, etc. rapidly diffuse across the lip ...
Fine Gating Properties of Channels Responsible for Persistent
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... constants, and the slowest of which are represented by relatively few samples (see Blatz and Magleby, 1986; Sigworth and Sine, 1987; McManus et al., 1987). Hence, logarithmic plots were routinely used for the analysis of intraburst open and closed times as well as burst duration, and in these cases ...
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Topics Covered MEMBRANE FUNCTION
Topics Covered MEMBRANE FUNCTION

electrochemical processing of regeneration solutions from ion
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Synaptic Integration in Rat Frontal Cortex Shaped by Network Activity

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The Role of Lipid Domains in Bacterial Cell Processes

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... (via NMDA receptors) can bring the neuron into an enabled state. Informational (for instance, cue or positional) input (via AMPA receptors) can fire a neuron only from this enabled state. Where might such an architecture be used? In the CAl region of the hippocampus, pyramidal cells receive two dist ...
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Osmo-Sensitive and Stretch-Activated Calcium
Osmo-Sensitive and Stretch-Activated Calcium

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Membrane potential



Membrane potential (also transmembrane potential or membrane voltage) is the difference in electric potential between the interior and the exterior of a biological cell. With respect to the exterior of the cell, typical values of membrane potential range from –40 mV to –80 mV.All animal cells are surrounded by a membrane composed of a lipid bilayer with proteins embedded in it. The membrane serves as both an insulator and a diffusion barrier to the movement of ions. Ion transporter/pump proteins actively push ions across the membrane and establish concentration gradients across the membrane, and ion channels allow ions to move across the membrane down those concentration gradients. Ion pumps and ion channels are electrically equivalent to a set of batteries and resistors inserted in the membrane, and therefore create a voltage difference between the two sides of the membrane.Virtually all eukaryotic cells (including cells from animals, plants, and fungi) maintain a non-zero transmembrane potential, usually with a negative voltage in the cell interior as compared to the cell exterior ranging from –40 mV to –80 mV. The membrane potential has two basic functions. First, it allows a cell to function as a battery, providing power to operate a variety of ""molecular devices"" embedded in the membrane. Second, in electrically excitable cells such as neurons and muscle cells, it is used for transmitting signals between different parts of a cell. Signals are generated by opening or closing of ion channels at one point in the membrane, producing a local change in the membrane potential. This change in the electric field can be quickly affected by either adjacent or more distant ion channels in the membrane. Those ion channels can then open or close as a result of the potential change, reproducing the signal.In non-excitable cells, and in excitable cells in their baseline states, the membrane potential is held at a relatively stable value, called the resting potential. For neurons, typical values of the resting potential range from –70 to –80 millivolts; that is, the interior of a cell has a negative baseline voltage of a bit less than one-tenth of a volt. The opening and closing of ion channels can induce a departure from the resting potential. This is called a depolarization if the interior voltage becomes less negative (say from –70 mV to –60 mV), or a hyperpolarization if the interior voltage becomes more negative (say from –70 mV to –80 mV). In excitable cells, a sufficiently large depolarization can evoke an action potential, in which the membrane potential changes rapidly and significantly for a short time (on the order of 1 to 100 milliseconds), often reversing its polarity. Action potentials are generated by the activation of certain voltage-gated ion channels.In neurons, the factors that influence the membrane potential are diverse. They include numerous types of ion channels, some of which are chemically gated and some of which are voltage-gated. Because voltage-gated ion channels are controlled by the membrane potential, while the membrane potential itself is influenced by these same ion channels, feedback loops that allow for complex temporal dynamics arise, including oscillations and regenerative events such as action potentials.
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