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The Area Postrema - Queen`s University
The Area Postrema - Queen`s University

... of the paraventricular nucleus (PVN) and dorsomedial nucleus of the hypothalamus (DMH) (van der Kooy and Koda 1983; Shapiro and Miselis 1985; see Fig. 3). Intriguingly information from the AP reaches the PVN through both monosynaptic and polysynaptic connections suggesting an integrative capacity wi ...
Prenatal morphine exposure alters the layer II/III pyramidal neurons
Prenatal morphine exposure alters the layer II/III pyramidal neurons

Differential responses in three thalamic nuclei in moderately
Differential responses in three thalamic nuclei in moderately

... with survivals between 3 and 22 years after admission); 12 severely disabled patients (mean age 40 years, range 23–70, with survivals between 4 weeks and 8 years) and 10 vegetative patients (mean age 39 years, range 18–64, with survivals between 3 and 27 months). All but two of the severely disabled ...
Probing scale interaction in brain dynamics through synchronization
Probing scale interaction in brain dynamics through synchronization

... Even though the brain has been studied for centuries, a full theoretical description of its normal and pathological functioning is still missing. Owing partly to the lack of a full description of the anatomical connectivity, and partly to our incomplete knowledge of the interplay between different n ...
Projections from the superior temporal sulcus to the agranular frontal
Projections from the superior temporal sulcus to the agranular frontal

... see, e.g. Carey et al., 1997). It has been proposed that area STP is involved in visuomotor functions and in integration of information within and across modalities (Bruce et al., 1981; Bayliss et al., 1987). Furthermore, according to the studies of Perrett and colleagues (Perrett et al., 1989; see ...
Spatial Responsiveness of Monkey Hippocampal Neurons to
Spatial Responsiveness of Monkey Hippocampal Neurons to

... Andersen, 1987; Goldman-Rakic, 19871, mainly via the parahippocampal cortices (PH) (Jones and Powell, 1970; Van Hoesen, 1982; Amaral, 1987; Tranel et al., 1988). Recent results indicate that the HF, and the system to which it belongs, are essential for acquisition, relation, combination, and conjunc ...
Simulation of signal flow in 3D reconstructions of an anatomically
Simulation of signal flow in 3D reconstructions of an anatomically

... neuronal cell types. The single neuron represents the elemental functional unit of these networks. Depending on their dendrite morphology, as well as their synaptic innervations and conductance distributions, neurons perform (non-) linear computations that generate a variety of electrical responses ...
Enhanced Modulation of Neuronal Activity during
Enhanced Modulation of Neuronal Activity during

... traditionally been viewed as a part of the indirect pathway that relays signals in the striatum to the output nodes of the basal ganglia via the subthalamic nucleus (Alexander and Crutcher 1990). Recent anatomical data show that neurons in the GPe also have direct access to all other nuclei in the b ...
November 2000 Volume 3 Number Supp pp 1184
November 2000 Volume 3 Number Supp pp 1184

... silent but fire spontaneously at rates of 1–10 Hz between different trials of a working memory task, outside a task context, or even during the delay phases if they are not tuned to the current stimulus or response5, 41-43 (Fig. 1). This raises the question of how spontaneous network activity can re ...
moth`s nervous system - Wageningen UR E
moth`s nervous system - Wageningen UR E

... associated with the MGC: the male-specific local and projection neurons. Stimulus quality. By means of intracellular recording and staining methods, we have examined the activity of AL neurons in response to stimulation of the ipsilateral antenna with each of the sex-pheromone components aswell as p ...
different sensory modalities
different sensory modalities

... • there are many areas in the brain in which multiple sensory afferents converge • there are colliculus neurons that respond vigorously to low intensity auditory stimulus, but if the animal can’t see the visual stimulus the response is suppressed • the colliculus is an apt structure to study interac ...
Spinal motor neurons are regenerated after
Spinal motor neurons are regenerated after

... motor neuron regeneration (see above). However, no mCherry+ cells were observed for up to 8 dpf (n = 7, data not shown). In addition, at two weeks after a spinal lesion in adult Tg(mnx1:Gal4, UAS:nfsB-mCherry) fish (n = 3), we observed small strongly Hb9 immunoreactive cells, previously shown to be ...
Comparison of the Distributions of lpsilaterally and Contralaterally
Comparison of the Distributions of lpsilaterally and Contralaterally

... demonstrated in this study reflects the high degree of specificity of cortical connectivity. This anatomical organization may be the basis for a precise channeling of differential information at the single neuron level. Each of the cat’s numerous cortical representations of the visual hemifield is i ...
Got diversity? Wiring the fly brain with Dscam
Got diversity? Wiring the fly brain with Dscam

... each block seems to be independent, the Dscam gene has the potential to generate 38 016 cell-surface proteins [16]. (b) Dscam proteins show isoform-specific homophilic binding. Shown is a summary of the results obtained in Dscam-binding studies [17]. Only the seven N-terminal immunoglobulin domains ...
Reelin and apolipoprotein E receptor 2 in the embryonic and mature
Reelin and apolipoprotein E receptor 2 in the embryonic and mature

... migrate from the inner layer of the cerebellar cortex. (b) Reelin and the reelin gene The mouse reelin gene spans about 450 kb of genomic DNA and has 65 exons encoding a protein with 3461 amino acids (Miao et al. 1994; D’Arcangelo et al. 1995; Royaux et al. 1997). The mutant gene in the Edinburgh st ...
Septins promote dendrite and axon development by negatively
Septins promote dendrite and axon development by negatively

... relevance of those findings and to explore the molecular mechanism(s) involved, we employed mouse cerebrocortical neurons, which enable both physiological analyses in vivo and rigorous morphometry and live imaging in vitro17–19. By immunoprecipitation and immunoblot analyses, we found that perinatal ...
Neural Reflexes
Neural Reflexes

... class. This is where there is only one interneuron between the sensory and motor neurons creating two synapses. Disynaptic reexes are common in inhibitory circuits that keep antagonist muscle groups from becoming active during a muscle contraction. The polysynaptic reex shown in Figure 2 is more s ...
PDF file - Izhikevich
PDF file - Izhikevich

... neurons, each making thousands of synaptic contacts with its neighbors. Given the complexity of the connectivity inherent in cortical anatomy, efforts to describe the pattern of electrical activity in exact detail within even a highly localized population of cortical neurons would be extremely diffi ...
Histamine reduces firing and bursting of anterior and intralaminar
Histamine reduces firing and bursting of anterior and intralaminar

Simulation of myelinated neuron with focus on conduction speed
Simulation of myelinated neuron with focus on conduction speed

... Myelin sheath is a protective coat around the axon of a neuron and acts as an insulator to the electrical signal that is conducted down the axon as a neuron fires. This increases the conduction speed of action potential and thus is a critical factor in maintaining the proper communication within the ...
Neural computations associated with goal
Neural computations associated with goal

... Consider  a  canonical  decision  making  problem.  Every  day  a  hungry  animal  is   placed  at  the  bottom  of  a  Y-­‐maze  and  is  allowed  to  run  towards  the  upper  left  or   right  to  collect  a  reward.  The  left ...
Volitional enhancement of firing synchrony and oscillation by
Volitional enhancement of firing synchrony and oscillation by

... Following these pioneering and memorable experiments, several intriguing studies by Fetz and other researchers have been published. Recently, for example, Kobayashi et al. (2010) has demonstrated a remarkable capacity of single neurons to be driven by volition by adapting to specific operant require ...
Rich-club organization in effective connectivity among cortical neurons
Rich-club organization in effective connectivity among cortical neurons

... were killed after the recording session; and brain tissue was sectioned, immunostained for NeuN, and imaged to verify the silicon prong placement. Signals from all recording sites were simultaneously sampled at 25 kHz. Spike sorting was performed off-line using a semi-automated Matlab script. The da ...
Functional Synaptic Contacts by Intranuclear
Functional Synaptic Contacts by Intranuclear

... synapses onto intralaminar interneurons. studied in the geniculate lamina. The dendritic trees of the cells were always perpendicular to the long axis of lamina A1 (Lam. A1). Such an arrangement provides an addi- A, B, Right panels show higher magnification of interneurons. Note the small soma size ...
- Hayden Lab
- Hayden Lab

... (r = 0.218, p = 0.006) (Figure 4B). We confirmed the significance of this correlation using a bootstrap correlation test (p = 0.0061; see Experimental Procedures). To match the criteria used above, these analyses do not include trials with safe options; however, if we repeat the analysis but include ...
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Mirror neuron

A mirror neuron is a neuron that fires both when an animal acts and when the animal observes the same action performed by another. Thus, the neuron ""mirrors"" the behavior of the other, as though the observer were itself acting. Such neurons have been directly observed in primate species. Birds have been shown to have imitative resonance behaviors and neurological evidence suggests the presence of some form of mirroring system. In humans, brain activity consistent with that of mirror neurons has been found in the premotor cortex, the supplementary motor area, the primary somatosensory cortex and the inferior parietal cortex.The function of the mirror system is a subject of much speculation. Many researchers in cognitive neuroscience and cognitive psychology consider that this system provides the physiological mechanism for the perception/action coupling (see the common coding theory). They argue that mirror neurons may be important for understanding the actions of other people, and for learning new skills by imitation. Some researchers also speculate that mirror systems may simulate observed actions, and thus contribute to theory of mind skills, while others relate mirror neurons to language abilities. Neuroscientists such as Marco Iacoboni (UCLA) have argued that mirror neuron systems in the human brain help us understand the actions and intentions of other people. In a study published in March 2005 Iacoboni and his colleagues reported that mirror neurons could discern if another person who was picking up a cup of tea planned to drink from it or clear it from the table. In addition, Iacoboni has argued that mirror neurons are the neural basis of the human capacity for emotions such as empathy.It has also been proposed that problems with the mirror neuron system may underlie cognitive disorders, particularly autism. However the connection between mirror neuron dysfunction and autism is tentative and it remains to be seen how mirror neurons may be related to many of the important characteristics of autism.Despite the excitement generated by these findings, to date, no widely accepted neural or computational models have been put forward to describe how mirror neuron activity supports cognitive functions such as imitation. There are neuroscientists who caution that the claims being made for the role of mirror neurons are not supported by adequate research.
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