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The Anatomical Substrates of Wolff-Parkinson-White
The Anatomical Substrates of Wolff-Parkinson-White

... the underlying pathology. Indeed at present there is still a dispute regarding the precise anatomy that underlies the abnormal ventricular activation pattern found in this syndrome. Paladino' and Kent2 had described myocardial fibers ...
Predictors of Right Ventricular Systolic Dysfunction
Predictors of Right Ventricular Systolic Dysfunction

... Background: Right Ventricular (RV) functions are known to have an impact on determining the prognosis of patients with Non-Ischemic Dilated Cardiomyopathy (NICMP). Objectives: This study aimed to investigate the echocardiographic determinants of RV systolic dysfunction in patients with NICMP. Patien ...
The importance of long axis function
The importance of long axis function

... mitral valve disease. Hertz developed a camera that could display the motion mode (M-mode) of echo signals, and the first echocardiogram (or ultrasoundcardiogram as it was then known) was performed on 29 October 1953. Edler's work inspired new innovations in the field, and more than 25 million echoc ...
The Mechanics of Left Ventricular Contraction in Acute
The Mechanics of Left Ventricular Contraction in Acute

... or plasma expanders (3). In addition, this approach does not offer the possibility of quantitative comparison of ventricular contraction properties among different animals. It was considered, therefore, that a more promising avenue to the characterization of ventricular contraction in heart failure ...
Atrioventricular Junction Ablation In Atrial Fibrillation
Atrioventricular Junction Ablation In Atrial Fibrillation

... regurgitation secondary to mitral valve leaflet apposition due to RVA pacing,15 and sudden cardiac death (Figure 2).16 The latter has been described to occur more frequently in patients with certain comorbidities (diabetes mellitus, aortic valve lesions, ventricular rhythm disturbances, and chronic ...
Feasibility and efficacy of bypassing the right ventricle and
Feasibility and efficacy of bypassing the right ventricle and

... approach of right - sided assistance bypassing the right ventricle and pulmonary circulation in order to better decompress the right ventricle and optimize left ventricular filling. Methods: From a microaxial pump (Abiomed), a low resistance oxygenator (Maquet and Novalung) and two cannulas (28 and ...
Effect of the Intertrain Pause on the Ventricular Effective Refractory
Effect of the Intertrain Pause on the Ventricular Effective Refractory

... lengths typically used during clinical electrophysiology studies. Therefore, during determinations of the VERP, every few seconds the ventricular cycle length changed by an average of 350 msec. Prior experimental and clinical studies have demonstrated that when there is an abrupt decrease in cycle l ...
Current strategy for treatment of patient with Wolff–Parkinson–White
Current strategy for treatment of patient with Wolff–Parkinson–White

... The major finding from this EHRA EP network survey is that ablation in children with WPW is still performed in low numbers even in European high volume ablation centres, and the majority of centres will only perform ablation in children with overt WPW syndrome and recurrent episodes of AV reentry ta ...
Experimental Models of Heart Failure
Experimental Models of Heart Failure

... Congestive heart failure is one of the leading causes of cardiovascular morbidity and mortality. In the United States alone 550,000 new cases are diagnosed each year. Heart failure causes approximately 40,000 deaths a year and is a contributing factor in another 225,000 deaths in the US, where the d ...
Female athlete's heart: Systolic and diastolic function related to circulatory dimensions
Female athlete's heart: Systolic and diastolic function related to circulatory dimensions

... abstinence. All participants underwent a maximal upright bicycle cardiopulmonary exercise test including a 6-min steady state workload of 100 W followed by a continuous increment in workload of 10 W each minute until exhaustion, using an electrically braked bicycle ergometer (eBike Basic, GE Medical ...
Relative Contributions of the Atrial Systole
Relative Contributions of the Atrial Systole

... at the end of the experiment with a challenge infusion of isoproterenol, 5 ^g/min. Ganglionic blockade was demonstrated by observing the absence of heart rate changes to abrupt changes in arterial pressure. Isovolumic Left Ventricle Preparation.—Experiments were also performed in ten mongrel dogs of ...
Gene Transfer of a Synthetic Pacemaker Channel Into
Gene Transfer of a Synthetic Pacemaker Channel Into

... Flexibility for Frequency Tuning of SPC Unlike previous studies with adenoviral HCN2 delivered into other regions of the heart,2,3 we induced biopacemaker activity with SPC in ventricular myocardium. An alternative approach has been to use mesenchymal stem cells as a platform for gene delivery to th ...
Why Do We Have Purkinje Fibers Deep in Our Heart?
Why Do We Have Purkinje Fibers Deep in Our Heart?

... network of cells in the sheep heart, and noted their microscopic characteristics, including the presence of one or two nuclei and cross striations, which made him, after some discussion, consider them a special form muscular tissue (Eliska 2006). It took more than fifty years before a Swiss physiolo ...
Larger Cell Size in Rabbits With Heart Failure Increases Myocardial
Larger Cell Size in Rabbits With Heart Failure Increases Myocardial

... Background—Patients with heart failure (HF) have an increased QRS duration, usually attributed to decreased conduction velocity (CV) due to ionic remodeling but which may alternatively result from increased heart size or cellular uncoupling. We investigated the relationship between QRS width, heart ...
Management of Arrhythmias in Heart Failure
Management of Arrhythmias in Heart Failure

... hearts is a prolonged action potential duration, reflecting delayed terminal repolarization of the cardiac myocyte [24]. These cellular electrophysiological changes were mechanistically linked to downregulation of repolarizing potassium currents, an increase in late sodium current density, as well a ...
Heart Rate Variability in Time Domain after Acute Myocardial Infarction
Heart Rate Variability in Time Domain after Acute Myocardial Infarction

... for various clinical indications. There were 245 sudden deaths (3.7%) during two years of follow-up. A comparison of HRV variables and other clinical panmcters in these sudden death patients as well as in 230 patients randomly selected out of the rest of the large population showed SD and SDANN as b ...
Complex inheritance for susceptibility to sudden cardiac death
Complex inheritance for susceptibility to sudden cardiac death

... (< 65 years of age) independent of parental history of MI contributed to a greater risk of SCD (RR = 2.7) 25. Similarly, in the Paris Prospective Study, selectively performed in men, among whom 118 cases of sudden death occurred, SCD of one parent was found to be an independent risk factor for sudd ...
Right Ventricular Ejection Fraction Angiography
Right Ventricular Ejection Fraction Angiography

... To evaluate the reproducibility of our method, six patients with ischemic heart disease who had normal right ventricular ejection fractions were injected twice with 8 mCi of 99mTc DTPA* within a 30 min time interval without changing position. Because of the smaller amount of activity injected the ga ...
Atrial fibrillation - Giornale Italiano di Cardiologia
Atrial fibrillation - Giornale Italiano di Cardiologia

... procedural endpoint is the total disconnection or dissociation of the PV. Additional ostial applications to eliminate all ostial PV potentials, notably between the PVs and at their posterior wall, reduce the risk of recurrence due to ostial foci. While the use of a circumferential mapping catheter p ...
Evaluation of Palpitations: Etiology and Diagnostic
Evaluation of Palpitations: Etiology and Diagnostic

... then analyzed. If palpitations occurred during the monitoring period, correlation of the symptoms with an underlying arrhythmia based on the rhythm strip and the diary may be possible. If symptoms occur but there is no arrhythmia, a cardiac cause is less likely, and it is appropriate to look for non ...
Cardiac magnetic resonance imaging-based myocardial strain study
Cardiac magnetic resonance imaging-based myocardial strain study

... high-tuning images allowed a SENC strain map to be plotted, which was overlaid pixel-by-pixel on the anatomical images [14, 19]. In contrast with conventional tagging, in SENC-CMR the gradient is applied in the slice selection direction [14], therefore, the short-axis view shows longitudinal myocard ...
Atrial Fibrillation Tutorial
Atrial Fibrillation Tutorial

... centers experienced in this technique. It therefore involves more procedural risks than other procedures to treat atrial fibrillation and is performed by a skilled cardiac electrophysiologist (a doctor specialized in the treatment of heart rhythm disorders). Procedures often take 3-5 hours to perfor ...
Backgrounder: The Risk of Stroke in Atrial Fibrillation
Backgrounder: The Risk of Stroke in Atrial Fibrillation

... Atrial fibrillation, or AF, is the most common type of arrhythmia, a problem with the rate or rhythm of the heartbeat. During an arrhythmia, the heart can beat too fast, too slow, or with an irregular rhythm. AF occurs if rapid, disorganised electrical signals cause the heart's two upper chambers, t ...
Arrhythmia Risk and Arterial Stiffness
Arrhythmia Risk and Arterial Stiffness

... PR interval prolongation exceeding 200 ms characterizes the first-degree atrioventricular block and is very common in clinical practice, its prevalence increasing with age and several clinical conditions [20,21]. It is related to increased vagal tone in young and degenerative changes in old subjects ...
Cardiac arrhythmias in acute coronary syndromes
Cardiac arrhythmias in acute coronary syndromes

... arrhythmogenic mechanisms, the currents flowing from the ischaemic/reperfused to the non-ischaemic zones are most important. The mechanisms responsible for the initiation of these VA may differ based on the underlying disease (Figure 1)4: (intramural) re-entry in ischaemia, whereas triggered activit ...
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Ventricular fibrillation



Ventricular fibrillation (V-fib or VF) is a condition in which there is uncoordinated contraction of the cardiac muscle of the ventricles in the heart, making them quiver rather than contract properly. Ventricular fibrillation is the most commonly identified arrhythmia in cardiac arrest patients. While there is some activity, the lay person is usually unable to detect it by palpating (feeling) the major pulse points of the carotid and femoral arteries. Such an arrhythmia is only confirmed by electrocardiography. Ventricular fibrillation is a medical emergency that requires prompt Advanced Life Support interventions. If this arrhythmia continues for more than a few seconds, it will likely degenerate further into asystole (""flatline""). This condition results in cardiogenic shock and cessation of effective blood circulation. As a consequence, sudden cardiac death (SCD) will result in a matter of minutes. If the patient is not revived after a sufficient period (within roughly 5 minutes at room temperature), the patient could sustain irreversible brain damage and possibly become brain-dead, due to the effects of cerebral hypoxia. On the other hand, death often occurs if sinus rhythm is not restored within 90 seconds of the onset of VF, especially if it has degenerated further into asystole.
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