Atrial-Selective Approaches for the Treatment of Atrial Fibrillation
... hampered by several important weaknesses. Besides limited clinical efficacy (cardioversion success and sinusrhythm maintenance), side effects like ventricular proarrhythmia and negative inotropy are important limitations to present class I and III drug therapy. Although no statistically significant ...
... hampered by several important weaknesses. Besides limited clinical efficacy (cardioversion success and sinusrhythm maintenance), side effects like ventricular proarrhythmia and negative inotropy are important limitations to present class I and III drug therapy. Although no statistically significant ...
Effects of the Purkinje system and cardiac geometry on
... criteria. Sub-optimal resynchronization resulting from current pacing protocols has been proposed as a potential cause underlying treatment failure.1,6 As the use of whole heart computational models for electrophysiological simulations becomes more feasible,31,43 they are starting to be considered a ...
... criteria. Sub-optimal resynchronization resulting from current pacing protocols has been proposed as a potential cause underlying treatment failure.1,6 As the use of whole heart computational models for electrophysiological simulations becomes more feasible,31,43 they are starting to be considered a ...
Atrial Fibrillation: Diagnosis and Treatment
... narrow unless other conduction abnormalities exist (e.g., bundle branch block, accessory pathways). The ventricular response is often rapid, between 90 and 170 beats per minute. Atrial fibrillation is a source of significant morbidity and mortality because it impairs cardiac function and increases t ...
... narrow unless other conduction abnormalities exist (e.g., bundle branch block, accessory pathways). The ventricular response is often rapid, between 90 and 170 beats per minute. Atrial fibrillation is a source of significant morbidity and mortality because it impairs cardiac function and increases t ...
Recommendations for participation in leisure
... document from the European Study Group on Sports Cardiology recommended the routine addition of an electrocardiogram (ECG), given its key role in the identification of cardiovascular diseases [10]. This section gives a brief summary of the diagnostic evaluation from an arrhythmic perspective, applyi ...
... document from the European Study Group on Sports Cardiology recommended the routine addition of an electrocardiogram (ECG), given its key role in the identification of cardiovascular diseases [10]. This section gives a brief summary of the diagnostic evaluation from an arrhythmic perspective, applyi ...
Na/K pump regulation of cardiac repolarization
... have allowed quantification of the specific role of the pump in cardiac electrophysiology, by monitoring the evolution of specific ionic properties under a variety of conditions. This has yielded novel insights on the importance of the Na/K pump in regulating cellular repolarization, both through di ...
... have allowed quantification of the specific role of the pump in cardiac electrophysiology, by monitoring the evolution of specific ionic properties under a variety of conditions. This has yielded novel insights on the importance of the Na/K pump in regulating cellular repolarization, both through di ...
Catheter Ablation in the Treatment of Atrial Fibrillation
... Frequently Asked Question Who is currently a candidate for AF ablation? ...
... Frequently Asked Question Who is currently a candidate for AF ablation? ...
Electrocardiographic Early Repolarization A Scientific Statement
... he early repolarization (ER) pattern (ERP), initially described as elevation of the ST segment of ≥1 leads on the 12-lead ECG, has long been considered a benign phenomenon. However, more recent studies have demonstrated positive, negative, and neutral associations between an ERP and various end poin ...
... he early repolarization (ER) pattern (ERP), initially described as elevation of the ST segment of ≥1 leads on the 12-lead ECG, has long been considered a benign phenomenon. However, more recent studies have demonstrated positive, negative, and neutral associations between an ERP and various end poin ...
Right Ventricular Geometry and Function in Pulmonary
... stratifying patients prognosis. However, it is important to underline that the prognostic power of RV longitudinal strain has been demonstrated in patients with pre-capillary PH, but not in patients with post-capillary PH (group 2 according to Dana Point classification) [45]. The exclusion of group ...
... stratifying patients prognosis. However, it is important to underline that the prognostic power of RV longitudinal strain has been demonstrated in patients with pre-capillary PH, but not in patients with post-capillary PH (group 2 according to Dana Point classification) [45]. The exclusion of group ...
electrocardiography
... Figure 5. Quick determination of the mean QRS axis using the quadrant method (example). If in lead aVF the QRS complex is predominantly positive (left image), the axis of the QRS complex lays in the lower semicircle (corresponding to the positive pole of lead aVF); if in lead I the QRS complex is p ...
... Figure 5. Quick determination of the mean QRS axis using the quadrant method (example). If in lead aVF the QRS complex is predominantly positive (left image), the axis of the QRS complex lays in the lower semicircle (corresponding to the positive pole of lead aVF); if in lead I the QRS complex is p ...
Antiarrhythmic Effect of Nifekalant on Atrial Tachyarrhythmia in Four
... Objectives. Nifekalant is a class Ⅲ antiarrhythmic drug, which prolongs the refractory period of the atrial and ventricular myocardium, without negative inotropic action. Intravenous nifekalant was administered in four patients with atrial tachyarrhythmia and severe heart failure to terminate or pre ...
... Objectives. Nifekalant is a class Ⅲ antiarrhythmic drug, which prolongs the refractory period of the atrial and ventricular myocardium, without negative inotropic action. Intravenous nifekalant was administered in four patients with atrial tachyarrhythmia and severe heart failure to terminate or pre ...
Prosthesis–patient mismatch after aortic valve replacement
... (BSA), or indexed EOA, of 0.85 cm2/m2 or less1 and has been observed in 19% to 70% of patients undergoing AVR.2,3 Smaller mismatch thresholds of 0.80 cm2/m2 or less, 0.75 cm2/m2 or less, and 0.65 cm2/m2 or less have been proposed by some investigators.2,3 The effect of PPM on survival and left ventr ...
... (BSA), or indexed EOA, of 0.85 cm2/m2 or less1 and has been observed in 19% to 70% of patients undergoing AVR.2,3 Smaller mismatch thresholds of 0.80 cm2/m2 or less, 0.75 cm2/m2 or less, and 0.65 cm2/m2 or less have been proposed by some investigators.2,3 The effect of PPM on survival and left ventr ...
A Study of Early Afterdepolarizations in a Model for Human
... Naz /Kz exchanger current. In many cases such changes were made to mimic the onset of the long-QT syndrome or to describe the action of a certain drug. Except in the study of Ref. [22], only a few parameters were changed and then set to very specific values. Comprehensive studies, which require grad ...
... Naz /Kz exchanger current. In many cases such changes were made to mimic the onset of the long-QT syndrome or to describe the action of a certain drug. Except in the study of Ref. [22], only a few parameters were changed and then set to very specific values. Comprehensive studies, which require grad ...
Ventricular Nuclei-DNA Relationships with Myocardial Growth and
... measurements of nuclear DNA, have described significant degrees of nuclear polyploidization in normal and hypertrophied human hearts; (c) there may have been increased mitotic activity of the cardiac muscle cells or any of the other ventricular cell types. Indeed, proliferation of the muscle nuclei ...
... measurements of nuclear DNA, have described significant degrees of nuclear polyploidization in normal and hypertrophied human hearts; (c) there may have been increased mitotic activity of the cardiac muscle cells or any of the other ventricular cell types. Indeed, proliferation of the muscle nuclei ...
Management of Patients with Atrial Fibrillation: Focus on
... play important role both in the diagnosis and treatment of atrial fibrillation. Incidence of pacemaker-detected AF may reach 50% and its burden is associated with increased stroke risk.40,41 However, it was found that patients with subclinical pacemaker-detected AF are significantly less frequently ...
... play important role both in the diagnosis and treatment of atrial fibrillation. Incidence of pacemaker-detected AF may reach 50% and its burden is associated with increased stroke risk.40,41 However, it was found that patients with subclinical pacemaker-detected AF are significantly less frequently ...
Arrhythmogenic right ventricular cardiomyopathy Is it right?
... cardiovascular disease has decreased in recent decades. In Europe as well as in the United States, the incidence of SCD is estimated at almost 50-100 cases/100.000 people per year with some geographic variation [1, 2]. Resuscitation is still unsuccessful in 70% to 95% of the cases of Out-of-Hospital ...
... cardiovascular disease has decreased in recent decades. In Europe as well as in the United States, the incidence of SCD is estimated at almost 50-100 cases/100.000 people per year with some geographic variation [1, 2]. Resuscitation is still unsuccessful in 70% to 95% of the cases of Out-of-Hospital ...
Circulation: Heart Failure Topic Review
... patients are more or less likely to benefit from CRT remains a therapeutic challenge. Left ventricular mechanical dyssynchrony has been suggested as a method for overcoming the limitations of estimating electric dyssynchrony. Echocardiographic assessments of both left ventricular mechanical dyssynch ...
... patients are more or less likely to benefit from CRT remains a therapeutic challenge. Left ventricular mechanical dyssynchrony has been suggested as a method for overcoming the limitations of estimating electric dyssynchrony. Echocardiographic assessments of both left ventricular mechanical dyssynch ...
Electrocardiography and Repolarization Abnormalities in Cardiac
... heterogeneity when all cells are uniformly delayed in repolarization, and also heterogeneity within the ventricle without prolongation of the QT. Repolarization in the ventricles is highly dependent on the function of a number of cardiac channels involved with the generation of individual action pot ...
... heterogeneity when all cells are uniformly delayed in repolarization, and also heterogeneity within the ventricle without prolongation of the QT. Repolarization in the ventricles is highly dependent on the function of a number of cardiac channels involved with the generation of individual action pot ...
Ibutilide Pretreatment to Facilitate Cardioversion of Refractory Atrial
... flutter.7 Pharmacokinetic studies with ibutilide have shown a dose-dependent, weight-based response in chemical cardioversion. A dose–response trial examined the effects of single doses of ibutilide, ranging from 0.005 to 0.025 mg/kg (total body weight), on the rate of chemical cardioversion of atri ...
... flutter.7 Pharmacokinetic studies with ibutilide have shown a dose-dependent, weight-based response in chemical cardioversion. A dose–response trial examined the effects of single doses of ibutilide, ranging from 0.005 to 0.025 mg/kg (total body weight), on the rate of chemical cardioversion of atri ...
Hemodynamics and Ventricular Function in the Day-12 Rat
... In seven embryos, cardiac image was recorded by a highspeed video system (HSV-400, NAC, Tokyo, Japan) with a speed of 200 framesls. From the images, a ventricular outer (epicardial) border was manually traced and its area was obtained by a computer-assisted planimetry for each frame to construct a t ...
... In seven embryos, cardiac image was recorded by a highspeed video system (HSV-400, NAC, Tokyo, Japan) with a speed of 200 framesls. From the images, a ventricular outer (epicardial) border was manually traced and its area was obtained by a computer-assisted planimetry for each frame to construct a t ...
AHA Scientific Statement
... he early repolarization (ER) pattern (ERP), initially described as elevation of the ST segment of ≥1 leads on the 12-lead ECG, has long been considered a benign phenomenon. However, more recent studies have demonstrated positive, negative, and neutral associations between an ERP and various end poin ...
... he early repolarization (ER) pattern (ERP), initially described as elevation of the ST segment of ≥1 leads on the 12-lead ECG, has long been considered a benign phenomenon. However, more recent studies have demonstrated positive, negative, and neutral associations between an ERP and various end poin ...
Myocardial Volume and Organization Are Changed by Failure of
... but appears to have a normal length in postmortem specimens even though the configuration of the outflow tract is abnormal (Waldo et al., 1999; Yelbuz et al., 2002). This finding suggests a rearrangement of myocardial cells in the looping heart tube to compensate for the lack of myocardial cells that s ...
... but appears to have a normal length in postmortem specimens even though the configuration of the outflow tract is abnormal (Waldo et al., 1999; Yelbuz et al., 2002). This finding suggests a rearrangement of myocardial cells in the looping heart tube to compensate for the lack of myocardial cells that s ...
Heart failure post-myocardial infarction: a review of the - Heart
... By resynchronising the contraction of the ventricle following its injury by myocardial infarction, or other disease process, it is possible to improve cardiac function and to keep patients out of hospital. The MUSTIC9 and MIRACLE10 trials both showed clinical benefit from biventricular pacing. There ...
... By resynchronising the contraction of the ventricle following its injury by myocardial infarction, or other disease process, it is possible to improve cardiac function and to keep patients out of hospital. The MUSTIC9 and MIRACLE10 trials both showed clinical benefit from biventricular pacing. There ...
Biventricular Pacing in Patients with Bradycardia and Normal
... or biventricular pacing, depending on the programming of the device (InSync III, Medtronic). In brief, the right atrial and right ventricular leads were positioned at the right atrial appendage and the right ventricular apex, respectively, through a transvenous route. The left ventricular lead was p ...
... or biventricular pacing, depending on the programming of the device (InSync III, Medtronic). In brief, the right atrial and right ventricular leads were positioned at the right atrial appendage and the right ventricular apex, respectively, through a transvenous route. The left ventricular lead was p ...
Immediate Hemodynamic Response of Patients with
... period after pacing were allowed to elapse before continuing the study. Left ventricular minute work, in kg-m, was calculated as the product of the cardiac output (L/min), the planimeterized mean systolic aortic pressure (mm Hg), and 0.0144. The left ventricular stroke work, in g-m, was the product ...
... period after pacing were allowed to elapse before continuing the study. Left ventricular minute work, in kg-m, was calculated as the product of the cardiac output (L/min), the planimeterized mean systolic aortic pressure (mm Hg), and 0.0144. The left ventricular stroke work, in g-m, was the product ...
Applications of transesophageal echocardiography in treating
... TEE-guided VSD closure occluder, the shunt opening might be increased than before, the release of the left disk 31 patients were performed successful closure may cause significant residual shunt, and if (91.1%, 31/34), and immediately evaluated inthe occluder was selected appropriately, the traopera ...
... TEE-guided VSD closure occluder, the shunt opening might be increased than before, the release of the left disk 31 patients were performed successful closure may cause significant residual shunt, and if (91.1%, 31/34), and immediately evaluated inthe occluder was selected appropriately, the traopera ...
Ventricular fibrillation
Ventricular fibrillation (V-fib or VF) is a condition in which there is uncoordinated contraction of the cardiac muscle of the ventricles in the heart, making them quiver rather than contract properly. Ventricular fibrillation is the most commonly identified arrhythmia in cardiac arrest patients. While there is some activity, the lay person is usually unable to detect it by palpating (feeling) the major pulse points of the carotid and femoral arteries. Such an arrhythmia is only confirmed by electrocardiography. Ventricular fibrillation is a medical emergency that requires prompt Advanced Life Support interventions. If this arrhythmia continues for more than a few seconds, it will likely degenerate further into asystole (""flatline""). This condition results in cardiogenic shock and cessation of effective blood circulation. As a consequence, sudden cardiac death (SCD) will result in a matter of minutes. If the patient is not revived after a sufficient period (within roughly 5 minutes at room temperature), the patient could sustain irreversible brain damage and possibly become brain-dead, due to the effects of cerebral hypoxia. On the other hand, death often occurs if sinus rhythm is not restored within 90 seconds of the onset of VF, especially if it has degenerated further into asystole.