Human Cardiac Troponin Complex. Structure and Functions
... as to impede the actomyosin complex formation [76, 77]. A few variants of the inhibitory domain structure are presented in the literature. In the work of Brown et al. [74] on artificial troponin complex composed of different animal troponins, by means of site-directed spin labeling (SDSL-EPR) it was ...
... as to impede the actomyosin complex formation [76, 77]. A few variants of the inhibitory domain structure are presented in the literature. In the work of Brown et al. [74] on artificial troponin complex composed of different animal troponins, by means of site-directed spin labeling (SDSL-EPR) it was ...
The Platform Protein Is Essential for Type IV Pilus
... both the motor and alignment subcomplexes in the T4P and T2S systems have been suggested to transduce the conformational changes of the ATPases (26, 27), making it challenging to propose a unifying model of fiber assembly and function. In the P. aeruginosa T4aP system, the platform protein PilC was ...
... both the motor and alignment subcomplexes in the T4P and T2S systems have been suggested to transduce the conformational changes of the ATPases (26, 27), making it challenging to propose a unifying model of fiber assembly and function. In the P. aeruginosa T4aP system, the platform protein PilC was ...
Slide 1
... • there is a high diversity between the SSH libraries of O2 and O78 strains, with only a few shared genes coding for virulence factors • unexpected for two strains causing the ...
... • there is a high diversity between the SSH libraries of O2 and O78 strains, with only a few shared genes coding for virulence factors • unexpected for two strains causing the ...
Biogenesis and multifaceted roles of outer membrane
... are needed for a distant activity, for example degradation of complex molecules from a solid surface, then OMVs can co-transport proteins so that they reach the remote site simultaneously. Thus, the energy expenditure of the cell in making OMVs is justified by their action on remote targets with hig ...
... are needed for a distant activity, for example degradation of complex molecules from a solid surface, then OMVs can co-transport proteins so that they reach the remote site simultaneously. Thus, the energy expenditure of the cell in making OMVs is justified by their action on remote targets with hig ...
Outer Membrane Vesicle-Mediated Export of
... which has recently been referred to as the “Type 0” (zero) secretion system [14]. Outer membrane vesicles (OMVs) (diameter 20–200 nm) are constantly discharged from the surface of the Gram-negative bacteria during growth, and may entrap outer membrane proteins, LPS, phospholipids, and some periplas ...
... which has recently been referred to as the “Type 0” (zero) secretion system [14]. Outer membrane vesicles (OMVs) (diameter 20–200 nm) are constantly discharged from the surface of the Gram-negative bacteria during growth, and may entrap outer membrane proteins, LPS, phospholipids, and some periplas ...
Klebsiella Pneumoniae
... I am occasionally pathogenic and I affect the liver, urinary tract and lung. It is important to mention I have virulence factors, below is brief explanation of how this relates to me; “First, the presence of cell wall receptors enables K. pneumoniae to attach to the host cell, thereby altering the b ...
... I am occasionally pathogenic and I affect the liver, urinary tract and lung. It is important to mention I have virulence factors, below is brief explanation of how this relates to me; “First, the presence of cell wall receptors enables K. pneumoniae to attach to the host cell, thereby altering the b ...
Bacterial Symbioses and the Innate Immune Response of the Model
... I would first like to thank my advisor, Dr. Spencer Nyholm for supervising my research for the past seven years. I am also grateful to the members of my committee, Dr. Joerg Graf, Dr. Daniel Gage, Dr. David Benson and Dr. Steven Geary, who asked held me to a high standard and asked really good quest ...
... I would first like to thank my advisor, Dr. Spencer Nyholm for supervising my research for the past seven years. I am also grateful to the members of my committee, Dr. Joerg Graf, Dr. Daniel Gage, Dr. David Benson and Dr. Steven Geary, who asked held me to a high standard and asked really good quest ...
Mechanisms of transport through the Golgi complex
... coat complex (blue) to the membrane by the GTP-bound form of the G protein. Membrane curvature and sorting of cargo (yellow) into the forming bud ensue, followed by fission of the coated bud to form a vesicle. Hydrolysis of GTP eventually leads to release of the coat from the vesicle. The vesicle is ...
... coat complex (blue) to the membrane by the GTP-bound form of the G protein. Membrane curvature and sorting of cargo (yellow) into the forming bud ensue, followed by fission of the coated bud to form a vesicle. Hydrolysis of GTP eventually leads to release of the coat from the vesicle. The vesicle is ...
original version
... This superfamily consists of a great diversity of protein set, ranging from no metal, mononuclear zinc, dinuclear zinc to dinuclear iron active sites. At least 17 different catalytic activities and mechanisms have been reported within this superfamily, including nitric oxide and oxygen reduction [33 ...
... This superfamily consists of a great diversity of protein set, ranging from no metal, mononuclear zinc, dinuclear zinc to dinuclear iron active sites. At least 17 different catalytic activities and mechanisms have been reported within this superfamily, including nitric oxide and oxygen reduction [33 ...
QUORUM SENSING: Cell-to-Cell Communication in Bacteria
... Abstract Bacteria communicate with one another using chemical signal molecules. As in higher organisms, the information supplied by these molecules is critical for synchronizing the activities of large groups of cells. In bacteria, chemical communication involves producing, releasing, detecting, and ...
... Abstract Bacteria communicate with one another using chemical signal molecules. As in higher organisms, the information supplied by these molecules is critical for synchronizing the activities of large groups of cells. In bacteria, chemical communication involves producing, releasing, detecting, and ...
Anders Nilsson
... Interfering with antibiotic resistance genes Inhibition of bacterial metabolism Genes for wider host spectrum ...
... Interfering with antibiotic resistance genes Inhibition of bacterial metabolism Genes for wider host spectrum ...
Targeted wild-type and jerker espins reveal a novel, WH2
... Moreover, deletion of the 17-aa core also reduced the rapid recovery of photobleached GFP--actin observed throughout the length of the long microvilli of espin-expressing epithelial cells, suggesting that the WH2 domain of PAB-associated espins can also bind actin monomer in vivo (Loomis et al., 20 ...
... Moreover, deletion of the 17-aa core also reduced the rapid recovery of photobleached GFP--actin observed throughout the length of the long microvilli of espin-expressing epithelial cells, suggesting that the WH2 domain of PAB-associated espins can also bind actin monomer in vivo (Loomis et al., 20 ...
Orally Used Aminoglycosides
... They preserve the Gram (+) properties of ampicillin but have higher activities against Gram (-) bacteria. Longer side chain moiety may better mimic the peptidoglycan chain resulting in better binding interactions with the PBPs. β-lactamases are a source of resistance. Tazobactam is sometimes ...
... They preserve the Gram (+) properties of ampicillin but have higher activities against Gram (-) bacteria. Longer side chain moiety may better mimic the peptidoglycan chain resulting in better binding interactions with the PBPs. β-lactamases are a source of resistance. Tazobactam is sometimes ...
PapD-like chaperones and pilus biogenesis
... subunit groove. In other words, the chaperone may couple the folding of the subunit with the capping of the groove. Then, during donor strand exchange, the N-terminal extension of the neighboring subunit would replace the G1 strand of the chaperone in the groove, thus preventing the exposure of the ...
... subunit groove. In other words, the chaperone may couple the folding of the subunit with the capping of the groove. Then, during donor strand exchange, the N-terminal extension of the neighboring subunit would replace the G1 strand of the chaperone in the groove, thus preventing the exposure of the ...
- Wiley Online Library
... (11). Even there, the identities of most transporters are not known, while their activities have been demonstrated. The published latex-bead-containing phagosomes (LBP) protein inventory, surprisingly, does not list relevant transporter proteins either (12), indicating that there is a whole area of ...
... (11). Even there, the identities of most transporters are not known, while their activities have been demonstrated. The published latex-bead-containing phagosomes (LBP) protein inventory, surprisingly, does not list relevant transporter proteins either (12), indicating that there is a whole area of ...
Intestinal microbiota and metabolites—Implications for broiler
... as much as 30% of their energy from SCFAproducing hindgut fermentation [37, 38]. Ruminants obtain almost all their energy from SCFA produced in the rumen. In addition to energyyielding activity, SCFA formation in chicken cecum reduces pH of the intestinal environment, which may inhibit acid-sensitiv ...
... as much as 30% of their energy from SCFAproducing hindgut fermentation [37, 38]. Ruminants obtain almost all their energy from SCFA produced in the rumen. In addition to energyyielding activity, SCFA formation in chicken cecum reduces pH of the intestinal environment, which may inhibit acid-sensitiv ...
Neisseria - Caangay.com
... with poor survival –cool temperature • Structure is typical of Gram negative • Outer surface is not covered with a true CHON capsule ...
... with poor survival –cool temperature • Structure is typical of Gram negative • Outer surface is not covered with a true CHON capsule ...
J. Exp. Microbiol. Immunol. 2004. 6:52-58.
... an optimum pH of 6.0-9.0, temperature range of 20°C to 30°C and under aerobic metabolism conditions. In addition to the previously mentioned conditions, a special selective medium that is inorganic and includes ammonia as an electron donor, bicarbonate as the sole carbon source for the isolation of ...
... an optimum pH of 6.0-9.0, temperature range of 20°C to 30°C and under aerobic metabolism conditions. In addition to the previously mentioned conditions, a special selective medium that is inorganic and includes ammonia as an electron donor, bicarbonate as the sole carbon source for the isolation of ...
Arguments Reinforcing the Three-Domain View of Diversified
... ToL reconstructions from concatenated ribosomal proteins and the small-subunit ribosomal RNA (SSU rRNA) gene produced conflicting topologies with the former supporting the AAS while the latter recovering the “Woesian” three-domain (3D) ToL [14] of cellular diversification into domains Archaea, Bacte ...
... ToL reconstructions from concatenated ribosomal proteins and the small-subunit ribosomal RNA (SSU rRNA) gene produced conflicting topologies with the former supporting the AAS while the latter recovering the “Woesian” three-domain (3D) ToL [14] of cellular diversification into domains Archaea, Bacte ...
SECONDARY SOLUTE TRANSPORT IN BACTERIA Poolman
... structure of the cell envelope into Gram-negative and Gram-positive. The cell envelope of Gram-negative bacteria is composed of a cytoplasmic membrane, a peptidoglycan layer, and an outer membrane that contains lipopolysaccharides (LPS) at its outer surface [1]. Gram-positive bacteria lack the outer ...
... structure of the cell envelope into Gram-negative and Gram-positive. The cell envelope of Gram-negative bacteria is composed of a cytoplasmic membrane, a peptidoglycan layer, and an outer membrane that contains lipopolysaccharides (LPS) at its outer surface [1]. Gram-positive bacteria lack the outer ...
Phylogeny of Prosthecobacter, the Fusiform Caulobacters: Members
... Pirellula staleyi 16s rRNA secondary-structure model (17) to check for correct alignment of homologous nucleotides and to allow for comparisons of secondarystructure motifs. Since the data set included sequences from taxa belonging to many divisions of the Bacteria, certain regions of the 16s rRNA g ...
... Pirellula staleyi 16s rRNA secondary-structure model (17) to check for correct alignment of homologous nucleotides and to allow for comparisons of secondarystructure motifs. Since the data set included sequences from taxa belonging to many divisions of the Bacteria, certain regions of the 16s rRNA g ...
Role of the leader sequence in tobacco pectin methylesterase
... belongs to PME clade Plant 1 [4]. Unprocessed proPME protein contained the 255-aa long N-terminal leader (PS) preceding the 319-aa mature PME portion (Fig. 1A, underlined sequence). The PME from Daucus carota (P83218) might be considered as the type member of this clade, since its 3D structure was r ...
... belongs to PME clade Plant 1 [4]. Unprocessed proPME protein contained the 255-aa long N-terminal leader (PS) preceding the 319-aa mature PME portion (Fig. 1A, underlined sequence). The PME from Daucus carota (P83218) might be considered as the type member of this clade, since its 3D structure was r ...
Loss of outer membrane porins in clonally related clinical isolates of
... CpxA-CpxR has also been shown to be required for K. pneumoniae survival in environments that mimic the host gastrointestinal tract (GI). This regulatory system is important in environments containing bile salts, high NaCl concentration, oxidative stressors (hydrogen peroxide), or disinfectants (chlo ...
... CpxA-CpxR has also been shown to be required for K. pneumoniae survival in environments that mimic the host gastrointestinal tract (GI). This regulatory system is important in environments containing bile salts, high NaCl concentration, oxidative stressors (hydrogen peroxide), or disinfectants (chlo ...
T R S M
... remain unidentified. The type V (two partner) system and type VI system act in adherence and/or competition with other microbes. Type I Secretion System: Metalloproteases and Adhesins The type I secretion system (T1SS) consists of only three proteins, and multiple T1SSs are encoded by SRE genomes. M ...
... remain unidentified. The type V (two partner) system and type VI system act in adherence and/or competition with other microbes. Type I Secretion System: Metalloproteases and Adhesins The type I secretion system (T1SS) consists of only three proteins, and multiple T1SSs are encoded by SRE genomes. M ...
Trimeric autotransporter adhesin
In molecular biology, trimeric autotransporter adhesins (TAAs), are proteins found on the outer membrane of Gram-negative bacteria. Bacteria use TAAs in order to infect their host cells via a process called cell adhesion. TAAs also go by another name, oligomeric coiled-coil adhesins, which is shortened to OCAs. In essence, they are virulence factors, factors that make the bacteria harmful and infective to the host organism.TAAs are just one of many methods bacteria use to infect their hosts, infection resulting in diseases such as pneumonia, sepsis, and meningitis. Most bacteria infect their host through a method named the secretion pathway. TAAs are part of the secretion pathway, to be more specific the type Vc secretion system.Trimeric autotransporter adhesins have a unique structure. The structure they hold is crucial to their function. They all appear to have a head-stalk-anchor structure. Each TAA is made up of three identical proteins, hence the name trimeric. Once the membrane anchor has been inserted into the outer membrane, the passenger domain passes through it into the host extracellular environment autonomously, hence the description of autotransporter. The head domain, once assembled, then adheres to an element of the host extracellular matrix, for example, collagen, fibronectin, etc.