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05. Motor Pathways 2011.jnt
05. Motor Pathways 2011.jnt

... brain must be conveyed to a single target, the large, alpha motor neurons. The efferent limb of reflexes. 3. Motor Unit. A single lower motor neuron (alpha) and all of the striated muscle cells innervated by its axon. Variations in force, range and type of movement are determined by the differences ...
Deep Tendon Reflex
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... affect the efferent fibers either directly or indirectly via interneurons.  When the reflex arc involves only one synapse, this is referred to as monosynaptic reflex arc. ...
Neuronal Activity and Ion Homeostasis in the Hypoxic Brain
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... depolarize en masse after having been silent for approximately a minute. In Chapter 4, initiation and propagation of spreading depolarization is investigated, a slow wave of depolarizing neurons. Simplified expressions will be derived that relate the wave form, propagation velocity, and triggering t ...
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Questions and Answers From Episode 27
Questions and Answers From Episode 27

... Answer: The olfactory consists of sensory receptors that are located in the nasal mucosa that are bathed in nasal mucus. The mucus protects the receptors and also contains growth factors that help to maintain the function of the receptors. In order for an odorant to be smelled, the receptor must be ...
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1 Introduction to Behavioral Endocrinology
1 Introduction to Behavioral Endocrinology

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... in an increase in probability of release and mEPSC frequency without a change in synapse density [33,35,36,42–46]. In contrast, decreasing AP generation in individual neurons decreases mESPC frequency and the size and density of presynaptic terminals formed with the silenced neuron [47], though it i ...
Sensory Receptors
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... had been denervated during early stages of their development, that is, before stabilization had taken place, muscle stimulation produces, in the absence of the nerve, metabolic stabilization of synaptic AChRs comparable to that during normal development (Rotzler and Brenner, 1990). Therefore, metabo ...
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The Autonomic Nervous System
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distribution of leucine-3h during axoplasmic
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PRESYNAPTIC IONOTROPIC RECEPTORS AND CONTROL OF
PRESYNAPTIC IONOTROPIC RECEPTORS AND CONTROL OF

... action potential. The associated membrane depolarization activates voltage-gated Ca2+-channels (VGCCs) within the terminal, including channels that are strategically placed near vesicle docking sites. Ca2+ entry stimulates release by promoting fusion of synaptic vesicles with the plasma membrane. Ac ...
Abnormal Neurotransmitter Release Underlying Behavioral and
Abnormal Neurotransmitter Release Underlying Behavioral and

... scarce, let us assume that depolarization-induced acetylcholine (ACh) release is decreased. Certainly, contemporary efforts to halt cognitive decline by administering acetylcholinesterase inhibitors (Koontz and Baskys, 2005) correspond with this scenario. However, an enormous number of neuropharmaco ...
Sensory Pathways and the Somatic Nervous System
Sensory Pathways and the Somatic Nervous System

... May be sensitive to: Temperature extremes, mechanical damage, dissolved chemicals, such as chemicals released by injured cells Are free nerve endings with large receptive fields. Two types of axons - Type A (myelinated for fast pain or prickling pain) ...
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Ca Channels As Integrators of G Protein
Ca Channels As Integrators of G Protein

... Modulation of calcium current by protein kinase C can occur through the activation of Gi or Gq. In the case of Gi, the ␤␥-subunits activate phospholipase C, which leads to the activation of protein kinase C (Fig. 2c). This response is prevented by pertussis toxin. Gq can inhibit Cav2.2 channels in a ...
Neural Oscillations
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... questions: function and mechanism It is not clear to date if oscillations are a necessary byproduct of neural interactions, or if they serve a specific function More is known about how oscillations arise in neural circuits; in fact, it seems quite difficult not to have oscillations to emerge when ne ...
14. Development and Plasticity
14. Development and Plasticity

... all presynaptic spike trains) in simulation of an IF-neuron with 1000 input channels. The spike trains that lead to the results shown by stars were generated with each weight value fixed to value 0.015. The cross-correlations are consistent with zero when considered within the variance indicated by ...
14. Development and Plasticity
14. Development and Plasticity

... all presynaptic spike trains) in simulation of an IF-neuron with 1000 input channels. The spike trains that lead to the results shown by stars were generated with each weight value fixed to value 0.015. The cross-correlations are consistent with zero when considered within the variance indicated by ...
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End-plate potential



End plate potentials (EPPs) are the depolarizations of skeletal muscle fibers caused by neurotransmitters binding to the postsynaptic membrane in the neuromuscular junction. They are called ""end plates"" because the postsynaptic terminals of muscle fibers have a large, saucer-like appearance. When an action potential reaches the axon terminal of a motor neuron, vesicles carrying neurotransmitters (mostly acetylcholine) are exocytosed and the contents are released into the neuromuscular junction. These neurotransmitters bind to receptors on the postsynaptic membrane and lead to its depolarization. In the absence of an action potential, acetylcholine vesicles spontaneously leak into the neuromuscular junction and cause very small depolarizations in the postsynaptic membrane. This small response (~0.5mV) is called a miniature end plate potential (MEPP) and is generated by one acetylcholine-containing vesicle. It represents the smallest possible depolarization which can be induced in a muscle.
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