3. Antiproliferative and antimetabolic drugs
... and B and T lymphocytes are highly dependent on this pathway for cell proliferation ...
... and B and T lymphocytes are highly dependent on this pathway for cell proliferation ...
3. Antiproliferative and antimetabolic drugs
... and B and T lymphocytes are highly dependent on this pathway for cell proliferation ...
... and B and T lymphocytes are highly dependent on this pathway for cell proliferation ...
Combined CBRT for 147 and 07 Posts of Drugs Inspector
... An antibiotic was given at a dose of 10 mg/kg by a single intravenous bolus injection to a 62 year old woman who weighed 80 kg. The antibiotic followed the pharmacokinetics of a onecompartment model and has an elimination half-life of 4 hours. The apparent volume of distribution is 0.50 L/kg. What i ...
... An antibiotic was given at a dose of 10 mg/kg by a single intravenous bolus injection to a 62 year old woman who weighed 80 kg. The antibiotic followed the pharmacokinetics of a onecompartment model and has an elimination half-life of 4 hours. The apparent volume of distribution is 0.50 L/kg. What i ...
ARVs and communities in crisis
... Before ARV drugs became available, it was possible to treat these ancillary infections, but not the HI virus itself. ARVs work by slowing the replication of HIV in the body. Different types of drugs suppress the process at different stages of the HIV lifecycle, making it necessary to take two - or p ...
... Before ARV drugs became available, it was possible to treat these ancillary infections, but not the HI virus itself. ARVs work by slowing the replication of HIV in the body. Different types of drugs suppress the process at different stages of the HIV lifecycle, making it necessary to take two - or p ...
Slide 1
... relatively resistant to antibiotics II. Mycobacterial cells can also be dormant and thus completely resistant to many drugs III. Lipid rich mycobacterial cell wall is impermeable to many agents IV. Substantial proportion of mycobacterial organism are intracellular, residing with macrophages and inac ...
... relatively resistant to antibiotics II. Mycobacterial cells can also be dormant and thus completely resistant to many drugs III. Lipid rich mycobacterial cell wall is impermeable to many agents IV. Substantial proportion of mycobacterial organism are intracellular, residing with macrophages and inac ...
Chapter 21
... well as members of genus Mycobacterium – Primarily used to treat tuberculosis and Hansen’s disease as well as preventing meningitis after exposure to N. meningitidis – Resistance due to mutation coding RNA polymerase • Resistance develops rapidly ...
... well as members of genus Mycobacterium – Primarily used to treat tuberculosis and Hansen’s disease as well as preventing meningitis after exposure to N. meningitidis – Resistance due to mutation coding RNA polymerase • Resistance develops rapidly ...
New TKI toward highly targeted therapies
... •Pan Bcr-Abl inhibitor (WT+ t315i + other mutated forms •Binding to the inactive form + ethinyl linkage (C≡C) •FDA-approved dec. 2012 ; Ariad ...
... •Pan Bcr-Abl inhibitor (WT+ t315i + other mutated forms •Binding to the inactive form + ethinyl linkage (C≡C) •FDA-approved dec. 2012 ; Ariad ...
3rd year antidepressant part 22011-09
... Moderate length (~24hr): Sertraline, Paroxetine, Citalopram. Metabolism: P450 through glucuronide or sulfate conjugation They are enzyme inhibitor Weak inhibitors < Sertraline, Citalopram interaction Strong inhibitors > Fluoxetine, Paroxetine metabolism of TCA, neuroleptic, some antiarrh ...
... Moderate length (~24hr): Sertraline, Paroxetine, Citalopram. Metabolism: P450 through glucuronide or sulfate conjugation They are enzyme inhibitor Weak inhibitors < Sertraline, Citalopram interaction Strong inhibitors > Fluoxetine, Paroxetine metabolism of TCA, neuroleptic, some antiarrh ...
Antiviral Therapy for Epstein-Barr Virus-Associated Diseases REVIEW ARTICLE Jung-Chung Lin
... of host cells (for a review see reference [32]). The selection of a suitable antiviral drug for treating virus diseases has been hampered by the fact that most antiviral compounds are capable of interfering with the molecular processes of host cell functions. Thus, the ideal antiviral drug would int ...
... of host cells (for a review see reference [32]). The selection of a suitable antiviral drug for treating virus diseases has been hampered by the fact that most antiviral compounds are capable of interfering with the molecular processes of host cell functions. Thus, the ideal antiviral drug would int ...
Perelson_Utrecht 2005
... Have developed a model of acute HBV infection that reproduces the observed HBV DNA and ALT kinetic patterns Model suggests that both cytolytic and noncytolytic responses play a role in viral clearance. The model also reveals that as infected cells are cleared and replaced by uninfected ones a mechan ...
... Have developed a model of acute HBV infection that reproduces the observed HBV DNA and ALT kinetic patterns Model suggests that both cytolytic and noncytolytic responses play a role in viral clearance. The model also reveals that as infected cells are cleared and replaced by uninfected ones a mechan ...
Drugs used to treat hypertension
... impairment, or in patients with hypertensive heart failure. - relatively short-acting (diuresis occurs over the 4 hours following a dose) used in hypertension if response to thiazides is inadequate Mechanism of action: - they inhibit the co-transport of Na+, K+ and Cl- of Ca2+ and Mg2+ excretion ...
... impairment, or in patients with hypertensive heart failure. - relatively short-acting (diuresis occurs over the 4 hours following a dose) used in hypertension if response to thiazides is inadequate Mechanism of action: - they inhibit the co-transport of Na+, K+ and Cl- of Ca2+ and Mg2+ excretion ...
Molecular Pharmacology of Nucleoside and Nucleotide HIV
... antiviral drug to be approved for clinical use. Zidovudine is a thymidine analog in which the 3’-OH group has been replaced with an azido (-N3) group (Figure 1). Zidovudine permeates the cell membrane by passive transport and not via a nucleoside carrier transporter (Zimmerman et al., 1987). It has ...
... antiviral drug to be approved for clinical use. Zidovudine is a thymidine analog in which the 3’-OH group has been replaced with an azido (-N3) group (Figure 1). Zidovudine permeates the cell membrane by passive transport and not via a nucleoside carrier transporter (Zimmerman et al., 1987). It has ...
CVS 5
... Platelet adhesion to site of vascular injury Activation of platelets by factors that include TxA2, ADP, serotonin, collagen & thrombin Increase expression of glycoprotein IIb/IIIa ...
... Platelet adhesion to site of vascular injury Activation of platelets by factors that include TxA2, ADP, serotonin, collagen & thrombin Increase expression of glycoprotein IIb/IIIa ...
Drugs - BIDD - National University of Singapore
... Molecules that restrict the action of the enzyme on its substrate are called inhibitors. Inhibitors may be irreversible or reversible. Reversible inhibitors may be: ...
... Molecules that restrict the action of the enzyme on its substrate are called inhibitors. Inhibitors may be irreversible or reversible. Reversible inhibitors may be: ...
8NMJ
... • Phase II: End-plate eventually repolarizes, but because succinycholine is not metabolized like ACh it continues to occupy the AChRs to “desensitize” the end-plate. ...
... • Phase II: End-plate eventually repolarizes, but because succinycholine is not metabolized like ACh it continues to occupy the AChRs to “desensitize” the end-plate. ...
protein binding - Website Staff UI
... distribution ( 440 L / 70 kg) and long t1/2 (40 hrs) • Some drugs complex with melanin in the skin and eye after long term administration of high doses of phenothiazine to chronic schizophrenic patients • Tetracycline – forms an insoluble chelate with calcium on teeth and bones • Amphetamin (phenile ...
... distribution ( 440 L / 70 kg) and long t1/2 (40 hrs) • Some drugs complex with melanin in the skin and eye after long term administration of high doses of phenothiazine to chronic schizophrenic patients • Tetracycline – forms an insoluble chelate with calcium on teeth and bones • Amphetamin (phenile ...
Therapeutic Potential of Spirooxindoles as Antiviral Agents
... reported to have antiviral activity against L100I, I135T, I135V, E138K, and F227L mutant viruses, poor antiviral activity was found against K103N, Y188C, and Y188L. 42 Further optimization would be required to achieve potency in all NNRTI-resistant mutant viruses. In addition, viral protein R (Vpr), ...
... reported to have antiviral activity against L100I, I135T, I135V, E138K, and F227L mutant viruses, poor antiviral activity was found against K103N, Y188C, and Y188L. 42 Further optimization would be required to achieve potency in all NNRTI-resistant mutant viruses. In addition, viral protein R (Vpr), ...
Chemotherapy of Viral Infections
... responds best to ganciclovir therapy, but recurs after treatment is stopped. The most frequent adverse side effects are granulocytopenia (neutropenia) and thrombocytopenia. Foscarnet (Foscavir) is the second drug used in the treatment of CMV infections, particularly CMV retinitis, in immunocompromis ...
... responds best to ganciclovir therapy, but recurs after treatment is stopped. The most frequent adverse side effects are granulocytopenia (neutropenia) and thrombocytopenia. Foscarnet (Foscavir) is the second drug used in the treatment of CMV infections, particularly CMV retinitis, in immunocompromis ...
Antimicrobial Agents
... protein synthesis that has already initiated and induce misreading of the mRNA. By binding to the 16 S r-RNA the aminoglycosides increase the affinity of the A site for t-RNA regardless of the anticodon specificity. May also destabilize bacterial membranes. • Spectrum of Activity -Many gram-negative ...
... protein synthesis that has already initiated and induce misreading of the mRNA. By binding to the 16 S r-RNA the aminoglycosides increase the affinity of the A site for t-RNA regardless of the anticodon specificity. May also destabilize bacterial membranes. • Spectrum of Activity -Many gram-negative ...
Antimicrobial Agents - Hashemite University
... protein synthesis that has already initiated and induce misreading of the mRNA. By binding to the 16 S r-RNA the aminoglycosides increase the affinity of the A site for t-RNA regardless of the anticodon specificity. May also destabilize bacterial membranes. • Spectrum of Activity -Many gram-negative ...
... protein synthesis that has already initiated and induce misreading of the mRNA. By binding to the 16 S r-RNA the aminoglycosides increase the affinity of the A site for t-RNA regardless of the anticodon specificity. May also destabilize bacterial membranes. • Spectrum of Activity -Many gram-negative ...
Freeman 1e: How we got there
... antimicrobial drug resistance in some human pathogens. A few organisms have developed resistance to all known antimicrobial drugs. ...
... antimicrobial drug resistance in some human pathogens. A few organisms have developed resistance to all known antimicrobial drugs. ...
Direct cholinergic agonists
... (muscarinic). In addition, because they increase the concentration of acetylcholine, they have effects at the neuromuscular junction (nicotinic). These drugs will cause the same side effects as the direct cholinergic agonists. They also affect nicotinic receptors, primarily at the neuromuscular junc ...
... (muscarinic). In addition, because they increase the concentration of acetylcholine, they have effects at the neuromuscular junction (nicotinic). These drugs will cause the same side effects as the direct cholinergic agonists. They also affect nicotinic receptors, primarily at the neuromuscular junc ...
Nonsteroidal Anti-inflammatory Drugs
... • Mainly on liver due to its active metabolite ( N-acetyl-pbenzoquinone). • At therapeutic doses increases hepatic enzymes. • At high doses causes hepatic necrosis & renal necrosis. • Treatment of paracetamol toxicity with N-acetylcystine (SH donor ) as life saving ...
... • Mainly on liver due to its active metabolite ( N-acetyl-pbenzoquinone). • At therapeutic doses increases hepatic enzymes. • At high doses causes hepatic necrosis & renal necrosis. • Treatment of paracetamol toxicity with N-acetylcystine (SH donor ) as life saving ...